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The map label for this gene is coaA

Identifier: 16272574

GI number: 16272574

Start: 670124

End: 671059

Strand: Reverse

Name: coaA

Synonym: HI0631

Alternate gene names: 16272574

Gene position: 671059-670124 (Counterclockwise)

Preceding gene: 30995391

Following gene: 16272563

Centisome position: 36.67

GC content: 33.55

Gene sequence:

>936_bases
GTGGAATTTTCAACTCAGCAAACACCTTTTTTAAGCTTTAATCGTGAACAATGGGCGGAATTACGTAAATCCGTTCCATT
AAAATTGACAGAACAGGATCTCAAACCACTCTTAGGCTTTAATGAAGACCTTTCATTAGATGAAGTAAGTACAATTTACC
TACCATTAACTCGTCTTATTAACTATTACATTGATGAAAATTTACATCGCCAAACGGTACTACATCGTTTTTTAGGCAGA
AATAATGCCAAAACACCTTACATAATTAGTATTGCTGGCAGTGTCGCTGTTGGGAAAAGCACTTCTGCACGTATTCTACA
ATCTCTACTTTCTCATTGGCCAACTGAAAGAAAAGTTGATCTCATCACAACAGATGGGTTTCTTTATCCATTAAACAAGC
TTAAACAAGATAATCTTTTACAAAAGAAAGGTTTTCCCGTTTCTTATGACACACCTAAACTCATTCGCTTTTTAGCGGAT
GTAAAATCAGGTAAAAGCAATGTTACAGCACCAATTTACTCTCATTTAACATACGATATTATTCCCGATAAATTTGATGT
GGTAGATAAACCTGACATTCTTATTTTAGAAGGCTTGAATGTACTTCAAACGGGTAATAATAAAACCGATCAAACATTCG
TATCAGATTTTGTGGATTTCTCTATTTATGTTGATGCTGAAGAAAAATTATTGAAAGAATGGTATATCAAACGATTTCTG
AAATTCCGCGAAAGTGCATTCAACGATCCTAATTCTTACTTTAAACATTACGCAAGCTTATCAAAAGAAGAGGCTATCGC
GACGGCAAGTAAAATCTGGGATGAAATTAACGGATTAAATCTCAATCAAAACATTCTTCCAACCCGTGAGCGAGCAAATT
TAATTCTAAAAAAAGGTCATAATCACCAAGTAGAATTAATAAAATTAAGAAAATAA

Upstream 100 bases:

>100_bases
TTTTAATCAAATTAGCGTACATTTAATGAAAAATGAATGCTAAATTTTTATTTATAGCGTATATTTTTCTCTGTTTATTT
AGCCATCAAATAAAATTATT

Downstream 100 bases:

>100_bases
AAATTCGCACGTAAAAACGTGCGAATCTTAGTCAATGCCTAACTCAAAATCAGTTATTGATAAAAATATCGTAAAAAATT
ACCGCACTTTTTATCTAAAT

Product: pantothenate kinase

Products: NA

Alternate protein names: Pantothenic acid kinase

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MEFSTQQTPFLSFNREQWAELRKSVPLKLTEQDLKPLLGFNEDLSLDEVSTIYLPLTRLINYYIDENLHRQTVLHRFLGR
NNAKTPYIISIAGSVAVGKSTSARILQSLLSHWPTERKVDLITTDGFLYPLNKLKQDNLLQKKGFPVSYDTPKLIRFLAD
VKSGKSNVTAPIYSHLTYDIIPDKFDVVDKPDILILEGLNVLQTGNNKTDQTFVSDFVDFSIYVDAEEKLLKEWYIKRFL
KFRESAFNDPNSYFKHYASLSKEEAIATASKIWDEINGLNLNQNILPTRERANLILKKGHNHQVELIKLRK

Sequences:

>Translated_311_residues
MEFSTQQTPFLSFNREQWAELRKSVPLKLTEQDLKPLLGFNEDLSLDEVSTIYLPLTRLINYYIDENLHRQTVLHRFLGR
NNAKTPYIISIAGSVAVGKSTSARILQSLLSHWPTERKVDLITTDGFLYPLNKLKQDNLLQKKGFPVSYDTPKLIRFLAD
VKSGKSNVTAPIYSHLTYDIIPDKFDVVDKPDILILEGLNVLQTGNNKTDQTFVSDFVDFSIYVDAEEKLLKEWYIKRFL
KFRESAFNDPNSYFKHYASLSKEEAIATASKIWDEINGLNLNQNILPTRERANLILKKGHNHQVELIKLRK
>Mature_311_residues
MEFSTQQTPFLSFNREQWAELRKSVPLKLTEQDLKPLLGFNEDLSLDEVSTIYLPLTRLINYYIDENLHRQTVLHRFLGR
NNAKTPYIISIAGSVAVGKSTSARILQSLLSHWPTERKVDLITTDGFLYPLNKLKQDNLLQKKGFPVSYDTPKLIRFLAD
VKSGKSNVTAPIYSHLTYDIIPDKFDVVDKPDILILEGLNVLQTGNNKTDQTFVSDFVDFSIYVDAEEKLLKEWYIKRFL
KFRESAFNDPNSYFKHYASLSKEEAIATASKIWDEINGLNLNQNILPTRERANLILKKGHNHQVELIKLRK

Specific function: Coenzyme A (CoA) biosynthesis; first step. [C]

COG id: COG1072

COG function: function code H; Panthothenate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic pantothenate kinase family

Homologues:

Organism=Escherichia coli, GI1790409, Length=310, Percent_Identity=64.5161290322581, Blast_Score=410, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAA_HAEIN (P44793)

Other databases:

- EMBL:   L42023
- PIR:   I64082
- RefSeq:   NP_438791.1
- ProteinModelPortal:   P44793
- SMR:   P44793
- GeneID:   949538
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0631
- NMPDR:   fig|71421.1.peg.601
- TIGR:   HI_0631
- HOGENOM:   HBG732538
- OMA:   GLNVLQP
- ProtClustDB:   PRK05439
- BioCyc:   HINF71421:HI_0631-MONOMER
- BRENDA:   2.7.1.33
- GO:   GO:0005737
- HAMAP:   MF_00215
- InterPro:   IPR004566
- InterPro:   IPR006083
- PANTHER:   PTHR10285:SF7
- PIRSF:   PIRSF000545
- TIGRFAMs:   TIGR00554

Pfam domain/function: PF00485 PRK

EC number: =2.7.1.33

Molecular weight: Translated: 35908; Mature: 35908

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSTQQTPFLSFNREQWAELRKSVPLKLTEQDLKPLLGFNEDLSLDEVSTIYLPLTRLI
CCCCCCCCCCEECCHHHHHHHHHCCCCEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
NYYIDENLHRQTVLHRFLGRNNAKTPYIISIAGSVAVGKSTSARILQSLLSHWPTERKVD
HHHHCCCHHHHHHHHHHHCCCCCCCCEEEEECCCEEECCCHHHHHHHHHHHHCCCCCEEE
LITTDGFLYPLNKLKQDNLLQKKGFPVSYDTPKLIRFLADVKSGKSNVTAPIYSHLTYDI
EEECCCEEECHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCC
IPDKFDVVDKPDILILEGLNVLQTGNNKTDQTFVSDFVDFSIYVDAEEKLLKEWYIKRFL
CCCCCCCCCCCCEEEECCCHHEECCCCCCHHHHHHHHHCEEEEECHHHHHHHHHHHHHHH
KFRESAFNDPNSYFKHYASLSKEEAIATASKIWDEINGLNLNQNILPTRERANLILKKGH
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCEEEECCC
NHQVELIKLRK
CCCEEEEEECC
>Mature Secondary Structure
MEFSTQQTPFLSFNREQWAELRKSVPLKLTEQDLKPLLGFNEDLSLDEVSTIYLPLTRLI
CCCCCCCCCCEECCHHHHHHHHHCCCCEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
NYYIDENLHRQTVLHRFLGRNNAKTPYIISIAGSVAVGKSTSARILQSLLSHWPTERKVD
HHHHCCCHHHHHHHHHHHCCCCCCCCEEEEECCCEEECCCHHHHHHHHHHHHCCCCCEEE
LITTDGFLYPLNKLKQDNLLQKKGFPVSYDTPKLIRFLADVKSGKSNVTAPIYSHLTYDI
EEECCCEEECHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCC
IPDKFDVVDKPDILILEGLNVLQTGNNKTDQTFVSDFVDFSIYVDAEEKLLKEWYIKRFL
CCCCCCCCCCCCEEEECCCHHEECCCCCCHHHHHHHHHCEEEEECHHHHHHHHHHHHHHH
KFRESAFNDPNSYFKHYASLSKEEAIATASKIWDEINGLNLNQNILPTRERANLILKKGH
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCEEEECCC
NHQVELIKLRK
CCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1916268; 7542800