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The map label for this gene is ppiB

Identifier: 16272053

GI number: 16272053

Start: 86062

End: 86571

Strand: Direct

Name: ppiB

Synonym: HI0079

Alternate gene names: 16272053

Gene position: 86062-86571 (Clockwise)

Preceding gene: 16272051

Following gene: 16272054

Centisome position: 4.7

GC content: 37.25

Gene sequence:

>510_bases
ATGGTTACATTACACACAAACTTTGGCGACATTAAAATTAAATTGGATTTTGATAAAGCTCCAGTTACAGCAGAAAACTT
CTTAAATTACTGCAAAGACGGTTTTTATAATAACACAATTTTTCATCGTGTTATTGATGGCTTTATGATTCAAGGTGGCG
GTATGGAAAGCGGTATGCGCGAAAAAGCAACTAAAGCCCCAATCCAAAATGAAGCGAACAATCGTTTAAGTAACAAACGT
GGAACCATTGCAATGGCTCGCACTTCAGATCCACATTCAGCGACAGCACAATTTTTCATTAACGTGGCAGACAATGATTT
CTTAAATTATCGTTCAAAAGAAATGTTTGGTCGCGAAGTCGTTCAAGAATGGGGCTATGCAGTATTTGGCGAAGTGGTTG
AAGGTATGGATGTTGTGGATAAAATCAAAAAAGTGAAAACAGGCAACAAAGGCTTTCATCAAGATGTTCCAACTGAAGAT
GTAGTGATTACATCGGTTTCTATTGAGTAA

Upstream 100 bases:

>100_bases
TTAAGCTCGTAAAATGAAATAAAAACAAACCGCACTTTTATAGCACTTTTACCTCGATTGTGGAATAATACAACCCTTAA
TTTTTTAGAGGGAAAACAAA

Downstream 100 bases:

>100_bases
CAAATGAGCATAAAACAACATCGCCCTAAAGTTGGAGAAATTCTAGAATGTGATTATGGTCAATTTTCGCATACCTGTCA
CGTTGATGGACATATTCCAC

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase B; Rotamase B

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MVTLHTNFGDIKIKLDFDKAPVTAENFLNYCKDGFYNNTIFHRVIDGFMIQGGGMESGMREKATKAPIQNEANNRLSNKR
GTIAMARTSDPHSATAQFFINVADNDFLNYRSKEMFGREVVQEWGYAVFGEVVEGMDVVDKIKKVKTGNKGFHQDVPTED
VVITSVSIE

Sequences:

>Translated_169_residues
MVTLHTNFGDIKIKLDFDKAPVTAENFLNYCKDGFYNNTIFHRVIDGFMIQGGGMESGMREKATKAPIQNEANNRLSNKR
GTIAMARTSDPHSATAQFFINVADNDFLNYRSKEMFGREVVQEWGYAVFGEVVEGMDVVDKIKKVKTGNKGFHQDVPTED
VVITSVSIE
>Mature_169_residues
MVTLHTNFGDIKIKLDFDKAPVTAENFLNYCKDGFYNNTIFHRVIDGFMIQGGGMESGMREKATKAPIQNEANNRLSNKR
GTIAMARTSDPHSATAQFFINVADNDFLNYRSKEMFGREVVQEWGYAVFGEVVEGMDVVDKIKKVKTGNKGFHQDVPTED
VVITSVSIE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain

Homologues:

Organism=Homo sapiens, GI19557636, Length=172, Percent_Identity=34.3023255813954, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI22547215, Length=170, Percent_Identity=32.9411764705882, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI22547212, Length=170, Percent_Identity=32.9411764705882, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI7657473, Length=170, Percent_Identity=32.9411764705882, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI24308049, Length=169, Percent_Identity=34.3195266272189, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI64276486, Length=121, Percent_Identity=41.3223140495868, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI7706339, Length=165, Percent_Identity=31.5151515151515, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI5454154, Length=169, Percent_Identity=32.5443786982249, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI310110104, Length=159, Percent_Identity=31.4465408805031, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI310129267, Length=159, Percent_Identity=30.188679245283, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI310120620, Length=159, Percent_Identity=30.188679245283, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1786736, Length=168, Percent_Identity=70.2380952380952, Blast_Score=241, Evalue=3e-65,
Organism=Escherichia coli, GI1789763, Length=167, Percent_Identity=55.0898203592814, Blast_Score=185, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71980590, Length=152, Percent_Identity=36.8421052631579, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71980594, Length=152, Percent_Identity=36.8421052631579, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17506311, Length=170, Percent_Identity=34.7058823529412, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17532641, Length=171, Percent_Identity=32.7485380116959, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=150, Percent_Identity=32, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71997782, Length=106, Percent_Identity=34.9056603773585, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532643, Length=153, Percent_Identity=35.9477124183007, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19922376, Length=172, Percent_Identity=33.7209302325581, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17986117, Length=170, Percent_Identity=31.1764705882353, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922912, Length=170, Percent_Identity=34.1176470588235, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24652460, Length=171, Percent_Identity=29.8245614035088, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357249, Length=121, Percent_Identity=34.7107438016529, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): PPIB_HAEIN (P44499)

Other databases:

- EMBL:   L42023
- PIR:   D64047
- RefSeq:   NP_438252.1
- ProteinModelPortal:   P44499
- SMR:   P44499
- GeneID:   950978
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0079
- NMPDR:   fig|71421.1.peg.78
- TIGR:   HI_0079
- HOGENOM:   HBG610621
- OMA:   NDFLNYR
- ProtClustDB:   CLSK870307
- BioCyc:   HINF71421:HI_0079-MONOMER
- BRENDA:   5.2.1.8
- GO:   GO:0005737
- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130
- Gene3D:   G3DSA:2.40.100.10
- PRINTS:   PR00153

Pfam domain/function: PF00160 Pro_isomerase; SSF50891 CSA_PPIase

EC number: =5.2.1.8

Molecular weight: Translated: 18966; Mature: 18966

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00170 CSA_PPIASE_1; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTLHTNFGDIKIKLDFDKAPVTAENFLNYCKDGFYNNTIFHRVIDGFMIQGGGMESGMR
CEEEECCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHEEECCCCCCCHH
EKATKAPIQNEANNRLSNKRGTIAMARTSDPHSATAQFFINVADNDFLNYRSKEMFGREV
HHHHHCCCCCCHHHHCCCCCCEEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHH
VQEWGYAVFGEVVEGMDVVDKIKKVKTGNKGFHQDVPTEDVVITSVSIE
HHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MVTLHTNFGDIKIKLDFDKAPVTAENFLNYCKDGFYNNTIFHRVIDGFMIQGGGMESGMR
CEEEECCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHEEECCCCCCCHH
EKATKAPIQNEANNRLSNKRGTIAMARTSDPHSATAQFFINVADNDFLNYRSKEMFGREV
HHHHHCCCCCCHHHHCCCCCCEEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHH
VQEWGYAVFGEVVEGMDVVDKIKKVKTGNKGFHQDVPTEDVVITSVSIE
HHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800