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The map label for this gene is hslO

Identifier: 162448214

GI number: 162448214

Start: 1441973

End: 1442845

Strand: Direct

Name: hslO

Synonym: ACL_1379

Alternate gene names: 162448214

Gene position: 1441973-1442845 (Clockwise)

Preceding gene: 162448207

Following gene: 162448219

Centisome position: 96.32

GC content: 35.05

Gene sequence:

>873_bases
ATGAAAGATTACACATTAATTGCATTAGCTTACAATCAAGAAATAAGAATTTATACATCTGTTTCAACAAACTTAGTTGA
AAAATCTAGGAAGTTACATAAAACACTCCCAACCGCATCTGCTGCAATGGGCAGATTTTTAACAGCTTCTGCCATGATGT
CTTTAATGTATAAAGACGGTGAAAGACTTACCCTAAAAATAGATGGTGATGGTCCGATTGGACAAATGACAGTTGAGGCG
AAAAATGGGGTAGTTCGTTCTACAATTTTAAATCCAAATGTCTACCTAGTCTACGGTGAAGGACCTAAGATGGGTAAACT
TAATGTTGGTGCTGCAGTTGGTGCAGGCACATTAAGTGTTACCAAAGACTGGAAAGAAAATTATTTCACCTCAAGTTCTC
CACTTCAAACAGGAGAAATTGGAGATGATTTCACTTACTACTATGCAACCAGTGAACAAACACCATCAGCAGTTGGTTTA
GGTGTTTTGGTATCTCGTGGTAAAAAGGTGATTCAAGCTGGTGGTTTTATTATTCAAGTACTTCCACACGCTAGTGAAAA
AACACTCAACCAACTAGAATCAATTATTTCAAAAATCAATTCAGTTACCGATTTATTAAAAAGTAACCACACACCGGAAG
ATATGATTAATATTCTATCTGATAACACTGGTGAAATTTTAGAAAAACATGAACTCAAATACCACTGTGGTTGTAGCCGT
AAAAAATACTTCGATGCACTTTCAAGATTAAACAAACAAGCACTTGAAGATATCTTACACGAAGATGGACAAGCTGAAGT
GGTTTGTCAGTACTGTAATAAAAAGTACATTTATACAAGTGAAGATTTAACTAAGATGATTGCTTCAAAATAG

Upstream 100 bases:

>100_bases
TGTTTTCTACAACATAATTTCCCAATTTGAAACTCATATTTATCACCGAGTGTTATTTTAACATACAATATAGGTTATAA
TAGGATTTGAGGATTATTAT

Downstream 100 bases:

>100_bases
CATTAAAAAGGGATGAAAAATTTCATCCCTTTTTTGTTAGTTTGTATAAATATTTATATTGCCTGCACTTGTTATAACAT
CAACTAAACTACCTGTTCCA

Product: molecular chaperone Hsp33

Products: NA

Alternate protein names: Heat shock protein 33 homolog; HSP33

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MKDYTLIALAYNQEIRIYTSVSTNLVEKSRKLHKTLPTASAAMGRFLTASAMMSLMYKDGERLTLKIDGDGPIGQMTVEA
KNGVVRSTILNPNVYLVYGEGPKMGKLNVGAAVGAGTLSVTKDWKENYFTSSSPLQTGEIGDDFTYYYATSEQTPSAVGL
GVLVSRGKKVIQAGGFIIQVLPHASEKTLNQLESIISKINSVTDLLKSNHTPEDMINILSDNTGEILEKHELKYHCGCSR
KKYFDALSRLNKQALEDILHEDGQAEVVCQYCNKKYIYTSEDLTKMIASK

Sequences:

>Translated_290_residues
MKDYTLIALAYNQEIRIYTSVSTNLVEKSRKLHKTLPTASAAMGRFLTASAMMSLMYKDGERLTLKIDGDGPIGQMTVEA
KNGVVRSTILNPNVYLVYGEGPKMGKLNVGAAVGAGTLSVTKDWKENYFTSSSPLQTGEIGDDFTYYYATSEQTPSAVGL
GVLVSRGKKVIQAGGFIIQVLPHASEKTLNQLESIISKINSVTDLLKSNHTPEDMINILSDNTGEILEKHELKYHCGCSR
KKYFDALSRLNKQALEDILHEDGQAEVVCQYCNKKYIYTSEDLTKMIASK
>Mature_290_residues
MKDYTLIALAYNQEIRIYTSVSTNLVEKSRKLHKTLPTASAAMGRFLTASAMMSLMYKDGERLTLKIDGDGPIGQMTVEA
KNGVVRSTILNPNVYLVYGEGPKMGKLNVGAAVGAGTLSVTKDWKENYFTSSSPLQTGEIGDDFTYYYATSEQTPSAVGL
GVLVSRGKKVIQAGGFIIQVLPHASEKTLNQLESIISKINSVTDLLKSNHTPEDMINILSDNTGEILEKHELKYHCGCSR
KKYFDALSRLNKQALEDILHEDGQAEVVCQYCNKKYIYTSEDLTKMIASK

Specific function: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress

COG id: COG1281

COG function: function code O; Disulfide bond chaperones of the HSP33 family

Gene ontology:
GO:0005737: 33 kDa chaperonin
GO:0006457: 33 kDa chaperonin
GO:0051082: 33 kDa chaperonin

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HSP33 family

Homologues:

Organism=Escherichia coli, GI87082260, Length=251, Percent_Identity=23.5059760956175, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSLO_ACHLI (A9NE10)

Other databases:

- EMBL:   CP000896
- RefSeq:   YP_001621346.1
- ProteinModelPortal:   A9NE10
- SMR:   A9NE10
- GeneID:   5803835
- GenomeReviews:   CP000896_GR
- KEGG:   acl:ACL_1379
- HOGENOM:   HBG286231
- OMA:   VMLGRAM
- BioCyc:   ALAI441768:ACL_1379-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00117
- InterPro:   IPR000397
- InterPro:   IPR016154
- InterPro:   IPR016153
- Gene3D:   G3DSA:3.90.1280.10
- Gene3D:   G3DSA:3.55.30.10
- PIRSF:   PIRSF005261

Pfam domain/function: PF01430 HSP33; SSF64397 Heat_shock_Hsp33_N

EC number: NA

Molecular weight: Translated: 31985; Mature: 31985

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDYTLIALAYNQEIRIYTSVSTNLVEKSRKLHKTLPTASAAMGRFLTASAMMSLMYKDG
CCCEEEEEEEECCEEEEEEECHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCC
ERLTLKIDGDGPIGQMTVEAKNGVVRSTILNPNVYLVYGEGPKMGKLNVGAAVGAGTLSV
CEEEEEECCCCCCCEEEEECCCCEEEEEEECCCEEEEECCCCCCCEEECCCEECCCEEEE
TKDWKENYFTSSSPLQTGEIGDDFTYYYATSEQTPSAVGLGVLVSRGKKVIQAGGFIIQV
CHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCHHHHHCCCEEEEE
LPHASEKTLNQLESIISKINSVTDLLKSNHTPEDMINILSDNTGEILEKHELKYHCGCSR
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCCEEECCCCH
KKYFDALSRLNKQALEDILHEDGQAEVVCQYCNKKYIYTSEDLTKMIASK
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEECHHHHHHHHCC
>Mature Secondary Structure
MKDYTLIALAYNQEIRIYTSVSTNLVEKSRKLHKTLPTASAAMGRFLTASAMMSLMYKDG
CCCEEEEEEEECCEEEEEEECHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCC
ERLTLKIDGDGPIGQMTVEAKNGVVRSTILNPNVYLVYGEGPKMGKLNVGAAVGAGTLSV
CEEEEEECCCCCCCEEEEECCCCEEEEEEECCCEEEEECCCCCCCEEECCCEECCCEEEE
TKDWKENYFTSSSPLQTGEIGDDFTYYYATSEQTPSAVGLGVLVSRGKKVIQAGGFIIQV
CHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCHHHHHCCCEEEEE
LPHASEKTLNQLESIISKINSVTDLLKSNHTPEDMINILSDNTGEILEKHELKYHCGCSR
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCCEEECCCCH
KKYFDALSRLNKQALEDILHEDGQAEVVCQYCNKKYIYTSEDLTKMIASK
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEECHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA