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The map label for this gene is typA [H]

Identifier: 162447074

GI number: 162447074

Start: 194960

End: 196774

Strand: Direct

Name: typA [H]

Synonym: ACL_0204

Alternate gene names: 162447074

Gene position: 194960-196774 (Clockwise)

Preceding gene: 162447073

Following gene: 162447075

Centisome position: 13.02

GC content: 33.33

Gene sequence:

>1815_bases
ATGGAAATTAGAAACGTTGCCATCATCGCTCACGTCGATCATGGAAAAACTACTTTAGTAGATAAACTACTACAACAATC
AAGTGAATATCGTGAAAACTCACACATGCAAGAACGTGCAATGGACAACATTGATATTGAACGTGAAAGAGGTATTACAA
TTCTTGCAAAAGCTACCTCAATTGAATACGGTAATTATCGTATTAACATTATGGATACCCCAGGGCACGCCGATTTTGGT
GGTGAAGTTGAACGTATTATGAAACTTGTTGATGGTGTATTACTATTAGTAGACGCTAAAGACGGTGTCATGCCACAAAC
AAAATTCGTTTTAAGAAAAGCTTTAGAAGAAAAATTAAAACCGATTGTTGTTATCAATAAAATTGACAGACCATTTGCAG
ATCCTAAAAAGACTGTAAACCAAGTGTTTGACCTATTTATTGATCTAGGTGCAACCGATGATCAATTGGAATTTCCAATT
ATTTATGCTTCTGGTTTATTAGGTTTATCAAGTTTTGATGTTGAATTTGAATCAGCTAAAAATATGAAACCATTATTAGA
TACAATTGTTAACCATGTATCTAAACCAGATGTTAAACTTGATGGACCATTACTTTTCCAACCAGCATTAATTGACTATA
ATGACTATGTTGGTCGTATGGGTATTGGTAAAGTATTTCAAGGCACATTAAAAGTAAACTCATTTGTATCTTGTCTACGT
CCTAATGGAAAAGTAGATAATTTTAGAATTCAAAAACTATATCGTTATAGTGGTTTAACAAAAGTTGAAACTGCTGAAGC
TTATGCTGGCGATATTGTTGCGATTGCTGGATTAAGTGATATCTTTGTTGGAGACACCATTACTGAAGTTGGTGAAACTA
CAAGATTACCTTTACTACACATCGATGAACCAACTGTTCAAATGACTTTCTTAACAAATAGTTCACCTTTTGCAGGTCAA
GAAGGTAAGTTTGTTACAGCAAGTAAGATTGATGAAAGATTAACTAGAGAAGTTCAAAAAGACGTATCCTTAAAAGTGGA
AAAAGAACCAGGTTCTGAAAGTTGGTTAGTTTCAGGACGCGGAGAATTACACTTAGGTATTTTAATTGAAACAATGCGTA
GAGAAGGCTTTGAATTTGCTGTATCTAGGCCTAAAGTTATTATTAAAAATATCGATGGCGTATTAAGTGAACCACATGAA
GAAGTTCAAGTGGATACACCTAATGAATTTGTTGGTAGCGTGATGGAATTACTCGGTAACCGTAAAGGTGAAGTTATTAA
AATGGACCAAGGTGTTAACGAAACAAGACTTGTATATAACATGTCTTCACGTGGATTAATTGGCCTTATGACACAATTTT
TAACTGCTACTAAAGGTTATGGTGTACTAGCACATAGTTTCTTAGAATACAAAAAAATGTCAAATGACAATATAGGTAGT
CGCCAAAACGGAGCACTTGTCTCACTTAAAGATGGTCAAACTACAGCTTATGCCATTGGACACTTAGAAGATAGAGGACA
ATTCTTTATCGAACCAAGAGTCAATGTTTACGAAGGTATGATTGTTGGTATGAATAATAAAGATAATGACTTAGTCATCA
ACGTCGTTGAAGAAAAGAAATTAACAAATATGCGTACATCTGGTAAAGACAATACAGTTGTCTTAAAAAGACCAATTGAA
ATGAGTTTAGAAGCATGTATGGACTTCATCAATGATGATGAATTAATTGAAATTACTCCAAAATCAATTCGTATTAGAAA
AAAATATTTAAAAGCAAACGAACGTAAAAAAGCAAACTATAGTCAAAATCAATAA

Upstream 100 bases:

>100_bases
TTGATGAAATAATGAAAGTTCTTGAAAAATAGAACTTTTTTCATGAAAATTTTTCATTATATGATAAAATGATAAAGGCT
TATAAAAGGAAGTATAAAAT

Downstream 100 bases:

>100_bases
TTGATATGAATATCAACCAATTAATCGATATTATTATGTTATAATAAATAAAAATGAGGATGGTGACATATGAAAATAGG
CATTGGCGCAGATCATGCGG

Product: translational GTPase, TypA/BipA type

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MEIRNVAIIAHVDHGKTTLVDKLLQQSSEYRENSHMQERAMDNIDIERERGITILAKATSIEYGNYRINIMDTPGHADFG
GEVERIMKLVDGVLLLVDAKDGVMPQTKFVLRKALEEKLKPIVVINKIDRPFADPKKTVNQVFDLFIDLGATDDQLEFPI
IYASGLLGLSSFDVEFESAKNMKPLLDTIVNHVSKPDVKLDGPLLFQPALIDYNDYVGRMGIGKVFQGTLKVNSFVSCLR
PNGKVDNFRIQKLYRYSGLTKVETAEAYAGDIVAIAGLSDIFVGDTITEVGETTRLPLLHIDEPTVQMTFLTNSSPFAGQ
EGKFVTASKIDERLTREVQKDVSLKVEKEPGSESWLVSGRGELHLGILIETMRREGFEFAVSRPKVIIKNIDGVLSEPHE
EVQVDTPNEFVGSVMELLGNRKGEVIKMDQGVNETRLVYNMSSRGLIGLMTQFLTATKGYGVLAHSFLEYKKMSNDNIGS
RQNGALVSLKDGQTTAYAIGHLEDRGQFFIEPRVNVYEGMIVGMNNKDNDLVINVVEEKKLTNMRTSGKDNTVVLKRPIE
MSLEACMDFINDDELIEITPKSIRIRKKYLKANERKKANYSQNQ

Sequences:

>Translated_604_residues
MEIRNVAIIAHVDHGKTTLVDKLLQQSSEYRENSHMQERAMDNIDIERERGITILAKATSIEYGNYRINIMDTPGHADFG
GEVERIMKLVDGVLLLVDAKDGVMPQTKFVLRKALEEKLKPIVVINKIDRPFADPKKTVNQVFDLFIDLGATDDQLEFPI
IYASGLLGLSSFDVEFESAKNMKPLLDTIVNHVSKPDVKLDGPLLFQPALIDYNDYVGRMGIGKVFQGTLKVNSFVSCLR
PNGKVDNFRIQKLYRYSGLTKVETAEAYAGDIVAIAGLSDIFVGDTITEVGETTRLPLLHIDEPTVQMTFLTNSSPFAGQ
EGKFVTASKIDERLTREVQKDVSLKVEKEPGSESWLVSGRGELHLGILIETMRREGFEFAVSRPKVIIKNIDGVLSEPHE
EVQVDTPNEFVGSVMELLGNRKGEVIKMDQGVNETRLVYNMSSRGLIGLMTQFLTATKGYGVLAHSFLEYKKMSNDNIGS
RQNGALVSLKDGQTTAYAIGHLEDRGQFFIEPRVNVYEGMIVGMNNKDNDLVINVVEEKKLTNMRTSGKDNTVVLKRPIE
MSLEACMDFINDDELIEITPKSIRIRKKYLKANERKKANYSQNQ
>Mature_604_residues
MEIRNVAIIAHVDHGKTTLVDKLLQQSSEYRENSHMQERAMDNIDIERERGITILAKATSIEYGNYRINIMDTPGHADFG
GEVERIMKLVDGVLLLVDAKDGVMPQTKFVLRKALEEKLKPIVVINKIDRPFADPKKTVNQVFDLFIDLGATDDQLEFPI
IYASGLLGLSSFDVEFESAKNMKPLLDTIVNHVSKPDVKLDGPLLFQPALIDYNDYVGRMGIGKVFQGTLKVNSFVSCLR
PNGKVDNFRIQKLYRYSGLTKVETAEAYAGDIVAIAGLSDIFVGDTITEVGETTRLPLLHIDEPTVQMTFLTNSSPFAGQ
EGKFVTASKIDERLTREVQKDVSLKVEKEPGSESWLVSGRGELHLGILIETMRREGFEFAVSRPKVIIKNIDGVLSEPHE
EVQVDTPNEFVGSVMELLGNRKGEVIKMDQGVNETRLVYNMSSRGLIGLMTQFLTATKGYGVLAHSFLEYKKMSNDNIGS
RQNGALVSLKDGQTTAYAIGHLEDRGQFFIEPRVNVYEGMIVGMNNKDNDLVINVVEEKKLTNMRTSGKDNTVVLKRPIE
MSLEACMDFINDDELIEITPKSIRIRKKYLKANERKKANYSQNQ

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=474, Percent_Identity=27.4261603375527, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI94966754, Length=145, Percent_Identity=44.1379310344828, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI25306287, Length=451, Percent_Identity=27.9379157427938, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI4503483, Length=144, Percent_Identity=38.8888888888889, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI18390331, Length=146, Percent_Identity=37.6712328767123, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI25306283, Length=170, Percent_Identity=37.0588235294118, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI19923640, Length=161, Percent_Identity=37.888198757764, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI217272892, Length=203, Percent_Identity=32.0197044334975, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI217272894, Length=203, Percent_Identity=32.0197044334975, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI310132016, Length=110, Percent_Identity=41.8181818181818, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI310110807, Length=110, Percent_Identity=41.8181818181818, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI310123363, Length=110, Percent_Identity=41.8181818181818, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI94966752, Length=96, Percent_Identity=43.75, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI34147630, Length=232, Percent_Identity=31.8965517241379, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI53729339, Length=138, Percent_Identity=35.5072463768116, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI53729337, Length=138, Percent_Identity=35.5072463768116, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI48994988, Length=601, Percent_Identity=53.2445923460898, Blast_Score=646, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=509, Percent_Identity=27.5049115913556, Blast_Score=140, Evalue=3e-34,
Organism=Escherichia coli, GI1789738, Length=148, Percent_Identity=41.2162162162162, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790835, Length=145, Percent_Identity=31.0344827586207, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1789559, Length=247, Percent_Identity=29.9595141700405, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1789737, Length=240, Percent_Identity=27.5, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790412, Length=237, Percent_Identity=27.8481012658228, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17557151, Length=304, Percent_Identity=32.2368421052632, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17556745, Length=445, Percent_Identity=26.5168539325843, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17506493, Length=172, Percent_Identity=33.7209302325581, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17552882, Length=134, Percent_Identity=40.2985074626866, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17533571, Length=145, Percent_Identity=40, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71988811, Length=141, Percent_Identity=37.5886524822695, Blast_Score=102, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI71988819, Length=141, Percent_Identity=37.5886524822695, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17556456, Length=234, Percent_Identity=31.1965811965812, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994658, Length=142, Percent_Identity=36.6197183098592, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323320, Length=469, Percent_Identity=30.0639658848614, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324707, Length=202, Percent_Identity=35.6435643564356, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6320593, Length=202, Percent_Identity=35.6435643564356, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6323098, Length=177, Percent_Identity=36.1581920903955, Blast_Score=107, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6322359, Length=150, Percent_Identity=39.3333333333333, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324166, Length=155, Percent_Identity=38.7096774193548, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324761, Length=231, Percent_Identity=31.6017316017316, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324550, Length=295, Percent_Identity=26.7796610169492, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI78706572, Length=468, Percent_Identity=27.7777777777778, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28574573, Length=138, Percent_Identity=44.2028985507246, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI21357743, Length=190, Percent_Identity=37.8947368421053, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24585709, Length=164, Percent_Identity=35.3658536585366, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24585711, Length=164, Percent_Identity=35.3658536585366, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24585713, Length=164, Percent_Identity=35.3658536585366, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24582462, Length=145, Percent_Identity=38.6206896551724, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI221458488, Length=170, Percent_Identity=38.8235294117647, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281363316, Length=212, Percent_Identity=32.0754716981132, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17864358, Length=212, Percent_Identity=32.0754716981132, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI28572034, Length=290, Percent_Identity=28.6206896551724, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19921738, Length=235, Percent_Identity=29.7872340425532, Blast_Score=79, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 67679; Mature: 67679

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRNVAIIAHVDHGKTTLVDKLLQQSSEYRENSHMQERAMDNIDIERERGITILAKATS
CCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEE
IEYGNYRINIMDTPGHADFGGEVERIMKLVDGVLLLVDAKDGVMPQTKFVLRKALEEKLK
EEECCEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHCC
PIVVINKIDRPFADPKKTVNQVFDLFIDLGATDDQLEFPIIYASGLLGLSSFDVEFESAK
CEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCEEHHCCC
NMKPLLDTIVNHVSKPDVKLDGPLLFQPALIDYNDYVGRMGIGKVFQGTLKVNSFVSCLR
CCHHHHHHHHHHCCCCCEEECCCEEECCEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHC
PNGKVDNFRIQKLYRYSGLTKVETAEAYAGDIVAIAGLSDIFVGDTITEVGETTRLPLLH
CCCCCCCCHHHHHHHHCCCCEEEEHHHHCCCEEEEECCCHHHCCCCHHHCCCCCCCCEEE
IDEPTVQMTFLTNSSPFAGQEGKFVTASKIDERLTREVQKDVSLKVEKEPGSESWLVSGR
ECCCCEEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEECC
GELHLGILIETMRREGFEFAVSRPKVIIKNIDGVLSEPHEEVQVDTPNEFVGSVMELLGN
CCEEEHHHHHHHHHCCCEEECCCCEEEEECCCHHHCCCCHHEEECCCHHHHHHHHHHHCC
RKGEVIKMDQGVNETRLVYNMSSRGLIGLMTQFLTATKGYGVLAHSFLEYKKMSNDNIGS
CCCCEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCC
RQNGALVSLKDGQTTAYAIGHLEDRGQFFIEPRVNVYEGMIVGMNNKDNDLVINVVEEKK
CCCCCEEEEECCCEEEEEEEEECCCCCEEECCCCEEECCEEEECCCCCCCEEEEEECHHH
LTNMRTSGKDNTVVLKRPIEMSLEACMDFINDDELIEITPKSIRIRKKYLKANERKKANY
HHCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCHHCCCC
SQNQ
CCCC
>Mature Secondary Structure
MEIRNVAIIAHVDHGKTTLVDKLLQQSSEYRENSHMQERAMDNIDIERERGITILAKATS
CCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEE
IEYGNYRINIMDTPGHADFGGEVERIMKLVDGVLLLVDAKDGVMPQTKFVLRKALEEKLK
EEECCEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHCC
PIVVINKIDRPFADPKKTVNQVFDLFIDLGATDDQLEFPIIYASGLLGLSSFDVEFESAK
CEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCEEHHCCC
NMKPLLDTIVNHVSKPDVKLDGPLLFQPALIDYNDYVGRMGIGKVFQGTLKVNSFVSCLR
CCHHHHHHHHHHCCCCCEEECCCEEECCEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHC
PNGKVDNFRIQKLYRYSGLTKVETAEAYAGDIVAIAGLSDIFVGDTITEVGETTRLPLLH
CCCCCCCCHHHHHHHHCCCCEEEEHHHHCCCEEEEECCCHHHCCCCHHHCCCCCCCCEEE
IDEPTVQMTFLTNSSPFAGQEGKFVTASKIDERLTREVQKDVSLKVEKEPGSESWLVSGR
ECCCCEEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEECC
GELHLGILIETMRREGFEFAVSRPKVIIKNIDGVLSEPHEEVQVDTPNEFVGSVMELLGN
CCEEEHHHHHHHHHCCCEEECCCCEEEEECCCHHHCCCCHHEEECCCHHHHHHHHHHHCC
RKGEVIKMDQGVNETRLVYNMSSRGLIGLMTQFLTATKGYGVLAHSFLEYKKMSNDNIGS
CCCCEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCC
RQNGALVSLKDGQTTAYAIGHLEDRGQFFIEPRVNVYEGMIVGMNNKDNDLVINVVEEKK
CCCCCEEEEECCCEEEEEEEEECCCCCEEECCCCEEECCEEEECCCCCCCEEEEEECHHH
LTNMRTSGKDNTVVLKRPIEMSLEACMDFINDDELIEITPKSIRIRKKYLKANERKKANY
HHCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCHHCCCC
SQNQ
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]