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The map label for this gene is fhs

Identifier: 162446919

GI number: 162446919

Start: 37086

End: 38669

Strand: Direct

Name: fhs

Synonym: ACL_0032

Alternate gene names: 162446919

Gene position: 37086-38669 (Clockwise)

Preceding gene: 162446918

Following gene: 162446920

Centisome position: 2.48

GC content: 32.89

Gene sequence:

>1584_bases
ATGAATACATATAATTACCTAATTGATGAATTACATATCTTAGATGATGAAATCATATCCTATGGTAAGGATAAGTTTAA
AATAGAGTTAAGTTTACAAGAAAGATTAAAGGATAAAGCACCTGGTAAACTTATTCTTGTAACATCGATTAACCCTACAT
CTAGTGGTGAAGGTAAAACAACACTTTCCATTGGTTTAGCCCAAGGGTTTAAGAAAAATGGTAAAGATGTTATGTTAGCA
CTTAGAGAACCATCCATGGGTCCTGTTTTTGGTATGAAGGGTGGTGCTACTGGTGGAGGTGTTTCTATTTTAGAACCTTC
ATTAGATATCGACCTTCACTTTAATGGTGACATACATGCACTCACATCAGCGAATAATCTTTTATCAGCAATCATTGATA
ATCATATGTACTTTGGTAATGAATTAAATATTAAAGATGTTTACTGGCAACGCGCACTAGATGTTAATGATCGTAGCTTA
AGAGAAGTTAAGACAAAAGCTAGAGATGATAAATTTACCATTACAGCAGCAAGTGAAATGATGGCGATTTTGGCACTAGC
AAGGGATTTTAAAGACTTAAAAGAAAGATTAAATAATATCTTAATAGGTACCGATAAAGATGGAAAAGATTTATTTGTAA
GTGACTTAAAGTGTGCGGATAGTTTAGCATTACTACTAAAGGATGCTATTAAGCCAAATTTAGTATTTGCTAAAGAAATG
GTACCAGCACTTGTTCATGCTGGACCATTTGCAAATATAGCACATGGATGTAATAGCGTTATAGCAACAAATACTGCTTT
AAAGTTAGCTGATTATGTCATCACAGAAGCTGGTTTTGGTGCAGATTTAGGTATGGAAAAGTTTTTACATATTAAGCAAC
CACATTTATACACAAAGGCTAGTGTAGTGGTTGTAGTTGCAACTATTAAAGCGCTTAAACTACATGGTGGTGTTACAGAA
TCTAATTTAGATGAACCTAATATTGAGGCACTTTCTAAGGGATTAGAAAACATTGAAAAACACTTAGAAAATATTAAACT
GTTTGGTTTAAACAGTGTTGTAGCACTTAATAAGTTTGATACTGATTCAGAAGAGGAATTACAATTCTTAAAAAACTGGG
CAAGAATCAATCACCTAAATTATGGTATTTCAGAAGGGTATAGTAAGGGTGGTGAAGGTACCAAAGACTTAGCTAAGTTA
GTTGAAAAAGTGGCATACGAACCATCTAAATTTAAGAGAATTTATTCTAATGAAGAAAATCATGAATATAAGATCAGAAA
AATAGCGGAAAATATTTATGGGGCAAAGGATGTGATTTTCTCTCAACAAGCAAAGAAGAAACTAAACCAATATAAACATT
TAGAAATTCCTATTTGCATTGCTAAAACACCACTTTCTTTATCTGGAGATCCTAAATTAAAGGGTAGACCAAGAGATTTT
GTTTTAGAGATTAGCGACATTAAAGTGTCTTTAGGTGCGAACCTTTTAGTAGTGCTTACAAAAGGGATTAATACGATGCC
TGGTTTAAATAATCGTCCACGGGCACTGGATTTTAAGTTGGATGATAAAGGAGAACTTATATAA

Upstream 100 bases:

>100_bases
TTTAATAATACTAAAAGGTTATTTTACAAAAATTACACTCGTAAATTTTGTATAATATACATATATGTTCTATTGAAATA
AAATAAACGAGGTTGATTGC

Downstream 100 bases:

>100_bases
TGTTATTAGATGGAAGAAAAACAGCAGATATACTTAATGAAGCACTTCGTGTTAAAGTTCAATATTTAACTAAAAAGCCT
AAATTAGAAATCATTTTAAT

Product: formyltetrahydrofolate synthetase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MNTYNYLIDELHILDDEIISYGKDKFKIELSLQERLKDKAPGKLILVTSINPTSSGEGKTTLSIGLAQGFKKNGKDVMLA
LREPSMGPVFGMKGGATGGGVSILEPSLDIDLHFNGDIHALTSANNLLSAIIDNHMYFGNELNIKDVYWQRALDVNDRSL
REVKTKARDDKFTITAASEMMAILALARDFKDLKERLNNILIGTDKDGKDLFVSDLKCADSLALLLKDAIKPNLVFAKEM
VPALVHAGPFANIAHGCNSVIATNTALKLADYVITEAGFGADLGMEKFLHIKQPHLYTKASVVVVVATIKALKLHGGVTE
SNLDEPNIEALSKGLENIEKHLENIKLFGLNSVVALNKFDTDSEEELQFLKNWARINHLNYGISEGYSKGGEGTKDLAKL
VEKVAYEPSKFKRIYSNEENHEYKIRKIAENIYGAKDVIFSQQAKKKLNQYKHLEIPICIAKTPLSLSGDPKLKGRPRDF
VLEISDIKVSLGANLLVVLTKGINTMPGLNNRPRALDFKLDDKGELI

Sequences:

>Translated_527_residues
MNTYNYLIDELHILDDEIISYGKDKFKIELSLQERLKDKAPGKLILVTSINPTSSGEGKTTLSIGLAQGFKKNGKDVMLA
LREPSMGPVFGMKGGATGGGVSILEPSLDIDLHFNGDIHALTSANNLLSAIIDNHMYFGNELNIKDVYWQRALDVNDRSL
REVKTKARDDKFTITAASEMMAILALARDFKDLKERLNNILIGTDKDGKDLFVSDLKCADSLALLLKDAIKPNLVFAKEM
VPALVHAGPFANIAHGCNSVIATNTALKLADYVITEAGFGADLGMEKFLHIKQPHLYTKASVVVVVATIKALKLHGGVTE
SNLDEPNIEALSKGLENIEKHLENIKLFGLNSVVALNKFDTDSEEELQFLKNWARINHLNYGISEGYSKGGEGTKDLAKL
VEKVAYEPSKFKRIYSNEENHEYKIRKIAENIYGAKDVIFSQQAKKKLNQYKHLEIPICIAKTPLSLSGDPKLKGRPRDF
VLEISDIKVSLGANLLVVLTKGINTMPGLNNRPRALDFKLDDKGELI
>Mature_527_residues
MNTYNYLIDELHILDDEIISYGKDKFKIELSLQERLKDKAPGKLILVTSINPTSSGEGKTTLSIGLAQGFKKNGKDVMLA
LREPSMGPVFGMKGGATGGGVSILEPSLDIDLHFNGDIHALTSANNLLSAIIDNHMYFGNELNIKDVYWQRALDVNDRSL
REVKTKARDDKFTITAASEMMAILALARDFKDLKERLNNILIGTDKDGKDLFVSDLKCADSLALLLKDAIKPNLVFAKEM
VPALVHAGPFANIAHGCNSVIATNTALKLADYVITEAGFGADLGMEKFLHIKQPHLYTKASVVVVVATIKALKLHGGVTE
SNLDEPNIEALSKGLENIEKHLENIKLFGLNSVVALNKFDTDSEEELQFLKNWARINHLNYGISEGYSKGGEGTKDLAKL
VEKVAYEPSKFKRIYSNEENHEYKIRKIAENIYGAKDVIFSQQAKKKLNQYKHLEIPICIAKTPLSLSGDPKLKGRPRDF
VLEISDIKVSLGANLLVVLTKGINTMPGLNNRPRALDFKLDDKGELI

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:
GO:0000166: Formate--tetrahydrofolate ligase
GO:0004329: Formate--tetrahydrofolate ligase
GO:0005524: Formate--tetrahydrofolate ligase
GO:0006730: Formate--tetrahydrofolate ligase
GO:0009396: Formate--tetrahydrofolate ligase
GO:0016874: Formate--tetrahydrofolate ligase

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI36796743, Length=600, Percent_Identity=40.6666666666667, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI222136639, Length=598, Percent_Identity=38.628762541806, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI310124614, Length=79, Percent_Identity=46.8354430379747, Blast_Score=76, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17568737, Length=604, Percent_Identity=38.9072847682119, Blast_Score=350, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI17568739, Length=604, Percent_Identity=38.9072847682119, Blast_Score=350, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6321643, Length=607, Percent_Identity=37.8912685337727, Blast_Score=332, Evalue=7e-92,
Organism=Saccharomyces cerevisiae, GI6319558, Length=612, Percent_Identity=37.0915032679739, Blast_Score=330, Evalue=3e-91,
Organism=Drosophila melanogaster, GI24645718, Length=598, Percent_Identity=38.1270903010033, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI17137370, Length=598, Percent_Identity=38.1270903010033, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI62472483, Length=598, Percent_Identity=38.1270903010033, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI45551871, Length=598, Percent_Identity=38.1270903010033, Blast_Score=365, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_ACHLI (A9NE95)

Other databases:

- EMBL:   CP000896
- RefSeq:   YP_001620051.1
- ProteinModelPortal:   A9NE95
- SMR:   A9NE95
- GeneID:   5803464
- GenomeReviews:   CP000896_GR
- KEGG:   acl:ACL_0032
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- BioCyc:   ALAI441768:ACL_0032-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 58202; Mature: 58202

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTYNYLIDELHILDDEIISYGKDKFKIELSLQERLKDKAPGKLILVTSINPTSSGEGKT
CCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHCCCCCEEEEEECCCCCCCCCCE
TLSIGLAQGFKKNGKDVMLALREPSMGPVFGMKGGATGGGVSILEPSLDIDLHFNGDIHA
EEEEEHHHHHCCCCCEEEEEEECCCCCCEECCCCCCCCCCCEEECCCCEEEEEECCCEEE
LTSANNLLSAIIDNHMYFGNELNIKDVYWQRALDVNDRSLREVKTKARDDKFTITAASEM
ECCHHHHHHHHHHCCEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEHHHH
MAILALARDFKDLKERLNNILIGTDKDGKDLFVSDLKCADSLALLLKDAIKPNLVFAKEM
HHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEHHHH
VPALVHAGPFANIAHGCNSVIATNTALKLADYVITEAGFGADLGMEKFLHIKQPHLYTKA
HHHHHHCCCHHHHHHCCCCHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCHH
SVVVVVATIKALKLHGGVTESNLDEPNIEALSKGLENIEKHLENIKLFGLNSVVALNKFD
HHEEHEEHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEECCCEEEEECCC
TDSEEELQFLKNWARINHLNYGISEGYSKGGEGTKDLAKLVEKVAYEPSKFKRIYSNEEN
CCCHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCC
HEYKIRKIAENIYGAKDVIFSQQAKKKLNQYKHLEIPICIAKTPLSLSGDPKLKGRPRDF
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCEE
VLEISDIKVSLGANLLVVLTKGINTMPGLNNRPRALDFKLDDKGELI
EEEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MNTYNYLIDELHILDDEIISYGKDKFKIELSLQERLKDKAPGKLILVTSINPTSSGEGKT
CCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHCCCCCEEEEEECCCCCCCCCCE
TLSIGLAQGFKKNGKDVMLALREPSMGPVFGMKGGATGGGVSILEPSLDIDLHFNGDIHA
EEEEEHHHHHCCCCCEEEEEEECCCCCCEECCCCCCCCCCCEEECCCCEEEEEECCCEEE
LTSANNLLSAIIDNHMYFGNELNIKDVYWQRALDVNDRSLREVKTKARDDKFTITAASEM
ECCHHHHHHHHHHCCEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEHHHH
MAILALARDFKDLKERLNNILIGTDKDGKDLFVSDLKCADSLALLLKDAIKPNLVFAKEM
HHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEHHHH
VPALVHAGPFANIAHGCNSVIATNTALKLADYVITEAGFGADLGMEKFLHIKQPHLYTKA
HHHHHHCCCHHHHHHCCCCHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCHH
SVVVVVATIKALKLHGGVTESNLDEPNIEALSKGLENIEKHLENIKLFGLNSVVALNKFD
HHEEHEEHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEECCCEEEEECCC
TDSEEELQFLKNWARINHLNYGISEGYSKGGEGTKDLAKLVEKVAYEPSKFKRIYSNEEN
CCCHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCC
HEYKIRKIAENIYGAKDVIFSQQAKKKLNQYKHLEIPICIAKTPLSLSGDPKLKGRPRDF
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCEE
VLEISDIKVSLGANLLVVLTKGINTMPGLNNRPRALDFKLDDKGELI
EEEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA