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The map label for this gene is dxr2 [H]

Identifier: 162382777

GI number: 162382777

Start: 3666391

End: 3667533

Strand: Reverse

Name: dxr2 [H]

Synonym: BALH_3451

Alternate gene names: 162382777

Gene position: 3667533-3666391 (Counterclockwise)

Preceding gene: 118479044

Following gene: 118479042

Centisome position: 69.76

GC content: 38.93

Gene sequence:

>1143_bases
ATGAAAAACATTAGTTTATTAGGTGCAAGCGGATCAATTGGTACACAAACTTTAGATGTATTACGCTCGCACCCAGACCA
ATTCCGTCTCGTTGCTTTTTCTGTAGGGAAAAATATTGACTACGCAGTAAAGGTCATTCAAGAATTTTCTCCACAAATTG
TCTCTGTGCAAAGAGAGGAAGATGTTTTAAAATTACAAGCTGTTTCTGGTAATACAAAAGTTGTATATGGTAGTGAAGGG
CTTTTAGAAGTAGCATTACATCCAGATGCGGAGATTGTAGTAAACGCTGTTGTAGGTAGCGTAGGGTTGTTACCAACACT
TCGTGCAATTGAGGCGAAAAAAACAATTGGAATTGCAAACAAAGAAACGTTAGTAACTGCAGGGCATCTTGTAATGGAAG
CAGCGCGAAAACATAATGTTTCGTTACTTCCAGTAGACAGTGAACATTCAGCTATTTTTCAATGCTTGAATGGTGAAAAT
GAAAAAAGAATTTCTCGACTAATTATAACGGCTTCTGGTGGAAGTTTCCGTGATAAAACGAGAGATGAATTGCATCATGT
GACCGTAGAAGATGCGCTTCGACATCCAAACTGGTCAATGGGTTCGAAAATTACAATTGATTCTGCTACAATGATGAATA
AGGGGCTAGAAGTAATTGAAGCACATTGGCTTTTTGGTATCCCTTATGAGCAAATCGATGTTGTTTTACATAAAGAAAGT
ATTATTCATTCTATGGTTGAATTTGAAGATCGTAGTGTGATGGCACAGCTTGGCTCACCTGATATGCGAGTACCAATTCA
ATACGCGCTTACATATCCTGATCGATTACCTCTTTCAGACACAAAGCAGTTAAACTTATGGGAAATAGGAACGTTGCATT
TTGAGAAGATGAACCAAGAGCGTTTCCGTTGCCTACGTTTTGCGTATGAAGCTGGAAAAGCAGGTGGAAGTATGCCAGCT
GTAATGAATGCAGCGAATGAAGTAGCTGTGGAAGCTTTTTTACAAAAGAGAATTGGTTTCTTAACAGTGGAAGACCTCAT
TGAAAAAGCAATGAACCATCACAATGTCATTGCACGTCCGAGCTTAGAGGAAATTCTGGAAATTGATGCAGCCACAAGAC
GGTTTGTGATGGAACAAATTTAG

Upstream 100 bases:

>100_bases
ATGGTGGTATATTAGATCGAACAGATAGTTGGTTATTCGTTTTACCAATTCTCTACTTCTTATTACAATATAATTAATGA
ATGAACGAGGGGTTGGAATC

Downstream 100 bases:

>100_bases
CAAAGGTGGTATGGAATTGAATACAGCGATTGCCTTTATATTAATTTTCGGTGCACTCGTATTTTTCCATGAGCTAGGGC
ATCTATATTTCGCAAAAAGA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase 2; 1-deoxyxylulose-5-phosphate reductoisomerase 2; 2-C-methyl-D-erythritol 4-phosphate synthase 2 [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKNISLLGASGSIGTQTLDVLRSHPDQFRLVAFSVGKNIDYAVKVIQEFSPQIVSVQREEDVLKLQAVSGNTKVVYGSEG
LLEVALHPDAEIVVNAVVGSVGLLPTLRAIEAKKTIGIANKETLVTAGHLVMEAARKHNVSLLPVDSEHSAIFQCLNGEN
EKRISRLIITASGGSFRDKTRDELHHVTVEDALRHPNWSMGSKITIDSATMMNKGLEVIEAHWLFGIPYEQIDVVLHKES
IIHSMVEFEDRSVMAQLGSPDMRVPIQYALTYPDRLPLSDTKQLNLWEIGTLHFEKMNQERFRCLRFAYEAGKAGGSMPA
VMNAANEVAVEAFLQKRIGFLTVEDLIEKAMNHHNVIARPSLEEILEIDAATRRFVMEQI

Sequences:

>Translated_380_residues
MKNISLLGASGSIGTQTLDVLRSHPDQFRLVAFSVGKNIDYAVKVIQEFSPQIVSVQREEDVLKLQAVSGNTKVVYGSEG
LLEVALHPDAEIVVNAVVGSVGLLPTLRAIEAKKTIGIANKETLVTAGHLVMEAARKHNVSLLPVDSEHSAIFQCLNGEN
EKRISRLIITASGGSFRDKTRDELHHVTVEDALRHPNWSMGSKITIDSATMMNKGLEVIEAHWLFGIPYEQIDVVLHKES
IIHSMVEFEDRSVMAQLGSPDMRVPIQYALTYPDRLPLSDTKQLNLWEIGTLHFEKMNQERFRCLRFAYEAGKAGGSMPA
VMNAANEVAVEAFLQKRIGFLTVEDLIEKAMNHHNVIARPSLEEILEIDAATRRFVMEQI
>Mature_380_residues
MKNISLLGASGSIGTQTLDVLRSHPDQFRLVAFSVGKNIDYAVKVIQEFSPQIVSVQREEDVLKLQAVSGNTKVVYGSEG
LLEVALHPDAEIVVNAVVGSVGLLPTLRAIEAKKTIGIANKETLVTAGHLVMEAARKHNVSLLPVDSEHSAIFQCLNGEN
EKRISRLIITASGGSFRDKTRDELHHVTVEDALRHPNWSMGSKITIDSATMMNKGLEVIEAHWLFGIPYEQIDVVLHKES
IIHSMVEFEDRSVMAQLGSPDMRVPIQYALTYPDRLPLSDTKQLNLWEIGTLHFEKMNQERFRCLRFAYEAGKAGGSMPA
VMNAANEVAVEAFLQKRIGFLTVEDLIEKAMNHHNVIARPSLEEILEIDAATRRFVMEQI

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=394, Percent_Identity=41.6243654822335, Blast_Score=302, Evalue=3e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42225; Mature: 42225

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNISLLGASGSIGTQTLDVLRSHPDQFRLVAFSVGKNIDYAVKVIQEFSPQIVSVQREE
CCCEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCC
DVLKLQAVSGNTKVVYGSEGLLEVALHPDAEIVVNAVVGSVGLLPTLRAIEAKKTIGIAN
CEEEEEEECCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KETLVTAGHLVMEAARKHNVSLLPVDSEHSAIFQCLNGENEKRISRLIITASGGSFRDKT
CCCEEHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCHHEEEEEEEEECCCCCCCCC
RDELHHVTVEDALRHPNWSMGSKITIDSATMMNKGLEVIEAHWLFGIPYEQIDVVLHKES
HHHHHEEEHHHHHCCCCCCCCCEEEECHHHHHHCCHHHEEEHEEECCCHHHHHHEEHHHH
IIHSMVEFEDRSVMAQLGSPDMRVPIQYALTYPDRLPLSDTKQLNLWEIGTLHFEKMNQE
HHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCCEEEEECCHHHHHHCHH
RFRCLRFAYEAGKAGGSMPAVMNAANEVAVEAFLQKRIGFLTVEDLIEKAMNHHNVIARP
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHCCCEEECC
SLEEILEIDAATRRFVMEQI
CHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNISLLGASGSIGTQTLDVLRSHPDQFRLVAFSVGKNIDYAVKVIQEFSPQIVSVQREE
CCCEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCC
DVLKLQAVSGNTKVVYGSEGLLEVALHPDAEIVVNAVVGSVGLLPTLRAIEAKKTIGIAN
CEEEEEEECCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KETLVTAGHLVMEAARKHNVSLLPVDSEHSAIFQCLNGENEKRISRLIITASGGSFRDKT
CCCEEHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCHHEEEEEEEEECCCCCCCCC
RDELHHVTVEDALRHPNWSMGSKITIDSATMMNKGLEVIEAHWLFGIPYEQIDVVLHKES
HHHHHEEEHHHHHCCCCCCCCCEEEECHHHHHHCCHHHEEEHEEECCCHHHHHHEEHHHH
IIHSMVEFEDRSVMAQLGSPDMRVPIQYALTYPDRLPLSDTKQLNLWEIGTLHFEKMNQE
HHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCCEEEEECCHHHHHHCHH
RFRCLRFAYEAGKAGGSMPAVMNAANEVAVEAFLQKRIGFLTVEDLIEKAMNHHNVIARP
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHCCCEEECC
SLEEILEIDAATRRFVMEQI
CHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]