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The map label for this gene is tyrR

Identifier: 16272359

GI number: 16272359

Start: 431377

End: 432333

Strand: Direct

Name: tyrR

Synonym: HI0410

Alternate gene names: 16272359

Gene position: 431377-432333 (Clockwise)

Preceding gene: 16272358

Following gene: 30995373

Centisome position: 23.57

GC content: 37.51

Gene sequence:

>957_bases
ATGACGATTTCTAAATTTAATCCTCAAAAACCTTTCGAGTGTTTTATTGTACAAAGTGAAGCGATGAAAAGTGCGGTAGA
AAACGCGAAACGTTTTGCTATGTTTGATGCGCCTTTGTTAATTCAAGGCGAAACGGGGAGTGGAAAAGATTTGTTAGCGA
AAGCCTGCCATTATCAGAGTTTGCGTCGCGATAAAAAATTTATCGCAGTAAACTGTGCGGGTTTGCCTGATGAAGATGCG
GAAAGTGAAATGTTTGGTCGAAAAGTCGGAGACAGTGAAACCATTGGTTTTTTTGAATACGCTAATAAAGGGACAGTTTT
ACTCGATGGCATTGCCGAACTTTCATTAAGTTTACAGGCTAAATTATTGCGTTTTTTAACGGATGGATCTTTCCGTCGAG
TAGGCGAAGAAAAAGAGCATTATGCAAATGTGCGCGTGATTTGCACATCACAGGTTCCACTTCATTTGCTTGTTGAGCAA
GGTAAAGTACGTGCTGATTTGTTTCATCGCTTAAATGTTCTCACTATTAATGTGCCTGCATTACGAGATCGCATGGCTGA
TATTGAGCCACTGGCACAAGGTTTTTTACAGGAAATCAGTGAAGAATTAAAAATTGCAAAACCAACTTTCGATAAAGATT
TTCTTCTTTATTTGCAGAAATATGATTGGAAAGGGAATGTTCGAGAGCTTTATAACACTCTTTATCGCGCTTGTTCGTTA
GTACAAGATAATCATTTAACTATCGAAAGTTTAAATCTTGCTCTGCCACAAAGTGCGGTGATTTCTTTGGATGAATTTGA
AAATAAAACCTTAGATGAAATTATTGGTTTCTATGAAGCACAAGTCCTAAAATTATTTTATGCAGAATATCCAAGCACGA
GAAAATTGGCTCAACGTTTAGGCGTCTCCCATACTGCCATTGCGAATAAATTGAAACAATATGGAATTGGAAAGTAG

Upstream 100 bases:

>100_bases
GTCAAAAATGGTCGCATTTTTACCTTATGTAAAATAATATTTACACTTTGTTGTAAAGAAATTATCATAGCCATATCTTA
ATTATCTCCATTCCCTGAAT

Downstream 100 bases:

>100_bases
TTTTCACATTTGAGATGAAAAAAAGTGCGGTTGAAATTTCCTGAGAATTTTCAACCGCACTTAATAAATATTGATTACCC
ATTAATGGTATTGTGATTAC

Product: transcriptional regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MTISKFNPQKPFECFIVQSEAMKSAVENAKRFAMFDAPLLIQGETGSGKDLLAKACHYQSLRRDKKFIAVNCAGLPDEDA
ESEMFGRKVGDSETIGFFEYANKGTVLLDGIAELSLSLQAKLLRFLTDGSFRRVGEEKEHYANVRVICTSQVPLHLLVEQ
GKVRADLFHRLNVLTINVPALRDRMADIEPLAQGFLQEISEELKIAKPTFDKDFLLYLQKYDWKGNVRELYNTLYRACSL
VQDNHLTIESLNLALPQSAVISLDEFENKTLDEIIGFYEAQVLKLFYAEYPSTRKLAQRLGVSHTAIANKLKQYGIGK

Sequences:

>Translated_318_residues
MTISKFNPQKPFECFIVQSEAMKSAVENAKRFAMFDAPLLIQGETGSGKDLLAKACHYQSLRRDKKFIAVNCAGLPDEDA
ESEMFGRKVGDSETIGFFEYANKGTVLLDGIAELSLSLQAKLLRFLTDGSFRRVGEEKEHYANVRVICTSQVPLHLLVEQ
GKVRADLFHRLNVLTINVPALRDRMADIEPLAQGFLQEISEELKIAKPTFDKDFLLYLQKYDWKGNVRELYNTLYRACSL
VQDNHLTIESLNLALPQSAVISLDEFENKTLDEIIGFYEAQVLKLFYAEYPSTRKLAQRLGVSHTAIANKLKQYGIGK
>Mature_317_residues
TISKFNPQKPFECFIVQSEAMKSAVENAKRFAMFDAPLLIQGETGSGKDLLAKACHYQSLRRDKKFIAVNCAGLPDEDAE
SEMFGRKVGDSETIGFFEYANKGTVLLDGIAELSLSLQAKLLRFLTDGSFRRVGEEKEHYANVRVICTSQVPLHLLVEQG
KVRADLFHRLNVLTINVPALRDRMADIEPLAQGFLQEISEELKIAKPTFDKDFLLYLQKYDWKGNVRELYNTLYRACSLV
QDNHLTIESLNLALPQSAVISLDEFENKTLDEIIGFYEAQVLKLFYAEYPSTRKLAQRLGVSHTAIANKLKQYGIGK

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain

Homologues:

Organism=Escherichia coli, GI1787583, Length=308, Percent_Identity=48.0519480519481, Blast_Score=285, Evalue=3e-78,
Organism=Escherichia coli, GI1788550, Length=312, Percent_Identity=36.5384615384615, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI87082117, Length=320, Percent_Identity=36.25, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI1789087, Length=326, Percent_Identity=34.0490797546012, Blast_Score=175, Evalue=3e-45,
Organism=Escherichia coli, GI1789233, Length=328, Percent_Identity=31.4024390243902, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1790299, Length=255, Percent_Identity=37.6470588235294, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI87082152, Length=325, Percent_Identity=33.5384615384615, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1788905, Length=282, Percent_Identity=33.6879432624113, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1790437, Length=251, Percent_Identity=35.8565737051793, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1786524, Length=316, Percent_Identity=34.1772151898734, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI87081872, Length=219, Percent_Identity=36.986301369863, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI87081858, Length=286, Percent_Identity=29.3706293706294, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1789828, Length=229, Percent_Identity=29.2576419213974, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYRR_HAEIN (P44694)

Other databases:

- EMBL:   L42023
- PIR:   C64066
- RefSeq:   NP_438572.1
- PDB:   1G2H
- PDBsum:   1G2H
- ProteinModelPortal:   P44694
- SMR:   P44694
- GeneID:   950074
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0410
- NMPDR:   fig|71421.1.peg.385
- TIGR:   HI_0410
- HOGENOM:   HBG740884
- OMA:   HTIERAL
- ProtClustDB:   CLSK870292
- BioCyc:   HINF71421:HI_0410-MONOMER
- GO:   GO:0005737
- GO:   GO:0006350
- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR002078
- Gene3D:   G3DSA:1.10.10.60
- SMART:   SM00382

Pfam domain/function: PF00158 Sigma54_activat; SSF46689 Homeodomain_like

EC number: NA

Molecular weight: Translated: 35955; Mature: 35824

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00675 SIGMA54_INTERACT_1; PS00676 SIGMA54_INTERACT_2; PS00688 SIGMA54_INTERACT_3; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISKFNPQKPFECFIVQSEAMKSAVENAKRFAMFDAPLLIQGETGSGKDLLAKACHYQS
CCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHEEECCCEEEECCCCCCHHHHHHHHHHHH
LRRDKKFIAVNCAGLPDEDAESEMFGRKVGDSETIGFFEYANKGTVLLDGIAELSLSLQA
HHCCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCEEHEEECCCCCEEEHHHHHHHHHHHH
KLLRFLTDGSFRRVGEEKEHYANVRVICTSQVPLHLLVEQGKVRADLFHRLNVLTINVPA
HHHHHHCCCHHHHHCCHHHHHCCEEEEEECCCCEEEHHHCCCHHHHHHHCCEEEEEECHH
LRDRMADIEPLAQGFLQEISEELKIAKPTFDKDFLLYLQKYDWKGNVRELYNTLYRACSL
HHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VQDNHLTIESLNLALPQSAVISLDEFENKTLDEIIGFYEAQVLKLFYAEYPSTRKLAQRL
HCCCCEEEEECCCCCCHHHHEEHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
GVSHTAIANKLKQYGIGK
CCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TISKFNPQKPFECFIVQSEAMKSAVENAKRFAMFDAPLLIQGETGSGKDLLAKACHYQS
CCCCCCCCCCCEEEEECHHHHHHHHHHHHHHEEECCCEEEECCCCCCHHHHHHHHHHHH
LRRDKKFIAVNCAGLPDEDAESEMFGRKVGDSETIGFFEYANKGTVLLDGIAELSLSLQA
HHCCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCEEHEEECCCCCEEEHHHHHHHHHHHH
KLLRFLTDGSFRRVGEEKEHYANVRVICTSQVPLHLLVEQGKVRADLFHRLNVLTINVPA
HHHHHHCCCHHHHHCCHHHHHCCEEEEEECCCCEEEHHHCCCHHHHHHHCCEEEEEECHH
LRDRMADIEPLAQGFLQEISEELKIAKPTFDKDFLLYLQKYDWKGNVRELYNTLYRACSL
HHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VQDNHLTIESLNLALPQSAVISLDEFENKTLDEIIGFYEAQVLKLFYAEYPSTRKLAQRL
HCCCCEEEEECCCCCCHHHHEEHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
GVSHTAIANKLKQYGIGK
CCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800