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The map label for this gene is lysA

Identifier: 16272667

GI number: 16272667

Start: 778807

End: 780054

Strand: Reverse

Name: lysA

Synonym: HI0727

Alternate gene names: 16272667

Gene position: 780054-778807 (Counterclockwise)

Preceding gene: 16272671

Following gene: 16272666

Centisome position: 42.62

GC content: 39.74

Gene sequence:

>1248_bases
ATGAATTTCTTCCAATATAAACATAACAAACTTTATGCCGAAGATATGCCAGTTCAACAACTTGCTGAACAATTTGGCAC
GCCTCTCTATGTATATTCTCGCGCGACACTTGAACGTCATTGGCACGCTTTTGACTCTGCTTTCGGTAATCGTCCTCACT
TAATTTGTTTTGCCGTGAAATCTTGCTCAAATATTGGCGTGTTAAATATTATGGCAAAACTTGGTTCAGGTTTCGATATT
GTCTCGCAAGGCGAACTTGAGCGTGTACTGGCAGCAGGTGGCGATGCGTCAAAAGTGGTCTTTTCTGGCGTTGCGAAATC
TCGAGAAGAAATTATGCGTGCATTAGAAGTTAGAATCCGTTGCTTTAATGTGGAATCAGTTTCTGAACTCAAGCACATTA
ACCAAATCGCGGGAGAAATGGGTAAAATCGCACCTATTTCTTTACGTGTAAATCCAGATGTTGATGCTCATACACACCCT
TATATTTCAACAGGATTAAAAGAAAATAAATTTGGTGTAAGCGTAAATGAAGCTCGAGAGGTATATAAATTAGCCTCAAC
GCTACCAAACATAAAAATAACAGGGATGGATTGCCACATAGGCTCACAGCTCACCGAATTACAACCATTCTTAGATGCAA
CAGATCGATTAATTGTCCTAATGGAACAATTAAAAGAAGATGGAATTACATTAAAACATCTCGATCTGGGCGGTGGTTTA
GGCGTGACTTATACGGATGAAACACCACCGCATCCAAGCGATTACGCAAATGCGTTATTAGAAAAACTAAAAAATTATCC
CGAACTTGAAATTATTCTTGAACCCGGCAGAGCAATTTCTGCAAATGCAGGAATTCTAGTAGCAAAAGTACAATACTTAA
AAAGTAATGAAAGCCGTAATTTCGCCATTACCGATACAGGAATGAACGATATGATCCGACCAGCATTGTATGAGGCTTAC
ATGAACATCGTCGAAATTGACCGCACTTTAGAAAGAGAAAAAGCCATTTATGATGTTGTAGGGCCTGTTTGCGAAACGTC
TGATTTCTTAGGCAAACAACGGGAACTTTCAATTGCTGAAGGGGATTATATTGCTCAATGTTCTGCTGGTGCCTATGGAG
CAAGTATGTCATCAAACTATAATTCAAGAGCCCGCACTGCAGAAGTTTTAGTAGATGGCGATCAATCCTATCTAATTCGT
CGTCGAGAAACCTTACAGGAACTTTGGGCATTAGAATCGACCATTTAA

Upstream 100 bases:

>100_bases
TAAAAGGTTCTTTATATTTTCCTGAAAAAGATCAAGCTCAACAAACTCAATAATCTATTATCTAATATCATTCCCAAAAT
AACTAAAACAGGCACACAAC

Downstream 100 bases:

>100_bases
TATTTCTTATCTTAAAAAAGAGCGGTAAAAAATTATCTATTTTTCTACCGCACTTTTTCTATTTTTATCCATCAATAAAC
CTACCTCAAATAGTAAGTTT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MNFFQYKHNKLYAEDMPVQQLAEQFGTPLYVYSRATLERHWHAFDSAFGNRPHLICFAVKSCSNIGVLNIMAKLGSGFDI
VSQGELERVLAAGGDASKVVFSGVAKSREEIMRALEVRIRCFNVESVSELKHINQIAGEMGKIAPISLRVNPDVDAHTHP
YISTGLKENKFGVSVNEAREVYKLASTLPNIKITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKEDGITLKHLDLGGGL
GVTYTDETPPHPSDYANALLEKLKNYPELEIILEPGRAISANAGILVAKVQYLKSNESRNFAITDTGMNDMIRPALYEAY
MNIVEIDRTLEREKAIYDVVGPVCETSDFLGKQRELSIAEGDYIAQCSAGAYGASMSSNYNSRARTAEVLVDGDQSYLIR
RRETLQELWALESTI

Sequences:

>Translated_415_residues
MNFFQYKHNKLYAEDMPVQQLAEQFGTPLYVYSRATLERHWHAFDSAFGNRPHLICFAVKSCSNIGVLNIMAKLGSGFDI
VSQGELERVLAAGGDASKVVFSGVAKSREEIMRALEVRIRCFNVESVSELKHINQIAGEMGKIAPISLRVNPDVDAHTHP
YISTGLKENKFGVSVNEAREVYKLASTLPNIKITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKEDGITLKHLDLGGGL
GVTYTDETPPHPSDYANALLEKLKNYPELEIILEPGRAISANAGILVAKVQYLKSNESRNFAITDTGMNDMIRPALYEAY
MNIVEIDRTLEREKAIYDVVGPVCETSDFLGKQRELSIAEGDYIAQCSAGAYGASMSSNYNSRARTAEVLVDGDQSYLIR
RRETLQELWALESTI
>Mature_415_residues
MNFFQYKHNKLYAEDMPVQQLAEQFGTPLYVYSRATLERHWHAFDSAFGNRPHLICFAVKSCSNIGVLNIMAKLGSGFDI
VSQGELERVLAAGGDASKVVFSGVAKSREEIMRALEVRIRCFNVESVSELKHINQIAGEMGKIAPISLRVNPDVDAHTHP
YISTGLKENKFGVSVNEAREVYKLASTLPNIKITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKEDGITLKHLDLGGGL
GVTYTDETPPHPSDYANALLEKLKNYPELEIILEPGRAISANAGILVAKVQYLKSNESRNFAITDTGMNDMIRPALYEAY
MNIVEIDRTLEREKAIYDVVGPVCETSDFLGKQRELSIAEGDYIAQCSAGAYGASMSSNYNSRARTAEVLVDGDQSYLIR
RRETLQELWALESTI

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family

Homologues:

Organism=Homo sapiens, GI4505489, Length=350, Percent_Identity=24.5714285714286, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI22538418, Length=361, Percent_Identity=25.7617728531856, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI21361583, Length=361, Percent_Identity=25.7617728531856, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI16506287, Length=345, Percent_Identity=24.6376811594203, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1789203, Length=416, Percent_Identity=32.4519230769231, Blast_Score=177, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17562780, Length=368, Percent_Identity=23.0978260869565, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24586474, Length=399, Percent_Identity=24.3107769423559, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCDA_HAEIN (P44316)

Other databases:

- EMBL:   L42023
- PIR:   B64089
- RefSeq:   NP_438885.1
- ProteinModelPortal:   P44316
- SMR:   P44316
- GeneID:   949755
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0727
- NMPDR:   fig|71421.1.peg.695
- TIGR:   HI_0727
- HOGENOM:   HBG672375
- OMA:   HLICFAV
- ProtClustDB:   CLSK870477
- BioCyc:   HINF71421:HI_0727-MONOMER
- BRENDA:   4.1.1.20
- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR01181
- PRINTS:   PR01179
- TIGRFAMs:   TIGR01048

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC; SSF50621 Racem_decarbox_C

EC number: =4.1.1.20

Molecular weight: Translated: 46108; Mature: 46108

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00878 ODR_DC_2_1; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFFQYKHNKLYAEDMPVQQLAEQFGTPLYVYSRATLERHWHAFDSAFGNRPHLICFAVK
CCCCCCCCCEEECCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEC
SCSNIGVLNIMAKLGSGFDIVSQGELERVLAAGGDASKVVFSGVAKSREEIMRALEVRIR
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHE
CFNVESVSELKHINQIAGEMGKIAPISLRVNPDVDAHTHPYISTGLKENKFGVSVNEARE
EECCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCCCCHHHHHH
VYKLASTLPNIKITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKEDGITLKHLDLGGGL
HHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
GVTYTDETPPHPSDYANALLEKLKNYPELEIILEPGRAISANAGILVAKVQYLKSNESRN
EEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCEEEEEHHHHHCCCCCC
FAITDTGMNDMIRPALYEAYMNIVEIDRTLEREKAIYDVVGPVCETSDFLGKQRELSIAE
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHCCCCCCEEECC
GDYIAQCSAGAYGASMSSNYNSRARTAEVLVDGDQSYLIRRRETLQELWALESTI
CCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNFFQYKHNKLYAEDMPVQQLAEQFGTPLYVYSRATLERHWHAFDSAFGNRPHLICFAVK
CCCCCCCCCEEECCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEC
SCSNIGVLNIMAKLGSGFDIVSQGELERVLAAGGDASKVVFSGVAKSREEIMRALEVRIR
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHE
CFNVESVSELKHINQIAGEMGKIAPISLRVNPDVDAHTHPYISTGLKENKFGVSVNEARE
EECCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCCCCHHHHHH
VYKLASTLPNIKITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKEDGITLKHLDLGGGL
HHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
GVTYTDETPPHPSDYANALLEKLKNYPELEIILEPGRAISANAGILVAKVQYLKSNESRN
EEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCEEEEEHHHHHCCCCCC
FAITDTGMNDMIRPALYEAYMNIVEIDRTLEREKAIYDVVGPVCETSDFLGKQRELSIAE
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHCCCCCCEEECC
GDYIAQCSAGAYGASMSSNYNSRARTAEVLVDGDQSYLIRRRETLQELWALESTI
CCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800