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The map label for this gene is ushA [C]

Identifier: 16272169

GI number: 16272169

Start: 220104

End: 221915

Strand: Direct

Name: ushA [C]

Synonym: HI0206

Alternate gene names: 16272169

Gene position: 220104-221915 (Clockwise)

Preceding gene: 16272168

Following gene: 16272170

Centisome position: 12.03

GC content: 36.48

Gene sequence:

>1812_bases
ATGCTTTTATCCAAAAAATCAGCCTCCTTTGCACTCAGTGCATTTGCGATGCTTTTCACTAGTGTAGCTCTTGCCAAAGA
GGCACCACAAGCTCACAAAGCTGTGGAATTAAGTATTTTGCATATCAATGATCACCATTCTTATTTAGAACCGCACGAAA
CACGGATTAATTTAAATGGTCAGCAAACCAAAGTGGATATTGGTGGTTTTTCTGCTGTCAATGCAAAACTTAACAAATTG
CGTAAAAAATACAAAAATCCATTAGTACTGCATGCAGGCGATGCCATTACTGGTACACTTTACTTCACGCTGTTTGGTGG
TTCTGCAGATGCAGCTGTGATGAATGCAGGTAATTTCCATTATTTTACTTTAGGTAATCATGAATTTGACGCGGGTAATG
AAGGGTTATTAAAACTGCTTGAACCATTAAAAATCCCAGTGCTTTCAGCTAATGTGATTCCTGATAAAAATTCAATTTTG
TATAACAAATGGAAACCTTACGATATTTTCACTGTGGATGGAGAAAAAATTGCCATTATCGGTTTAGATACTGTGAATAA
AACAGTGAATTCCTCTTCTCCGGGTAAGGATGTGAAGTTCTACGATGAAATTGCTACTGCACAAATTATGGCAAATGCGC
TAAAACAGCAAGGAATTAATAAAATTATCCTACTTTCACACGCAGGTAGTGAAAAAAATATCGAAATTGCTCAAAAAGTA
AATGATATTGATGTGATCGTTACTGGCGATTCACATTATTTATACGGAAATGATGAATTACGTAGTTTAAAACTTCCAGT
AATCTATGAATATCCACTTGAATTTAAAAATCCAAATGGAGACCCTGTATTTGTAATGGAAGGCTGGGCTTATTCTGCCG
TGGTGGGGGATTTGGGTGTTAAATTCAGTCCTGAAGGTATAGCGTCTATTACTCGTAAAATTCCTCATGTGTTAATGAGT
TCTCATAAACTTCAAGTGAAAAATGCGGAAGGTAAATGGACGGAATTAACTGGCGATGAACGTAAAAAAGCACTTGATAC
TTTAAAATCAATGAAGAGTATTTCACTTGATGATCATGATGCAAAAACAGACATGCTTATTTCAAAATATAAAAGTGAAA
AAGATCGTTTAGCACAAGAAATTGTTGGTGTCATCACAGGTTCTGCAATGCCGGGTGGTTCAGCAAACCGTATCCCAAAT
AAAGCAGGCTCAAATCCAGAAGGTTCTATTGCAACGCGTTTTATTGCAGAAACAATGTATAACGAACTCAAAACAGTGGA
TTTAACTATTCAAAATGCTGGCGGTGTACGCGCAGATATTTTACCGGGTAATGTAACCTTTAACGATGCTTATACTTTCT
TACCTTTCGGGAATACGTTATATACCTATAAAATGGAAGGTTCATTAGTGAAACAAGTGCTTGAAGATGCAATGCAATTT
GCTTTGGTTGATGGCTCTACAGGCGCATTCCCTTATGGTGCAGGTATTCGTTATGAAGCGAATGAAACACCAAATGCGGA
AGGTAAGCGTTTAGTGAGTGTTGAAGTCTTGAATAAACAAACCCAACAATGGGAACCGATTGATGATAACAAACGTTATC
TTGTCGGAACAAATGCTTATGTTGCAGGCGGTAAAGACGGTTATAAAACCTTTGGTAAATTATTTAACGATCCAAAATAT
GAAGGCGTTGATACCTACTTACCTGATGCAGAAAGTTTCATAAAATTTATGAAAAAACATCCGCACTTTGAGGCTTACAC
TTCATCAAATGTGAAATTTAATGCTTCAACTGATGCATTACCTAAAAAATAA

Upstream 100 bases:

>100_bases
CCTCGAGAAAATTTACAGCACAATAATGATGCAATTCGTTACAAAACCTTTCAAGCAATGCTAGAAGGTTTAAATTAATC
CCTTACCAATAGGAGTTTTT

Downstream 100 bases:

>100_bases
AATTGAAAAATAGGCTAAAAATAGCGCGTATTTAACGCGCTATTTTTGTTATTAGTCCTAGGTTTGAAGACTTCATAGAT
GATTAAGAATTTTAACTATT

Product: NAD nucleotidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MLLSKKSASFALSAFAMLFTSVALAKEAPQAHKAVELSILHINDHHSYLEPHETRINLNGQQTKVDIGGFSAVNAKLNKL
RKKYKNPLVLHAGDAITGTLYFTLFGGSADAAVMNAGNFHYFTLGNHEFDAGNEGLLKLLEPLKIPVLSANVIPDKNSIL
YNKWKPYDIFTVDGEKIAIIGLDTVNKTVNSSSPGKDVKFYDEIATAQIMANALKQQGINKIILLSHAGSEKNIEIAQKV
NDIDVIVTGDSHYLYGNDELRSLKLPVIYEYPLEFKNPNGDPVFVMEGWAYSAVVGDLGVKFSPEGIASITRKIPHVLMS
SHKLQVKNAEGKWTELTGDERKKALDTLKSMKSISLDDHDAKTDMLISKYKSEKDRLAQEIVGVITGSAMPGGSANRIPN
KAGSNPEGSIATRFIAETMYNELKTVDLTIQNAGGVRADILPGNVTFNDAYTFLPFGNTLYTYKMEGSLVKQVLEDAMQF
ALVDGSTGAFPYGAGIRYEANETPNAEGKRLVSVEVLNKQTQQWEPIDDNKRYLVGTNAYVAGGKDGYKTFGKLFNDPKY
EGVDTYLPDAESFIKFMKKHPHFEAYTSSNVKFNASTDALPKK

Sequences:

>Translated_603_residues
MLLSKKSASFALSAFAMLFTSVALAKEAPQAHKAVELSILHINDHHSYLEPHETRINLNGQQTKVDIGGFSAVNAKLNKL
RKKYKNPLVLHAGDAITGTLYFTLFGGSADAAVMNAGNFHYFTLGNHEFDAGNEGLLKLLEPLKIPVLSANVIPDKNSIL
YNKWKPYDIFTVDGEKIAIIGLDTVNKTVNSSSPGKDVKFYDEIATAQIMANALKQQGINKIILLSHAGSEKNIEIAQKV
NDIDVIVTGDSHYLYGNDELRSLKLPVIYEYPLEFKNPNGDPVFVMEGWAYSAVVGDLGVKFSPEGIASITRKIPHVLMS
SHKLQVKNAEGKWTELTGDERKKALDTLKSMKSISLDDHDAKTDMLISKYKSEKDRLAQEIVGVITGSAMPGGSANRIPN
KAGSNPEGSIATRFIAETMYNELKTVDLTIQNAGGVRADILPGNVTFNDAYTFLPFGNTLYTYKMEGSLVKQVLEDAMQF
ALVDGSTGAFPYGAGIRYEANETPNAEGKRLVSVEVLNKQTQQWEPIDDNKRYLVGTNAYVAGGKDGYKTFGKLFNDPKY
EGVDTYLPDAESFIKFMKKHPHFEAYTSSNVKFNASTDALPKK
>Mature_603_residues
MLLSKKSASFALSAFAMLFTSVALAKEAPQAHKAVELSILHINDHHSYLEPHETRINLNGQQTKVDIGGFSAVNAKLNKL
RKKYKNPLVLHAGDAITGTLYFTLFGGSADAAVMNAGNFHYFTLGNHEFDAGNEGLLKLLEPLKIPVLSANVIPDKNSIL
YNKWKPYDIFTVDGEKIAIIGLDTVNKTVNSSSPGKDVKFYDEIATAQIMANALKQQGINKIILLSHAGSEKNIEIAQKV
NDIDVIVTGDSHYLYGNDELRSLKLPVIYEYPLEFKNPNGDPVFVMEGWAYSAVVGDLGVKFSPEGIASITRKIPHVLMS
SHKLQVKNAEGKWTELTGDERKKALDTLKSMKSISLDDHDAKTDMLISKYKSEKDRLAQEIVGVITGSAMPGGSANRIPN
KAGSNPEGSIATRFIAETMYNELKTVDLTIQNAGGVRADILPGNVTFNDAYTFLPFGNTLYTYKMEGSLVKQVLEDAMQF
ALVDGSTGAFPYGAGIRYEANETPNAEGKRLVSVEVLNKQTQQWEPIDDNKRYLVGTNAYVAGGKDGYKTFGKLFNDPKY
EGVDTYLPDAESFIKFMKKHPHFEAYTSSNVKFNASTDALPKK

Specific function: Degradation Of External Udp-Glucose To Uridine Monophosphate And Glucose-1-Phosphate, Which Can Then Be Used By The Cell. [C]

COG id: COG0737

COG function: function code F; 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 5'-nucleotidase family

Homologues:

Organism=Homo sapiens, GI4505467, Length=548, Percent_Identity=29.7445255474453, Blast_Score=162, Evalue=6e-40,
Organism=Escherichia coli, GI1786687, Length=239, Percent_Identity=30.1255230125523, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19922446, Length=540, Percent_Identity=27.962962962963, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24654424, Length=540, Percent_Identity=27.962962962963, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI19922444, Length=596, Percent_Identity=26.8456375838926, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI28573524, Length=575, Percent_Identity=26.9565217391304, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24641187, Length=532, Percent_Identity=27.2556390977444, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI221329836, Length=554, Percent_Identity=25.812274368231, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI19921980, Length=219, Percent_Identity=27.8538812785388, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI161076508, Length=219, Percent_Identity=28.310502283105, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24652512, Length=219, Percent_Identity=27.8538812785388, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): 5NTD_HAEIN (P44569)

Other databases:

- EMBL:   L42023
- PIR:   E64054
- RefSeq:   NP_438375.1
- ProteinModelPortal:   P44569
- SMR:   P44569
- GeneID:   951116
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0206
- TIGR:   HI_0206
- HOGENOM:   HBG534106
- OMA:   NDTHSHF
- ProtClustDB:   CLSK793390
- BioCyc:   HINF71421:HI_0206-MONOMER
- BioCyc:   MetaCyc:MONOMER-8341
- BRENDA:   3.1.3.5
- InterPro:   IPR008334
- InterPro:   IPR006146
- InterPro:   IPR006179
- InterPro:   IPR004843
- InterPro:   IPR006420
- Gene3D:   G3DSA:3.90.780.10
- PANTHER:   PTHR11575
- PRINTS:   PR01607
- TIGRFAMs:   TIGR01530

Pfam domain/function: PF02872 5_nucleotid_C; PF00149 Metallophos; SSF55816 5'-Nucleotdase_C

EC number: =3.1.3.5

Molecular weight: Translated: 66246; Mature: 66246

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00785 5_NUCLEOTIDASE_1; PS00786 5_NUCLEOTIDASE_2

Important sites: BINDING 456-456

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSKKSASFALSAFAMLFTSVALAKEAPQAHKAVELSILHINDHHSYLEPHETRINLNG
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCEEEEECC
QQTKVDIGGFSAVNAKLNKLRKKYKNPLVLHAGDAITGTLYFTLFGGSADAAVMNAGNFH
CEEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEEEECCCCCEEEEECCCEE
YFTLGNHEFDAGNEGLLKLLEPLKIPVLSANVIPDKNSILYNKWKPYDIFTVDGEKIAII
EEEECCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCEEEECCCCEEEEEECCCEEEEE
GLDTVNKTVNSSSPGKDVKFYDEIATAQIMANALKQQGINKIILLSHAGSEKNIEIAQKV
EECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEHEECC
NDIDVIVTGDSHYLYGNDELRSLKLPVIYEYPLEFKNPNGDPVFVMEGWAYSAVVGDLGV
CCEEEEEECCCEEEECCCCCEEEECCEEEECCCEECCCCCCEEEEECCCEEEEHHHCCCC
KFSPEGIASITRKIPHVLMSSHKLQVKNAEGKWTELTGDERKKALDTLKSMKSISLDDHD
EECCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCC
AKTDMLISKYKSEKDRLAQEIVGVITGSAMPGGSANRIPNKAGSNPEGSIATRFIAETMY
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
NELKTVDLTIQNAGGVRADILPGNVTFNDAYTFLPFGNTLYTYKMEGSLVKQVLEDAMQF
HHCEEEEEEEECCCCEEEEEECCCEEECCCEEEEECCCEEEEEEECHHHHHHHHHHHHHE
ALVDGSTGAFPYGAGIRYEANETPNAEGKRLVSVEVLNKQTQQWEPIDDNKRYLVGTNAY
EEECCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEECCCHHHCCCCCCCCCCEEEECCEE
VAGGKDGYKTFGKLFNDPKYEGVDTYLPDAESFIKFMKKHPHFEAYTSSNVKFNASTDAL
EECCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCEEECCCCCCC
PKK
CCC
>Mature Secondary Structure
MLLSKKSASFALSAFAMLFTSVALAKEAPQAHKAVELSILHINDHHSYLEPHETRINLNG
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCEEEEECC
QQTKVDIGGFSAVNAKLNKLRKKYKNPLVLHAGDAITGTLYFTLFGGSADAAVMNAGNFH
CEEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEEEECCCCCEEEEECCCEE
YFTLGNHEFDAGNEGLLKLLEPLKIPVLSANVIPDKNSILYNKWKPYDIFTVDGEKIAII
EEEECCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCEEEECCCCEEEEEECCCEEEEE
GLDTVNKTVNSSSPGKDVKFYDEIATAQIMANALKQQGINKIILLSHAGSEKNIEIAQKV
EECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEHEECC
NDIDVIVTGDSHYLYGNDELRSLKLPVIYEYPLEFKNPNGDPVFVMEGWAYSAVVGDLGV
CCEEEEEECCCEEEECCCCCEEEECCEEEECCCEECCCCCCEEEEECCCEEEEHHHCCCC
KFSPEGIASITRKIPHVLMSSHKLQVKNAEGKWTELTGDERKKALDTLKSMKSISLDDHD
EECCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCC
AKTDMLISKYKSEKDRLAQEIVGVITGSAMPGGSANRIPNKAGSNPEGSIATRFIAETMY
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
NELKTVDLTIQNAGGVRADILPGNVTFNDAYTFLPFGNTLYTYKMEGSLVKQVLEDAMQF
HHCEEEEEEEECCCCEEEEEECCCEEECCCEEEEECCCEEEEEEECHHHHHHHHHHHHHE
ALVDGSTGAFPYGAGIRYEANETPNAEGKRLVSVEVLNKQTQQWEPIDDNKRYLVGTNAY
EEECCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEECCCHHHCCCCCCCCCCEEEECCEE
VAGGKDGYKTFGKLFNDPKYEGVDTYLPDAESFIKFMKKHPHFEAYTSSNVKFNASTDAL
EECCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCEEECCCCCCC
PKK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023