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The map label for this gene is gmhB

Identifier: 16272564

GI number: 16272564

Start: 656212

End: 656766

Strand: Direct

Name: gmhB

Synonym: HI0621.1

Alternate gene names: 16272564

Gene position: 656212-656766 (Clockwise)

Preceding gene: 16272561

Following gene: 16272565

Centisome position: 35.86

GC content: 36.22

Gene sequence:

>555_bases
ATGAATAAGGCTATTTTTTTAGATCGCGATGGCACGTTAAATATTGATTATGGTTATGTACACGAAATTGATAACTTTAA
ATTTATTGATGGTGTGATTGATGCATTGCGAGAATTAAAGAAAATGGGATATATGTTGGTATTAGTGACCAACCAGTCGG
GCATTGCACGTGGTTATTTTTCTGAGGATCAGTTTTTACAATTAACAGAATGGATGGATTGGTCGTTAGCTGAACAAGAT
GTGGATTTGGATGGTATTTACTATTGTCCACATCATTCTGAGGGAAAGGGCGAATATAAAGAAGATTGTGATTGTCGGAA
GCCTAAATCGGGAATGTTATTGCAAGCGATCAAAGAATTAAAGATCGATCCTACGCAATCTATTATGGTTGGAGATAAAG
TTGAAGACCTAAAAGCGGGGATTGGTGCGAAAGTAAAAATGAACGTATTAGTTCGTACTGGTAAACCAGTAACAGGGGAA
GGAGAAGGAATAGCGGATTATGTGTTAGATTCTATCGTAGATCTTCCGAGAATTTTAAAACGCTTAAAAAAATAG

Upstream 100 bases:

>100_bases
GATTATCTTTTTTAGACAGATTAGTTATGACTTATATTTGCTAATTGCTTGGATTAAATAGATAATTTTTGTCAATTTGA
CATGTATAAAAGGTAAGAGA

Downstream 100 bases:

>100_bases
CCAAAAAGATCTATATTTTGCTCTAATCGCTTGTACTTTAATCAAAAGATCATTTTTTTAAATATTTTTACAAAAAAGTA
CTTGCAAGGGATTTGAAAAT

Product: D,D-heptose 1,7-bisphosphate phosphatase

Products: NA

Alternate protein names: D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MNKAIFLDRDGTLNIDYGYVHEIDNFKFIDGVIDALRELKKMGYMLVLVTNQSGIARGYFSEDQFLQLTEWMDWSLAEQD
VDLDGIYYCPHHSEGKGEYKEDCDCRKPKSGMLLQAIKELKIDPTQSIMVGDKVEDLKAGIGAKVKMNVLVRTGKPVTGE
GEGIADYVLDSIVDLPRILKRLKK

Sequences:

>Translated_184_residues
MNKAIFLDRDGTLNIDYGYVHEIDNFKFIDGVIDALRELKKMGYMLVLVTNQSGIARGYFSEDQFLQLTEWMDWSLAEQD
VDLDGIYYCPHHSEGKGEYKEDCDCRKPKSGMLLQAIKELKIDPTQSIMVGDKVEDLKAGIGAKVKMNVLVRTGKPVTGE
GEGIADYVLDSIVDLPRILKRLKK
>Mature_184_residues
MNKAIFLDRDGTLNIDYGYVHEIDNFKFIDGVIDALRELKKMGYMLVLVTNQSGIARGYFSEDQFLQLTEWMDWSLAEQD
VDLDGIYYCPHHSEGKGEYKEDCDCRKPKSGMLLQAIKELKIDPTQSIMVGDKVEDLKAGIGAKVKMNVLVRTGKPVTGE
GEGIADYVLDSIVDLPRILKRLKK

Specific function: Converts the D-glycero-beta-D-manno-heptose 1,7- bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position

COG id: COG0241

COG function: function code E; Histidinol phosphatase and related phosphatases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gmhB family

Homologues:

Organism=Escherichia coli, GI1786399, Length=182, Percent_Identity=67.032967032967, Blast_Score=262, Evalue=1e-71,
Organism=Escherichia coli, GI87082027, Length=140, Percent_Identity=33.5714285714286, Blast_Score=80, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GMHB_HAEIN (P46452)

Other databases:

- EMBL:   L42023
- RefSeq:   NP_438781.1
- ProteinModelPortal:   P46452
- SMR:   P46452
- GeneID:   949688
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0621.1
- NMPDR:   fig|71421.1.peg.591
- TIGR:   HI_0621.1
- HOGENOM:   HBG613347
- OMA:   VVLDSIA
- ProtClustDB:   PRK08942
- BioCyc:   HINF71421:HI_0621.1-MONOMER
- GO:   GO:0005737
- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR004446
- InterPro:   IPR006543
- InterPro:   IPR013954
- Gene3D:   G3DSA:3.40.50.1000
- TIGRFAMs:   TIGR00213
- TIGRFAMs:   TIGR01662
- TIGRFAMs:   TIGR01656

Pfam domain/function: PF08645 PNK3P; SSF56784 SSF56784

EC number: 3.1.1.-

Molecular weight: Translated: 20810; Mature: 20810

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKAIFLDRDGTLNIDYGYVHEIDNFKFIDGVIDALRELKKMGYMLVLVTNQSGIARGYF
CCCCEEEECCCEEEECCCEEEECCCEEHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCC
SEDQFLQLTEWMDWSLAEQDVDLDGIYYCPHHSEGKGEYKEDCDCRKPKSGMLLQAIKEL
CCCHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
KIDPTQSIMVGDKVEDLKAGIGAKVKMNVLVRTGKPVTGEGEGIADYVLDSIVDLPRILK
CCCCCCCEEECCCHHHHHHCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
RLKK
HHCC
>Mature Secondary Structure
MNKAIFLDRDGTLNIDYGYVHEIDNFKFIDGVIDALRELKKMGYMLVLVTNQSGIARGYF
CCCCEEEECCCEEEECCCEEEECCCEEHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCC
SEDQFLQLTEWMDWSLAEQDVDLDGIYYCPHHSEGKGEYKEDCDCRKPKSGMLLQAIKEL
CCCHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
KIDPTQSIMVGDKVEDLKAGIGAKVKMNVLVRTGKPVTGEGEGIADYVLDSIVDLPRILK
CCCCCCCEEECCCHHHHHHCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
RLKK
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 12101286