Click here to switch to the map view.

The map label for this gene is rnd

Identifier: 16272339

GI number: 16272339

Start: 411952

End: 413151

Strand: Direct

Name: rnd

Synonym: HI0390

Alternate gene names: 16272339

Gene position: 411952-413151 (Clockwise)

Preceding gene: 16272338

Following gene: 16272344

Centisome position: 22.51

GC content: 36.25

Gene sequence:

>1200_bases
ATGTCAAAATGGGATAGCAATATCCCATTTTTGTTCTTTTCAAATAAAAAAATCACTATGATAAAAGAATGTCAAAATCC
ACCGCACTTTAGGGTCGTTACGGATAATACTGCGCTATTAGAAGTTTGTAATTTAGCCCAACAGAAAAGTGCGGTCGCCT
TAGATACAGAATTTATGCGTGTTTCCACTTATTTTCCCAAGTTGGGATTAATCCAGCTTTATGATGGAGAGCACGTCTCT
TTAATTGATCCTTTAGCGATTACGGATTTTTCGCCTTTTGTTGCATTGTTAGCCAATCCTAAGGTATTAAAAATCTTACA
TTCTTGTAGTGAAGATTTATTGGTTTTCTTACAAGAATTTGATCAGCTTCCACGCCCAATGATTGATACGCAAATTATGG
CACGATTTCTTGGGCTTGGCACATCAGCAGGATTGGCAAAATTAGCACAACAATATTTAAATGTAGAAATCGATAAAGGC
GCAACTCGCACCAATTGGATCAAACGCCCCCTTTCTGATATTCAACTTCAATATGCCGCAGGCGATGTTTGGTATTTGTT
GCCACTTTATCATATTCTTGAAAAAGAGTTAGCGAAAACACCTTGGGAACAAGCAGTAAGAGATGATTGCGAACTTGTTC
TTGCTAAAACGCATAAATTACAAGAGCGAGATTCAGAAAAAGCGTATTTAGATATTCCAAATGCTTGGAAATTAAATCCA
TTAGAATTGTCTCGTTTAAGAGTTTTGGCACAGTGGCGACAAAACGTGGCAATAGAACGTGATTTAGCACTTTCTTATAT
TGTGAAATCAGAACATCTTTGGAAAGTGGCAAAGAATAATCCACGTAATACATCTGAAATGTTAGAAATGGGATTAACTG
AAAATGAAGTGCGTGTACGTGGTAAGGAAATTCTACAATTACTTTCTCAAGCAAGACGTATTTCGTCTAATGACTATCCA
AAATCTATTGAACGTATTTCTGAAGATCCTCGTTATAAAAAAACAATTCGATTATTACAAGAAAAAGTGAATAGCTTAAC
ACCAGAAGGTTTAACCCCTGAAATCGTTGCAAGTAAACGCACTTTGGAAGAATTGATTAAATGGGTTTGGAAATATGATT
GTTCTCAAGATAAACGACCAGAGTTGCTGATTGGCTGGCGAAAACCTATTGGTGAAAAGTTAGTCGATGCACTTAAGTAG

Upstream 100 bases:

>100_bases
AAGAAATTGAGTTCCGAGACGAACTACCAAAAACTAATGTTGGCAAGATTTTACGTCGGGTTTTACGCGATGAAGAGATC
GCAAAACGTCCAAAACATTA

Downstream 100 bases:

>100_bases
ATATAAAAAAGCGTTGAGTAAATAGCTCAACGCTTTTCGTTTCTACTCGTAGAGTTTTTTCACTTGTTCAGGTGTCATCA
CTCGTTGGTATTTACTAAAT

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MSKWDSNIPFLFFSNKKITMIKECQNPPHFRVVTDNTALLEVCNLAQQKSAVALDTEFMRVSTYFPKLGLIQLYDGEHVS
LIDPLAITDFSPFVALLANPKVLKILHSCSEDLLVFLQEFDQLPRPMIDTQIMARFLGLGTSAGLAKLAQQYLNVEIDKG
ATRTNWIKRPLSDIQLQYAAGDVWYLLPLYHILEKELAKTPWEQAVRDDCELVLAKTHKLQERDSEKAYLDIPNAWKLNP
LELSRLRVLAQWRQNVAIERDLALSYIVKSEHLWKVAKNNPRNTSEMLEMGLTENEVRVRGKEILQLLSQARRISSNDYP
KSIERISEDPRYKKTIRLLQEKVNSLTPEGLTPEIVASKRTLEELIKWVWKYDCSQDKRPELLIGWRKPIGEKLVDALK

Sequences:

>Translated_399_residues
MSKWDSNIPFLFFSNKKITMIKECQNPPHFRVVTDNTALLEVCNLAQQKSAVALDTEFMRVSTYFPKLGLIQLYDGEHVS
LIDPLAITDFSPFVALLANPKVLKILHSCSEDLLVFLQEFDQLPRPMIDTQIMARFLGLGTSAGLAKLAQQYLNVEIDKG
ATRTNWIKRPLSDIQLQYAAGDVWYLLPLYHILEKELAKTPWEQAVRDDCELVLAKTHKLQERDSEKAYLDIPNAWKLNP
LELSRLRVLAQWRQNVAIERDLALSYIVKSEHLWKVAKNNPRNTSEMLEMGLTENEVRVRGKEILQLLSQARRISSNDYP
KSIERISEDPRYKKTIRLLQEKVNSLTPEGLTPEIVASKRTLEELIKWVWKYDCSQDKRPELLIGWRKPIGEKLVDALK
>Mature_398_residues
SKWDSNIPFLFFSNKKITMIKECQNPPHFRVVTDNTALLEVCNLAQQKSAVALDTEFMRVSTYFPKLGLIQLYDGEHVSL
IDPLAITDFSPFVALLANPKVLKILHSCSEDLLVFLQEFDQLPRPMIDTQIMARFLGLGTSAGLAKLAQQYLNVEIDKGA
TRTNWIKRPLSDIQLQYAAGDVWYLLPLYHILEKELAKTPWEQAVRDDCELVLAKTHKLQERDSEKAYLDIPNAWKLNPL
ELSRLRVLAQWRQNVAIERDLALSYIVKSEHLWKVAKNNPRNTSEMLEMGLTENEVRVRGKEILQLLSQARRISSNDYPK
SIERISEDPRYKKTIRLLQEKVNSLTPEGLTPEIVASKRTLEELIKWVWKYDCSQDKRPELLIGWRKPIGEKLVDALK

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain

Homologues:

Organism=Homo sapiens, GI4505917, Length=277, Percent_Identity=25.2707581227437, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI50301240, Length=277, Percent_Identity=25.2707581227437, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1788105, Length=371, Percent_Identity=40.9703504043127, Blast_Score=304, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI17531757, Length=270, Percent_Identity=24.4444444444444, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161078302, Length=253, Percent_Identity=25.296442687747, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RND_HAEIN (P44442)

Other databases:

- EMBL:   L42023
- PIR:   B64065
- RefSeq:   NP_438552.1
- ProteinModelPortal:   P44442
- SMR:   P44442
- GeneID:   950674
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0390
- NMPDR:   fig|71421.1.peg.365
- TIGR:   HI_0390
- HOGENOM:   HBG311289
- OMA:   KSKYLHK
- ProtClustDB:   CLSK870210
- BioCyc:   HINF71421:HI_0390-MONOMER
- BRENDA:   3.1.13.5
- GO:   GO:0005737
- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337
- SMART:   SM00474
- SMART:   SM00341
- TIGRFAMs:   TIGR01388

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC; SSF47819 HRDC_like; SSF53098 RNaseH_fold

EC number: =3.1.13.5

Molecular weight: Translated: 46066; Mature: 45935

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKWDSNIPFLFFSNKKITMIKECQNPPHFRVVTDNTALLEVCNLAQQKSAVALDTEFMR
CCCCCCCCCEEEECCCCEEEHHHCCCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHH
VSTYFPKLGLIQLYDGEHVSLIDPLAITDFSPFVALLANPKVLKILHSCSEDLLVFLQEF
HHHHCCCCCEEEEECCCEEEEECCHHHCCHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHH
DQLPRPMIDTQIMARFLGLGTSAGLAKLAQQYLNVEIDKGATRTNWIKRPLSDIQLQYAA
HHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCEEECCCCCHHHHHHCCHHHHEEEECC
GDVWYLLPLYHILEKELAKTPWEQAVRDDCELVLAKTHKLQERDSEKAYLDIPNAWKLNP
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCH
LELSRLRVLAQWRQNVAIERDLALSYIVKSEHLWKVAKNNPRNTSEMLEMGLTENEVRVR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHH
GKEILQLLSQARRISSNDYPKSIERISEDPRYKKTIRLLQEKVNSLTPEGLTPEIVASKR
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
TLEELIKWVWKYDCSQDKRPELLIGWRKPIGEKLVDALK
HHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHCC
>Mature Secondary Structure 
SKWDSNIPFLFFSNKKITMIKECQNPPHFRVVTDNTALLEVCNLAQQKSAVALDTEFMR
CCCCCCCCEEEECCCCEEEHHHCCCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHH
VSTYFPKLGLIQLYDGEHVSLIDPLAITDFSPFVALLANPKVLKILHSCSEDLLVFLQEF
HHHHCCCCCEEEEECCCEEEEECCHHHCCHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHH
DQLPRPMIDTQIMARFLGLGTSAGLAKLAQQYLNVEIDKGATRTNWIKRPLSDIQLQYAA
HHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCEEECCCCCHHHHHHCCHHHHEEEECC
GDVWYLLPLYHILEKELAKTPWEQAVRDDCELVLAKTHKLQERDSEKAYLDIPNAWKLNP
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCH
LELSRLRVLAQWRQNVAIERDLALSYIVKSEHLWKVAKNNPRNTSEMLEMGLTENEVRVR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHH
GKEILQLLSQARRISSNDYPKSIERISEDPRYKKTIRLLQEKVNSLTPEGLTPEIVASKR
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
TLEELIKWVWKYDCSQDKRPELLIGWRKPIGEKLVDALK
HHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800