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The map label for this gene is cyaA

Identifier: 16272546

GI number: 16272546

Start: 633161

End: 635692

Strand: Direct

Name: cyaA

Synonym: HI0604

Alternate gene names: 16272546

Gene position: 633161-635692 (Clockwise)

Preceding gene: 30995388

Following gene: 16272547

Centisome position: 34.6

GC content: 38.63

Gene sequence:

>2532_bases
GTGGAATGTAATCTAGCACAAGCAAAACAATGGGTTAGCGCCTTGGATCAACGCCGTTTTGAGCGTGCATTACAAGGTTC
AGGCGATGCATTCCAACACGTTTTAGCGATTGTCCCTTTACTTTTACACCTAAACCATCCACAACTTCCCGGCTATGTTA
TTCACGCCCCCTCAGGTATTGCAAGTTTCCTCGCATCTGATTATCAAAAAAAGTGGCTCACCAATGAATACGGTATTCAT
TATGCCGATCATAAACCATCAACACTCAAAAGTGCGGTAAATTTTCACGAAGTTTTTCCACCAATTTTAGGTGTTTATGT
AATGGGTAGCTTTGGCTCAATAAGTCAAACCTCTTCTTCAGATCTTGATACTTGGATTTGTGTCCGTGATGGCTTGAGTC
TAGATGAATATACACTTCTTACTCAAAAAGCCAAGCGGATTAGTGAATGGGCTATGCAATTTAATGTGGAAATTAATTTT
TATTTGATGGATCAACAACGTTTCCGCAATGAACATTATGCTGACCCACTGACTATTGAAAATAGCGGCTCTGCGCAATA
TATGTTATTGCTTGATGAGTTCTATCGCTCCGCCGTACGCTTGGCAGGTAAACCTCTACTTTGGTTGCATTTATGGGTGG
AAAATGAAAAAGACTATGAAAAAGAGGTGGCACGTTTAATTACGGAAGGGGAAATTGATCCAAATGATTGGGTAGATTTC
GGCGGTTTAGGACAATTTTCTGCAAACGAATATTTCGGTGCCAGTTTATGGCATCTTTATAAAGGGATTGATTCACCTTA
TAAATCTGTGCTCAAAATTTTGTTGTTGGAAGCCTATTCCAAGGAATACCCAAACACTTGCTTAATTGCCCGCACTTTTA
AGCGAGATTTACTTGCAGGCAATACCAATCCTGATCACCATTTTGATCCTTACATTGCCATTCTTGCAAAAGTAACCCAA
TATTTAACCGCACTTTCTGAATTTAAACGTTTGGATTTTGTGCACCGTTGTTTCTATGTGAAAGCAACGGAAGATTTTGC
ACGTTACCAAGCCAATAATTGGCGTATTCGTTATATGGAAATCCTTGCGCAAGAATGGGGATGGTCTGCAGAAACGGTAA
AACATCTCAATAAGCGTCCATTTTGGAAAATTAAGGCAGTAAAAGAAAACCACGATAACATAATGAAATTTTTAATGTTG
AGTTATCGTAATTTAGTGGAATTTGCTCGAAAGCATCACATTCACTCGAGCGTCGTGCCACAAGATATCAACATTCTTTC
TCGTAAACTTTATACTGCTTTTGAAGAACTTCCCGGCAAAGTGTCCTTACTCAACACACAGATATCTCACAATTTATCAG
AAGCACACCTGACTTTTGTGGAAGTTCGCGGCAATAAACATTTTAAGGATGGTTGGTACCTTATCAATCAACCAATACAC
CATATTATGTTCTCCAAAGAACGGGTGATCGAATACGGAGAAAGCCTGAATAAATTAGTTTCTTGGGCTTATTTCAATCA
TTTACTCACTGAAAAAACCGAATTGTCAATTTTTAGCAAGAATGTGACTTTAAGCACATTACAACGCTTTGTCACTAACT
TGCGTCAGTCTTTTCCAAGCACCATCGCTAAACAACCTAAAAACAGCGATTTATTAAATCAATGTGAAATTCGTAGCTTG
TTTATTGCCATAAATCTCACGACCGATCCAACATCCAAAGTAGAAGAAGTATTAACGGGTATTTCATCGCGAGATTTATT
TAGTTTTGGATCCCTCGAGCAAAGCCTTGTGGGCAGTATCGATTTTACTTATCGTAACGTGTGGAACGAAATCCGAACGC
TCCATTTTGAAGGGCAAAATGCCATTTTGCTTGCGCTAAAAGTACTTTCTAACAAAATTTATCGTGGTGTTAATCGCCCA
GATTCAATCCAAGTCTATTGTTATAGTGAACGTTATCGCCAAGATTTACGTCAATTAGTGATGGGATTAGTCAATCGATG
CGTTAGCATCCAAGTCGGCGATATTCAACAACCTTGCCAAACGTCACGTTTACGCGTAGCGGGTAAAAACTGGCAATTAT
TTTTTGAAGATCGCGGGATTAGCTTACAAGAAATCGGAAATGAATCGGTCTGTAATGAAGCTGAAAGTGCGGTGGATTTT
GACGAAGTTTTACAAACACCAATTGAAGATGGCGAGACAAACCAAGAAAGTCGTCGCTATCCACCAGAAATGGATGCCTT
CGCCAGTGAAGGATTCCTACAATTCTTTTTTGAAGATAATTCTGATCACAGCTTCAATGTTTATATTTTAGATGAATCTA
ATCATCTCGAAATCTATCGCCACTGCGATGGTGAAAAAGATGAAAAAGTGCGGGAGATTAATCAACTTTATCAAAACGCC
AAACAGGAAGGCGATAAAAATCCTTACAATATCGTTCAACATAATTTTAACTACCCTCAATTTTATCAACTACAAAATGG
AAAAAATGGCATATCCATCGTGCCGTTTAAATTCCGCCAAATGAATAAGTAA

