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The map label for this gene is alsR [H]

Identifier: 162418162

GI number: 162418162

Start: 2213063

End: 2213941

Strand: Direct

Name: alsR [H]

Synonym: YpAngola_A2119

Alternate gene names: 162418162

Gene position: 2213063-2213941 (Clockwise)

Preceding gene: 162419932

Following gene: 162421686

Centisome position: 49.13

GC content: 51.08

Gene sequence:

>879_bases
ATGGAGTTACGTCATATACGCTATTTTCTGGCTGTTGCTGAAGAACGACATTTCACACACGCTGCCGCCCGGCTAGGAAT
AGGACAGCCTCCTCTCAGTCAGCAAATTAAGGATCTGGAGAGGGAACTCGGTGCGTTGTTGTTCCGGCGGGTTTCTTATG
GCGCAGAATTAACTGAGGCAGGTATTGCATTTCTGGATGTTGTCAAAGAGATACCTGTGATGGCAGAAAGAGCGGCCCAA
GCTGCGCAGCGGGCTGTCAGGGGAGAACTCGGCGTACTCAGAGTTGGCTTTACCGCGTCATCAGCATTTAACAGCGTAGT
GCCTACGGCGATCCGTGCCTTTAGACGTGCATATCCTGATGTACGATTACAGCTAGAGGAAGATAACACGACTCGACTGG
CTGATGGATTGAATGAAGGCTCGCTCGATGTCGCTTTCCTGAGGCCAGGCTTTGCTGGCAGCGAACGTTTCCACCTCAGA
ATGCTATCTGAAGAGCCGATGATGATTGTCATGGCGGAAAATCACCCGGCGGCATCGTATGAAGAAATTTCGCTTAGCGC
ATTCAGGGATGAAACTTTCCTGCTATTTCCACGAGAGATTGGTCTGACGCTTTACGATTCAGTGATTGAGTCATGCCGTA
CTGCGGGTTTTGAGCCGACTATTGGCCAACTGGCACCACAAATCGCTTCGGTCATTAATCTCGTTGCGGCAGAAATGGGC
GTTTCAATCGTTCCGGCTTCCATGAGCCAAGTGAAAGTTATTGGGGTTGTATATCGACACATTGCTGACCAGACGCCGAC
AGCAAAGCTCGCGTTGGCGTACCGGCGAGGGGATACCTCGCCGGTATTAAGAAACTTTGTCCTGACCGTGTTTCCTTGA

Upstream 100 bases:

>100_bases
AGACATGATGTTCCTCCTCCAACTTCGCTTAGTCTATGGTCGCCGTTATCATTTATCCAATATATGATACCGGTGTGTTT
AATTGCTTTTGGATATGAAG

Downstream 100 bases:

>100_bases
ATTCTCTCCGTAGGTTAAGGCGACTCTATAGGTTAAAACGATCCAATCGGTTAAAAAACGCCCCAAGAGCAAAATTATTG
GCTATCAATATCCGGCCTGC

Product: LysR family substrate-binding transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MELRHIRYFLAVAEERHFTHAAARLGIGQPPLSQQIKDLERELGALLFRRVSYGAELTEAGIAFLDVVKEIPVMAERAAQ
AAQRAVRGELGVLRVGFTASSAFNSVVPTAIRAFRRAYPDVRLQLEEDNTTRLADGLNEGSLDVAFLRPGFAGSERFHLR
MLSEEPMMIVMAENHPAASYEEISLSAFRDETFLLFPREIGLTLYDSVIESCRTAGFEPTIGQLAPQIASVINLVAAEMG
VSIVPASMSQVKVIGVVYRHIADQTPTAKLALAYRRGDTSPVLRNFVLTVFP

Sequences:

>Translated_292_residues
MELRHIRYFLAVAEERHFTHAAARLGIGQPPLSQQIKDLERELGALLFRRVSYGAELTEAGIAFLDVVKEIPVMAERAAQ
AAQRAVRGELGVLRVGFTASSAFNSVVPTAIRAFRRAYPDVRLQLEEDNTTRLADGLNEGSLDVAFLRPGFAGSERFHLR
MLSEEPMMIVMAENHPAASYEEISLSAFRDETFLLFPREIGLTLYDSVIESCRTAGFEPTIGQLAPQIASVINLVAAEMG
VSIVPASMSQVKVIGVVYRHIADQTPTAKLALAYRRGDTSPVLRNFVLTVFP
>Mature_292_residues
MELRHIRYFLAVAEERHFTHAAARLGIGQPPLSQQIKDLERELGALLFRRVSYGAELTEAGIAFLDVVKEIPVMAERAAQ
AAQRAVRGELGVLRVGFTASSAFNSVVPTAIRAFRRAYPDVRLQLEEDNTTRLADGLNEGSLDVAFLRPGFAGSERFHLR
MLSEEPMMIVMAENHPAASYEEISLSAFRDETFLLFPREIGLTLYDSVIESCRTAGFEPTIGQLAPQIASVINLVAAEMG
VSIVPASMSQVKVIGVVYRHIADQTPTAKLALAYRRGDTSPVLRNFVLTVFP

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=287, Percent_Identity=40.418118466899, Blast_Score=200, Evalue=9e-53,
Organism=Escherichia coli, GI1788887, Length=290, Percent_Identity=33.7931034482759, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI2367136, Length=282, Percent_Identity=30.8510638297872, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1790399, Length=283, Percent_Identity=31.4487632508834, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI157672245, Length=250, Percent_Identity=32, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1787601, Length=300, Percent_Identity=27.3333333333333, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1790262, Length=245, Percent_Identity=25.7142857142857, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87081904, Length=189, Percent_Identity=29.6296296296296, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788297, Length=252, Percent_Identity=26.5873015873016, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787530, Length=251, Percent_Identity=24.3027888446215, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788748, Length=246, Percent_Identity=23.1707317073171, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789173, Length=138, Percent_Identity=36.9565217391304, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI87082132, Length=298, Percent_Identity=24.8322147651007, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32173; Mature: 32173

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRHIRYFLAVAEERHFTHAAARLGIGQPPLSQQIKDLERELGALLFRRVSYGAELTEA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GIAFLDVVKEIPVMAERAAQAAQRAVRGELGVLRVGFTASSAFNSVVPTAIRAFRRAYPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCC
VRLQLEEDNTTRLADGLNEGSLDVAFLRPGFAGSERFHLRMLSEEPMMIVMAENHPAASY
EEEEECCCCCHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCEEEEEECCCCCCCH
EEISLSAFRDETFLLFPREIGLTLYDSVIESCRTAGFEPTIGQLAPQIASVINLVAAEMG
HHHHHHHCCCCEEEEEHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHC
VSIVPASMSQVKVIGVVYRHIADQTPTAKLALAYRRGDTSPVLRNFVLTVFP
CEEECCCHHHHHHHHHHHHHHCCCCCCHHEEEEEECCCCCHHHHHHHHEECC
>Mature Secondary Structure
MELRHIRYFLAVAEERHFTHAAARLGIGQPPLSQQIKDLERELGALLFRRVSYGAELTEA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GIAFLDVVKEIPVMAERAAQAAQRAVRGELGVLRVGFTASSAFNSVVPTAIRAFRRAYPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCC
VRLQLEEDNTTRLADGLNEGSLDVAFLRPGFAGSERFHLRMLSEEPMMIVMAENHPAASY
EEEEECCCCCHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCEEEEEECCCCCCCH
EEISLSAFRDETFLLFPREIGLTLYDSVIESCRTAGFEPTIGQLAPQIASVINLVAAEMG
HHHHHHHCCCCEEEEEHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHC
VSIVPASMSQVKVIGVVYRHIADQTPTAKLALAYRRGDTSPVLRNFVLTVFP
CEEECCCHHHHHHHHHHHHHHCCCCCCHHEEEEEECCCCCHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]