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The map label for this gene is ffh [H]

Identifier: 162447215

GI number: 162447215

Start: 364231

End: 365634

Strand: Direct

Name: ffh [H]

Synonym: ACL_0349

Alternate gene names: 162447215

Gene position: 364231-365634 (Clockwise)

Preceding gene: 162447214

Following gene: 162447216

Centisome position: 24.33

GC content: 36.4

Gene sequence:

>1404_bases
ATGTCAAACTCGCTATCTGATCGCCTACAAATGTTTGTACGCCGTGCAACCGGTCGTGGGCGTTTAACTGAAAAAGATGT
TGAAGAAATGATGCGTGAAGTACGTCTATCTTTATTAGAGGCAGACGTCAATTTTAAAATTGTTAAAGAATTTACTAATA
ATGTTAAAGAGCAAGCCCTTGGTGAAAAGATCTTAAACGGACTCAATCCTGGTCAACAAGTTGTAAAAATTGTGCATGAT
GAATTAAAACGTGTCATGGGTGAAGAGTCCGTAGGGCTTAATTACGCAAACACTGGTTTATCTACATTTATGACCATTGG
TCTACAAGGTAGTGGTAAAACAACTGCTATTGGTAAAATGGGACTTTATATTCGTAAAAAAGATAAAAAGAAAGTCATGC
TTGTTGCTGCTGACGTTTACCGTCCTGCAGCCATTGATCAACTTGTTACAATCGGTAAAGGATTAGGCATTCATGTCTAT
GAAGAAGGTATTAAAGACGCTAGAGTTATTGTTAAAAACGGTTTAAAGTATGCCAAAGATAACAATTATGATGTAGTGAT
TGTCGATACTGCAGGTCGCTTAACGATTGATGAAGACATGATGCAAGAATTAAAAGATGTTAAAGAAATCCTAAAACCTA
ATGAAGTACTTCTAACAGTAGATGCGATGATGGGTCAAGAAGCTGCAAATGTTGCTAAATCATTCCATGATCAAATTGGT
GCAACCGGCGTTATCTTAACTAAAATGGATGGCGATACGCGTGGAGGTGCTGCCTTATCTATTAGAGAAATATCTCAAAT
ACCAATTAAATTCGCATCCAGCGGAGAAAAGATGGATAGCCTAGAAGCATTCCATCCAGAACGTATGGCTTCTCGTATTC
TTGGTATGGGTGATATGTTAACGTTAATTGAAGAAGTGACATCAAATATCGATGAAGATGAAGCAAAATCCATGATGGAA
AAGATGATGAGTGATTCATATAATTACTTAGATCTTCAAAAACAATTTAAAATGATTAAACGTATGGGTTCTATTTCAAA
AATCTTAGGGTTCATTCCAGGACTAGGAAAAATGAAAGAAGCATTAAGCCAAGTAGATGATAAGCAATTTGATAGAATTA
ATGTCATCATCCAAAGTATGACAGAAGATGAAAGAAAATATCCTGAACTTATCGATAAATCCTCTAAGCGTCGTCAAAGA
ATTGCTAAAGGTGCTGGAGTTGAGGTATCCGATGTCAACCGCTTAAGAGACTCACTCGTACAACAAAAACAAATGATGAA
ACAAATGTCTAATATGGACGAAAAACAAATGGAGCGTTTAAGCAAGAACCCAAGCAGTTTCCAACCTAGTCAAACCAAGG
TTAAAAAAGGAAAAGGTAAGGGTAAAGGCGGCTTTAGATTTTAA

Upstream 100 bases:

>100_bases
AACTTGTTGAGACAAGCCAAAAAAGATCTAAACTATTAGATCAATTGGAATCAACAAAAGATTTAAAATATATTGATGAG
TTAAGAAAGTTGGATGAATA

Downstream 100 bases:

>100_bases
ACATAAAAGGTAGTTTCCTTTAGGATTCTACCTTTCATAATATAGGGATAAGTTTCCCACATTTTTTGTGGAAAACTTAT
CTAGATAACTATGTTAAAAT

Product: signal recognition particle GTPase

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MSNSLSDRLQMFVRRATGRGRLTEKDVEEMMREVRLSLLEADVNFKIVKEFTNNVKEQALGEKILNGLNPGQQVVKIVHD
ELKRVMGEESVGLNYANTGLSTFMTIGLQGSGKTTAIGKMGLYIRKKDKKKVMLVAADVYRPAAIDQLVTIGKGLGIHVY
EEGIKDARVIVKNGLKYAKDNNYDVVIVDTAGRLTIDEDMMQELKDVKEILKPNEVLLTVDAMMGQEAANVAKSFHDQIG
ATGVILTKMDGDTRGGAALSIREISQIPIKFASSGEKMDSLEAFHPERMASRILGMGDMLTLIEEVTSNIDEDEAKSMME
KMMSDSYNYLDLQKQFKMIKRMGSISKILGFIPGLGKMKEALSQVDDKQFDRINVIIQSMTEDERKYPELIDKSSKRRQR
IAKGAGVEVSDVNRLRDSLVQQKQMMKQMSNMDEKQMERLSKNPSSFQPSQTKVKKGKGKGKGGFRF

Sequences:

>Translated_467_residues
MSNSLSDRLQMFVRRATGRGRLTEKDVEEMMREVRLSLLEADVNFKIVKEFTNNVKEQALGEKILNGLNPGQQVVKIVHD
ELKRVMGEESVGLNYANTGLSTFMTIGLQGSGKTTAIGKMGLYIRKKDKKKVMLVAADVYRPAAIDQLVTIGKGLGIHVY
EEGIKDARVIVKNGLKYAKDNNYDVVIVDTAGRLTIDEDMMQELKDVKEILKPNEVLLTVDAMMGQEAANVAKSFHDQIG
ATGVILTKMDGDTRGGAALSIREISQIPIKFASSGEKMDSLEAFHPERMASRILGMGDMLTLIEEVTSNIDEDEAKSMME
KMMSDSYNYLDLQKQFKMIKRMGSISKILGFIPGLGKMKEALSQVDDKQFDRINVIIQSMTEDERKYPELIDKSSKRRQR
IAKGAGVEVSDVNRLRDSLVQQKQMMKQMSNMDEKQMERLSKNPSSFQPSQTKVKKGKGKGKGGFRF
>Mature_466_residues
SNSLSDRLQMFVRRATGRGRLTEKDVEEMMREVRLSLLEADVNFKIVKEFTNNVKEQALGEKILNGLNPGQQVVKIVHDE
LKRVMGEESVGLNYANTGLSTFMTIGLQGSGKTTAIGKMGLYIRKKDKKKVMLVAADVYRPAAIDQLVTIGKGLGIHVYE
EGIKDARVIVKNGLKYAKDNNYDVVIVDTAGRLTIDEDMMQELKDVKEILKPNEVLLTVDAMMGQEAANVAKSFHDQIGA
TGVILTKMDGDTRGGAALSIREISQIPIKFASSGEKMDSLEAFHPERMASRILGMGDMLTLIEEVTSNIDEDEAKSMMEK
MMSDSYNYLDLQKQFKMIKRMGSISKILGFIPGLGKMKEALSQVDDKQFDRINVIIQSMTEDERKYPELIDKSSKRRQRI
AKGAGVEVSDVNRLRDSLVQQKQMMKQMSNMDEKQMERLSKNPSSFQPSQTKVKKGKGKGKGGFRF

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:
GO:0000166: Signal recognition particle GTPase
GO:0005525: Signal recognition particle GTPase
GO:0006614: Signal recognition particle GTPase
GO:0008312: Signal recognition particle GTPase
GO:0017111: Signal recognition particle GTPase
GO:0048500: Signal recognition particle GTPase

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=441, Percent_Identity=32.1995464852608, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI226371618, Length=401, Percent_Identity=31.1720698254364, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI89061728, Length=158, Percent_Identity=34.8101265822785, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI295424842, Length=320, Percent_Identity=24.6875, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI23308697, Length=320, Percent_Identity=24.6875, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1788963, Length=418, Percent_Identity=50, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI1789874, Length=251, Percent_Identity=33.0677290836653, Blast_Score=138, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17539958, Length=423, Percent_Identity=31.2056737588652, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI193206261, Length=257, Percent_Identity=28.7937743190661, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325345, Length=420, Percent_Identity=32.1428571428571, Blast_Score=216, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6320498, Length=330, Percent_Identity=23.030303030303, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17647949, Length=416, Percent_Identity=30.7692307692308, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24641198, Length=254, Percent_Identity=29.1338582677165, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 52274; Mature: 52142

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSLSDRLQMFVRRATGRGRLTEKDVEEMMREVRLSLLEADVNFKIVKEFTNNVKEQAL
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GEKILNGLNPGQQVVKIVHDELKRVMGEESVGLNYANTGLSTFMTIGLQGSGKTTAIGKM
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHEEEECCCCCEEEEEHH
GLYIRKKDKKKVMLVAADVYRPAAIDQLVTIGKGLGIHVYEEGIKDARVIVKNGLKYAKD
CCEEEECCCCEEEEEEHHHHCHHHHHHHHHHCCCCCEEHHHHCHHHHHHHHHCCCHHCCC
NNYDVVIVDTAGRLTIDEDMMQELKDVKEILKPNEVLLTVDAMMGQEAANVAKSFHDQIG
CCCEEEEEECCCCEEECHHHHHHHHHHHHHHCCCCEEEEHHHHHCHHHHHHHHHHHHHHC
ATGVILTKMDGDTRGGAALSIREISQIPIKFASSGEKMDSLEAFHPERMASRILGMGDML
CCEEEEEECCCCCCCCCEEEHHHHHHCCHHHCCCCCHHHHHHHCCHHHHHHHHHCCHHHH
TLIEEVTSNIDEDEAKSMMEKMMSDSYNYLDLQKQFKMIKRMGSISKILGFIPGLGKMKE
HHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ALSQVDDKQFDRINVIIQSMTEDERKYPELIDKSSKRRQRIAKGAGVEVSDVNRLRDSLV
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
QQKQMMKQMSNMDEKQMERLSKNPSSFQPSQTKVKKGKGKGKGGFRF
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SNSLSDRLQMFVRRATGRGRLTEKDVEEMMREVRLSLLEADVNFKIVKEFTNNVKEQAL
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GEKILNGLNPGQQVVKIVHDELKRVMGEESVGLNYANTGLSTFMTIGLQGSGKTTAIGKM
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHEEEECCCCCEEEEEHH
GLYIRKKDKKKVMLVAADVYRPAAIDQLVTIGKGLGIHVYEEGIKDARVIVKNGLKYAKD
CCEEEECCCCEEEEEEHHHHCHHHHHHHHHHCCCCCEEHHHHCHHHHHHHHHCCCHHCCC
NNYDVVIVDTAGRLTIDEDMMQELKDVKEILKPNEVLLTVDAMMGQEAANVAKSFHDQIG
CCCEEEEEECCCCEEECHHHHHHHHHHHHHHCCCCEEEEHHHHHCHHHHHHHHHHHHHHC
ATGVILTKMDGDTRGGAALSIREISQIPIKFASSGEKMDSLEAFHPERMASRILGMGDML
CCEEEEEECCCCCCCCCEEEHHHHHHCCHHHCCCCCHHHHHHHCCHHHHHHHHHCCHHHH
TLIEEVTSNIDEDEAKSMMEKMMSDSYNYLDLQKQFKMIKRMGSISKILGFIPGLGKMKE
HHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ALSQVDDKQFDRINVIIQSMTEDERKYPELIDKSSKRRQRIAKGAGVEVSDVNRLRDSLV
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
QQKQMMKQMSNMDEKQMERLSKNPSSFQPSQTKVKKGKGKGKGGFRF
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]