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The map label for this gene is pip [H]

Identifier: 162148882

GI number: 162148882

Start: 3205325

End: 3206290

Strand: Direct

Name: pip [H]

Synonym: GDI_3112

Alternate gene names: 162148882

Gene position: 3205325-3206290 (Clockwise)

Preceding gene: 162148878

Following gene: 162148883

Centisome position: 81.27

GC content: 71.33

Gene sequence:

>966_bases
TTGACGTATAGTCGCCCCATGCCACGCCACGACCTGTTCCCGGACATCGCGCCCTACGACAGCGGCTACCTGCCTGTCGG
CGACGGGCACGAACTCTATTGGGAACAGGCGGGCAACCCCGCAGGGCGGACGGTGCTGTTCCTGCATGGCGGTCCGGGCG
CGGGCGCGGGCGCGGTCCATCGCCGCTTCTTCGACCCGGAACATTGGCGCGTCGTCCTGTTCGACCAGCGGGGGGCCGGG
CGGTCGCGGCCGCATGCGTCGATCGCGGCCAACACGACACCGCACCTGGTGCGCGATATCGAAACGCTGCGCCAGGCGCT
GGGCATCGGGGACTGGCTGCTGTTCGGCGGGTCGTGGGGATCGACGCTGGCGCTGGCCTACGCCCAGGCGCACCCCGAAC
GGGTGCGCGCGATGATCCTGCGCGGGATCTTCCTGGGCCGGCCGCGCGAACTGGACTGGTTCTTCCACGGCCTGGCCCAT
GTCTTCCCCGACGCGCACGCGGCCTTCCTGTCGCACCTGCCCGAAGCGGAACGGGATGATCCGCTGGGCGCCTATGGCCG
GCTGCTGTTCGATCCCGACCCCGCGATCCACCTGCCGGCGGCGCGGGCCTGGTCGGCCTACGAGGGAACGTGCTCGACGC
TGATTCCCGCCCCCGCCGCCGTCGCCGGCTTCGCGCAGGACCGCGCCGTCATCGGCCTGGCGCGGATCGAGGCCCATTAT
TTCCGGCACGGCCTGTTCCTGCCGCCCGAGGGCCTGCTGGGCGCGATGGAGCGGATCGCGCATATTCCCTGCACCATCGT
CCAGGGCCGGTATGACATGATCTGCCCCAGCGAGTCCGCCTGGGACCTGTCCCGGCACTGGCCGCGCGCCACCCTGGTCA
TGGTGCCGGATGCCGGGCACTCGGCCCTGGAACCGGGCATCCGCCGCCGGCTGGTCGCGTGCGTCGAGGAGATGCGCGAC
GCATGA

Upstream 100 bases:

>100_bases
AGGAACGGCCGCCCGTCCGCCGGGGACGGGGCAGCGGGAGGAACGGAAGACGAAACAGGCAAGACGGTCATGATGGCATC
AGTCTAGCCGCGCCGCCCGC

Downstream 100 bases:

>100_bases
CAGCCCGTACCAAACCCGCCGCGACCGGATGCGTTCGGTATCCGTTTACCTCTTTCAGGAACGGATCGCATCCATGAAGA
CATATGTACGCTGGGCATTC

Product: alpha/beta hydrolase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MTYSRPMPRHDLFPDIAPYDSGYLPVGDGHELYWEQAGNPAGRTVLFLHGGPGAGAGAVHRRFFDPEHWRVVLFDQRGAG
RSRPHASIAANTTPHLVRDIETLRQALGIGDWLLFGGSWGSTLALAYAQAHPERVRAMILRGIFLGRPRELDWFFHGLAH
VFPDAHAAFLSHLPEAERDDPLGAYGRLLFDPDPAIHLPAARAWSAYEGTCSTLIPAPAAVAGFAQDRAVIGLARIEAHY
FRHGLFLPPEGLLGAMERIAHIPCTIVQGRYDMICPSESAWDLSRHWPRATLVMVPDAGHSALEPGIRRRLVACVEEMRD
A

Sequences:

>Translated_321_residues
MTYSRPMPRHDLFPDIAPYDSGYLPVGDGHELYWEQAGNPAGRTVLFLHGGPGAGAGAVHRRFFDPEHWRVVLFDQRGAG
RSRPHASIAANTTPHLVRDIETLRQALGIGDWLLFGGSWGSTLALAYAQAHPERVRAMILRGIFLGRPRELDWFFHGLAH
VFPDAHAAFLSHLPEAERDDPLGAYGRLLFDPDPAIHLPAARAWSAYEGTCSTLIPAPAAVAGFAQDRAVIGLARIEAHY
FRHGLFLPPEGLLGAMERIAHIPCTIVQGRYDMICPSESAWDLSRHWPRATLVMVPDAGHSALEPGIRRRLVACVEEMRD
A
>Mature_320_residues
TYSRPMPRHDLFPDIAPYDSGYLPVGDGHELYWEQAGNPAGRTVLFLHGGPGAGAGAVHRRFFDPEHWRVVLFDQRGAGR
SRPHASIAANTTPHLVRDIETLRQALGIGDWLLFGGSWGSTLALAYAQAHPERVRAMILRGIFLGRPRELDWFFHGLAHV
FPDAHAAFLSHLPEAERDDPLGAYGRLLFDPDPAIHLPAARAWSAYEGTCSTLIPAPAAVAGFAQDRAVIGLARIEAHYF
RHGLFLPPEGLLGAMERIAHIPCTIVQGRYDMICPSESAWDLSRHWPRATLVMVPDAGHSALEPGIRRRLVACVEEMRDA

Specific function: Specifically catalyzes the removal of N-terminal proline residues from peptides [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 35428; Mature: 35297

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYSRPMPRHDLFPDIAPYDSGYLPVGDGHELYWEQAGNPAGRTVLFLHGGPGAGAGAVH
CCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEHHCCCCCCCCCEEEEEECCCCCCHHHHH
RRFFDPEHWRVVLFDQRGAGRSRPHASIAANTTPHLVRDIETLRQALGIGDWLLFGGSWG
HHCCCCCCCEEEEEECCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCEEEECCCCC
STLALAYAQAHPERVRAMILRGIFLGRPRELDWFFHGLAHVFPDAHAAFLSHLPEAERDD
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
PLGAYGRLLFDPDPAIHLPAARAWSAYEGTCSTLIPAPAAVAGFAQDRAVIGLARIEAHY
CCCHHCEEEECCCCCEECCCHHCCCCCCCCHHHHCCCCHHHHHHHCCHHHHHHHHHHHHH
FRHGLFLPPEGLLGAMERIAHIPCTIVQGRYDMICPSESAWDLSRHWPRATLVMVPDAGH
HHCCCCCCCHHHHHHHHHHHHCCEEEECCCCEEECCCCCCCCHHHCCCCEEEEEECCCCC
SALEPGIRRRLVACVEEMRDA
HHHCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TYSRPMPRHDLFPDIAPYDSGYLPVGDGHELYWEQAGNPAGRTVLFLHGGPGAGAGAVH
CCCCCCCCCCCCCCCCCCCCCCEECCCCCEEHHCCCCCCCCCEEEEEECCCCCCHHHHH
RRFFDPEHWRVVLFDQRGAGRSRPHASIAANTTPHLVRDIETLRQALGIGDWLLFGGSWG
HHCCCCCCCEEEEEECCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCEEEECCCCC
STLALAYAQAHPERVRAMILRGIFLGRPRELDWFFHGLAHVFPDAHAAFLSHLPEAERDD
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
PLGAYGRLLFDPDPAIHLPAARAWSAYEGTCSTLIPAPAAVAGFAQDRAVIGLARIEAHY
CCCHHCEEEECCCCCEECCCHHCCCCCCCCHHHHCCCCHHHHHHHCCHHHHHHHHHHHHH
FRHGLFLPPEGLLGAMERIAHIPCTIVQGRYDMICPSESAWDLSRHWPRATLVMVPDAGH
HHCCCCCCCHHHHHHHHHHHHCCEEEECCCCEEECCCCCCCCHHHCCCCEEEEEECCCCC
SALEPGIRRRLVACVEEMRDA
HHHCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9348090; 11011150; 10467172 [H]