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The map label for this gene is fba

Identifier: 16272468

GI number: 16272468

Start: 547186

End: 548265

Strand: Reverse

Name: fba

Synonym: HI0524

Alternate gene names: 16272468

Gene position: 548265-547186 (Counterclockwise)

Preceding gene: 16272469

Following gene: 30995382

Centisome position: 29.96

GC content: 40.56

Gene sequence:

>1080_bases
ATGGCTAAATTATTAGATATTGTGAAACCCGGTGTTGTAACAGGCGAAGATGTGCAAAAAGTTTTTGCTTATGCTAAAGA
GCATAACTTTGCTATTCCTGCCGTAAACTGTGTGGGTTCAGACTCCGTTAATGCCGTGTTAGAAACTGCTGCACGCGTAA
AAGCACCAGTGATTATCCAATTTTCAAATGGTGGCGCAGCGTTCTACGCAGGTAAAGGTATCAAACCAACGAGTGGTACT
CGTCCTGATGTGCTTGGTGCGATTGCTGGAGCGAAACAGGTTCATACTTTAGCGAAAGAATACGGTGTGCCTGTTATTCT
TCATACTGATCACGCAGCGAAAAAATTATTACCTTGGATCGACGGTTTATTAGATGCAGGCGAAAAACATTTTGCCGAAA
CGGGTCGTCCACTTTTCTCTTCACATATGATCGATTTATCTGAAGAGTCAATGGAAGAAAATATGGCAATCTGTCGTGAA
TACCTCGCTCGTATGGATAAAATGGGGATGACCCTTGAAATCGAAATTGGCATTACTGGTGGCGAAGAAGACGGCGTTGA
TAACTCTGATGTTGATGAATCACGTTTATATACACAACCTTCTGATGTGCTTTATGTTTACGATCAATTGCATCCAGTAA
GCCCTAACTTTACCGTTGCTGCTGCATTCGGTAACGTACACGGTGTTTACAAACCAGGTAATGTAAAATTAAAACCATCT
ATTTTAGGTGAATCACAAGAGTTCGTTTCTAAAGAACGCAATCTTCCTGCAAAACCAATTAATTTCGTATTCCACGGTGG
TTCAGGTTCTAGCCGCGAAGAAATCCGCGAAGCAATTGGCTACGGTGCAATCAAAATGAACATTGATACTGATACGCAAT
GGGCATCTTGGAATGGTATTTTGAATTTCTATAAAGCAAATGAAGCATATCTTCAAGGTCAATTAGGTAACCCTGAAGGC
CCAGATGCACCAAACAAAAAATACTACGACCCACGTGTTTGGTTACGTAAAATGGAAGAATCTATGTCTAAACGCTTAGA
GCAATCTTTCGAAGACTTAAATTGTGTTGATGTTTTATAA

Upstream 100 bases:

>100_bases
CCTCTATAACATATTGATGGTGGCATCAAAAATGCCATCATCAATACAAATTCTTCAAATTGTGGGCTTATCCCGCTAAA
CATAAAAAGGAAACACAAGT

Downstream 100 bases:

>100_bases
TCCACAAAAATAACATAAAATACGACCGCACTTTCAAGTGCGGTTTTTTTATTTTAGCGGAGAAATTATGGAAAAGATTT
TAGTTATTCGTAACGATAAA

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MAKLLDIVKPGVVTGEDVQKVFAYAKEHNFAIPAVNCVGSDSVNAVLETAARVKAPVIIQFSNGGAAFYAGKGIKPTSGT
RPDVLGAIAGAKQVHTLAKEYGVPVILHTDHAAKKLLPWIDGLLDAGEKHFAETGRPLFSSHMIDLSEESMEENMAICRE
YLARMDKMGMTLEIEIGITGGEEDGVDNSDVDESRLYTQPSDVLYVYDQLHPVSPNFTVAAAFGNVHGVYKPGNVKLKPS
ILGESQEFVSKERNLPAKPINFVFHGGSGSSREEIREAIGYGAIKMNIDTDTQWASWNGILNFYKANEAYLQGQLGNPEG
PDAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCVDVL

Sequences:

>Translated_359_residues
MAKLLDIVKPGVVTGEDVQKVFAYAKEHNFAIPAVNCVGSDSVNAVLETAARVKAPVIIQFSNGGAAFYAGKGIKPTSGT
RPDVLGAIAGAKQVHTLAKEYGVPVILHTDHAAKKLLPWIDGLLDAGEKHFAETGRPLFSSHMIDLSEESMEENMAICRE
YLARMDKMGMTLEIEIGITGGEEDGVDNSDVDESRLYTQPSDVLYVYDQLHPVSPNFTVAAAFGNVHGVYKPGNVKLKPS
ILGESQEFVSKERNLPAKPINFVFHGGSGSSREEIREAIGYGAIKMNIDTDTQWASWNGILNFYKANEAYLQGQLGNPEG
PDAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCVDVL
>Mature_358_residues
AKLLDIVKPGVVTGEDVQKVFAYAKEHNFAIPAVNCVGSDSVNAVLETAARVKAPVIIQFSNGGAAFYAGKGIKPTSGTR
PDVLGAIAGAKQVHTLAKEYGVPVILHTDHAAKKLLPWIDGLLDAGEKHFAETGRPLFSSHMIDLSEESMEENMAICREY
LARMDKMGMTLEIEIGITGGEEDGVDNSDVDESRLYTQPSDVLYVYDQLHPVSPNFTVAAAFGNVHGVYKPGNVKLKPSI
LGESQEFVSKERNLPAKPINFVFHGGSGSSREEIREAIGYGAIKMNIDTDTQWASWNGILNFYKANEAYLQGQLGNPEGP
DAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCVDVL

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family

Homologues:

Organism=Escherichia coli, GI1789293, Length=359, Percent_Identity=71.3091922005571, Blast_Score=559, Evalue=1e-161,
Organism=Escherichia coli, GI87082041, Length=331, Percent_Identity=26.5861027190332, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788072, Length=274, Percent_Identity=26.2773722627737, Blast_Score=65, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322790, Length=352, Percent_Identity=50.8522727272727, Blast_Score=380, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALF_HAEIN (P44429)

Other databases:

- EMBL:   L42023
- PIR:   C64074
- RefSeq:   NP_438682.1
- ProteinModelPortal:   P44429
- SMR:   P44429
- GeneID:   949539
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0524
- NMPDR:   fig|71421.1.peg.495
- TIGR:   HI_0524
- HOGENOM:   HBG327581
- OMA:   QAYCAEK
- ProtClustDB:   PRK09197
- BioCyc:   HINF71421:HI_0524-MONOMER
- BRENDA:   4.1.2.13
- GO:   GO:0006096
- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF001359
- TIGRFAMs:   TIGR00167
- TIGRFAMs:   TIGR01520

Pfam domain/function: PF01116 F_bP_aldolase

EC number: =4.1.2.13

Molecular weight: Translated: 39340; Mature: 39209

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00602 ALDOLASE_CLASS_II_1; PS00806 ALDOLASE_CLASS_II_2; PS00152 ATPASE_ALPHA_BETA

Important sites: ACT_SITE 110-110 BINDING 62-62 BINDING 228-228

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLLDIVKPGVVTGEDVQKVFAYAKEHNFAIPAVNCVGSDSVNAVLETAARVKAPVIIQ
CCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEE
FSNGGAAFYAGKGIKPTSGTRPDVLGAIAGAKQVHTLAKEYGVPVILHTDHAAKKLLPWI
ECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHH
DGLLDAGEKHFAETGRPLFSSHMIDLSEESMEENMAICREYLARMDKMGMTLEIEIGITG
HHHHHCCHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEC
GEEDGVDNSDVDESRLYTQPSDVLYVYDQLHPVSPNFTVAAAFGNVHGVYKPGNVKLKPS
CCCCCCCCCCCCHHHCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCEECCCCEEECHH
ILGESQEFVSKERNLPAKPINFVFHGGSGSSREEIREAIGYGAIKMNIDTDTQWASWNGI
HCCCCHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCE
LNFYKANEAYLQGQLGNPEGPDAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCVDVL
EEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AKLLDIVKPGVVTGEDVQKVFAYAKEHNFAIPAVNCVGSDSVNAVLETAARVKAPVIIQ
CHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEE
FSNGGAAFYAGKGIKPTSGTRPDVLGAIAGAKQVHTLAKEYGVPVILHTDHAAKKLLPWI
ECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHH
DGLLDAGEKHFAETGRPLFSSHMIDLSEESMEENMAICREYLARMDKMGMTLEIEIGITG
HHHHHCCHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEC
GEEDGVDNSDVDESRLYTQPSDVLYVYDQLHPVSPNFTVAAAFGNVHGVYKPGNVKLKPS
CCCCCCCCCCCCHHHCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCEECCCCEEECHH
ILGESQEFVSKERNLPAKPINFVFHGGSGSSREEIREAIGYGAIKMNIDTDTQWASWNGI
HCCCCHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCE
LNFYKANEAYLQGQLGNPEGPDAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCVDVL
EEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800