Click here to switch to the map view.

The map label for this gene is htrA [H]

Identifier: 162447061

GI number: 162447061

Start: 184145

End: 185233

Strand: Direct

Name: htrA [H]

Synonym: ACL_0191

Alternate gene names: 162447061

Gene position: 184145-185233 (Clockwise)

Preceding gene: 162447060

Following gene: 162447062

Centisome position: 12.3

GC content: 31.86

Gene sequence:

>1089_bases
ATGAAAAAAGTATACGCATTTAGTTTAGTGCTATTACTACTTTTATTAACGAGTTGCTTGCCTAGTGACATAGCACATCC
AATAAGGGATGTGCCAACAGAAGCCGAATTTCAAGCGTTAGTAGAAGATTTAAGTGATAGTACAGTCAATTTATTTGGCT
ATTACATGACTTTTGAAGTGTCATTAGGATCAGGGTTAATCTTTGATAGAGAACCTTCAAAAGACGGTATGTATTACTAT
TATGTTTTAACGAATAATCATGTGGTGGAAACCATGACTTATATGAAAGTTAAAACAAATCAAGGTAACATCGAAATTGG
TGATATCTACGCTTTTCCACTCTCAGAAACTGATAACGATGACATAGCAATTGTTCGTTTTGAATCTAGTTATGAATATC
CATTAATTGAAATTAAACCACTAGATACTGAAACAAATACTCACGTTCAATTATCTGTTGGACAATATGTATTTGGTATA
GGTACGCCAGTATCTAAAGATAATTTTAATTTAACAACTAATCTAGGTATTATTTCTGATCTTAATAGCTACTATGTCAG
TCATACAGCAAATATTAATCCAGGTAACTCAGGGGGACCACTATTTAGTTATGATGGTACATTTATTGGTGTCAATACTC
AACGTGTTGAAATCATTAATGGTGAAACAATTTATTTAGTGGGTGATGCCATCCATGTTAATAAAGTAGCAGAAGTTATT
CAAAGAAGATTAGGTAATGTGACACCTAAATTAGGTATTATCATCCGTCCATATGATGATTTTGTAAGTATGGAATATGA
AGCATATTTTGGTGATAAAGCAGCAGACTTTGATCCTTATGATTATGTACCTAAAAATTCTAGTGGTGTTGTAATCATAG
AAGTTAATAGTACAAGATCAAGTGCTGGTGTTTTAGAAAGATTTGATTTGGTTCAAAAACTAAATGGTGTTGAGATTAAA
TCAAATGAGGACTTAATTAATGCAATCGGCACACTTCAAGTAGGTAATACTTACACATTTGAAGTGGTTAGATTCAATGA
AGATTTACACATATTTGAAAATCTTGAACTGGAGGTAGTTATCAAATGA

Upstream 100 bases:

>100_bases
AAATATTCATTTACAGCTGGTGGTCGCCCTGAAGTTTTAATTAATGAAGCGATACATATTAATAGGGTGATAGATCTTGT
TGAAGGGTACCTATAAGTCT

Downstream 100 bases:

>100_bases
AACTTGTACATAACTATTTAACAAAAACAAATCAAACGATAAGCTTTGCAGAATCTATGACTGGAGGACGCTTAAGTTAC
GAATTGGTTAAGTTCCAAGG

Product: trypsin-like serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MKKVYAFSLVLLLLLLTSCLPSDIAHPIRDVPTEAEFQALVEDLSDSTVNLFGYYMTFEVSLGSGLIFDREPSKDGMYYY
YVLTNNHVVETMTYMKVKTNQGNIEIGDIYAFPLSETDNDDIAIVRFESSYEYPLIEIKPLDTETNTHVQLSVGQYVFGI
GTPVSKDNFNLTTNLGIISDLNSYYVSHTANINPGNSGGPLFSYDGTFIGVNTQRVEIINGETIYLVGDAIHVNKVAEVI
QRRLGNVTPKLGIIIRPYDDFVSMEYEAYFGDKAADFDPYDYVPKNSSGVVIIEVNSTRSSAGVLERFDLVQKLNGVEIK
SNEDLINAIGTLQVGNTYTFEVVRFNEDLHIFENLELEVVIK

Sequences:

>Translated_362_residues
MKKVYAFSLVLLLLLLTSCLPSDIAHPIRDVPTEAEFQALVEDLSDSTVNLFGYYMTFEVSLGSGLIFDREPSKDGMYYY
YVLTNNHVVETMTYMKVKTNQGNIEIGDIYAFPLSETDNDDIAIVRFESSYEYPLIEIKPLDTETNTHVQLSVGQYVFGI
GTPVSKDNFNLTTNLGIISDLNSYYVSHTANINPGNSGGPLFSYDGTFIGVNTQRVEIINGETIYLVGDAIHVNKVAEVI
QRRLGNVTPKLGIIIRPYDDFVSMEYEAYFGDKAADFDPYDYVPKNSSGVVIIEVNSTRSSAGVLERFDLVQKLNGVEIK
SNEDLINAIGTLQVGNTYTFEVVRFNEDLHIFENLELEVVIK
>Mature_362_residues
MKKVYAFSLVLLLLLLTSCLPSDIAHPIRDVPTEAEFQALVEDLSDSTVNLFGYYMTFEVSLGSGLIFDREPSKDGMYYY
YVLTNNHVVETMTYMKVKTNQGNIEIGDIYAFPLSETDNDDIAIVRFESSYEYPLIEIKPLDTETNTHVQLSVGQYVFGI
GTPVSKDNFNLTTNLGIISDLNSYYVSHTANINPGNSGGPLFSYDGTFIGVNTQRVEIINGETIYLVGDAIHVNKVAEVI
QRRLGNVTPKLGIIIRPYDDFVSMEYEAYFGDKAADFDPYDYVPKNSSGVVIIEVNSTRSSAGVLERFDLVQKLNGVEIK
SNEDLINAIGTLQVGNTYTFEVVRFNEDLHIFENLELEVVIK

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI24308541, Length=335, Percent_Identity=26.2686567164179, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4506141, Length=312, Percent_Identity=28.8461538461538, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI22129776, Length=315, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1786356, Length=312, Percent_Identity=28.8461538461538, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1789629, Length=305, Percent_Identity=26.8852459016393, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 40520; Mature: 40520

Theoretical pI: Translated: 4.19; Mature: 4.19

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVYAFSLVLLLLLLTSCLPSDIAHPIRDVPTEAEFQALVEDLSDSTVNLFGYYMTFEV
CCEEHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEEEEEEEE
SLGSGLIFDREPSKDGMYYYYVLTNNHVVETMTYMKVKTNQGNIEIGDIYAFPLSETDND
ECCCCEEEECCCCCCCEEEEEEEECCEEEEEEEEEEEEECCCCEEEEEEEEEECCCCCCC
DIAIVRFESSYEYPLIEIKPLDTETNTHVQLSVGQYVFGIGTPVSKDNFNLTTNLGIISD
CEEEEEECCCCCCCEEEEEECCCCCCCEEEEEECCEEEECCCCCCCCCCEEEECCCEEEC
LNSYYVSHTANINPGNSGGPLFSYDGTFIGVNTQRVEIINGETIYLVGDAIHVNKVAEVI
CCCEEEEEECCCCCCCCCCCEEEECCEEEECCCEEEEEECCCEEEEEECEEEHHHHHHHH
QRRLGNVTPKLGIIIRPYDDFVSMEYEAYFGDKAADFDPYDYVPKNSSGVVIIEVNSTRS
HHHHCCCCCCCEEEEECCHHHHEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCC
SAGVLERFDLVQKLNGVEIKSNEDLINAIGTLQVGNTYTFEVVRFNEDLHIFENLELEVV
CHHHHHHHHHHHHCCCEEEECCCHHHHHEEEEEECCEEEEEEEEECCCEEEEECCEEEEE
IK
EC
>Mature Secondary Structure
MKKVYAFSLVLLLLLLTSCLPSDIAHPIRDVPTEAEFQALVEDLSDSTVNLFGYYMTFEV
CCEEHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEEEEEEEE
SLGSGLIFDREPSKDGMYYYYVLTNNHVVETMTYMKVKTNQGNIEIGDIYAFPLSETDND
ECCCCEEEECCCCCCCEEEEEEEECCEEEEEEEEEEEEECCCCEEEEEEEEEECCCCCCC
DIAIVRFESSYEYPLIEIKPLDTETNTHVQLSVGQYVFGIGTPVSKDNFNLTTNLGIISD
CEEEEEECCCCCCCEEEEEECCCCCCCEEEEEECCEEEECCCCCCCCCCEEEECCCEEEC
LNSYYVSHTANINPGNSGGPLFSYDGTFIGVNTQRVEIINGETIYLVGDAIHVNKVAEVI
CCCEEEEEECCCCCCCCCCCEEEECCEEEECCCEEEEEECCCEEEEEECEEEHHHHHHHH
QRRLGNVTPKLGIIIRPYDDFVSMEYEAYFGDKAADFDPYDYVPKNSSGVVIIEVNSTRS
HHHHCCCCCCCEEEEECCHHHHEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCC
SAGVLERFDLVQKLNGVEIKSNEDLINAIGTLQVGNTYTFEVVRFNEDLHIFENLELEVV
CHHHHHHHHHHHHCCCEEEECCCHHHHHEEEEEECCEEEEEEEEECCCEEEEECCEEEEE
IK
EC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]