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The map label for this gene is ubiA [H]

Identifier: 162149022

GI number: 162149022

Start: 3342716

End: 3343726

Strand: Direct

Name: ubiA [H]

Synonym: GDI_3252

Alternate gene names: 162149022

Gene position: 3342716-3343726 (Clockwise)

Preceding gene: 162149017

Following gene: 162149023

Centisome position: 84.75

GC content: 71.22

Gene sequence:

>1011_bases
TTGACCGCGTCCCCCCGGCGCCCCATCACACGCGGGCATAGCAGCCCCGCGCGCCGGCGTCATGGCCGGACGGCCCAAGC
TGGAGAGACGAGCGTGAATCGATCCCTGCCCCATACCGATATCCGGACCGGAGGATGGATCGCCCGGCTGCCCGTGCCGC
TGCGCCCCTACGCGCTGCTGGCGCGGCTGGATCGTCCCATCGGCACGTGGCTGCTGTTCCTGCCCGGCATGTGGGGCATC
CTGCTGGCATCCGGCGTCGATGCCCGCACGCGCCTGCGGCTGATCGTGCTGTTCGGCATCGGCAGCGTGGTGATGCGTTC
GGCGGGCTGCGTGGTCAACGACATGTGGGATCGCGACATCGACCGGCTGGTGGCGCGGACCGCCGGGCGCCCGCTGGCCT
CGGGCGCCCTGCGCATGCGCCAGGCGGCCCTGTTCCTGGCGGGGCTGCTGGTGATCGGGCTGGTGATCCTGCTGCAGCTC
AATCCGCTGGCCCGGGTCCTGGGGGCCTCGTCACTGATCCTGGTGGGGCTGTATCCCCTGGCCAAGCGCTTCACCTGGTG
GCCGCAACTGGTGATGGGCTTCACGTTCGGCTTCGGCGCGCCGCTGGGCTATGCCGCCGCGACCGGCCGCGTCGATGCCG
CCTGGGGCGCGCTCTACGCCGCCACCATCCTGTGGCAACTGGGGTTCGATACGATCTACGGCTTCCAGGACATGGAGGAC
GACGCCCGCATCGGGGTCAAATCCACGTCGCGCCTGTGGGCGGGGCAGCCGCGCCTCTTCGTCGGCGCCTGCTATGCCCT
GGCCGTGGCCGCGCTGCTGCTGGCGGGATGGCTGGCCGGATGCGGCGCGGGCTTCTGGATCGCGATGGCGCTGCCCACCA
TCGCCCTGGCCTGGCAGGTCGCGCAACTGGACAGTACCGACCCCGCCCGCTGCCTGAGCCTGTTCCGCTTCAACCGCGAA
ACCGGCCTGGCGATCGCGCTGGCCATCCTGGCCGGACTGGCCGGACAATGA

Upstream 100 bases:

>100_bases
GCGGCTGCGTCGCCGGATCGGCGAACAGACGGGGACAATCCTTCATGACGGCACCACTCCACGCGACACACAACCCGGGG
CCGCAGCGGGACCTCGGCTC

Downstream 100 bases:

>100_bases
CGGCGCCCGCCGATGCCCGCGCCTTCGTCGCGGCCCACACCGCCCTGTCCCACGCCCCCCTGGTGCCGGAGATCGCCCTG
CACCTGGCCACCGAGATCAC

Product: 4-hydroxybenzoate polyprenyl transferase

Products: @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

Alternate protein names: 4-HB polyprenyltransferase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MTASPRRPITRGHSSPARRRHGRTAQAGETSVNRSLPHTDIRTGGWIARLPVPLRPYALLARLDRPIGTWLLFLPGMWGI
LLASGVDARTRLRLIVLFGIGSVVMRSAGCVVNDMWDRDIDRLVARTAGRPLASGALRMRQAALFLAGLLVIGLVILLQL
NPLARVLGASSLILVGLYPLAKRFTWWPQLVMGFTFGFGAPLGYAAATGRVDAAWGALYAATILWQLGFDTIYGFQDMED
DARIGVKSTSRLWAGQPRLFVGACYALAVAALLLAGWLAGCGAGFWIAMALPTIALAWQVAQLDSTDPARCLSLFRFNRE
TGLAIALAILAGLAGQ

Sequences:

>Translated_336_residues
MTASPRRPITRGHSSPARRRHGRTAQAGETSVNRSLPHTDIRTGGWIARLPVPLRPYALLARLDRPIGTWLLFLPGMWGI
LLASGVDARTRLRLIVLFGIGSVVMRSAGCVVNDMWDRDIDRLVARTAGRPLASGALRMRQAALFLAGLLVIGLVILLQL
NPLARVLGASSLILVGLYPLAKRFTWWPQLVMGFTFGFGAPLGYAAATGRVDAAWGALYAATILWQLGFDTIYGFQDMED
DARIGVKSTSRLWAGQPRLFVGACYALAVAALLLAGWLAGCGAGFWIAMALPTIALAWQVAQLDSTDPARCLSLFRFNRE
TGLAIALAILAGLAGQ
>Mature_335_residues
TASPRRPITRGHSSPARRRHGRTAQAGETSVNRSLPHTDIRTGGWIARLPVPLRPYALLARLDRPIGTWLLFLPGMWGIL
LASGVDARTRLRLIVLFGIGSVVMRSAGCVVNDMWDRDIDRLVARTAGRPLASGALRMRQAALFLAGLLVIGLVILLQLN
PLARVLGASSLILVGLYPLAKRFTWWPQLVMGFTFGFGAPLGYAAATGRVDAAWGALYAATILWQLGFDTIYGFQDMEDD
ARIGVKSTSRLWAGQPRLFVGACYALAVAALLLAGWLAGCGAGFWIAMALPTIALAWQVAQLDSTDPARCLSLFRFNRET
GLAIALAILAGLAGQ

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate [H]

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI260656052, Length=283, Percent_Identity=42.4028268551237, Blast_Score=213, Evalue=2e-55,
Organism=Escherichia coli, GI1790473, Length=271, Percent_Identity=34.3173431734317, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1786631, Length=167, Percent_Identity=32.9341317365269, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17553718, Length=289, Percent_Identity=43.2525951557093, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI32565247, Length=287, Percent_Identity=41.8118466898955, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17553720, Length=344, Percent_Identity=36.9186046511628, Blast_Score=174, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI32565245, Length=147, Percent_Identity=53.0612244897959, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI32565243, Length=146, Percent_Identity=52.7397260273973, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324370, Length=291, Percent_Identity=36.426116838488, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI21355567, Length=279, Percent_Identity=42.6523297491039, Blast_Score=214, Evalue=8e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006370
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.- [C]

Molecular weight: Translated: 36199; Mature: 36068

Theoretical pI: Translated: 11.70; Mature: 11.70

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASPRRPITRGHSSPARRRHGRTAQAGETSVNRSLPHTDIRTGGWIARLPVPLRPYALL
CCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHCCCCCCCCCCCCCEEEECCCCCCHHHHH
ARLDRPIGTWLLFLPGMWGILLASGVDARTRLRLIVLFGIGSVVMRSAGCVVNDMWDRDI
HHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
DRLVARTAGRPLASGALRMRQAALFLAGLLVIGLVILLQLNPLARVLGASSLILVGLYPL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHH
AKRFTWWPQLVMGFTFGFGAPLGYAAATGRVDAAWGALYAATILWQLGFDTIYGFQDMED
HHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DARIGVKSTSRLWAGQPRLFVGACYALAVAALLLAGWLAGCGAGFWIAMALPTIALAWQV
CHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLDSTDPARCLSLFRFNRETGLAIALAILAGLAGQ
HHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TASPRRPITRGHSSPARRRHGRTAQAGETSVNRSLPHTDIRTGGWIARLPVPLRPYALL
CCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHCCCCCCCCCCCCCEEEECCCCCCHHHHH
ARLDRPIGTWLLFLPGMWGILLASGVDARTRLRLIVLFGIGSVVMRSAGCVVNDMWDRDI
HHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
DRLVARTAGRPLASGALRMRQAALFLAGLLVIGLVILLQLNPLARVLGASSLILVGLYPL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHH
AKRFTWWPQLVMGFTFGFGAPLGYAAATGRVDAAWGALYAATILWQLGFDTIYGFQDMED
HHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DARIGVKSTSRLWAGQPRLFVGACYALAVAALLLAGWLAGCGAGFWIAMALPTIALAWQV
CHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLDSTDPARCLSLFRFNRETGLAIALAILAGLAGQ
HHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-Hydroxybenzoate; Farnesylfarnesylgeraniol [C]

Specific reaction: 4-Hydroxybenzoate + Farnesylfarnesylgeraniol = @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA