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The map label for this gene is trpC [H]

Identifier: 162419128

GI number: 162419128

Start: 2430731

End: 2432158

Strand: Direct

Name: trpC [H]

Synonym: YpAngola_A2315

Alternate gene names: 162419128

Gene position: 2430731-2432158 (Clockwise)

Preceding gene: 162420907

Following gene: 162420718

Centisome position: 53.97

GC content: 50.84

Gene sequence:

>1428_bases
ATGCAGGAAACTGGGGGTTACAAAACCGAGGGTTATAACGTTGGCAGTGACAAAGTTGACAGTGATAAAACCAAAACCGT
GCTCCACCAAATCGTACACGATAAAGAAATTTGGGTTGCCGCGCGGAAACTGCAACAGCCTCTAACCCGCTTCCAAAACG
AAATCACCCAGAGTCAGCGCGATTTTTATCACGCGCTACAAGGCGATAAAACGGTCTTTATTTTGGAATGCAAAAAAGCC
TCACCTTCTAAAGGGGTTATCCGTGACAACTTTAACCCGGCGGAGATTGCCGGTGTTTATAAGCACTATGCGTCGGCTAT
CTCAGTATTAACGGATGAGAAATATTTCCAGGGCAGTTTTGATTTCTTGCCACAAGTCAGTGCCGCCGTCACTCAGCCGG
TATTGTGTAAAGATTTTATTATTGATGCTTATCAGATTCAGCTAGCGCGGTTTTACCACGCTGACGCCATTTTACTGATG
CTGTCGGTCTTGGACGATGAGGCTTACCGCCAATTGGCCGCCGTCGCACACAGCCTGAACATGGGGGTGTTGACCGAAGC
CAGTAACGCCGAAGAATTGGAGCGTGCTATTACCTTGGGTGCCAAAGTTGTTGGCATCAATAACCGCGACCTGCGTGACC
TGTCTATCGATCTGAATCGCACCCGTGAATTGGCACCACGCCTACCAGAAGGTGTCACAATAATCAGTGAATCTGGCATT
AGTCATTATCGTCAGGTCCGTGAATTGAGCCAATTTGCCAACGGTTTCCTGATTGGCAGTGCCCTGATGTCCGAACCTGA
TCTCAACGCGGCCGTCCGCCGGGTGTTACTGGGCGAAAATAAAGTTTGCGGCCTGACACGCGCACAAGATGCCGCCACGG
CTTACCACGCAGGTGCGGTGTACGGCGGGTTGATTTTTGTCGACAGTTCACCCCGGTATGTGGATATCGCCAGCGCCCGT
ACGGTTATCAGTGGTGCGCCGCTAAAGTATGTCGGTGTTTTTCGTCATGCTGAAATAGAAACTGTACGGCAAACGGCTGA
ACAACTCTCACTGGCAGCAGTGCAATTGCATGGGCATGAAGATCAACAGTATATCAATCAACTGCGCAAAGTATTACCTG
CGGATTGCCAGATTTGGAAGGCACTGAGTGTCGGTGACACGATGCCGGAACGCAACTTACAGCAAGTTGAACGCTACGTA
TTGGATCACGGTACGGGTGGCACAGGGCAACGTTTCGACTGGTCATTATTGGCAGATCAAACACTAGATAATGTCTTGCT
GGCAGGCGGCTTGGGGCCAGATAACTGTGATGTGGCAGCCCAACTAGGCTGTGCCGGGCTGGATGTCAATTCCGGCGTAG
AAAGCGCCCCTGGCATCAAAGACCCCCAACGGATCGCCGCTGTATTCCAGGCATTACGCGTGTACTGA

Upstream 100 bases:

>100_bases
CCAAGAAAACCTGCGCCATAATGCGCAACAGGCATTGGAAATGATTCACAGCGGTCAGGCTTTTGATCGTGTTACTGCTC
TGGCAGCGAGAGGATAAATC

Downstream 100 bases:

>100_bases
TTGACTCTATTTCAAGATTTACTTTATCCCCAAACAAGATTTACTTTATCCCAAAAATAGTTGGCGTCGCAGCTAACACC
ACTGCGGCTTCAAATACCAA

Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MQETGGYKTEGYNVGSDKVDSDKTKTVLHQIVHDKEIWVAARKLQQPLTRFQNEITQSQRDFYHALQGDKTVFILECKKA
SPSKGVIRDNFNPAEIAGVYKHYASAISVLTDEKYFQGSFDFLPQVSAAVTQPVLCKDFIIDAYQIQLARFYHADAILLM
LSVLDDEAYRQLAAVAHSLNMGVLTEASNAEELERAITLGAKVVGINNRDLRDLSIDLNRTRELAPRLPEGVTIISESGI
SHYRQVRELSQFANGFLIGSALMSEPDLNAAVRRVLLGENKVCGLTRAQDAATAYHAGAVYGGLIFVDSSPRYVDIASAR
TVISGAPLKYVGVFRHAEIETVRQTAEQLSLAAVQLHGHEDQQYINQLRKVLPADCQIWKALSVGDTMPERNLQQVERYV
LDHGTGGTGQRFDWSLLADQTLDNVLLAGGLGPDNCDVAAQLGCAGLDVNSGVESAPGIKDPQRIAAVFQALRVY

Sequences:

>Translated_475_residues
MQETGGYKTEGYNVGSDKVDSDKTKTVLHQIVHDKEIWVAARKLQQPLTRFQNEITQSQRDFYHALQGDKTVFILECKKA
SPSKGVIRDNFNPAEIAGVYKHYASAISVLTDEKYFQGSFDFLPQVSAAVTQPVLCKDFIIDAYQIQLARFYHADAILLM
LSVLDDEAYRQLAAVAHSLNMGVLTEASNAEELERAITLGAKVVGINNRDLRDLSIDLNRTRELAPRLPEGVTIISESGI
SHYRQVRELSQFANGFLIGSALMSEPDLNAAVRRVLLGENKVCGLTRAQDAATAYHAGAVYGGLIFVDSSPRYVDIASAR
TVISGAPLKYVGVFRHAEIETVRQTAEQLSLAAVQLHGHEDQQYINQLRKVLPADCQIWKALSVGDTMPERNLQQVERYV
LDHGTGGTGQRFDWSLLADQTLDNVLLAGGLGPDNCDVAAQLGCAGLDVNSGVESAPGIKDPQRIAAVFQALRVY
>Mature_475_residues
MQETGGYKTEGYNVGSDKVDSDKTKTVLHQIVHDKEIWVAARKLQQPLTRFQNEITQSQRDFYHALQGDKTVFILECKKA
SPSKGVIRDNFNPAEIAGVYKHYASAISVLTDEKYFQGSFDFLPQVSAAVTQPVLCKDFIIDAYQIQLARFYHADAILLM
LSVLDDEAYRQLAAVAHSLNMGVLTEASNAEELERAITLGAKVVGINNRDLRDLSIDLNRTRELAPRLPEGVTIISESGI
SHYRQVRELSQFANGFLIGSALMSEPDLNAAVRRVLLGENKVCGLTRAQDAATAYHAGAVYGGLIFVDSSPRYVDIASAR
TVISGAPLKYVGVFRHAEIETVRQTAEQLSLAAVQLHGHEDQQYINQLRKVLPADCQIWKALSVGDTMPERNLQQVERYV
LDHGTGGTGQRFDWSLLADQTLDNVLLAGGLGPDNCDVAAQLGCAGLDVNSGVESAPGIKDPQRIAAVFQALRVY

Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain [H]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=451, Percent_Identity=72.9490022172949, Blast_Score=666, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322638, Length=228, Percent_Identity=38.5964912280702, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6320210, Length=211, Percent_Identity=33.6492890995261, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS; PF00697 PRAI [H]

EC number: =4.1.1.48; =5.3.1.24 [H]

Molecular weight: Translated: 52148; Mature: 52148

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQETGGYKTEGYNVGSDKVDSDKTKTVLHQIVHDKEIWVAARKLQQPLTRFQNEITQSQR
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DFYHALQGDKTVFILECKKASPSKGVIRDNFNPAEIAGVYKHYASAISVLTDEKYFQGSF
HHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCC
DFLPQVSAAVTQPVLCKDFIIDAYQIQLARFYHADAILLMLSVLDDEAYRQLAAVAHSLN
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCC
MGVLTEASNAEELERAITLGAKVVGINNRDLRDLSIDLNRTRELAPRLPEGVTIISESGI
CCEEECCCCHHHHHHHHHHCCEEEECCCCCCCEEEECHHHHHHHHCCCCCCEEEEECCCH
SHYRQVRELSQFANGFLIGSALMSEPDLNAAVRRVLLGENKVCGLTRAQDAATAYHAGAV
HHHHHHHHHHHHHCCEEEHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
YGGLIFVDSSPRYVDIASARTVISGAPLKYVGVFRHAEIETVRQTAEQLSLAAVQLHGHE
CCCEEEECCCCCEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
DQQYINQLRKVLPADCQIWKALSVGDTMPERNLQQVERYVLDHGTGGTGQRFDWSLLADQ
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
TLDNVLLAGGLGPDNCDVAAQLGCAGLDVNSGVESAPGIKDPQRIAAVFQALRVY
HHHHEEEECCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MQETGGYKTEGYNVGSDKVDSDKTKTVLHQIVHDKEIWVAARKLQQPLTRFQNEITQSQR
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DFYHALQGDKTVFILECKKASPSKGVIRDNFNPAEIAGVYKHYASAISVLTDEKYFQGSF
HHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCC
DFLPQVSAAVTQPVLCKDFIIDAYQIQLARFYHADAILLMLSVLDDEAYRQLAAVAHSLN
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCC
MGVLTEASNAEELERAITLGAKVVGINNRDLRDLSIDLNRTRELAPRLPEGVTIISESGI
CCEEECCCCHHHHHHHHHHCCEEEECCCCCCCEEEECHHHHHHHHCCCCCCEEEEECCCH
SHYRQVRELSQFANGFLIGSALMSEPDLNAAVRRVLLGENKVCGLTRAQDAATAYHAGAV
HHHHHHHHHHHHHCCEEEHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
YGGLIFVDSSPRYVDIASARTVISGAPLKYVGVFRHAEIETVRQTAEQLSLAAVQLHGHE
CCCEEEECCCCCEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
DQQYINQLRKVLPADCQIWKALSVGDTMPERNLQQVERYVLDHGTGGTGQRFDWSLLADQ
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
TLDNVLLAGGLGPDNCDVAAQLGCAGLDVNSGVESAPGIKDPQRIAAVFQALRVY
HHHHEEEECCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]