Upstream 100 bases:

>100_bases
ATTTTTCGAAAAATTGTGATTTATGTCACATTTTTTTGCATTTATACTCCCTAAGTGGTAAATTGTTCGCCAATTTTTGT
TGTTCTGGTAGGGACACCAC

Downstream 100 bases:

>100_bases
TATTTTCCTGTGGTTGATAGGTTACCGAAAGATATCTATACTTATTTCCTCTTTTACTAGATAAATTGTAGATATGATAA
CTTCGCAAACACCAATCACT

Product: adenylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase; Adenylyl cyclase

Number of amino acids: Translated: 843; Mature: 843

Protein sequence:

>843_residues
MECNLAQAKQWVSALDQRRFERALQGSGDAFQHVLAIVPLLLHLNHPQLPGYVIHAPSGIASFLASDYQKKWLTNEYGIH
YADHKPSTLKSAVNFHEVFPPILGVYVMGSFGSISQTSSSDLDTWICVRDGLSLDEYTLLTQKAKRISEWAMQFNVEINF
YLMDQQRFRNEHYADPLTIENSGSAQYMLLLDEFYRSAVRLAGKPLLWLHLWVENEKDYEKEVARLITEGEIDPNDWVDF
GGLGQFSANEYFGASLWHLYKGIDSPYKSVLKILLLEAYSKEYPNTCLIARTFKRDLLAGNTNPDHHFDPYIAILAKVTQ
YLTALSEFKRLDFVHRCFYVKATEDFARYQANNWRIRYMEILAQEWGWSAETVKHLNKRPFWKIKAVKENHDNIMKFLML
SYRNLVEFARKHHIHSSVVPQDINILSRKLYTAFEELPGKVSLLNTQISHNLSEAHLTFVEVRGNKHFKDGWYLINQPIH
HIMFSKERVIEYGESLNKLVSWAYFNHLLTEKTELSIFSKNVTLSTLQRFVTNLRQSFPSTIAKQPKNSDLLNQCEIRSL
FIAINLTTDPTSKVEEVLTGISSRDLFSFGSLEQSLVGSIDFTYRNVWNEIRTLHFEGQNAILLALKVLSNKIYRGVNRP
DSIQVYCYSERYRQDLRQLVMGLVNRCVSIQVGDIQQPCQTSRLRVAGKNWQLFFEDRGISLQEIGNESVCNEAESAVDF
DEVLQTPIEDGETNQESRRYPPEMDAFASEGFLQFFFEDNSDHSFNVYILDESNHLEIYRHCDGEKDEKVREINQLYQNA
KQEGDKNPYNIVQHNFNYPQFYQLQNGKNGISIVPFKFRQMNK

Sequences:

>Translated_843_residues
MECNLAQAKQWVSALDQRRFERALQGSGDAFQHVLAIVPLLLHLNHPQLPGYVIHAPSGIASFLASDYQKKWLTNEYGIH
YADHKPSTLKSAVNFHEVFPPILGVYVMGSFGSISQTSSSDLDTWICVRDGLSLDEYTLLTQKAKRISEWAMQFNVEINF
YLMDQQRFRNEHYADPLTIENSGSAQYMLLLDEFYRSAVRLAGKPLLWLHLWVENEKDYEKEVARLITEGEIDPNDWVDF
GGLGQFSANEYFGASLWHLYKGIDSPYKSVLKILLLEAYSKEYPNTCLIARTFKRDLLAGNTNPDHHFDPYIAILAKVTQ
YLTALSEFKRLDFVHRCFYVKATEDFARYQANNWRIRYMEILAQEWGWSAETVKHLNKRPFWKIKAVKENHDNIMKFLML
SYRNLVEFARKHHIHSSVVPQDINILSRKLYTAFEELPGKVSLLNTQISHNLSEAHLTFVEVRGNKHFKDGWYLINQPIH
HIMFSKERVIEYGESLNKLVSWAYFNHLLTEKTELSIFSKNVTLSTLQRFVTNLRQSFPSTIAKQPKNSDLLNQCEIRSL
FIAINLTTDPTSKVEEVLTGISSRDLFSFGSLEQSLVGSIDFTYRNVWNEIRTLHFEGQNAILLALKVLSNKIYRGVNRP
DSIQVYCYSERYRQDLRQLVMGLVNRCVSIQVGDIQQPCQTSRLRVAGKNWQLFFEDRGISLQEIGNESVCNEAESAVDF
DEVLQTPIEDGETNQESRRYPPEMDAFASEGFLQFFFEDNSDHSFNVYILDESNHLEIYRHCDGEKDEKVREINQLYQNA
KQEGDKNPYNIVQHNFNYPQFYQLQNGKNGISIVPFKFRQMNK
>Mature_843_residues
MECNLAQAKQWVSALDQRRFERALQGSGDAFQHVLAIVPLLLHLNHPQLPGYVIHAPSGIASFLASDYQKKWLTNEYGIH
YADHKPSTLKSAVNFHEVFPPILGVYVMGSFGSISQTSSSDLDTWICVRDGLSLDEYTLLTQKAKRISEWAMQFNVEINF
YLMDQQRFRNEHYADPLTIENSGSAQYMLLLDEFYRSAVRLAGKPLLWLHLWVENEKDYEKEVARLITEGEIDPNDWVDF
GGLGQFSANEYFGASLWHLYKGIDSPYKSVLKILLLEAYSKEYPNTCLIARTFKRDLLAGNTNPDHHFDPYIAILAKVTQ
YLTALSEFKRLDFVHRCFYVKATEDFARYQANNWRIRYMEILAQEWGWSAETVKHLNKRPFWKIKAVKENHDNIMKFLML
SYRNLVEFARKHHIHSSVVPQDINILSRKLYTAFEELPGKVSLLNTQISHNLSEAHLTFVEVRGNKHFKDGWYLINQPIH
HIMFSKERVIEYGESLNKLVSWAYFNHLLTEKTELSIFSKNVTLSTLQRFVTNLRQSFPSTIAKQPKNSDLLNQCEIRSL
FIAINLTTDPTSKVEEVLTGISSRDLFSFGSLEQSLVGSIDFTYRNVWNEIRTLHFEGQNAILLALKVLSNKIYRGVNRP
DSIQVYCYSERYRQDLRQLVMGLVNRCVSIQVGDIQQPCQTSRLRVAGKNWQLFFEDRGISLQEIGNESVCNEAESAVDF
DEVLQTPIEDGETNQESRRYPPEMDAFASEGFLQFFFEDNSDHSFNVYILDESNHLEIYRHCDGEKDEKVREINQLYQNA
KQEGDKNPYNIVQHNFNYPQFYQLQNGKNGISIVPFKFRQMNK

Specific function: Plays an essential role in competence development

COG id: COG3072

COG function: function code F; Adenylate cyclase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylyl cyclase class-1 family

Homologues:

Organism=Escherichia coli, GI1790238, Length=843, Percent_Identity=42.3487544483986, Blast_Score=653, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYAA_HAEIN (P40134)

Other databases:

- EMBL:   L23824
- EMBL:   L42023
- PIR:   A49922
- RefSeq:   NP_438762.1
- GeneID:   950010
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0604
- NMPDR:   fig|71421.1.peg.573
- TIGR:   HI_0604
- HOGENOM:   HBG678054
- OMA:   LWQLYKG
- ProtClustDB:   PRK09450
- BioCyc:   HINF71421:HI_0604-MONOMER
- BRENDA:   4.6.1.1
- GO:   GO:0005737
- InterPro:   IPR000274
- PIRSF:   PIRSF001444

Pfam domain/function: PF01295 Adenylate_cycl

EC number: =4.6.1.1

Molecular weight: Translated: 97928; Mature: 97928

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS01092 ADENYLATE_CYCLASE_1_1; PS01093 ADENYLATE_CYCLASE_1_2; PS00589 PTS_HPR_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MECNLAQAKQWVSALDQRRFERALQGSGDAFQHVLAIVPLLLHLNHPQLPGYVIHAPSGI
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHH
ASFLASDYQKKWLTNEYGIHYADHKPSTLKSAVNFHEVFPPILGVYVMGSFGSISQTSSS
HHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DLDTWICVRDGLSLDEYTLLTQKAKRISEWAMQFNVEINFYLMDQQRFRNEHYADPLTIE
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEEECHHHHCCCCCCCCEEEE
NSGSAQYMLLLDEFYRSAVRLAGKPLLWLHLWVENEKDYEKEVARLITEGEIDPNDWVDF
CCCCCEEEHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCC
GGLGQFSANEYFGASLWHLYKGIDSPYKSVLKILLLEAYSKEYPNTCLIARTFKRDLLAG
CCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCC
NTNPDHHFDPYIAILAKVTQYLTALSEFKRLDFVHRCFYVKATEDFARYQANNWRIRYME
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHCCCCCEEHHHH
ILAQEWGWSAETVKHLNKRPFWKIKAVKENHDNIMKFLMLSYRNLVEFARKHHIHSSVVP
HHHHHHCCCHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QDINILSRKLYTAFEELPGKVSLLNTQISHNLSEAHLTFVEVRGNKHFKDGWYLINQPIH
CHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCCCHHEEEEEEEECCCCCCCCCEEECCCHH
HIMFSKERVIEYGESLNKLVSWAYFNHLLTEKTELSIFSKNVTLSTLQRFVTNLRQSFPS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEECCCHHHHHHHHHHHHHHHCCH
TIAKQPKNSDLLNQCEIRSLFIAINLTTDPTSKVEEVLTGISSRDLFSFGSLEQSLVGSI
HHHCCCCCCCHHHHHCEEEEEEEEEECCCCHHHHHHHHHCCCCCCHHHHCCHHHHHHCCC
DFTYRNVWNEIRTLHFEGQNAILLALKVLSNKIYRGVNRPDSIQVYCYSERYRQDLRQLV
CHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHH
MGLVNRCVSIQVGDIQQPCQTSRLRVAGKNWQLFFEDRGISLQEIGNESVCNEAESAVDF
HHHHHHHEEEEECCCCCCHHHCCEEEECCCEEEEEECCCCCHHHCCCHHHHHHHHHCCCH
DEVLQTPIEDGETNQESRRYPPEMDAFASEGFLQFFFEDNSDHSFNVYILDESNHLEIYR
HHHHCCCCCCCCCCCHHCCCCCCHHHHHCCCEEEEEEECCCCCEEEEEEEECCCCEEEEE
HCDGEKDEKVREINQLYQNAKQEGDKNPYNIVQHNFNYPQFYQLQNGKNGISIVPFKFRQ
CCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEEECCCCCCCEEEEEHHHC
MNK
CCC
>Mature Secondary Structure
MECNLAQAKQWVSALDQRRFERALQGSGDAFQHVLAIVPLLLHLNHPQLPGYVIHAPSGI
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHH
ASFLASDYQKKWLTNEYGIHYADHKPSTLKSAVNFHEVFPPILGVYVMGSFGSISQTSSS
HHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DLDTWICVRDGLSLDEYTLLTQKAKRISEWAMQFNVEINFYLMDQQRFRNEHYADPLTIE
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEEECHHHHCCCCCCCCEEEE
NSGSAQYMLLLDEFYRSAVRLAGKPLLWLHLWVENEKDYEKEVARLITEGEIDPNDWVDF
CCCCCEEEHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCC
GGLGQFSANEYFGASLWHLYKGIDSPYKSVLKILLLEAYSKEYPNTCLIARTFKRDLLAG
CCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCC
NTNPDHHFDPYIAILAKVTQYLTALSEFKRLDFVHRCFYVKATEDFARYQANNWRIRYME
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHCCCCCEEHHHH
ILAQEWGWSAETVKHLNKRPFWKIKAVKENHDNIMKFLMLSYRNLVEFARKHHIHSSVVP
HHHHHHCCCHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QDINILSRKLYTAFEELPGKVSLLNTQISHNLSEAHLTFVEVRGNKHFKDGWYLINQPIH
CHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCCCHHEEEEEEEECCCCCCCCCEEECCCHH
HIMFSKERVIEYGESLNKLVSWAYFNHLLTEKTELSIFSKNVTLSTLQRFVTNLRQSFPS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEECCCHHHHHHHHHHHHHHHCCH
TIAKQPKNSDLLNQCEIRSLFIAINLTTDPTSKVEEVLTGISSRDLFSFGSLEQSLVGSI
HHHCCCCCCCHHHHHCEEEEEEEEEECCCCHHHHHHHHHCCCCCCHHHHCCHHHHHHCCC
DFTYRNVWNEIRTLHFEGQNAILLALKVLSNKIYRGVNRPDSIQVYCYSERYRQDLRQLV
CHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHH
MGLVNRCVSIQVGDIQQPCQTSRLRVAGKNWQLFFEDRGISLQEIGNESVCNEAESAVDF
HHHHHHHEEEEECCCCCCHHHCCEEEECCCEEEEEECCCCCHHHCCCHHHHHHHHHCCCH
DEVLQTPIEDGETNQESRRYPPEMDAFASEGFLQFFFEDNSDHSFNVYILDESNHLEIYR
HHHHCCCCCCCCCCCHHCCCCCCHHHHHCCCEEEEEEECCCCCEEEEEEEECCCCEEEEE
HCDGEKDEKVREINQLYQNAKQEGDKNPYNIVQHNFNYPQFYQLQNGKNGISIVPFKFRQ
CCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEEECCCCCCCEEEEEHHHC
MNK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226661; 7542800