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The map label for this gene is pyrC [H]

Identifier: 162149033

GI number: 162149033

Start: 3353869

End: 3355245

Strand: Reverse

Name: pyrC [H]

Synonym: GDI_3263

Alternate gene names: 162149033

Gene position: 3355245-3353869 (Counterclockwise)

Preceding gene: 162149034

Following gene: 162149032

Centisome position: 85.07

GC content: 69.06

Gene sequence:

>1377_bases
TTGCCGTGTGCCCGTTGTGGGGATACGTCGGAGGCACCGACAGGCTGCGAGGAACCGATGCATTACGACCTGATCATCCG
CAATGGCGTCTGCCTTCTGCCCTGGGGCGAGGCCCGTACCGACATCGGCGTGCGCTCGGGCCGGATCGCCAGCCTGACGG
CGGGTGTGGCGGACGAGGCCGATACGGTCATCGACGCGTCCGGCCTGCATGTGCTGCCCGGGCTGATCGACCCGCACGTG
CATCTGCGCGACCCGGGCGACGCCGCGGTCGAGAGCATTCCCACCGGCACGCGCGCGGCGGCCCTGGGCGGGGTGACGAC
GGTGTTCGACATGCCCAACACCGCGCCATCGGTGACCGACGCCGAGATGCTGCGCTGGAAGCAGGAATACGCGTCGCGCG
AAAGCTGGGTGGATTTCGCGCTGTATGTCGGCGCCACGCGCGGCAATACGCCGCGCCTGGGCGAGTACGAGTGTTTCGAC
GGGGTCTGCGCCATCAAGGTCTTCGCCGGATCGTCGACCGGCGACCTGATGATCGAGGATGACGAGGGCATCCGGCAGGT
GCTGGAGAACGGCCACCGCCGCGTCGCCTTCCATTCCGAGGACGAATACCGCCTGCAGGACCGCAAGAAGCTGCTGACCG
AGGGCATGTCCTACGACAGCCATCCCTTCTGGCGGGACGAGGAATGCGCCTTCCTGGGCACGCGGCGTATCGTGGATCTG
GCGCGGCGGGCGGGGCGGCCGGTCCATATCCTGCATACCTCGACCGCCGAGGAACTGGACTGGCTGCCGGCGCATCGCGA
CGTCGCGACCGTCGAGGTGCTGGTGAACCATCTGACCCAGGTCGCCCCCGAATGCTATGAGACGCTGGGCCCGCTTGCGA
TCATGAACCCGCCGATCCGCGACCGCCGGCATTACGAGGCCAGTTGGGAGGCCGTGCGCAACGGCACCGTGGACACGATC
GGGTCGGACCACGCGCCCCATTCCCTGGCGGCGAAGGCGCGGCCCTGGCCCGCCACCCCGGCGGGGCTGACGGGGGTGCA
GACGCTGGTTCCCGTCATGCTGGACCACGTCAATGCCGGGCGTCTGTCGCTGGGCCGGATGGTGGACCTGATGGCGGCAG
GGCCGGCGCGGGTCTATGGCCTGCAGGCCAAGGGGCGGATCGCCATGGGCTATGACGCCGATTTCACCCTGGTGGACATG
AAGGCGCGGCGCCGTATCACCAATGACTGGATCGCCACCCCGGCGGGCTGGACGCCGTTCGACGGGATGGAGGTGACGGG
CTGGCCGATGGCGACGATCGTGCGGGGCCACGCCGTCATGCGCGAGGATACGATCCTGGGCGCGCCGGCCGGCAGGCTTG
CGCATTTCGCACCCTGA

Upstream 100 bases:

>100_bases
TTCTGCGCGCCCGTCCAGTCCGCCCGGCTGGAGGCACGGCTGCTGTCGCTGCTGCCAGGGGCGACGGGATGAGGGGCGAC
GGGATGAGGGGACGCGAACC

Downstream 100 bases:

>100_bases
TTTCGCCATGGTCTTCGAATATATCTGAAGATCGCTGAAGAAGCGGATCGAAGAAGGAAGACATCCCTTGCGTGCTCCAG
TATCGGGCCTGTTCCTGGCC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MPCARCGDTSEAPTGCEEPMHYDLIIRNGVCLLPWGEARTDIGVRSGRIASLTAGVADEADTVIDASGLHVLPGLIDPHV
HLRDPGDAAVESIPTGTRAAALGGVTTVFDMPNTAPSVTDAEMLRWKQEYASRESWVDFALYVGATRGNTPRLGEYECFD
GVCAIKVFAGSSTGDLMIEDDEGIRQVLENGHRRVAFHSEDEYRLQDRKKLLTEGMSYDSHPFWRDEECAFLGTRRIVDL
ARRAGRPVHILHTSTAEELDWLPAHRDVATVEVLVNHLTQVAPECYETLGPLAIMNPPIRDRRHYEASWEAVRNGTVDTI
GSDHAPHSLAAKARPWPATPAGLTGVQTLVPVMLDHVNAGRLSLGRMVDLMAAGPARVYGLQAKGRIAMGYDADFTLVDM
KARRRITNDWIATPAGWTPFDGMEVTGWPMATIVRGHAVMREDTILGAPAGRLAHFAP

Sequences:

>Translated_458_residues
MPCARCGDTSEAPTGCEEPMHYDLIIRNGVCLLPWGEARTDIGVRSGRIASLTAGVADEADTVIDASGLHVLPGLIDPHV
HLRDPGDAAVESIPTGTRAAALGGVTTVFDMPNTAPSVTDAEMLRWKQEYASRESWVDFALYVGATRGNTPRLGEYECFD
GVCAIKVFAGSSTGDLMIEDDEGIRQVLENGHRRVAFHSEDEYRLQDRKKLLTEGMSYDSHPFWRDEECAFLGTRRIVDL
ARRAGRPVHILHTSTAEELDWLPAHRDVATVEVLVNHLTQVAPECYETLGPLAIMNPPIRDRRHYEASWEAVRNGTVDTI
GSDHAPHSLAAKARPWPATPAGLTGVQTLVPVMLDHVNAGRLSLGRMVDLMAAGPARVYGLQAKGRIAMGYDADFTLVDM
KARRRITNDWIATPAGWTPFDGMEVTGWPMATIVRGHAVMREDTILGAPAGRLAHFAP
>Mature_457_residues
PCARCGDTSEAPTGCEEPMHYDLIIRNGVCLLPWGEARTDIGVRSGRIASLTAGVADEADTVIDASGLHVLPGLIDPHVH
LRDPGDAAVESIPTGTRAAALGGVTTVFDMPNTAPSVTDAEMLRWKQEYASRESWVDFALYVGATRGNTPRLGEYECFDG
VCAIKVFAGSSTGDLMIEDDEGIRQVLENGHRRVAFHSEDEYRLQDRKKLLTEGMSYDSHPFWRDEECAFLGTRRIVDLA
RRAGRPVHILHTSTAEELDWLPAHRDVATVEVLVNHLTQVAPECYETLGPLAIMNPPIRDRRHYEASWEAVRNGTVDTIG
SDHAPHSLAAKARPWPATPAGLTGVQTLVPVMLDHVNAGRLSLGRMVDLMAAGPARVYGLQAKGRIAMGYDADFTLVDMK
ARRRITNDWIATPAGWTPFDGMEVTGWPMATIVRGHAVMREDTILGAPAGRLAHFAP

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=383, Percent_Identity=30.2872062663185, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI4503375, Length=413, Percent_Identity=26.634382566586, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI19923821, Length=411, Percent_Identity=27.007299270073, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786722, Length=457, Percent_Identity=33.0415754923414, Blast_Score=192, Evalue=6e-50,
Organism=Escherichia coli, GI87082175, Length=450, Percent_Identity=28, Blast_Score=152, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI193204318, Length=435, Percent_Identity=27.1264367816092, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71989490, Length=445, Percent_Identity=27.6404494382022, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17539558, Length=441, Percent_Identity=26.530612244898, Blast_Score=108, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6322218, Length=396, Percent_Identity=29.7979797979798, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24642586, Length=386, Percent_Identity=29.7927461139896, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI18859883, Length=434, Percent_Identity=28.8018433179723, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI221377917, Length=401, Percent_Identity=28.428927680798, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI17137462, Length=399, Percent_Identity=29.0726817042606, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24644287, Length=206, Percent_Identity=31.0679611650485, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 50011; Mature: 49880

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPCARCGDTSEAPTGCEEPMHYDLIIRNGVCLLPWGEARTDIGVRSGRIASLTAGVADEA
CCCCCCCCCCCCCCCCCCCCEEEEEEECCEEEEECCCCCCCCCCCCCCEEEEECCCCCCC
DTVIDASGLHVLPGLIDPHVHLRDPGDAAVESIPTGTRAAALGGVTTVFDMPNTAPSVTD
CCEECCCCCEECCCCCCCCEEECCCCHHHHHHCCCCCHHHHHCCEEEEEECCCCCCCCCH
AEMLRWKQEYASRESWVDFALYVGATRGNTPRLGEYECFDGVCAIKVFAGSSTGDLMIED
HHHHHHHHHHHCHHHHEEEEEEEECCCCCCCCCCCCHHHCCEEEEEEEECCCCCCEEEEC
DEGIRQVLENGHRRVAFHSEDEYRLQDRKKLLTEGMSYDSHPFWRDEECAFLGTRRIVDL
CHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
ARRAGRPVHILHTSTAEELDWLPAHRDVATVEVLVNHLTQVAPECYETLGPLAIMNPPIR
HHHCCCCEEEEECCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCC
DRRHYEASWEAVRNGTVDTIGSDHAPHSLAAKARPWPATPAGLTGVQTLVPVMLDHVNAG
CCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
RLSLGRMVDLMAAGPARVYGLQAKGRIAMGYDADFTLVDMKARRRITNDWIATPAGWTPF
CHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCCEEEEEHHHHHHHCCCCCCCCCCCCCC
DGMEVTGWPMATIVRGHAVMREDTILGAPAGRLAHFAP
CCEEECCCCHHHHHHCCHHEECCCEECCCCCCCCCCCC
>Mature Secondary Structure 
PCARCGDTSEAPTGCEEPMHYDLIIRNGVCLLPWGEARTDIGVRSGRIASLTAGVADEA
CCCCCCCCCCCCCCCCCCCEEEEEEECCEEEEECCCCCCCCCCCCCCEEEEECCCCCCC
DTVIDASGLHVLPGLIDPHVHLRDPGDAAVESIPTGTRAAALGGVTTVFDMPNTAPSVTD
CCEECCCCCEECCCCCCCCEEECCCCHHHHHHCCCCCHHHHHCCEEEEEECCCCCCCCCH
AEMLRWKQEYASRESWVDFALYVGATRGNTPRLGEYECFDGVCAIKVFAGSSTGDLMIED
HHHHHHHHHHHCHHHHEEEEEEEECCCCCCCCCCCCHHHCCEEEEEEEECCCCCCEEEEC
DEGIRQVLENGHRRVAFHSEDEYRLQDRKKLLTEGMSYDSHPFWRDEECAFLGTRRIVDL
CHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
ARRAGRPVHILHTSTAEELDWLPAHRDVATVEVLVNHLTQVAPECYETLGPLAIMNPPIR
HHHCCCCEEEEECCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCC
DRRHYEASWEAVRNGTVDTIGSDHAPHSLAAKARPWPATPAGLTGVQTLVPVMLDHVNAG
CCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
RLSLGRMVDLMAAGPARVYGLQAKGRIAMGYDADFTLVDMKARRRITNDWIATPAGWTPF
CHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCCEEEEEHHHHHHHCCCCCCCCCCCCCC
DGMEVTGWPMATIVRGHAVMREDTILGAPAGRLAHFAP
CCEEECCCCHHHHHHCCHHEECCCEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA