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The map label for this gene is tktA [H]

Identifier: 162446947

GI number: 162446947

Start: 68248

End: 70203

Strand: Direct

Name: tktA [H]

Synonym: ACL_0062

Alternate gene names: 162446947

Gene position: 68248-70203 (Clockwise)

Preceding gene: 162446946

Following gene: 162446948

Centisome position: 4.56

GC content: 34.87

Gene sequence:

>1956_bases
ATGGATATAAACAAGTTATCTATTGATACGATTCGTTTTTTAGGGATTGACGCTATTAATAAAGCAAATAGTGGACATCC
TGGTATTGTCATTGGTGCTGCACCAATGGCGCATACTCTATTTACAAAACACATCAACATTTATCCAAAGATGAGTCGCT
GGATAAACCGTGACCGCTTTATTCTTTCTGCAGGTCATGGTTCTATGCTACTTTATGCATTAAATCATTTATCGGGTTAC
AAAGTCTCTATTGATGATTTAAAAAACTTTAGAAACTATCCAGGAAATACACCAGGACATCCAGAGTATGGTCATACAGA
TGGTGTTGAAACAACATCTGGTCCGCTTGGACAAGGTATTTCTAATGCTGTGGGTATGGCAATTGCTGAAAAGCATTTAG
CTGCACGTTTTAATGAACCAAACTTTGATTTAATCAGTCACTATACTTATGTATTAGTAGGTGATGGTGACTTACAAGAA
GGGGTAGCTTTAGAAGCTATTTCACTTGCGGGACATTTAGGGTTAGGTAAACTTATTGTTTTATATGATTCTAATGATAT
TCAATTAGACGGTGAAACAAATCTAGCAATATCAGAAGATGTTAAAAAGAAGTTTGAAGCACAAAACTGGCACTACACTA
AAGTAGAAGACGGTGAAGATTTAGATCAAATTAACCGCGCTATTTTACGGGCTAAAAAGATCGTTGATAAACCAACCATT
ATTGAAGTTAAAACAATTATTGGTAGAGGTACAACATCAGAAGGTACTTCAAAAGTTCATGGTTCACCTTTAGGGGAAGC
TGAACGTGAAAAATTAGCACAAAAATCAGGCTATAACTACAAACCATTTGAAGTAGACGGTGAAGTATATAGTTTCTATA
AGAGCAAAGTATTTAACAAAGGTAAACGTGTCTACAACAAATGGGTTAAGATGTTAGATGCTTATAAAGCACAATTCCCA
GAAAAACATGATTTATTCAACCAATTCTTAAGTGGAAATATGCAAATAGATTTAAGTAGCCTAGTATATAATGCAGGTTC
TAAAGAAGCAACACGTAACGTATTAGGTAAAGCTTTAACACTTGCAAGTCATCAAAACTTAAATATTGTTGGTGGATCAG
CAGATCTAACTTCATCAACTAAAGCTAAAGGTAATGATGGACATTTCAGTAGAGATAATGCTTTAGCAAGAAATATTAAC
TTTGGTGTTAGAGAACACGCAATGGGTGCTGTAGTTAATGGTATGACACTGCATGGTGGTTTAAAATCATTTACAGGTGC
ATTCTTTGTCTTCTCAGACTATATGAAACCACCAATTCGTTTAGCTGCAATGATGAAAATACCTAGTGTATTTATCTTCT
CACATGACTCAGTTGCAGTTGGTGAAGACGGTCCAACACATGAACCGATTGAACAACTTATTGGATTACGTAGTATTCCA
GATTTAAACGTTATTCGTCCAGCGGATGCAAATGAAACAAAAGCAGCAGTTGAGATTGCATTTGAATCTAAAGATACAGC
AACAGCGATTATCACTTCTAGACAAAATGTCTTAAATTTAGAACACACAAGTAAAGAGGGTGTTTTAAAGGGAGCATATA
TCGTAAGTAAAGAAGAAAACAAATTAGACGGTATCTTATTAGCATCTGGTTCTGAAGTGGGACTAGCTTATGAAGCAAAA
CAAATCCTTAAAGAAAAAGGATTAGATATCCGTGTTGTTTCTATGCCATCACATCATGCATTTTTATTGCAAAATGAAGA
CTACAGAAGTAAAATACTTCCGGCAAATGTCAAAACCCTTGCAGTAGAGATGGGATCTAGCTATTCATGGTATAGATTTA
CACCTCATGTATACGGTATTGATACATTTGGACTTTCTGCAAATGCTGATGTGGTATTAAAACATTTCGGCTTTAACAAA
GAAAGCATTGCAGAAGCATTTATAAATATTAAATAA

Upstream 100 bases:

>100_bases
ACAGAAGAAGAAGCATCTGAAGAAGAAACACCAACTCAATTAGAAGATTCAGAAACAGAAAACAATTCAGAAGAAAAGAC
TAATAAGGAGTAAAAAAATA

Downstream 100 bases:

>100_bases
AAGTTTTAAAGGAAGATATATATGATTTATGATGGCATTATTGTAGGTGCTGGACACGCCGGTGTCGAAGCTGCACTTGC
TATGGCAAAAATGAAACTTA

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 651; Mature: 651

Protein sequence:

>651_residues
MDINKLSIDTIRFLGIDAINKANSGHPGIVIGAAPMAHTLFTKHINIYPKMSRWINRDRFILSAGHGSMLLYALNHLSGY
KVSIDDLKNFRNYPGNTPGHPEYGHTDGVETTSGPLGQGISNAVGMAIAEKHLAARFNEPNFDLISHYTYVLVGDGDLQE
GVALEAISLAGHLGLGKLIVLYDSNDIQLDGETNLAISEDVKKKFEAQNWHYTKVEDGEDLDQINRAILRAKKIVDKPTI
IEVKTIIGRGTTSEGTSKVHGSPLGEAEREKLAQKSGYNYKPFEVDGEVYSFYKSKVFNKGKRVYNKWVKMLDAYKAQFP
EKHDLFNQFLSGNMQIDLSSLVYNAGSKEATRNVLGKALTLASHQNLNIVGGSADLTSSTKAKGNDGHFSRDNALARNIN
FGVREHAMGAVVNGMTLHGGLKSFTGAFFVFSDYMKPPIRLAAMMKIPSVFIFSHDSVAVGEDGPTHEPIEQLIGLRSIP
DLNVIRPADANETKAAVEIAFESKDTATAIITSRQNVLNLEHTSKEGVLKGAYIVSKEENKLDGILLASGSEVGLAYEAK
QILKEKGLDIRVVSMPSHHAFLLQNEDYRSKILPANVKTLAVEMGSSYSWYRFTPHVYGIDTFGLSANADVVLKHFGFNK
ESIAEAFINIK

Sequences:

>Translated_651_residues
MDINKLSIDTIRFLGIDAINKANSGHPGIVIGAAPMAHTLFTKHINIYPKMSRWINRDRFILSAGHGSMLLYALNHLSGY
KVSIDDLKNFRNYPGNTPGHPEYGHTDGVETTSGPLGQGISNAVGMAIAEKHLAARFNEPNFDLISHYTYVLVGDGDLQE
GVALEAISLAGHLGLGKLIVLYDSNDIQLDGETNLAISEDVKKKFEAQNWHYTKVEDGEDLDQINRAILRAKKIVDKPTI
IEVKTIIGRGTTSEGTSKVHGSPLGEAEREKLAQKSGYNYKPFEVDGEVYSFYKSKVFNKGKRVYNKWVKMLDAYKAQFP
EKHDLFNQFLSGNMQIDLSSLVYNAGSKEATRNVLGKALTLASHQNLNIVGGSADLTSSTKAKGNDGHFSRDNALARNIN
FGVREHAMGAVVNGMTLHGGLKSFTGAFFVFSDYMKPPIRLAAMMKIPSVFIFSHDSVAVGEDGPTHEPIEQLIGLRSIP
DLNVIRPADANETKAAVEIAFESKDTATAIITSRQNVLNLEHTSKEGVLKGAYIVSKEENKLDGILLASGSEVGLAYEAK
QILKEKGLDIRVVSMPSHHAFLLQNEDYRSKILPANVKTLAVEMGSSYSWYRFTPHVYGIDTFGLSANADVVLKHFGFNK
ESIAEAFINIK
>Mature_651_residues
MDINKLSIDTIRFLGIDAINKANSGHPGIVIGAAPMAHTLFTKHINIYPKMSRWINRDRFILSAGHGSMLLYALNHLSGY
KVSIDDLKNFRNYPGNTPGHPEYGHTDGVETTSGPLGQGISNAVGMAIAEKHLAARFNEPNFDLISHYTYVLVGDGDLQE
GVALEAISLAGHLGLGKLIVLYDSNDIQLDGETNLAISEDVKKKFEAQNWHYTKVEDGEDLDQINRAILRAKKIVDKPTI
IEVKTIIGRGTTSEGTSKVHGSPLGEAEREKLAQKSGYNYKPFEVDGEVYSFYKSKVFNKGKRVYNKWVKMLDAYKAQFP
EKHDLFNQFLSGNMQIDLSSLVYNAGSKEATRNVLGKALTLASHQNLNIVGGSADLTSSTKAKGNDGHFSRDNALARNIN
FGVREHAMGAVVNGMTLHGGLKSFTGAFFVFSDYMKPPIRLAAMMKIPSVFIFSHDSVAVGEDGPTHEPIEQLIGLRSIP
DLNVIRPADANETKAAVEIAFESKDTATAIITSRQNVLNLEHTSKEGVLKGAYIVSKEENKLDGILLASGSEVGLAYEAK
QILKEKGLDIRVVSMPSHHAFLLQNEDYRSKILPANVKTLAVEMGSSYSWYRFTPHVYGIDTFGLSANADVVLKHFGFNK
ESIAEAFINIK

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:
GO:0003824: Transketolase
GO:0004802: Transketolase
GO:0008152: Transketolase
GO:0016740: Transketolase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=574, Percent_Identity=28.0487804878049, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI4507521, Length=574, Percent_Identity=28.0487804878049, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI133778974, Length=573, Percent_Identity=27.0506108202443, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI225637459, Length=473, Percent_Identity=24.9471458773784, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI225637463, Length=473, Percent_Identity=24.9471458773784, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI225637461, Length=473, Percent_Identity=24.9471458773784, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI48994911, Length=662, Percent_Identity=40.4833836858006, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1788808, Length=650, Percent_Identity=40.9230769230769, Blast_Score=506, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17539652, Length=569, Percent_Identity=26.0105448154657, Blast_Score=137, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6325331, Length=656, Percent_Identity=44.6646341463415, Blast_Score=541, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6319593, Length=656, Percent_Identity=43.140243902439, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI45551847, Length=568, Percent_Identity=28.8732394366197, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI45550715, Length=568, Percent_Identity=28.8732394366197, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24645119, Length=540, Percent_Identity=28.8888888888889, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24666278, Length=565, Percent_Identity=26.9026548672566, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 71460; Mature: 71460

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDINKLSIDTIRFLGIDAINKANSGHPGIVIGAAPMAHTLFTKHINIYPKMSRWINRDRF
CCCCCEEHHEEEEECCHHHCCCCCCCCEEEEECCHHHHHHHHHHEECCCHHHHHCCCCEE
ILSAGHGSMLLYALNHLSGYKVSIDDLKNFRNYPGNTPGHPEYGHTDGVETTSGPLGQGI
EEECCCCCEEEEEHHHCCCCEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
SNAVGMAIAEKHLAARFNEPNFDLISHYTYVLVGDGDLQEGVALEAISLAGHLGLGKLIV
HHHHHHHHHHHHHHHHCCCCCCEEECCEEEEEEECCCCCCCCEEEHHHHHCCCCCCEEEE
LYDSNDIQLDGETNLAISEDVKKKFEAQNWHYTKVEDGEDLDQINRAILRAKKIVDKPTI
EECCCEEEECCCCCCEECHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCE
IEVKTIIGRGTTSEGTSKVHGSPLGEAEREKLAQKSGYNYKPFEVDGEVYSFYKSKVFNK
EEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHH
GKRVYNKWVKMLDAYKAQFPEKHDLFNQFLSGNMQIDLSSLVYNAGSKEATRNVLGKALT
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEHHHHHCCCCCHHHHHHHHHHHHH
LASHQNLNIVGGSADLTSSTKAKGNDGHFSRDNALARNINFGVREHAMGAVVNGMTLHGG
EECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHCCEEEECC
LKSFTGAFFVFSDYMKPPIRLAAMMKIPSVFIFSHDSVAVGEDGPTHEPIEQLIGLRSIP
HHHHHHHHEEHHHHCCCHHHHHHHHHCCEEEEEECCCEEECCCCCCHHHHHHHHCCCCCC
DLNVIRPADANETKAAVEIAFESKDTATAIITSRQNVLNLEHTSKEGVLKGAYIVSKEEN
CCCEECCCCCCCCCEEEEEEECCCCCEEEEEECCCCEEEEECCCCCCCEEEEEEEECCCC
KLDGILLASGSEVGLAYEAKQILKEKGLDIRVVSMPSHHAFLLQNEDYRSKILPANVKTL
CCCEEEEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCHHHCCCCCCCEEE
AVEMGSSYSWYRFTPHVYGIDTFGLSANADVVLKHFGFNKESIAEAFINIK
EEECCCCCCEEEECCEEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHCCC
>Mature Secondary Structure
MDINKLSIDTIRFLGIDAINKANSGHPGIVIGAAPMAHTLFTKHINIYPKMSRWINRDRF
CCCCCEEHHEEEEECCHHHCCCCCCCCEEEEECCHHHHHHHHHHEECCCHHHHHCCCCEE
ILSAGHGSMLLYALNHLSGYKVSIDDLKNFRNYPGNTPGHPEYGHTDGVETTSGPLGQGI
EEECCCCCEEEEEHHHCCCCEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
SNAVGMAIAEKHLAARFNEPNFDLISHYTYVLVGDGDLQEGVALEAISLAGHLGLGKLIV
HHHHHHHHHHHHHHHHCCCCCCEEECCEEEEEEECCCCCCCCEEEHHHHHCCCCCCEEEE
LYDSNDIQLDGETNLAISEDVKKKFEAQNWHYTKVEDGEDLDQINRAILRAKKIVDKPTI
EECCCEEEECCCCCCEECHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCE
IEVKTIIGRGTTSEGTSKVHGSPLGEAEREKLAQKSGYNYKPFEVDGEVYSFYKSKVFNK
EEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHH
GKRVYNKWVKMLDAYKAQFPEKHDLFNQFLSGNMQIDLSSLVYNAGSKEATRNVLGKALT
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEHHHHHCCCCCHHHHHHHHHHHHH
LASHQNLNIVGGSADLTSSTKAKGNDGHFSRDNALARNINFGVREHAMGAVVNGMTLHGG
EECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHCCEEEECC
LKSFTGAFFVFSDYMKPPIRLAAMMKIPSVFIFSHDSVAVGEDGPTHEPIEQLIGLRSIP
HHHHHHHHEEHHHHCCCHHHHHHHHHCCEEEEEECCCEEECCCCCCHHHHHHHHCCCCCC
DLNVIRPADANETKAAVEIAFESKDTATAIITSRQNVLNLEHTSKEGVLKGAYIVSKEEN
CCCEECCCCCCCCCEEEEEEECCCCCEEEEEECCCCEEEEECCCCCCCEEEEEEEECCCC
KLDGILLASGSEVGLAYEAKQILKEKGLDIRVVSMPSHHAFLLQNEDYRSKILPANVKTL
CCCEEEEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCHHHCCCCCCCEEE
AVEMGSSYSWYRFTPHVYGIDTFGLSANADVVLKHFGFNKESIAEAFINIK
EEECCCCCCEEEECCEEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9384377; 9068642 [H]