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The map label for this gene is fabB [H]

Identifier: 162447327

GI number: 162447327

Start: 489212

End: 490450

Strand: Direct

Name: fabB [H]

Synonym: ACL_0464

Alternate gene names: 162447327

Gene position: 489212-490450 (Clockwise)

Preceding gene: 162447326

Following gene: 162447328

Centisome position: 32.68

GC content: 35.11

Gene sequence:

>1239_bases
ATGAAAAGAAGAGTCGTTATTACAGGGATGGGTACAATTAACCCTGTTGGTAATAGTGTAGATGAATCATTTGATGCCAT
TATTGATGGTAAGAATGGATTAGGTCCAATTACTTATTTTGATACTGAAAAGGTAAAAATAAGTATTGCTGGTGAATTAA
AAAACATTAATTTTGAAGATTACCTAGATAAAAAAGAAATTAAACGTAGTGATAAAGTCATGATTTTAGGTACGATTGCA
GCCATGCAAGCATACGAGGATAGCGGACTAAAAGACACTGATTATGACCCATATAGATTTGGTACGTTTGTAACATCTGG
AATTGGTGGACTAGATACTATGGAAAAAGATATTTCTATAAAAGCACTACGTGGTGCTGATAGAATTTCACCTTTTTTCA
TACCAAATTCTATTGTAAATATGGTAGGTGGTATGATATCTATTAAGTTCCAAGTAAAGGGTCCAAATATACCGATTGTT
ACAGCATGTTCAGCTGCAACAAATGCAATAGGTGAAGCATTCAGAAATATCCGTGATGGATATTTAGATTTAGCTTTCGC
AGGTGGTGCAGAGGCAAGTATAAATGAAACTGGTATCGGTGGATTTGCAGCTTTAAAAGCACTTTCAACTGAAACAGATC
CTAATAAAGCAAGTCGTCCTTTCGATAAAGAAAGAAGTGGCTTTGTAATGGGAGAAGGTTCAGGGGTTCTTATTTTAGAA
TCTTTAGAAAGTGCCCAAAAACGTGGTGCTAAAATCTATGCTGAAATCGTTGGTTATGGTTCAACATCAGATGCATTCCA
TATGACTGCACCAGATAATGCTGCTGATGGATTAACTAAGGCTATTGAGTTAACACTTGAAGATGCTAAAGTATCACCAA
CTGACGTTGGATATATCAATGCACACGGTACATCCACATTACTAAATGATAAAATTGAAACACTAGGTATTAAACGTGCT
TTTAAAGAACATGCATACGATTTGAATGTATCTTCTACAAAAGGTGCAACAGGCCATATGTTAGGTGCAACCGGTGCAGT
AGAAAGTATCTTTTGTATCAAAGCACTACAAACAGGTTTAATTCCACCAACAATCAACTACAGTAATGTAGATCCTGAAT
GTGACTTAAACTATACAGTAAACAAAGCCGTAAAACGTGATATCAATTATGCTATGAATATCAACGTAGGTTTTGGTGGC
CAAAATGCAGTTGTGTTATATAAGAAATATGGAGAATAA

Upstream 100 bases:

>100_bases
CAAATCTAGTTGGATTTTTAGCATCACCAGAAGCAGGATACATCACTGGTGTAGTGATTGATGTTGACGGCGGGTTAACA
ATTTAAGAGTGGGTGAATAT

Downstream 100 bases:

>100_bases
ATATGGCATTATTAAATAGAGAACAAATTCAAGAAATATTACCACATAGAGATCCTTTTTTAATGGTTGATGAAGTTTTA
GAACTTGTTGAAAAAGAAAA

Product: beta-ketoacyl-(acyl carrier protein) synthetase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MKRRVVITGMGTINPVGNSVDESFDAIIDGKNGLGPITYFDTEKVKISIAGELKNINFEDYLDKKEIKRSDKVMILGTIA
AMQAYEDSGLKDTDYDPYRFGTFVTSGIGGLDTMEKDISIKALRGADRISPFFIPNSIVNMVGGMISIKFQVKGPNIPIV
TACSAATNAIGEAFRNIRDGYLDLAFAGGAEASINETGIGGFAALKALSTETDPNKASRPFDKERSGFVMGEGSGVLILE
SLESAQKRGAKIYAEIVGYGSTSDAFHMTAPDNAADGLTKAIELTLEDAKVSPTDVGYINAHGTSTLLNDKIETLGIKRA
FKEHAYDLNVSSTKGATGHMLGATGAVESIFCIKALQTGLIPPTINYSNVDPECDLNYTVNKAVKRDINYAMNINVGFGG
QNAVVLYKKYGE

Sequences:

>Translated_412_residues
MKRRVVITGMGTINPVGNSVDESFDAIIDGKNGLGPITYFDTEKVKISIAGELKNINFEDYLDKKEIKRSDKVMILGTIA
AMQAYEDSGLKDTDYDPYRFGTFVTSGIGGLDTMEKDISIKALRGADRISPFFIPNSIVNMVGGMISIKFQVKGPNIPIV
TACSAATNAIGEAFRNIRDGYLDLAFAGGAEASINETGIGGFAALKALSTETDPNKASRPFDKERSGFVMGEGSGVLILE
SLESAQKRGAKIYAEIVGYGSTSDAFHMTAPDNAADGLTKAIELTLEDAKVSPTDVGYINAHGTSTLLNDKIETLGIKRA
FKEHAYDLNVSSTKGATGHMLGATGAVESIFCIKALQTGLIPPTINYSNVDPECDLNYTVNKAVKRDINYAMNINVGFGG
QNAVVLYKKYGE
>Mature_412_residues
MKRRVVITGMGTINPVGNSVDESFDAIIDGKNGLGPITYFDTEKVKISIAGELKNINFEDYLDKKEIKRSDKVMILGTIA
AMQAYEDSGLKDTDYDPYRFGTFVTSGIGGLDTMEKDISIKALRGADRISPFFIPNSIVNMVGGMISIKFQVKGPNIPIV
TACSAATNAIGEAFRNIRDGYLDLAFAGGAEASINETGIGGFAALKALSTETDPNKASRPFDKERSGFVMGEGSGVLILE
SLESAQKRGAKIYAEIVGYGSTSDAFHMTAPDNAADGLTKAIELTLEDAKVSPTDVGYINAHGTSTLLNDKIETLGIKRA
FKEHAYDLNVSSTKGATGHMLGATGAVESIFCIKALQTGLIPPTINYSNVDPECDLNYTVNKAVKRDINYAMNINVGFGG
QNAVVLYKKYGE

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:
GO:0003824: 3-oxoacyl-[acyl-carrier-protein] synthase 2
GO:0006633: 3-oxoacyl-[acyl-carrier-protein] synthase 2
GO:0008152: 3-oxoacyl-[acyl-carrier-protein] synthase 2
GO:0008610: 3-oxoacyl-[acyl-carrier-protein] synthase 2
GO:0009058: 3-oxoacyl-[acyl-carrier-protein] synthase 2
GO:0016740: 3-oxoacyl-[acyl-carrier-protein] synthase 2
GO:0016746: 3-oxoacyl-[acyl-carrier-protein] synthase 2
GO:0016747: 3-oxoacyl-[acyl-carrier-protein] synthase 2
GO:0033817: 3-oxoacyl-[acyl-carrier-protein] synthase 2

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=40.2877697841727, Blast_Score=308, Evalue=7e-84,
Organism=Homo sapiens, GI223972627, Length=171, Percent_Identity=43.859649122807, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI41872631, Length=425, Percent_Identity=26.1176470588235, Blast_Score=96, Evalue=8e-20,
Organism=Escherichia coli, GI1787337, Length=410, Percent_Identity=46.0975609756098, Blast_Score=347, Evalue=7e-97,
Organism=Escherichia coli, GI1788663, Length=418, Percent_Identity=32.5358851674641, Blast_Score=209, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=33.4939759036145, Blast_Score=231, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI71983535, Length=255, Percent_Identity=39.2156862745098, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI212642053, Length=296, Percent_Identity=25.6756756756757, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17550940, Length=282, Percent_Identity=27.3049645390071, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=444, Percent_Identity=38.5135135135135, Blast_Score=290, Evalue=4e-79,
Organism=Drosophila melanogaster, GI24644341, Length=422, Percent_Identity=39.8104265402844, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI19920632, Length=375, Percent_Identity=28.5333333333333, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI221330659, Length=375, Percent_Identity=28.5333333333333, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24581345, Length=376, Percent_Identity=24.468085106383, Blast_Score=95, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44075; Mature: 44075

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRVVITGMGTINPVGNSVDESFDAIIDGKNGLGPITYFDTEKVKISIAGELKNINFED
CCCEEEEEECCCCCCCCCCHHHHHHHEECCCCCCCCEEEECCCEEEEEEEEEEECCCHHH
YLDKKEIKRSDKVMILGTIAAMQAYEDSGLKDTDYDPYRFGTFVTSGIGGLDTMEKDISI
HCCHHHHCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCEEHHHHHHCCCCCCCHHHCCCEE
KALRGADRISPFFIPNSIVNMVGGMISIKFQVKGPNIPIVTACSAATNAIGEAFRNIRDG
EEECCCCCCCCEECCHHHHHHCCCEEEEEEEEECCCCCEEEECHHHHHHHHHHHHHHCCC
YLDLAFAGGAEASINETGIGGFAALKALSTETDPNKASRPFDKERSGFVMGEGSGVLILE
EEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEH
SLESAQKRGAKIYAEIVGYGSTSDAFHMTAPDNAADGLTKAIELTLEDAKVSPTDVGYIN
HHHHHHHCCCEEEEEEEECCCCCCEEEEECCCCHHHHHHEEEEEEEECCCCCCCCEEEEE
AHGTSTLLNDKIETLGIKRAFKEHAYDLNVSSTKGATGHMLGATGAVESIFCIKALQTGL
CCCCCHHHHHHHHHHHHHHHHHHHCEECCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCC
IPPTINYSNVDPECDLNYTVNKAVKRDINYAMNINVGFGGQNAVVLYKKYGE
CCCCCCCCCCCCCCCCCEEHHHHHHHCCCEEEEEEEEECCCCEEEEEEECCC
>Mature Secondary Structure
MKRRVVITGMGTINPVGNSVDESFDAIIDGKNGLGPITYFDTEKVKISIAGELKNINFED
CCCEEEEEECCCCCCCCCCHHHHHHHEECCCCCCCCEEEECCCEEEEEEEEEEECCCHHH
YLDKKEIKRSDKVMILGTIAAMQAYEDSGLKDTDYDPYRFGTFVTSGIGGLDTMEKDISI
HCCHHHHCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCEEHHHHHHCCCCCCCHHHCCCEE
KALRGADRISPFFIPNSIVNMVGGMISIKFQVKGPNIPIVTACSAATNAIGEAFRNIRDG
EEECCCCCCCCEECCHHHHHHCCCEEEEEEEEECCCCCEEEECHHHHHHHHHHHHHHCCC
YLDLAFAGGAEASINETGIGGFAALKALSTETDPNKASRPFDKERSGFVMGEGSGVLILE
EEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEH
SLESAQKRGAKIYAEIVGYGSTSDAFHMTAPDNAADGLTKAIELTLEDAKVSPTDVGYIN
HHHHHHHCCCEEEEEEEECCCCCCEEEEECCCCHHHHHHEEEEEEEECCCCCCCCEEEEE
AHGTSTLLNDKIETLGIKRAFKEHAYDLNVSSTKGATGHMLGATGAVESIFCIKALQTGL
CCCCCHHHHHHHHHHHHHHHHHHHCEECCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCC
IPPTINYSNVDPECDLNYTVNKAVKRDINYAMNINVGFGGQNAVVLYKKYGE
CCCCCCCCCCCCCCCCCEEHHHHHHHCCCEEEEEEEEECCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]