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The map label for this gene is hemY

Identifier: 16272545

GI number: 16272545

Start: 630346

End: 631632

Strand: Reverse

Name: hemY

Synonym: HI0602

Alternate gene names: 16272545

Gene position: 631632-630346 (Counterclockwise)

Preceding gene: 16272551

Following gene: 16272543

Centisome position: 34.51

GC content: 36.83

Gene sequence:

>1287_bases
ATGTTTAGAGTGCTCTTTTTAATGCTGACATTGCTTGTAGGACTTGTAGCAGGGCCTTATATTTCTGGTCAGCAAGGTTA
TGTACGCATTGAGACAGCAAATCGTATTATAGAAATGTCCATCACTACCTTAGTGATTTTTTTCATTATTTCTTTAGCAA
TAATTTATGCTTTTGAATGGGGCGTCACTCGTTTCTTTCGTTTAAGTCGTAGCTCTTATCAATGGTTTTCTAATCGCAAA
CGTGTAAAAGCGCAAAAACAAACCCTTGAAGGCTTGGTAAAAATGGATGAAGGGGATTACGCTAAAGCAGAAAAATTAAT
TGGCAAAAATGCTAAACATTCTGCTGAACCTGTACTAAATCTCATCAAAGCAGCAGAAGCCGCTCAACAACGTGGCGACG
AATTTAGTGCAAATCGCTATTTAATTGAAGCAACAGAATTAGCCGGCTCTGATAATTTGCTCGTGGAAATTGCCCGTACT
CGCATTTTATTGCAACAAAACAAGTTACCTGCAGCGCGCAGTTCTGTAGATAGCTTATTAGAAATGGCTCGTCGCAATAA
AGAAGTATTAAAACTCGCGGTAGAAATTTATCTTCGCTCTAAAGCCTATCAAGCTCTAGATAAAATTTTAGACAATGTTG
CGAATAGCGGTTTATTCAATGATGAAGAATTCAAAGATCTTCGCTCTAAAACCGAAAATGGTTTACTCGACGAGAAAATG
AACGAAGAAGGAATTGATGGCTTACTAACTTGGTGGAATCAGCAACCTCGTCATCGCCGTAACAATATTGAACTTAAAAT
TAGCCTTATTCAACGTTTAATTGACTGTAATGATCATGAATCAGCTACTGAATTGACATTTGAAATACTGAAAAAACTCG
GTGACAATACAGCAATCAGTTTACCTCTTTGTACTCAAATTACACGTTTACAACCAGAAGATAACAGTAAACTTCTCAAG
CTAATAGAAAAACGTGCAAAACGTGTGGATGAAAAACAAAAATGCTGTATCAATCGTGCTTTGGGTTATTTATATGTTCG
TAACAATGAATTTATTAAAGCAGCAGATGTATTCAAAAACGTGATCGCTTGCCCTGAACAATTAGAACAAAATGATTTGA
TGATGGCATCTTATGTATTTGAACAAGCGGGCGATAAAGCATTAGCTGAACAAGTTCGCCAAGAGAGTTTGAAATCAGTG
ATGGCAATTCAGGATGTCATTCCAGAAAGTGCGGAAGAAAAAACAGAAGAAAATTCAACCGCACTTTTAGAAAGCAAATC
TGAGTAG

Upstream 100 bases:

>100_bases
CAAAAAGTGGAAATTGAAGCAGACAAGGCGATTGATACAATGCCTCAAGTAGAAGCTGTTAAACCAACACAATCTGAATC
ACAACAATAAGGATAAGTCT

Downstream 100 bases:

>100_bases
CTCAACTAAAAAGACAAAACGCACTTCAAATGAAGTGCGTTTTTTGTTGTTTTGAATCTAAAACTATATATTTCTCAGTT
TATTAGAATATAACACCAAA

Product: HemY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MFRVLFLMLTLLVGLVAGPYISGQQGYVRIETANRIIEMSITTLVIFFIISLAIIYAFEWGVTRFFRLSRSSYQWFSNRK
RVKAQKQTLEGLVKMDEGDYAKAEKLIGKNAKHSAEPVLNLIKAAEAAQQRGDEFSANRYLIEATELAGSDNLLVEIART
RILLQQNKLPAARSSVDSLLEMARRNKEVLKLAVEIYLRSKAYQALDKILDNVANSGLFNDEEFKDLRSKTENGLLDEKM
NEEGIDGLLTWWNQQPRHRRNNIELKISLIQRLIDCNDHESATELTFEILKKLGDNTAISLPLCTQITRLQPEDNSKLLK
LIEKRAKRVDEKQKCCINRALGYLYVRNNEFIKAADVFKNVIACPEQLEQNDLMMASYVFEQAGDKALAEQVRQESLKSV
MAIQDVIPESAEEKTEENSTALLESKSE

Sequences:

>Translated_428_residues
MFRVLFLMLTLLVGLVAGPYISGQQGYVRIETANRIIEMSITTLVIFFIISLAIIYAFEWGVTRFFRLSRSSYQWFSNRK
RVKAQKQTLEGLVKMDEGDYAKAEKLIGKNAKHSAEPVLNLIKAAEAAQQRGDEFSANRYLIEATELAGSDNLLVEIART
RILLQQNKLPAARSSVDSLLEMARRNKEVLKLAVEIYLRSKAYQALDKILDNVANSGLFNDEEFKDLRSKTENGLLDEKM
NEEGIDGLLTWWNQQPRHRRNNIELKISLIQRLIDCNDHESATELTFEILKKLGDNTAISLPLCTQITRLQPEDNSKLLK
LIEKRAKRVDEKQKCCINRALGYLYVRNNEFIKAADVFKNVIACPEQLEQNDLMMASYVFEQAGDKALAEQVRQESLKSV
MAIQDVIPESAEEKTEENSTALLESKSE
>Mature_428_residues
MFRVLFLMLTLLVGLVAGPYISGQQGYVRIETANRIIEMSITTLVIFFIISLAIIYAFEWGVTRFFRLSRSSYQWFSNRK
RVKAQKQTLEGLVKMDEGDYAKAEKLIGKNAKHSAEPVLNLIKAAEAAQQRGDEFSANRYLIEATELAGSDNLLVEIART
RILLQQNKLPAARSSVDSLLEMARRNKEVLKLAVEIYLRSKAYQALDKILDNVANSGLFNDEEFKDLRSKTENGLLDEKM
NEEGIDGLLTWWNQQPRHRRNNIELKISLIQRLIDCNDHESATELTFEILKKLGDNTAISLPLCTQITRLQPEDNSKLLK
LIEKRAKRVDEKQKCCINRALGYLYVRNNEFIKAADVFKNVIACPEQLEQNDLMMASYVFEQAGDKALAEQVRQESLKSV
MAIQDVIPESAEEKTEENSTALLESKSE

Specific function: Involved in a late step of protoheme IX synthesis

COG id: COG3071

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790234, Length=351, Percent_Identity=38.1766381766382, Blast_Score=258, Evalue=4e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMY_HAEIN (P44772)

Other databases:

- EMBL:   L42023
- PIR:   C64080
- RefSeq:   NP_438760.1
- GeneID:   949653
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0602
- NMPDR:   fig|71421.1.peg.571
- TIGR:   HI_0602
- HOGENOM:   HBG564211
- OMA:   FRVLFLM
- ProtClustDB:   CLSK870630
- BioCyc:   HINF71421:HI_0602-MONOMER
- GO:   GO:0005488
- InterPro:   IPR010817
- InterPro:   IPR005254
- InterPro:   IPR011990
- Gene3D:   G3DSA:1.25.40.10
- TIGRFAMs:   TIGR00540

Pfam domain/function: PF07219 HemY_N

EC number: NA

Molecular weight: Translated: 48777; Mature: 48777

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xcc6abf0)-; HASH(0xd00bbc0)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRVLFLMLTLLVGLVAGPYISGQQGYVRIETANRIIEMSITTLVIFFIISLAIIYAFEW
CHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVTRFFRLSRSSYQWFSNRKRVKAQKQTLEGLVKMDEGDYAKAEKLIGKNAKHSAEPVLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHH
LIKAAEAAQQRGDEFSANRYLIEATELAGSDNLLVEIARTRILLQQNKLPAARSSVDSLL
HHHHHHHHHHCCCCCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
EMARRNKEVLKLAVEIYLRSKAYQALDKILDNVANSGLFNDEEFKDLRSKTENGLLDEKM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHC
NEEGIDGLLTWWNQQPRHRRNNIELKISLIQRLIDCNDHESATELTFEILKKLGDNTAIS
CCCCCHHHHHHHCCCCHHCCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEE
LPLCTQITRLQPEDNSKLLKLIEKRAKRVDEKQKCCINRALGYLYVRNNEFIKAADVFKN
CHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEEECCCCCHHHHHHHH
VIACPEQLEQNDLMMASYVFEQAGDKALAEQVRQESLKSVMAIQDVIPESAEEKTEENST
HHHCHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCH
ALLESKSE
HHHCCCCH
>Mature Secondary Structure
MFRVLFLMLTLLVGLVAGPYISGQQGYVRIETANRIIEMSITTLVIFFIISLAIIYAFEW
CHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVTRFFRLSRSSYQWFSNRKRVKAQKQTLEGLVKMDEGDYAKAEKLIGKNAKHSAEPVLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHH
LIKAAEAAQQRGDEFSANRYLIEATELAGSDNLLVEIARTRILLQQNKLPAARSSVDSLL
HHHHHHHHHHCCCCCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
EMARRNKEVLKLAVEIYLRSKAYQALDKILDNVANSGLFNDEEFKDLRSKTENGLLDEKM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHC
NEEGIDGLLTWWNQQPRHRRNNIELKISLIQRLIDCNDHESATELTFEILKKLGDNTAIS
CCCCCHHHHHHHCCCCHHCCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEE
LPLCTQITRLQPEDNSKLLKLIEKRAKRVDEKQKCCINRALGYLYVRNNEFIKAADVFKN
CHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEEECCCCCHHHHHHHH
VIACPEQLEQNDLMMASYVFEQAGDKALAEQVRQESLKSVMAIQDVIPESAEEKTEENST
HHHCHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCH
ALLESKSE
HHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800