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The map label for this gene is rdgB [C]

Identifier: 162419754

GI number: 162419754

Start: 140863

End: 141522

Strand: Direct

Name: rdgB [C]

Synonym: YpAngola_A0142

Alternate gene names: 162419754

Gene position: 140863-141522 (Clockwise)

Preceding gene: 162418314

Following gene: 162420837

Centisome position: 3.13

GC content: 52.58

Gene sequence:

>660_bases
TTGTCAGCCCAACAGACTGCGCTCAATACCGATAGCCGTCAGCCTATAAAAATTCAGGATTCATCGATGCAAAAAATAGT
ATTAGCCACCGGCAACCCCGGCAAAGTACGTGAACTGGCAAACCTGCTGGCCGACTTTGGTTTGGATGTCGTCGCACAAA
CCGAACTGGGCGTTGAGTCTGCAGAAGAGACGGGCTTAACCTTTATTGAAAACGCCATTTTAAAAGCCCGCCATGCAGCG
CAAACCACCGGTTTACCGGCCATCGCCGATGATTCAGGCTTAGCAGTAGACGCGTTAGGCGGCGCTCCGGGGATTTATTC
CGCACGCTATGCCGGTACTGATGCCAGTGACCAAGAGAATCTGGAAAAGCTGTTGGTCGCATTGCAAAATGTCCCCGATG
AAAAACGCGGTGCTCAGTTCCATTGCGTATTGGTCTATATGCGTCATGCTGAAGATCCAACACCGCTGGTGTTCCACGGC
CAATGGCCAGGGGTAATTGCTCACCAACCTGCTGGGGCTGCTGGGTTTGGCTATGACCCTATTTTCTATGTACCCGCGCT
GGGTAAAACCGCAGCGGAACTGACTCGTGAAGAAAAGCACGCGGTATCCCATCGTGGTCAGGCCCTGAAATTGATGCTGG
ATGCGCTGCGCGATGCTTAA

Upstream 100 bases:

>100_bases
GCATAAGCAGATAAAAGTGATTAACCCGCAGCAGATTCCGCCAGAAGTCACCATACTGCTCGAGTGAGTTGATATTCCTC
CGCAAGAATTGGGTTATTGG

Downstream 100 bases:

>100_bases
ATTACCCCCGCTCAGTCTCTACATCCATATCCCTTGGTGCGTCCAGAAATGCCCTTATTGTGATTTCAACTCACATGCGT
TGAAAGGCGATGTCCCTCAT

Product: putative deoxyribonucleotide triphosphate pyrophosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase [H]

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MSAQQTALNTDSRQPIKIQDSSMQKIVLATGNPGKVRELANLLADFGLDVVAQTELGVESAEETGLTFIENAILKARHAA
QTTGLPAIADDSGLAVDALGGAPGIYSARYAGTDASDQENLEKLLVALQNVPDEKRGAQFHCVLVYMRHAEDPTPLVFHG
QWPGVIAHQPAGAAGFGYDPIFYVPALGKTAAELTREEKHAVSHRGQALKLMLDALRDA

Sequences:

>Translated_219_residues
MSAQQTALNTDSRQPIKIQDSSMQKIVLATGNPGKVRELANLLADFGLDVVAQTELGVESAEETGLTFIENAILKARHAA
QTTGLPAIADDSGLAVDALGGAPGIYSARYAGTDASDQENLEKLLVALQNVPDEKRGAQFHCVLVYMRHAEDPTPLVFHG
QWPGVIAHQPAGAAGFGYDPIFYVPALGKTAAELTREEKHAVSHRGQALKLMLDALRDA
>Mature_218_residues
SAQQTALNTDSRQPIKIQDSSMQKIVLATGNPGKVRELANLLADFGLDVVAQTELGVESAEETGLTFIENAILKARHAAQ
TTGLPAIADDSGLAVDALGGAPGIYSARYAGTDASDQENLEKLLVALQNVPDEKRGAQFHCVLVYMRHAEDPTPLVFHGQ
WPGVIAHQPAGAAGFGYDPIFYVPALGKTAAELTREEKHAVSHRGQALKLMLDALRDA

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions [H]

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family [H]

Homologues:

Organism=Homo sapiens, GI15626999, Length=189, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1789324, Length=196, Percent_Identity=79.5918367346939, Blast_Score=333, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI17556833, Length=198, Percent_Identity=28.7878787878788, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI19920712, Length=190, Percent_Identity=33.6842105263158, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002637
- InterPro:   IPR020922 [H]

Pfam domain/function: PF01725 Ham1p_like [H]

EC number: =3.6.1.15 [H]

Molecular weight: Translated: 23308; Mature: 23176

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQQTALNTDSRQPIKIQDSSMQKIVLATGNPGKVRELANLLADFGLDVVAQTELGVES
CCCCCCCCCCCCCCCEEEECCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCCC
AEETGLTFIENAILKARHAAQTTGLPAIADDSGLAVDALGGAPGIYSARYAGTDASDQEN
HHHCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEECCCCCCCCCCEECCCCCCCHHH
LEKLLVALQNVPDEKRGAQFHCVLVYMRHAEDPTPLVFHGQWPGVIAHQPAGAAGFGYDP
HHHHHHHHHCCCCHHHCCEEEEEEEEEECCCCCCCEEEECCCCCEEEECCCCCCCCCCCC
IFYVPALGKTAAELTREEKHAVSHRGQALKLMLDALRDA
EEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SAQQTALNTDSRQPIKIQDSSMQKIVLATGNPGKVRELANLLADFGLDVVAQTELGVES
CCCCCCCCCCCCCCEEEECCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCCC
AEETGLTFIENAILKARHAAQTTGLPAIADDSGLAVDALGGAPGIYSARYAGTDASDQEN
HHHCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEECCCCCCCCCCEECCCCCCCHHH
LEKLLVALQNVPDEKRGAQFHCVLVYMRHAEDPTPLVFHGQWPGVIAHQPAGAAGFGYDP
HHHHHHHHHCCCCHHHCCEEEEEEEEEECCCCCCCEEEECCCCCEEEECCCCCCCCCCCC
IFYVPALGKTAAELTREEKHAVSHRGQALKLMLDALRDA
EEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]