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The map label for this gene is pgsA

Identifier: 16272093

GI number: 16272093

Start: 138800

End: 139357

Strand: Direct

Name: pgsA

Synonym: HI0123

Alternate gene names: 16272093

Gene position: 138800-139357 (Clockwise)

Preceding gene: 16272089

Following gene: 16272095

Centisome position: 7.58

GC content: 37.1

Gene sequence:

>558_bases
ATGAAATTCAATATCCCAATTTTCCTAACGATCTTTCGAGTCATTTTGATTCCTTTTTTCGTGATTGCATTTTATTTACC
CATTGAATCATCTCCTTTCATCACAACGCTCATTTTTTTTATTGCAGGTGTCACTGACTGGCTAGATGGCTATCTAGCTC
GTAAATGGAAACAGACCACGCGCTTTGGTGCATTTCTTGATCCTGTTGCTGATAAAGTAATGGTAGTGGCTGCACTAGTT
TTAATTGTCGAACATCAACATACATTTTGGATAACCATTCCTGCCATTATTATGATTTCTCGTGAAATTATCATCTCCGC
ATTACGTGAATGGATGGCAGAGCTTGGGGAACGTAGCAAAATCGCAGTCTCTTGGTGGGGAAAATGGAAAACCACAGCGC
AAATGTTAGCACTAGGCGGATTATTATGGCGTTATAACAACTATATGGAAATAGCAGCAATTATCTTACTTTATATCGCC
GCTATTTTAACTATATGGTCAATGATCCAATATTTACAAGTAGCAAAAGGAAGCTTGCTAGATAATATTCAATTATAA

Upstream 100 bases:

>100_bases
TTTATCAATTATTTATAAAAAGCGACCTTAGGTGGCTTTTTTTATCATCAGAGATAATTTAGAATAAACCATCTTTAGCT
AAAGTGCGGTCAATTTTTCT

Downstream 100 bases:

>100_bases
ATTTAAATAAAACACAGTTATTTTTTATGATAACCATCTATATTTGAGTTATTTTTAATCAAATAAAATATTTTTTATTT
TTTTCGTTTGACAGCAATAT

Product: phosphatidylglycerophosphate synthase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MKFNIPIFLTIFRVILIPFFVIAFYLPIESSPFITTLIFFIAGVTDWLDGYLARKWKQTTRFGAFLDPVADKVMVVAALV
LIVEHQHTFWITIPAIIMISREIIISALREWMAELGERSKIAVSWWGKWKTTAQMLALGGLLWRYNNYMEIAAIILLYIA
AILTIWSMIQYLQVAKGSLLDNIQL

Sequences:

>Translated_185_residues
MKFNIPIFLTIFRVILIPFFVIAFYLPIESSPFITTLIFFIAGVTDWLDGYLARKWKQTTRFGAFLDPVADKVMVVAALV
LIVEHQHTFWITIPAIIMISREIIISALREWMAELGERSKIAVSWWGKWKTTAQMLALGGLLWRYNNYMEIAAIILLYIA
AILTIWSMIQYLQVAKGSLLDNIQL
>Mature_185_residues
MKFNIPIFLTIFRVILIPFFVIAFYLPIESSPFITTLIFFIAGVTDWLDGYLARKWKQTTRFGAFLDPVADKVMVVAALV
LIVEHQHTFWITIPAIIMISREIIISALREWMAELGERSKIAVSWWGKWKTTAQMLALGGLLWRYNNYMEIAAIILLYIA
AILTIWSMIQYLQVAKGSLLDNIQL

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family

Homologues:

Organism=Escherichia coli, GI1788220, Length=182, Percent_Identity=66.4835164835165, Blast_Score=255, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PGSA_HAEIN (P44528)

Other databases:

- EMBL:   L42023
- PIR:   F64049
- RefSeq:   NP_438295.1
- GeneID:   951031
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0123
- NMPDR:   fig|71421.1.peg.117
- TIGR:   HI_0123
- HOGENOM:   HBG686655
- OMA:   WSYMAAS
- ProtClustDB:   CLSK789577
- BioCyc:   HINF71421:HI_0123-MONOMER
- BRENDA:   2.7.8.5
- InterPro:   IPR000462
- InterPro:   IPR004570
- PIRSF:   PIRSF000847
- TIGRFAMs:   TIGR00560

Pfam domain/function: PF01066 CDP-OH_P_transf

EC number: =2.7.8.5

Molecular weight: Translated: 21331; Mature: 21331

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xbfe6e80)-; HASH(0xc232608)-; HASH(0xc2261b8)-; HASH(0xc2323a4)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFNIPIFLTIFRVILIPFFVIAFYLPIESSPFITTLIFFIAGVTDWLDGYLARKWKQTT
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFGAFLDPVADKVMVVAALVLIVEHQHTFWITIPAIIMISREIIISALREWMAELGERSK
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
IAVSWWGKWKTTAQMLALGGLLWRYNNYMEIAAIILLYIAAILTIWSMIQYLQVAKGSLL
EEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DNIQL
HCCCH
>Mature Secondary Structure
MKFNIPIFLTIFRVILIPFFVIAFYLPIESSPFITTLIFFIAGVTDWLDGYLARKWKQTT
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFGAFLDPVADKVMVVAALVLIVEHQHTFWITIPAIIMISREIIISALREWMAELGERSK
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
IAVSWWGKWKTTAQMLALGGLLWRYNNYMEIAAIILLYIAAILTIWSMIQYLQVAKGSLL
EEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DNIQL
HCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800