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The map label for this gene is glpK [H]

Identifier: 16272633

GI number: 16272633

Start: 735085

End: 736596

Strand: Direct

Name: glpK [H]

Synonym: HI0691

Alternate gene names: 16272633

Gene position: 735085-736596 (Clockwise)

Preceding gene: 16272632

Following gene: 16272635

Centisome position: 40.17

GC content: 42.59

Gene sequence:

>1512_bases
ATGACAGACAAAAAATACATCATTGCATTAGACCAAGGCACAACAAGCTCTCGCGCAGTATTATTAGATCATAATGCGAA
TGTGGTTGAAATTGCACAACGTGAATTTACCCAAATCTACCCTCGAGCTGGTTGGGTAGAACATAACCCAATGGAAATTT
GGGCAACTCAAAGCTCAACCTTAAACGAAGTCGTTGCAAAAGCGGGCATTACATCTGATGAAATCGCTGCTATCGGTATC
ACCAACCAACGTGAAACCACCATTGTATGGGAAAAATCAACCGGTACACCTGTTTACAACGCGATCGTTTGGCAATGCCG
CCGTACTGCAGACATTACCGATAAATTAAAAGCCGATGGCCATGAAGAATATATTCGTAATACCACAGGCTTAGTGGTTG
ACCCTTACTTCTCTGGTACAAAAGTAAAATGGATTTTGGATAACGTTGAAGGAGCACGAGAAAAAGCTGAACGAGGCGAA
TTATTATTTGGTACCGTTGATACTTGGCTTGTATGGAAATTGACTCAAGGCCGAGTGCACGTAACCGATTATACCAACGC
ATCTCGTACCATGTTATTTAACATCCATACTAAACAATGGGATGACAAGATGCTTGAAATCTTGAATATTCCTCGTTCAA
TGTTACCTGAAGTACGTAATTCTTCTGAAATTTACGGCCAAACCAATATCGGTGGTAAAGGTGGTGTGCGTATTCCTGTT
GCAGGGATTGCTGGTGACCAACAAGCCGCTCTTTACGGACATCTTTGCGTACATGCAGGCCAAGCCAAAAACACTTACGG
CACAGGTTGTTTTATGTTACTCCACACGGGTAACAAAGCTATTACATCCAAAAATGGACTACTCACAACCATTGCTTGTA
ATGCAAAAGGCGAACCAGAATATGCCTTAGAAGGTTCTGTATTTATCGCGGGTGCATCAATCCAATGGCTCCGTGATGAA
CTCAAAATTGTTCACGATAGTTTTGACTCTGAATACTTTGCACAAAAAGTGACTGATAGTAATGGCGTATATGTTGTTCC
AGCTTTCACAGGCTTAGGTGCACCATATTGGGATCCATATGCACGCGGTGCGATTTTTGGTCTTTCTCGCGGCGCAAACC
GTAATCATATTGTTCGAGCAACCTTAGAATCTATTGCTTACCAAACCCGTGATGTCTTAGAGGCTATGCAATCAGATTCG
GGTGAACGATTACAATATCTCCGTGTAGATGGTGGCGCGACAAACAATAACTTCTTAATGCAATTCCAAGCTGACATTTT
AGATGTAAATGTAGAGCGTCCAGTTGTGAAAGAAGTAACAGCGCTAGGCGCAGCTTATCTTGCTGGTTTAGCAACGGGCT
TCTGGAAAGATTTAGACGAGCTTCGCGATAAAGCTCGTGTAGAACGCACCTTCAGTCCAGACAGCGACAATGAAAAACGT
GAACGTCGCTACAAAGGCTGGAAAAAAGCAGTTAAACGCTCATTAGAATGGGCAAAAGAAGATGAAGAATAA

Upstream 100 bases:

>100_bases
TTTTAGGTGCATTAGCTGGTGCATGGTTATACAAAAAAGCAATTGGCGGCAATTTACCTTGTAATTGCGGCTGCGAATAA
TTATTTGAAGGAGTAATACT

Downstream 100 bases:

>100_bases
TTTATAAATTAATTCTCATACAAAAAGTGCGGTTAAAAATTCTTTTATTTTAACCGCACTTTTTTGTATAAAAATTATTT
TCTAGAGAGAGGTGGAACAA

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MTDKKYIIALDQGTTSSRAVLLDHNANVVEIAQREFTQIYPRAGWVEHNPMEIWATQSSTLNEVVAKAGITSDEIAAIGI
TNQRETTIVWEKSTGTPVYNAIVWQCRRTADITDKLKADGHEEYIRNTTGLVVDPYFSGTKVKWILDNVEGAREKAERGE
LLFGTVDTWLVWKLTQGRVHVTDYTNASRTMLFNIHTKQWDDKMLEILNIPRSMLPEVRNSSEIYGQTNIGGKGGVRIPV
AGIAGDQQAALYGHLCVHAGQAKNTYGTGCFMLLHTGNKAITSKNGLLTTIACNAKGEPEYALEGSVFIAGASIQWLRDE
LKIVHDSFDSEYFAQKVTDSNGVYVVPAFTGLGAPYWDPYARGAIFGLSRGANRNHIVRATLESIAYQTRDVLEAMQSDS
GERLQYLRVDGGATNNNFLMQFQADILDVNVERPVVKEVTALGAAYLAGLATGFWKDLDELRDKARVERTFSPDSDNEKR
ERRYKGWKKAVKRSLEWAKEDEE

Sequences:

>Translated_503_residues
MTDKKYIIALDQGTTSSRAVLLDHNANVVEIAQREFTQIYPRAGWVEHNPMEIWATQSSTLNEVVAKAGITSDEIAAIGI
TNQRETTIVWEKSTGTPVYNAIVWQCRRTADITDKLKADGHEEYIRNTTGLVVDPYFSGTKVKWILDNVEGAREKAERGE
LLFGTVDTWLVWKLTQGRVHVTDYTNASRTMLFNIHTKQWDDKMLEILNIPRSMLPEVRNSSEIYGQTNIGGKGGVRIPV
AGIAGDQQAALYGHLCVHAGQAKNTYGTGCFMLLHTGNKAITSKNGLLTTIACNAKGEPEYALEGSVFIAGASIQWLRDE
LKIVHDSFDSEYFAQKVTDSNGVYVVPAFTGLGAPYWDPYARGAIFGLSRGANRNHIVRATLESIAYQTRDVLEAMQSDS
GERLQYLRVDGGATNNNFLMQFQADILDVNVERPVVKEVTALGAAYLAGLATGFWKDLDELRDKARVERTFSPDSDNEKR
ERRYKGWKKAVKRSLEWAKEDEE
>Mature_502_residues
TDKKYIIALDQGTTSSRAVLLDHNANVVEIAQREFTQIYPRAGWVEHNPMEIWATQSSTLNEVVAKAGITSDEIAAIGIT
NQRETTIVWEKSTGTPVYNAIVWQCRRTADITDKLKADGHEEYIRNTTGLVVDPYFSGTKVKWILDNVEGAREKAERGEL
LFGTVDTWLVWKLTQGRVHVTDYTNASRTMLFNIHTKQWDDKMLEILNIPRSMLPEVRNSSEIYGQTNIGGKGGVRIPVA
GIAGDQQAALYGHLCVHAGQAKNTYGTGCFMLLHTGNKAITSKNGLLTTIACNAKGEPEYALEGSVFIAGASIQWLRDEL
KIVHDSFDSEYFAQKVTDSNGVYVVPAFTGLGAPYWDPYARGAIFGLSRGANRNHIVRATLESIAYQTRDVLEAMQSDSG
ERLQYLRVDGGATNNNFLMQFQADILDVNVERPVVKEVTALGAAYLAGLATGFWKDLDELRDKARVERTFSPDSDNEKRE
RRYKGWKKAVKRSLEWAKEDEE

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=502, Percent_Identity=47.0119521912351, Blast_Score=444, Evalue=1e-124,
Organism=Homo sapiens, GI4504007, Length=502, Percent_Identity=47.0119521912351, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI42794763, Length=506, Percent_Identity=46.6403162055336, Blast_Score=440, Evalue=1e-123,
Organism=Homo sapiens, GI41393575, Length=506, Percent_Identity=46.0474308300395, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI88196792, Length=508, Percent_Identity=34.0551181102362, Blast_Score=323, Evalue=2e-88,
Organism=Escherichia coli, GI1790361, Length=502, Percent_Identity=76.8924302788845, Blast_Score=835, Evalue=0.0,
Organism=Escherichia coli, GI1789987, Length=495, Percent_Identity=24.2424242424242, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789138, Length=511, Percent_Identity=23.091976516634, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1787789, Length=507, Percent_Identity=23.6686390532544, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790005, Length=509, Percent_Identity=23.3791748526523, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1789168, Length=499, Percent_Identity=21.0420841683367, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17535599, Length=504, Percent_Identity=42.0634920634921, Blast_Score=406, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71986140, Length=524, Percent_Identity=25.5725190839695, Blast_Score=178, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI71986147, Length=301, Percent_Identity=31.5614617940199, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6321755, Length=557, Percent_Identity=36.983842010772, Blast_Score=325, Evalue=1e-89,
Organism=Drosophila melanogaster, GI17864214, Length=510, Percent_Identity=43.1372549019608, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24655555, Length=474, Percent_Identity=42.4050632911392, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24655560, Length=474, Percent_Identity=42.4050632911392, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24655570, Length=474, Percent_Identity=42.4050632911392, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24655574, Length=474, Percent_Identity=42.4050632911392, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24655565, Length=474, Percent_Identity=42.4050632911392, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24654573, Length=456, Percent_Identity=44.5175438596491, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI19922058, Length=516, Percent_Identity=34.6899224806202, Blast_Score=294, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24652871, Length=495, Percent_Identity=34.5454545454545, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24656367, Length=514, Percent_Identity=28.5992217898833, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI21357867, Length=530, Percent_Identity=27.9245283018868, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24656372, Length=365, Percent_Identity=30.1369863013699, Blast_Score=181, Evalue=9e-46,
Organism=Drosophila melanogaster, GI45552909, Length=303, Percent_Identity=27.7227722772277, Blast_Score=125, Evalue=6e-29,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 56142; Mature: 56011

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKKYIIALDQGTTSSRAVLLDHNANVVEIAQREFTQIYPRAGWVEHNPMEIWATQSST
CCCCEEEEEEECCCCCCCEEEEECCCCEEHHHHHHHHHHCCCCCCCCCCCEEEEEECCHH
LNEVVAKAGITSDEIAAIGITNQRETTIVWEKSTGTPVYNAIVWQCRRTADITDKLKADG
HHHHHHHCCCCCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHCCC
HEEYIRNTTGLVVDPYFSGTKVKWILDNVEGAREKAERGELLFGTVDTWLVWKLTQGRVH
HHHHHHCCCCEEEECCCCCCEEEEEEECCHHHHHHHHCCCEEEEECCEEEEEEEECCEEE
VTDYTNASRTMLFNIHTKQWDDKMLEILNIPRSMLPEVRNSSEIYGQTNIGGKGGVRIPV
EEECCCCCEEEEEEEECCCHHHHHHHHHHCCHHHHHHHCCCCCEEEECCCCCCCCEEEEE
AGIAGDQQAALYGHLCVHAGQAKNTYGTGCFMLLHTGNKAITSKNGLLTTIACNAKGEPE
EECCCCCCHHHEEEHEEECCCCCCCCCCEEEEEEECCCEEEECCCCEEEEEEECCCCCCC
YALEGSVFIAGASIQWLRDELKIVHDSFDSEYFAQKVTDSNGVYVVPAFTGLGAPYWDPY
EEECCCEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCHH
ARGAIFGLSRGANRNHIVRATLESIAYQTRDVLEAMQSDSGERLQYLRVDGGATNNNFLM
HCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEE
QFQADILDVNVERPVVKEVTALGAAYLAGLATGFWKDLDELRDKARVERTFSPDSDNEKR
EEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
ERRYKGWKKAVKRSLEWAKEDEE
HHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TDKKYIIALDQGTTSSRAVLLDHNANVVEIAQREFTQIYPRAGWVEHNPMEIWATQSST
CCCEEEEEEECCCCCCCEEEEECCCCEEHHHHHHHHHHCCCCCCCCCCCEEEEEECCHH
LNEVVAKAGITSDEIAAIGITNQRETTIVWEKSTGTPVYNAIVWQCRRTADITDKLKADG
HHHHHHHCCCCCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHCCC
HEEYIRNTTGLVVDPYFSGTKVKWILDNVEGAREKAERGELLFGTVDTWLVWKLTQGRVH
HHHHHHCCCCEEEECCCCCCEEEEEEECCHHHHHHHHCCCEEEEECCEEEEEEEECCEEE
VTDYTNASRTMLFNIHTKQWDDKMLEILNIPRSMLPEVRNSSEIYGQTNIGGKGGVRIPV
EEECCCCCEEEEEEEECCCHHHHHHHHHHCCHHHHHHHCCCCCEEEECCCCCCCCEEEEE
AGIAGDQQAALYGHLCVHAGQAKNTYGTGCFMLLHTGNKAITSKNGLLTTIACNAKGEPE
EECCCCCCHHHEEEHEEECCCCCCCCCCEEEEEEECCCEEEECCCCEEEEEEECCCCCCC
YALEGSVFIAGASIQWLRDELKIVHDSFDSEYFAQKVTDSNGVYVVPAFTGLGAPYWDPY
EEECCCEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCHH
ARGAIFGLSRGANRNHIVRATLESIAYQTRDVLEAMQSDSGERLQYLRVDGGATNNNFLM
HCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEE
QFQADILDVNVERPVVKEVTALGAAYLAGLATGFWKDLDELRDKARVERTFSPDSDNEKR
EEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
ERRYKGWKKAVKRSLEWAKEDEE
HHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA