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The map label for this gene is fabD [H]

Identifier: 162447325

GI number: 162447325

Start: 487531

End: 488451

Strand: Direct

Name: fabD [H]

Synonym: ACL_0462

Alternate gene names: 162447325

Gene position: 487531-488451 (Clockwise)

Preceding gene: 162447324

Following gene: 162447326

Centisome position: 32.57

GC content: 33.01

Gene sequence:

>921_bases
ATGAAAACAGCGATTTTATTTTCTGGTCAAGGTGCTCAATACGTCAACATGGGACTAGATTTCATTGAAAATGTTCCAGA
GTTAAAGCATAAACTAGAGTCATACGCAGCTATTTTAGATTTAGACATCTTATCTCATTTAAAAGATGAAACCAAAATAA
ATGATACAAGATATACACAACCATTAATGGTTGTAGTAGAAATGTTAATCCATGATTACTTAGTATCACAAGGGTTAAAG
ATTGATGGATATGCAGGCTTTTCATTAGGTGAGTTTGCTGGTCTATATGCTGCGGGATTTTATGAAGCAGAAAACATCTT
AAAGATAATTAATATGCGAGCAAAACTTATGCAAGAGGCATCTACCCTAAACCCTGGCGCCATGGCAGCTATCTTATCCC
TTAGTGATGATGTTGTTGAGGCAATTTGTAAGGAAGTGTCAACACCAAATGATTTAGTAGTTGCAGCAAACTATAATAGT
GATGGTCAACTTGTTATCTCTGGATCTAAAAAAGCAGTACAGTTAGCTGTAGATTTAGCTAAAGAAAAAGGTGCTAGAAG
AGCGATGATGCTAAATGTATCAGGAGCCTTCCATTCACCTTATATGAAAGATGCAGGCTCAAGTTTAAAACTTTATGCAG
AAAATTTTAAACTTCATGATGCTCATAAAGTACTTTATGCCAATACAACAGCAATGCCATTAAAAAAAGAAGATGTTTTA
AATGAAATCTATGAGCAAATAGCAAATCCAGTATATTTCAAACAAACGATTCAACACATGGTTAAAGATGGATTTGAAAG
ATTTATTGAAGTCGGTCCAGGTCAAGTACTTTCAAGTTTAGTTAAAAAAATTAGTCCTGAAAGCAAAATATATAATGTAT
CCAAATTTGAGGATATAAAAAATTTAGAGGAGATTTTATAA

Upstream 100 bases:

>100_bases
ACATAAGACTAATAACCCTGAAGTTAAAAGAGTTATATTAGTTGGATTTGGCGGCGGATTTACTTGGGGTGCAGCCATCC
TAAATGTGTAGGTAACTTTT

Downstream 100 bases:

>100_bases
TGAGTTTAAAAGATAAAGTAGCATTAGTAACAGGTGGTTCTACAGGAATTGGTAAAGCTATTGCAACAAAATTAGCATCT
ATGGGTGCAAATATTGTCAT

Product: malonyl CoA-acyl carrier protein transacylase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKTAILFSGQGAQYVNMGLDFIENVPELKHKLESYAAILDLDILSHLKDETKINDTRYTQPLMVVVEMLIHDYLVSQGLK
IDGYAGFSLGEFAGLYAAGFYEAENILKIINMRAKLMQEASTLNPGAMAAILSLSDDVVEAICKEVSTPNDLVVAANYNS
DGQLVISGSKKAVQLAVDLAKEKGARRAMMLNVSGAFHSPYMKDAGSSLKLYAENFKLHDAHKVLYANTTAMPLKKEDVL
NEIYEQIANPVYFKQTIQHMVKDGFERFIEVGPGQVLSSLVKKISPESKIYNVSKFEDIKNLEEIL

Sequences:

>Translated_306_residues
MKTAILFSGQGAQYVNMGLDFIENVPELKHKLESYAAILDLDILSHLKDETKINDTRYTQPLMVVVEMLIHDYLVSQGLK
IDGYAGFSLGEFAGLYAAGFYEAENILKIINMRAKLMQEASTLNPGAMAAILSLSDDVVEAICKEVSTPNDLVVAANYNS
DGQLVISGSKKAVQLAVDLAKEKGARRAMMLNVSGAFHSPYMKDAGSSLKLYAENFKLHDAHKVLYANTTAMPLKKEDVL
NEIYEQIANPVYFKQTIQHMVKDGFERFIEVGPGQVLSSLVKKISPESKIYNVSKFEDIKNLEEIL
>Mature_306_residues
MKTAILFSGQGAQYVNMGLDFIENVPELKHKLESYAAILDLDILSHLKDETKINDTRYTQPLMVVVEMLIHDYLVSQGLK
IDGYAGFSLGEFAGLYAAGFYEAENILKIINMRAKLMQEASTLNPGAMAAILSLSDDVVEAICKEVSTPNDLVVAANYNS
DGQLVISGSKKAVQLAVDLAKEKGARRAMMLNVSGAFHSPYMKDAGSSLKLYAENFKLHDAHKVLYANTTAMPLKKEDVL
NEIYEQIANPVYFKQTIQHMVKDGFERFIEVGPGQVLSSLVKKISPESKIYNVSKFEDIKNLEEIL

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:
GO:0003824: Malonyl CoA-acyl carrier protein transacylase
GO:0004314: Malonyl CoA-acyl carrier protein transacylase
GO:0005488: Malonyl CoA-acyl carrier protein transacylase
GO:0008152: Malonyl CoA-acyl carrier protein transacylase
GO:0016740: Malonyl CoA-acyl carrier protein transacylase
GO:0016746: Malonyl CoA-acyl carrier protein transacylase

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=305, Percent_Identity=30.1639344262295, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI41872631, Length=322, Percent_Identity=25.4658385093168, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1787334, Length=287, Percent_Identity=34.1463414634146, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71984332, Length=291, Percent_Identity=29.553264604811, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=295, Percent_Identity=24.406779661017, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24665753, Length=303, Percent_Identity=29.7029702970297, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI19920632, Length=316, Percent_Identity=23.7341772151899, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221330659, Length=316, Percent_Identity=23.7341772151899, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24581345, Length=313, Percent_Identity=21.405750798722, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 33910; Mature: 33910

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTAILFSGQGAQYVNMGLDFIENVPELKHKLESYAAILDLDILSHLKDETKINDTRYTQ
CCEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PLMVVVEMLIHDYLVSQGLKIDGYAGFSLGEFAGLYAAGFYEAENILKIINMRAKLMQEA
HHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STLNPGAMAAILSLSDDVVEAICKEVSTPNDLVVAANYNSDGQLVISGSKKAVQLAVDLA
HCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHH
KEKGARRAMMLNVSGAFHSPYMKDAGSSLKLYAENFKLHDAHKVLYANTTAMPLKKEDVL
HHCCCCEEEEEEECCCCCCCHHHCCCCCEEEEECCCEEECHHEEEEECCCCCCCCHHHHH
NEIYEQIANPVYFKQTIQHMVKDGFERFIEVGPGQVLSSLVKKISPESKIYNVSKFEDIK
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHEECCHHHHHHH
NLEEIL
HHHHHC
>Mature Secondary Structure
MKTAILFSGQGAQYVNMGLDFIENVPELKHKLESYAAILDLDILSHLKDETKINDTRYTQ
CCEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PLMVVVEMLIHDYLVSQGLKIDGYAGFSLGEFAGLYAAGFYEAENILKIINMRAKLMQEA
HHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STLNPGAMAAILSLSDDVVEAICKEVSTPNDLVVAANYNSDGQLVISGSKKAVQLAVDLA
HCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHH
KEKGARRAMMLNVSGAFHSPYMKDAGSSLKLYAENFKLHDAHKVLYANTTAMPLKKEDVL
HHCCCCEEEEEEECCCCCCCHHHCCCCCEEEEECCCEEECHHEEEEECCCCCCCCHHHHH
NEIYEQIANPVYFKQTIQHMVKDGFERFIEVGPGQVLSSLVKKISPESKIYNVSKFEDIK
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHEECCHHHHHHH
NLEEIL
HHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]