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The map label for this gene is menA [H]

Identifier: 162330295

GI number: 162330295

Start: 2889558

End: 2890487

Strand: Direct

Name: menA [H]

Synonym: GTNG_2775

Alternate gene names: 162330295

Gene position: 2889558-2890487 (Clockwise)

Preceding gene: 138896406

Following gene: 138896413

Centisome position: 81.39

GC content: 54.73

Gene sequence:

>930_bases
ATGCAACCATCAACACATATTGATCACCAACCGCCTGCCCGCCGCGACTGGCGCGTCTTTTGGCGGCTGACGCGGCCGCA
TACGCTGACAGCGGCGTTCGTACCGGTATGTGTCGGCACGGTGCTGGCGCTTGGCGAGACGGGGGTTCGCTTTTCGCTCT
TTGCTGCTATGCTGGTCGCTTCACTGCTCATTCAAGCCGCAACCAACATGTTTAACGAATATTACGATTATAAGCGCGGG
CTCGATTCGCCGGAATCTGTTGGCATCGGTGGCGCCATCGTCCGCGATGGCCTCAAACCGAAAACCGTGTTAACACTGGC
GTTCGCCTGCTGTGGAGCGGCCATGCTCATTGGCGTTTACATTTGCGCGCAAAGCAGCTGGTGGCTTGCGGTCATCGGAA
CCATTTGTATGGCGGCGGGCTACTTTTATACCGGTGGACCTGTTCCGATTGCCTATACACCGTTTGGCGAACTGGCGGCC
GGGTTTTTTATGGGATTTGTCATCATTTTAATTTCATTTTTTATCCAAACCGGTGATGTCAGTGCGAAGGCTATATTGGT
GGCCGTTCCTGTCGCCATTTTAGTCGGGGCCATCTTGCTCGCCAACAACATCCGCGACCTAGACGGCGACCGCGAAAAAG
GGAGAAAAACGCTTGCCATTTTAGTCGGGCGCGATTGGGCAATCCGCGTGCTTGCGATGATGTTCGCCGCCGCGTTTCTT
TGGGTTGTGGCGCTTGTTCTGTTCAGCGTCGTACCGTTTTGGACATTGCTTGCTTTATTGAGTGTGCCAAAAGCGGTGGC
AGCGGCGCGCGGCTTTATCGGTAAAACGAAACCGATCGAGATGATGCCGGCAATGAAAGCGACCGCCCAAACGAATACGC
AGTTTGGCTTTTTGCTCGCTATCGGCTTGCTCGTCAACCATTGGCTGTGA

Upstream 100 bases:

>100_bases
TTATCTATCGGAAAGGGTTGACACACCTGAAACGTTTTCCTACACTTATTTTGAACGTAAATGAAACGATATTTTCACGA
AACATTAAGGGGAAATCAGT

Downstream 100 bases:

>100_bases
CACGGTCAGAATGACCGTGTTTTTTTTTGATTTTCGCCCATACTACACCATATAGACGCTATTGTGAAGGAAGGGGTTGC
AACCGATGTTGACGAGCGAA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MQPSTHIDHQPPARRDWRVFWRLTRPHTLTAAFVPVCVGTVLALGETGVRFSLFAAMLVASLLIQAATNMFNEYYDYKRG
LDSPESVGIGGAIVRDGLKPKTVLTLAFACCGAAMLIGVYICAQSSWWLAVIGTICMAAGYFYTGGPVPIAYTPFGELAA
GFFMGFVIILISFFIQTGDVSAKAILVAVPVAILVGAILLANNIRDLDGDREKGRKTLAILVGRDWAIRVLAMMFAAAFL
WVVALVLFSVVPFWTLLALLSVPKAVAAARGFIGKTKPIEMMPAMKATAQTNTQFGFLLAIGLLVNHWL

Sequences:

>Translated_309_residues
MQPSTHIDHQPPARRDWRVFWRLTRPHTLTAAFVPVCVGTVLALGETGVRFSLFAAMLVASLLIQAATNMFNEYYDYKRG
LDSPESVGIGGAIVRDGLKPKTVLTLAFACCGAAMLIGVYICAQSSWWLAVIGTICMAAGYFYTGGPVPIAYTPFGELAA
GFFMGFVIILISFFIQTGDVSAKAILVAVPVAILVGAILLANNIRDLDGDREKGRKTLAILVGRDWAIRVLAMMFAAAFL
WVVALVLFSVVPFWTLLALLSVPKAVAAARGFIGKTKPIEMMPAMKATAQTNTQFGFLLAIGLLVNHWL
>Mature_309_residues
MQPSTHIDHQPPARRDWRVFWRLTRPHTLTAAFVPVCVGTVLALGETGVRFSLFAAMLVASLLIQAATNMFNEYYDYKRG
LDSPESVGIGGAIVRDGLKPKTVLTLAFACCGAAMLIGVYICAQSSWWLAVIGTICMAAGYFYTGGPVPIAYTPFGELAA
GFFMGFVIILISFFIQTGDVSAKAILVAVPVAILVGAILLANNIRDLDGDREKGRKTLAILVGRDWAIRVLAMMFAAAFL
WVVALVLFSVVPFWTLLALLSVPKAVAAARGFIGKTKPIEMMPAMKATAQTNTQFGFLLAIGLLVNHWL

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=302, Percent_Identity=27.8145695364238, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1790365, Length=292, Percent_Identity=28.0821917808219, Blast_Score=118, Evalue=6e-28,
Organism=Drosophila melanogaster, GI17737429, Length=293, Percent_Identity=30.7167235494881, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 33390; Mature: 33390

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPSTHIDHQPPARRDWRVFWRLTRPHTLTAAFVPVCVGTVLALGETGVRFSLFAAMLVA
CCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
SLLIQAATNMFNEYYDYKRGLDSPESVGIGGAIVRDGLKPKTVLTLAFACCGAAMLIGVY
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
ICAQSSWWLAVIGTICMAAGYFYTGGPVPIAYTPFGELAAGFFMGFVIILISFFIQTGDV
HHHCCCHHHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCC
SAKAILVAVPVAILVGAILLANNIRDLDGDREKGRKTLAILVGRDWAIRVLAMMFAAAFL
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCEEEEEEECCCHHHHHHHHHHHHHHH
WVVALVLFSVVPFWTLLALLSVPKAVAAARGFIGKTKPIEMMPAMKATAQTNTQFGFLLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHH
IGLLVNHWL
HHHHHHHCC
>Mature Secondary Structure
MQPSTHIDHQPPARRDWRVFWRLTRPHTLTAAFVPVCVGTVLALGETGVRFSLFAAMLVA
CCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
SLLIQAATNMFNEYYDYKRGLDSPESVGIGGAIVRDGLKPKTVLTLAFACCGAAMLIGVY
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
ICAQSSWWLAVIGTICMAAGYFYTGGPVPIAYTPFGELAAGFFMGFVIILISFFIQTGDV
HHHCCCHHHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCC
SAKAILVAVPVAILVGAILLANNIRDLDGDREKGRKTLAILVGRDWAIRVLAMMFAAAFL
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCEEEEEEECCCHHHHHHHHHHHHHHH
WVVALVLFSVVPFWTLLALLSVPKAVAAARGFIGKTKPIEMMPAMKATAQTNTQFGFLLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHH
IGLLVNHWL
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]