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The map label for this gene is ldh [H]

Identifier: 162447882

GI number: 162447882

Start: 1053558

End: 1054502

Strand: Direct

Name: ldh [H]

Synonym: ACL_1028

Alternate gene names: 162447882

Gene position: 1053558-1054502 (Clockwise)

Preceding gene: 162447881

Following gene: 162447888

Centisome position: 70.38

GC content: 32.8

Gene sequence:

>945_bases
ATGAAAAATAGAGTTGTTATTGTAGGTACTGGTTTTGTAGGCATGAGCTATGCTTATGCACTTTTAAACCAAGGAACTTT
AGAAGAAATTATATTAGTAGATATTGATTCAAGAAAAGCCGAAGGTGAGGCAATGGATTTAAACCATGGGCTAGCGTTTG
CACCAAGAAAGATGCTCATTCGTTCTGGTACATATGAAGATTGTAAGGATGCTAAACTAGTTGTTATTACAGCAGGCGTT
AATCAAAAAGATGGAGAAACAAGAATTGATCTTTTAAACAGAAATGCTAAGATTATGCAGTCTGTTGTAAAAGAGATTAT
GAAACATGGTTTTAACGGCATCTTTTTAGTTGCAACAAACCCGGTGGATATCTTAACCTATATTGTATGGAAATCCTCTG
GATTACCATCAAATAGAGTCATTGGTAGTGGTACTTCTCTTGATACTGCAAGACTTCGTTATGAGATATCTCAATACATC
AACATTGATGTTCGAAACATCCATGCATATATCTTAGGTGAACATGGAGATTCTGAGTTTGTTTGTTGGTCAAATGCCTT
TGTTGGCGTTAAACCTTTAAAAGATGTTATAGACTCCATGCCTGCACAAATAAAGTTTTCTGATTTAGATAAGATTTACC
TTGACGTAAAAAATTCAGCCTATGAAATTATCCAAAGAAAAAGAGCCACTTATTATGGTATTGGTATGGCCTTAGTACGT
ATAACAAAGGCTATTTTCAATAATGAAAACAGAATTCTACCCATATCAGTATTTAACGATGATGACTATGATATTGATAA
TCTCTATATTGGCTTACCAGCTGTATTAAATGAAAATGGGGTAGACCATGTAGTAAAACTTAATTTAAATGATGAAGAGT
TAAAATCACTTAAAAAATCTTCAAGTATATTAAAACATAGTATAGATTCCATCACTTTAGAATAG

Upstream 100 bases:

>100_bases
AATTTGGGTTTGCTACTTTTATTATTTATTGCATACATTTCATGTTTTTTACCTTCTTAATATATACTATGTGATATACT
ATGTGTATAGGAGGCATTTC

Downstream 100 bases:

>100_bases
ACAAAGGATAAGCCTTCTAAGGCTTATCCTTTATTTTTCATAACTTCTAATATAGGTTTTAGATCACGAAATAATTCTAA
TGGAAATATACTAGTATCTA

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH 2 [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MKNRVVIVGTGFVGMSYAYALLNQGTLEEIILVDIDSRKAEGEAMDLNHGLAFAPRKMLIRSGTYEDCKDAKLVVITAGV
NQKDGETRIDLLNRNAKIMQSVVKEIMKHGFNGIFLVATNPVDILTYIVWKSSGLPSNRVIGSGTSLDTARLRYEISQYI
NIDVRNIHAYILGEHGDSEFVCWSNAFVGVKPLKDVIDSMPAQIKFSDLDKIYLDVKNSAYEIIQRKRATYYGIGMALVR
ITKAIFNNENRILPISVFNDDDYDIDNLYIGLPAVLNENGVDHVVKLNLNDEELKSLKKSSSILKHSIDSITLE

Sequences:

>Translated_314_residues
MKNRVVIVGTGFVGMSYAYALLNQGTLEEIILVDIDSRKAEGEAMDLNHGLAFAPRKMLIRSGTYEDCKDAKLVVITAGV
NQKDGETRIDLLNRNAKIMQSVVKEIMKHGFNGIFLVATNPVDILTYIVWKSSGLPSNRVIGSGTSLDTARLRYEISQYI
NIDVRNIHAYILGEHGDSEFVCWSNAFVGVKPLKDVIDSMPAQIKFSDLDKIYLDVKNSAYEIIQRKRATYYGIGMALVR
ITKAIFNNENRILPISVFNDDDYDIDNLYIGLPAVLNENGVDHVVKLNLNDEELKSLKKSSSILKHSIDSITLE
>Mature_314_residues
MKNRVVIVGTGFVGMSYAYALLNQGTLEEIILVDIDSRKAEGEAMDLNHGLAFAPRKMLIRSGTYEDCKDAKLVVITAGV
NQKDGETRIDLLNRNAKIMQSVVKEIMKHGFNGIFLVATNPVDILTYIVWKSSGLPSNRVIGSGTSLDTARLRYEISQYI
NIDVRNIHAYILGEHGDSEFVCWSNAFVGVKPLKDVIDSMPAQIKFSDLDKIYLDVKNSAYEIIQRKRATYYGIGMALVR
ITKAIFNNENRILPISVFNDDDYDIDNLYIGLPAVLNENGVDHVVKLNLNDEELKSLKKSSSILKHSIDSITLE

Specific function: Unknown

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:
GO:0003824: L-lactate dehydrogenase
GO:0004459: L-lactate dehydrogenase
GO:0005488: L-lactate dehydrogenase
GO:0005737: L-lactate dehydrogenase
GO:0005975: L-lactate dehydrogenase
GO:0006096: L-lactate dehydrogenase
GO:0016491: L-lactate dehydrogenase
GO:0016616: L-lactate dehydrogenase
GO:0044262: L-lactate dehydrogenase
GO:0055114: L-lactate dehydrogenase

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI47059044, Length=303, Percent_Identity=39.6039603960396, Blast_Score=237, Evalue=9e-63,
Organism=Homo sapiens, GI221136809, Length=303, Percent_Identity=39.6039603960396, Blast_Score=237, Evalue=9e-63,
Organism=Homo sapiens, GI15082234, Length=308, Percent_Identity=39.9350649350649, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI291575128, Length=303, Percent_Identity=37.6237623762376, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI4557032, Length=303, Percent_Identity=37.6237623762376, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI9257228, Length=304, Percent_Identity=40.1315789473684, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI4504973, Length=304, Percent_Identity=40.1315789473684, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI260099723, Length=304, Percent_Identity=36.8421052631579, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI5031857, Length=304, Percent_Identity=36.8421052631579, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI260099727, Length=193, Percent_Identity=41.4507772020725, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI260099725, Length=193, Percent_Identity=41.4507772020725, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI207028494, Length=205, Percent_Identity=35.609756097561, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI103472011, Length=308, Percent_Identity=25.974025974026, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI103472015, Length=208, Percent_Identity=26.9230769230769, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI21735621, Length=178, Percent_Identity=29.7752808988764, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17535107, Length=293, Percent_Identity=38.9078498293515, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI17136226, Length=306, Percent_Identity=37.9084967320261, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI45550422, Length=314, Percent_Identity=27.0700636942675, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24647881, Length=319, Percent_Identity=24.7648902821317, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 35093; Mature: 35093

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00064 L_LDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNRVVIVGTGFVGMSYAYALLNQGTLEEIILVDIDSRKAEGEAMDLNHGLAFAPRKMLI
CCCCEEEEECCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCEEECCCCCEECCHHHHE
RSGTYEDCKDAKLVVITAGVNQKDGETRIDLLNRNAKIMQSVVKEIMKHGFNGIFLVATN
ECCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECC
PVDILTYIVWKSSGLPSNRVIGSGTSLDTARLRYEISQYINIDVRNIHAYILGEHGDSEF
CHHEEEEEEECCCCCCCCCEEECCCCCCHHHHHHEEHHHEEEEEEEEEEEEEECCCCCCE
VCWSNAFVGVKPLKDVIDSMPAQIKFSDLDKIYLDVKNSAYEIIQRKRATYYGIGMALVR
EEECCCEECCHHHHHHHHCCCCEEEECCCCEEEEEECCHHHHHHHHHCCHHHHHHHHHHH
ITKAIFNNENRILPISVFNDDDYDIDNLYIGLPAVLNENGVDHVVKLNLNDEELKSLKKS
HHHHHHCCCCCEEEEEEECCCCCCCCEEEECCCCEECCCCCCEEEEECCCHHHHHHHHHH
SSILKHSIDSITLE
HHHHHHCCCCEECC
>Mature Secondary Structure
MKNRVVIVGTGFVGMSYAYALLNQGTLEEIILVDIDSRKAEGEAMDLNHGLAFAPRKMLI
CCCCEEEEECCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCEEECCCCCEECCHHHHE
RSGTYEDCKDAKLVVITAGVNQKDGETRIDLLNRNAKIMQSVVKEIMKHGFNGIFLVATN
ECCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECC
PVDILTYIVWKSSGLPSNRVIGSGTSLDTARLRYEISQYINIDVRNIHAYILGEHGDSEF
CHHEEEEEEECCCCCCCCCEEECCCCCCHHHHHHEEHHHEEEEEEEEEEEEEECCCCCCE
VCWSNAFVGVKPLKDVIDSMPAQIKFSDLDKIYLDVKNSAYEIIQRKRATYYGIGMALVR
EEECCCEECCHHHHHHHHCCCCEEEECCCCEEEEEECCHHHHHHHHHCCHHHHHHHHHHH
ITKAIFNNENRILPISVFNDDDYDIDNLYIGLPAVLNENGVDHVVKLNLNDEELKSLKKS
HHHHHHCCCCCEEEEEEECCCCCCCCEEEECCCCEECCCCCCEEEEECCCHHHHHHHHHH
SSILKHSIDSITLE
HHHHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]