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The map label for this gene is uvrC [H]

Identifier: 162447172

GI number: 162447172

Start: 314932

End: 316665

Strand: Direct

Name: uvrC [H]

Synonym: ACL_0306

Alternate gene names: 162447172

Gene position: 314932-316665 (Clockwise)

Preceding gene: 162447171

Following gene: 162447173

Centisome position: 21.04

GC content: 30.74

Gene sequence:

>1734_bases
TTGAAAGAAAAACTATCAATATTACCAACTGAACCAGGCTGTTACATGATGCTTGATCAATCAGGAGAAGTCATTTATGT
TGGTAAAGCTAAAAATTTAAAAAATAGAGTAAGTTCATACTTTAGAGGCGCACACAATGCTAAAACAGAGAAACTAATTT
CAGAGATTAGTGATTTTAACTATATCGTCACAAACTCTGAACAAGAATCTCTTATTTTAGAATACAATTTAATCAAAAAA
TATGCACCACTTTATAATATTCGCTTAATTGATGATAAAAGTTACCCGTATCTTGAAATCACAAACGAAAAAGATCCAAT
GCTTGTCGTATCAAGATATATTGAAGTTGATAAGACTAAAACTTTATTTGGACCTTATCCGAACTCAAAATCAGCAAGAG
AAACACTAAAACTACTACAACGCCTATATCCATTAAGACGCTGTAATCCAGTAGATAGTAAACCGTGTTTATATTATCAT
ATGGGTTTATGTTTAGGTCCTTGTGCACATGAAAAGGTAGACTATAAACCAAATATTGAACGTATTACTAGGTTTTTAAA
GGGTGACACTAAAGAAGTTTTAAATGAACTTGAAGAACGCATGAAACAAGCATCAGAAGATTTAGAGTTTGAACGCGCAG
TAGAATACCGTGATATGATTTTAGCTGTAAAAGATACAACTGAAAAACAGATCATGACGCTAAATGATTATAAAGATAGA
GACTTTATAAGTTTTGCATATAACGAAGATGATATGGCTATCCAAATATTGATGATGCGTCAAGGACGTATATTAGATAC
ACATAAAAATGTGATATCTTATATGACTGATCCTTATGAAACGTTTTTAACTTATATTAAAAACTATTATGATAAGTTTT
TATTACCTGATGAATTGGTGTTTGATCAACAAATCCCTTTTAAAGAACTACAAATGTACTTTAAAAATAAAGTTGTTGTA
CCTAAAATAGGAGATAAGAAAAAACTGGTTGATTTAGCACATAAGAATGCATTAGAAGATTTAACGCATTACTATAAACT
ATACCGAGCAAAAGAAGAAAAATTAGGTGAACAAATAGAAGCGTTAGAACAAATATTTGATAAAAAAATATCATATATTG
AAGTGTTTGATAATGCTCACCTATTTGGAACTGCACCTATTTCTGGTATGATAGTTTGGAAAGATTATCATTTTGAACGC
AAGATGTATCGTAAGTTTCACTTAAAAACTACAACCAATGATGACTACCAAGCCATGAAGGAAGTACTTTACCGCAGATA
TCAAAGACTTTTAGTTGAAAAACAAAAACTACCAGATTTAATTTGTGTGGATGGTGGTAAAGGACAGGTTTCTGCCGCTT
ATGAAGTGATTCAATTATTTAATTTAGATATACCTATTTTAGGTTTGAAAAAAGATAAGTATCACATGCTAGAGGGCTAT
GTTATCCAAAATGAGGTCACTATTTTGGATAAAAAATCACCACTCTATCAATTTTTAGGACAACTCTCAGAAGAAGTCCA
TAGATTTACAATCACTTTCCATCAAAAGACTAAAAATAGGAAAGACTATACATCGGTTTTAGATAACATACCTGGACTTG
GTCCAACACGTAAGAAAAAATTACTCGCAAGTTTTAAATCTATTGATGACATTAAAAATGCATCGACGGAAGATTTAAGA
AGTATTGGATTACCTGATAAGGTAATCAAAAGCATTAAGGAAGGTATTTCATGA

Upstream 100 bases:

>100_bases
ATAACAGTTTTTTTATTAAAATATGTTAAAAGATTATAGAATGTTCATGATTTATCAATAAGTGTACACAATTTTAGTAT
AATATAAACAAGGTGATTTT

Downstream 100 bases:

>100_bases
GAACTTTTATACACAGTACAGATACAAAACAAAAATTATTTTACGCGGTTGTAAATAATAAAAAGGAAACCTTTTATTTA
CCCAATCGATTAGCTAAAGT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MKEKLSILPTEPGCYMMLDQSGEVIYVGKAKNLKNRVSSYFRGAHNAKTEKLISEISDFNYIVTNSEQESLILEYNLIKK
YAPLYNIRLIDDKSYPYLEITNEKDPMLVVSRYIEVDKTKTLFGPYPNSKSARETLKLLQRLYPLRRCNPVDSKPCLYYH
MGLCLGPCAHEKVDYKPNIERITRFLKGDTKEVLNELEERMKQASEDLEFERAVEYRDMILAVKDTTEKQIMTLNDYKDR
DFISFAYNEDDMAIQILMMRQGRILDTHKNVISYMTDPYETFLTYIKNYYDKFLLPDELVFDQQIPFKELQMYFKNKVVV
PKIGDKKKLVDLAHKNALEDLTHYYKLYRAKEEKLGEQIEALEQIFDKKISYIEVFDNAHLFGTAPISGMIVWKDYHFER
KMYRKFHLKTTTNDDYQAMKEVLYRRYQRLLVEKQKLPDLICVDGGKGQVSAAYEVIQLFNLDIPILGLKKDKYHMLEGY
VIQNEVTILDKKSPLYQFLGQLSEEVHRFTITFHQKTKNRKDYTSVLDNIPGLGPTRKKKLLASFKSIDDIKNASTEDLR
SIGLPDKVIKSIKEGIS

Sequences:

>Translated_577_residues
MKEKLSILPTEPGCYMMLDQSGEVIYVGKAKNLKNRVSSYFRGAHNAKTEKLISEISDFNYIVTNSEQESLILEYNLIKK
YAPLYNIRLIDDKSYPYLEITNEKDPMLVVSRYIEVDKTKTLFGPYPNSKSARETLKLLQRLYPLRRCNPVDSKPCLYYH
MGLCLGPCAHEKVDYKPNIERITRFLKGDTKEVLNELEERMKQASEDLEFERAVEYRDMILAVKDTTEKQIMTLNDYKDR
DFISFAYNEDDMAIQILMMRQGRILDTHKNVISYMTDPYETFLTYIKNYYDKFLLPDELVFDQQIPFKELQMYFKNKVVV
PKIGDKKKLVDLAHKNALEDLTHYYKLYRAKEEKLGEQIEALEQIFDKKISYIEVFDNAHLFGTAPISGMIVWKDYHFER
KMYRKFHLKTTTNDDYQAMKEVLYRRYQRLLVEKQKLPDLICVDGGKGQVSAAYEVIQLFNLDIPILGLKKDKYHMLEGY
VIQNEVTILDKKSPLYQFLGQLSEEVHRFTITFHQKTKNRKDYTSVLDNIPGLGPTRKKKLLASFKSIDDIKNASTEDLR
SIGLPDKVIKSIKEGIS
>Mature_577_residues
MKEKLSILPTEPGCYMMLDQSGEVIYVGKAKNLKNRVSSYFRGAHNAKTEKLISEISDFNYIVTNSEQESLILEYNLIKK
YAPLYNIRLIDDKSYPYLEITNEKDPMLVVSRYIEVDKTKTLFGPYPNSKSARETLKLLQRLYPLRRCNPVDSKPCLYYH
MGLCLGPCAHEKVDYKPNIERITRFLKGDTKEVLNELEERMKQASEDLEFERAVEYRDMILAVKDTTEKQIMTLNDYKDR
DFISFAYNEDDMAIQILMMRQGRILDTHKNVISYMTDPYETFLTYIKNYYDKFLLPDELVFDQQIPFKELQMYFKNKVVV
PKIGDKKKLVDLAHKNALEDLTHYYKLYRAKEEKLGEQIEALEQIFDKKISYIEVFDNAHLFGTAPISGMIVWKDYHFER
KMYRKFHLKTTTNDDYQAMKEVLYRRYQRLLVEKQKLPDLICVDGGKGQVSAAYEVIQLFNLDIPILGLKKDKYHMLEGY
VIQNEVTILDKKSPLYQFLGQLSEEVHRFTITFHQKTKNRKDYTSVLDNIPGLGPTRKKKLLASFKSIDDIKNASTEDLR
SIGLPDKVIKSIKEGIS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=611, Percent_Identity=34.5335515548282, Blast_Score=324, Evalue=1e-89,
Organism=Escherichia coli, GI1788037, Length=175, Percent_Identity=29.1428571428571, Blast_Score=76, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 67693; Mature: 67693

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKLSILPTEPGCYMMLDQSGEVIYVGKAKNLKNRVSSYFRGAHNAKTEKLISEISDFN
CCCCCCCCCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCC
YIVTNSEQESLILEYNLIKKYAPLYNIRLIDDKSYPYLEITNEKDPMLVVSRYIEVDKTK
EEEECCCCCCEEEHHHHHHHHCCEEEEEEEECCCCCEEEECCCCCCHHHHHHHHHHCCCC
TLFGPYPNSKSARETLKLLQRLYPLRRCNPVDSKPCLYYHMGLCLGPCAHEKVDYKPNIE
EEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHCCCCCCCCCCCCCHH
RITRFLKGDTKEVLNELEERMKQASEDLEFERAVEYRDMILAVKDTTEKQIMTLNDYKDR
HHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEEEECCCCCCEEEECCCCCC
DFISFAYNEDDMAIQILMMRQGRILDTHKNVISYMTDPYETFLTYIKNYYDKFLLPDELV
CEEEEEECCCCCEEEEEEECCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHH
FDQQIPFKELQMYFKNKVVVPKIGDKKKLVDLAHKNALEDLTHYYKLYRAKEEKLGEQIE
CCCCCCHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALEQIFDKKISYIEVFDNAHLFGTAPISGMIVWKDYHFERKMYRKFHLKTTTNDDYQAMK
HHHHHHHCCCCEEEEECCCEEEEECCCCCEEEEECHHHHHHHHHHHEEECCCCHHHHHHH
EVLYRRYQRLLVEKQKLPDLICVDGGKGQVSAAYEVIQLFNLDIPILGLKKDKYHMLEGY
HHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHCCE
VIQNEVTILDKKSPLYQFLGQLSEEVHRFTITFHQKTKNRKDYTSVLDNIPGLGPTRKKK
EEECCEEEEECCCHHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHCCCCCCCHHHHH
LLASFKSIDDIKNASTEDLRSIGLPDKVIKSIKEGIS
HHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKEKLSILPTEPGCYMMLDQSGEVIYVGKAKNLKNRVSSYFRGAHNAKTEKLISEISDFN
CCCCCCCCCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCC
YIVTNSEQESLILEYNLIKKYAPLYNIRLIDDKSYPYLEITNEKDPMLVVSRYIEVDKTK
EEEECCCCCCEEEHHHHHHHHCCEEEEEEEECCCCCEEEECCCCCCHHHHHHHHHHCCCC
TLFGPYPNSKSARETLKLLQRLYPLRRCNPVDSKPCLYYHMGLCLGPCAHEKVDYKPNIE
EEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHCCCCCCCCCCCCCHH
RITRFLKGDTKEVLNELEERMKQASEDLEFERAVEYRDMILAVKDTTEKQIMTLNDYKDR
HHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEEEECCCCCCEEEECCCCCC
DFISFAYNEDDMAIQILMMRQGRILDTHKNVISYMTDPYETFLTYIKNYYDKFLLPDELV
CEEEEEECCCCCEEEEEEECCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHH
FDQQIPFKELQMYFKNKVVVPKIGDKKKLVDLAHKNALEDLTHYYKLYRAKEEKLGEQIE
CCCCCCHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALEQIFDKKISYIEVFDNAHLFGTAPISGMIVWKDYHFERKMYRKFHLKTTTNDDYQAMK
HHHHHHHCCCCEEEEECCCEEEEECCCCCEEEEECHHHHHHHHHHHEEECCCCHHHHHHH
EVLYRRYQRLLVEKQKLPDLICVDGGKGQVSAAYEVIQLFNLDIPILGLKKDKYHMLEGY
HHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHCCE
VIQNEVTILDKKSPLYQFLGQLSEEVHRFTITFHQKTKNRKDYTSVLDNIPGLGPTRKKK
EEECCEEEEECCCHHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHCCCCCCCHHHHH
LLASFKSIDDIKNASTEDLRSIGLPDKVIKSIKEGIS
HHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA