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The map label for this gene is mltC [H]

Identifier: 16272702

GI number: 16272702

Start: 824001

End: 825074

Strand: Direct

Name: mltC [H]

Synonym: HI0761

Alternate gene names: 16272702

Gene position: 824001-825074 (Clockwise)

Preceding gene: 16272701

Following gene: 16272705

Centisome position: 45.02

GC content: 37.24

Gene sequence:

>1074_bases
ATGAAAAAATATTTATTATTGGCATTATTGCCTTTTTTGTATGCTTGTAGTAATTCATCGAATCAAGGTATTAACTATGA
TGAAGCCTTTGCTAAAGACACGCAAGGGTTAGATATTCTCACAGGGCAATTCTCGCATAATATTGACCGTATTTGGGGCG
TCAATGAATTGTTAGTGGCAAGCCGTAAAGATTATGTGAAATATACAGATTCTTTTTATACGCGTAGCCATGTGAGTTTT
GATGAAGGTAATATCGTTATTGAAACCCAGCAAGATTTAAATCGATTACATAATGCTATTGTTCATACCTTGTTAATGGG
AGCGGATGCAAAAGGTATTGATTTATTTGCATCTGGTGATGTGCCGATTAGCTCTCGCCCATTCCTTTTGGGGCAGGTTG
TAGATCATCAAGGGCAACACATTGCTAATCAAGTTATCGCAAGTAATTTCGCCACTTATTTGATTCAAAATAAATTGCAA
ACACGTCGATTACAAAACGGGCATACCGTGCAATTTGTCTCTGTTCCTATGATTGCAAACCACGTAGAAGTGCGTGCACG
AAAATATTTACCATTGATTCGTAAAGCTGCACAACGTTATGGCATTGATGAAAGTTTGATTTTGGGCATTATGCAAACAG
AATCAAGTTTTAACCCATATGCGATTAGCTACGCAAATGCTATTGGTTTAATGCAAGTCGTGCCTCATACAGCAGGTCGA
GATGTATTTGCAATGAAAGGCAAAGGTGGACAGCCATCAACGCGTTATTTATATGATCCTGCGAATAATATTGATGCTGG
TGTATCTTATTTGTGGATTTTACAAAATCAATATTTAGATGGAATTACGAATCCAACCTCAAAACGTTTTGCCATGATTT
CTGCGTATAATAGTGGTGCAGGCGCAGTGTTACGTGTTTTTGATAATGATAAGGATACGGCGATTTACAAAATCAACCAA
ATGTATCCAGAACAAGTTTATCGCATTCTAACGACGGTTCACCCATCATCACAAGCACGCAATTATTTGTTGAAAGTAGA
TAAAGCACAGAAAAAATTCCGTGTTAGACGATAA

Upstream 100 bases:

>100_bases
GTAAATTATTAGAACAAGAAATGGTTAATTTTTTGTTTGAAGGTAAAGATGTTCATATTGAAGGTTATGTTCCACCATCA
AATTAGTTATCTATCCTACA

Downstream 100 bases:

>100_bases
TTGAATTTTTTCAGATAATCAAAAATGCTCGCTGGCTAACACCATTGAGCATTTTTTATTAAAAAAGTGCGGTAAATTTT
AAAATAGTTTTTATTATTTC

Product: murein transglycosylase C

Products: N-Acetylmuramic Acid Residues; N-Acetylglucosamine Residues [C]

Alternate protein names: Murein hydrolase C [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MKKYLLLALLPFLYACSNSSNQGINYDEAFAKDTQGLDILTGQFSHNIDRIWGVNELLVASRKDYVKYTDSFYTRSHVSF
DEGNIVIETQQDLNRLHNAIVHTLLMGADAKGIDLFASGDVPISSRPFLLGQVVDHQGQHIANQVIASNFATYLIQNKLQ
TRRLQNGHTVQFVSVPMIANHVEVRARKYLPLIRKAAQRYGIDESLILGIMQTESSFNPYAISYANAIGLMQVVPHTAGR
DVFAMKGKGGQPSTRYLYDPANNIDAGVSYLWILQNQYLDGITNPTSKRFAMISAYNSGAGAVLRVFDNDKDTAIYKINQ
MYPEQVYRILTTVHPSSQARNYLLKVDKAQKKFRVRR

Sequences:

>Translated_357_residues
MKKYLLLALLPFLYACSNSSNQGINYDEAFAKDTQGLDILTGQFSHNIDRIWGVNELLVASRKDYVKYTDSFYTRSHVSF
DEGNIVIETQQDLNRLHNAIVHTLLMGADAKGIDLFASGDVPISSRPFLLGQVVDHQGQHIANQVIASNFATYLIQNKLQ
TRRLQNGHTVQFVSVPMIANHVEVRARKYLPLIRKAAQRYGIDESLILGIMQTESSFNPYAISYANAIGLMQVVPHTAGR
DVFAMKGKGGQPSTRYLYDPANNIDAGVSYLWILQNQYLDGITNPTSKRFAMISAYNSGAGAVLRVFDNDKDTAIYKINQ
MYPEQVYRILTTVHPSSQARNYLLKVDKAQKKFRVRR
>Mature_357_residues
MKKYLLLALLPFLYACSNSSNQGINYDEAFAKDTQGLDILTGQFSHNIDRIWGVNELLVASRKDYVKYTDSFYTRSHVSF
DEGNIVIETQQDLNRLHNAIVHTLLMGADAKGIDLFASGDVPISSRPFLLGQVVDHQGQHIANQVIASNFATYLIQNKLQ
TRRLQNGHTVQFVSVPMIANHVEVRARKYLPLIRKAAQRYGIDESLILGIMQTESSFNPYAISYANAIGLMQVVPHTAGR
DVFAMKGKGGQPSTRYLYDPANNIDAGVSYLWILQNQYLDGITNPTSKRFAMISAYNSGAGAVLRVFDNDKDTAIYKINQ
MYPEQVYRILTTVHPSSQARNYLLKVDKAQKKFRVRR

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transglycosylase slt family [H]

Homologues:

Organism=Escherichia coli, GI87082191, Length=361, Percent_Identity=54.8476454293629, Blast_Score=387, Evalue=1e-109,
Organism=Escherichia coli, GI87081855, Length=165, Percent_Identity=40.6060606060606, Blast_Score=135, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008258
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 40207; Mature: 40207

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00922 TRANSGLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYLLLALLPFLYACSNSSNQGINYDEAFAKDTQGLDILTGQFSHNIDRIWGVNELLVA
CCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCEEEECCHHCCHHHHCCCHHHHHH
SRKDYVKYTDSFYTRSHVSFDEGNIVIETQQDLNRLHNAIVHTLLMGADAKGIDLFASGD
CCHHHHHHHHHHHCCCCCEECCCCEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
VPISSRPFLLGQVVDHQGQHIANQVIASNFATYLIQNKLQTRRLQNGHTVQFVSVPMIAN
CCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECHHHH
HVEVRARKYLPLIRKAAQRYGIDESLILGIMQTESSFNPYAISYANAIGLMQVVPHTAGR
HHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCCCEEEEHHHHHHHHHHCCCCCCC
DVFAMKGKGGQPSTRYLYDPANNIDAGVSYLWILQNQYLDGITNPTSKRFAMISAYNSGA
CEEEECCCCCCCCCCEEECCCCCCCCCCEEEEEEHHHHHCCCCCCCCCCEEEEEEECCCC
GAVLRVFDNDKDTAIYKINQMYPEQVYRILTTVHPSSQARNYLLKVDKAQKKFRVRR
CEEEEEEECCCCCEEEEECHHCHHHHHHHHHHCCCCHHHHHHEEEEHHHHHHHCCCC
>Mature Secondary Structure
MKKYLLLALLPFLYACSNSSNQGINYDEAFAKDTQGLDILTGQFSHNIDRIWGVNELLVA
CCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCEEEECCHHCCHHHHCCCHHHHHH
SRKDYVKYTDSFYTRSHVSFDEGNIVIETQQDLNRLHNAIVHTLLMGADAKGIDLFASGD
CCHHHHHHHHHHHCCCCCEECCCCEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
VPISSRPFLLGQVVDHQGQHIANQVIASNFATYLIQNKLQTRRLQNGHTVQFVSVPMIAN
CCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECHHHH
HVEVRARKYLPLIRKAAQRYGIDESLILGIMQTESSFNPYAISYANAIGLMQVVPHTAGR
HHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCCCEEEEHHHHHHHHHHCCCCCCC
DVFAMKGKGGQPSTRYLYDPANNIDAGVSYLWILQNQYLDGITNPTSKRFAMISAYNSGA
CEEEECCCCCCCCCCEEECCCCCCCCCCEEEEEEHHHHHCCCCCCCCCCEEEEEEECCCC
GAVLRVFDNDKDTAIYKINQMYPEQVYRILTTVHPSSQARNYLLKVDKAQKKFRVRR
CEEEEEEECCCCCEEEEECHHCHHHHHHHHHHCCCCHHHHHHEEEEHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA