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The map label for this gene is ffh [H]

Identifier: 162148863

GI number: 162148863

Start: 3186295

End: 3187680

Strand: Reverse

Name: ffh [H]

Synonym: GDI_3092

Alternate gene names: 162148863

Gene position: 3187680-3186295 (Counterclockwise)

Preceding gene: 162148864

Following gene: 162148862

Centisome position: 80.82

GC content: 67.89

Gene sequence:

>1386_bases
TTGTTCGAGACGCTGTCAGGCAAGCTCTCCGGTGTGTTCGATGGCCTCGCCAAGCGCGGCGCGCTGTCCGAGGCCGATGT
GGCCGAGGCGATGCGCGAAGTGCGCCTGGCGATGCTGGACGCCGACGTGGCGCTGCCCGTCGTCAAGGATTTCGTCGCCA
AGGTCCGCGAACGTGCCGTGGGGCACGAGGTGCTGGGCAGCATCTCGCCCGGCCAGGCTGTCGCCAAGATCGTCAATGAC
GCGCTGATCGACGCGCTGGGCGGGGCGGGTGCCGTTCCGCTGAACCTGAACGCCGTCCCGCCCGTGCCGATCCTGATGGT
CGGCCTGCAGGGATCGGGCAAGACCACGACGTCGGGCAAGATCGCCCTGCGCCTGGCGACGCGCGAGCGCAAGCGGGTGC
TGCTGGCCAGCCTGGACACCCAGCGCCCGGCCGCGCAGCTTCAGTTGCAGCAACTGGCCGAACGCGCGGGCGTCGCGTCC
CTGCCGATCGTGCCGGGCCAGACCCCGGTCGAGATCGCGCGGCGGGCGATGGATACCGGCCGGCGCGAAGGCTATGACGT
CGTCATCCTCGATACCGCCGGCCGCCTGTCGATCGACGAGGCCCTGATGGACGAGGTGCGGGCGATCCGCACCGAGACCA
CGCCGGCCGAAACCCTGCTGGTCGTCGATGCGATGACCGGCCAGGATGCGGTCAACACCGCCCGTGCGTTCAACGAGGCC
GTGGGCGTGACCGGCGTGGTGATGACCCGCATGGACGGTGACGCCCGCGGCGGCGCTGCGCTGTCGATGCGCGCGATGAC
CGGCGCGCCGATCAAGCTGACCGGTTCGGGCGAGAAGCTGGACGCGCTGGAGGAATTCCACCCCGAACGCGTCGCCGGCC
GCATCCTGGGGCTGGGCGACATCGCCGGCCTGGTCGAGAAGGCCGCCGACACCCTGGATCATGAAGAGAGCGAGAAACTC
GCCCTCAAGATGATGAAGGGCCAGTTCGACCTGGACGACTACGCGGCCCAGATCCGCCAGATCGCCAAAATGGGGTCGCT
GTCGGGCATTCTCGACATGCTGCCCGGCATGGGCAAGATCAAGCAGGCGATGGGCGACAAGGACCTGGATACCTCGGTCC
TGAAGCGGCACCAGGCCATCATTTCATCCATGACCCGGGCGGAGCGCAAGACGCCCGCCATCATCAAGGCGTCGCGCAAG
AAGCGCATCGCCGCCGGGTCGGGAACCAGCGTTCAGGACGTCAACCGGCTGCTGAAGCAGTTCGATGACATGTCCACGAT
GATGAAGCGGATCAACAAGCTCGGCATGAAGGGACTCATGCGCCAGGGAATGTCCGCTCTCATGCCCAAGGGGGCGAAGC
CGCCCGGCGGCCGTCCGTTCGGATGA

Upstream 100 bases:

>100_bases
TGACAGGTGATGGGGAGGCGCGTAAAGCCTCCCCCGAATCAGGAACGCCACTCCGCGAAGACTCGCGCAGTGGCGCGACT
TCTTTTGGGGTGAATGTCTT

Downstream 100 bases:

>100_bases
ACGGCCCGCCGCTTTTGCTTCGCCTTTGTCCGCATTCAGAATTTCACTTCGGAGAATCGTCTCAATGAGCCTCAAGATCC
GCCTTGCCCGCGCCGGTGCG

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MFETLSGKLSGVFDGLAKRGALSEADVAEAMREVRLAMLDADVALPVVKDFVAKVRERAVGHEVLGSISPGQAVAKIVND
ALIDALGGAGAVPLNLNAVPPVPILMVGLQGSGKTTTSGKIALRLATRERKRVLLASLDTQRPAAQLQLQQLAERAGVAS
LPIVPGQTPVEIARRAMDTGRREGYDVVILDTAGRLSIDEALMDEVRAIRTETTPAETLLVVDAMTGQDAVNTARAFNEA
VGVTGVVMTRMDGDARGGAALSMRAMTGAPIKLTGSGEKLDALEEFHPERVAGRILGLGDIAGLVEKAADTLDHEESEKL
ALKMMKGQFDLDDYAAQIRQIAKMGSLSGILDMLPGMGKIKQAMGDKDLDTSVLKRHQAIISSMTRAERKTPAIIKASRK
KRIAAGSGTSVQDVNRLLKQFDDMSTMMKRINKLGMKGLMRQGMSALMPKGAKPPGGRPFG

Sequences:

>Translated_461_residues
MFETLSGKLSGVFDGLAKRGALSEADVAEAMREVRLAMLDADVALPVVKDFVAKVRERAVGHEVLGSISPGQAVAKIVND
ALIDALGGAGAVPLNLNAVPPVPILMVGLQGSGKTTTSGKIALRLATRERKRVLLASLDTQRPAAQLQLQQLAERAGVAS
LPIVPGQTPVEIARRAMDTGRREGYDVVILDTAGRLSIDEALMDEVRAIRTETTPAETLLVVDAMTGQDAVNTARAFNEA
VGVTGVVMTRMDGDARGGAALSMRAMTGAPIKLTGSGEKLDALEEFHPERVAGRILGLGDIAGLVEKAADTLDHEESEKL
ALKMMKGQFDLDDYAAQIRQIAKMGSLSGILDMLPGMGKIKQAMGDKDLDTSVLKRHQAIISSMTRAERKTPAIIKASRK
KRIAAGSGTSVQDVNRLLKQFDDMSTMMKRINKLGMKGLMRQGMSALMPKGAKPPGGRPFG
>Mature_461_residues
MFETLSGKLSGVFDGLAKRGALSEADVAEAMREVRLAMLDADVALPVVKDFVAKVRERAVGHEVLGSISPGQAVAKIVND
ALIDALGGAGAVPLNLNAVPPVPILMVGLQGSGKTTTSGKIALRLATRERKRVLLASLDTQRPAAQLQLQQLAERAGVAS
LPIVPGQTPVEIARRAMDTGRREGYDVVILDTAGRLSIDEALMDEVRAIRTETTPAETLLVVDAMTGQDAVNTARAFNEA
VGVTGVVMTRMDGDARGGAALSMRAMTGAPIKLTGSGEKLDALEEFHPERVAGRILGLGDIAGLVEKAADTLDHEESEKL
ALKMMKGQFDLDDYAAQIRQIAKMGSLSGILDMLPGMGKIKQAMGDKDLDTSVLKRHQAIISSMTRAERKTPAIIKASRK
KRIAAGSGTSVQDVNRLLKQFDDMSTMMKRINKLGMKGLMRQGMSALMPKGAKPPGGRPFG

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=449, Percent_Identity=32.739420935412, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI226371618, Length=345, Percent_Identity=35.9420289855072, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI89061728, Length=159, Percent_Identity=35.2201257861635, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI23308697, Length=321, Percent_Identity=26.791277258567, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI295424842, Length=321, Percent_Identity=26.791277258567, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1788963, Length=426, Percent_Identity=53.0516431924883, Blast_Score=445, Evalue=1e-126,
Organism=Escherichia coli, GI1789874, Length=200, Percent_Identity=40, Blast_Score=131, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17539958, Length=458, Percent_Identity=32.0960698689956, Blast_Score=224, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI193206261, Length=302, Percent_Identity=28.476821192053, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6325345, Length=327, Percent_Identity=36.085626911315, Blast_Score=200, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6320498, Length=323, Percent_Identity=24.7678018575851, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17647949, Length=444, Percent_Identity=31.3063063063063, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24641198, Length=302, Percent_Identity=26.158940397351, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 48890; Mature: 48890

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFETLSGKLSGVFDGLAKRGALSEADVAEAMREVRLAMLDADVALPVVKDFVAKVRERAV
CCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
GHEVLGSISPGQAVAKIVNDALIDALGGAGAVPLNLNAVPPVPILMVGLQGSGKTTTSGK
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCEEEEEECCCCCCCCCCE
IALRLATRERKRVLLASLDTQRPAAQLQLQQLAERAGVASLPIVPGQTPVEIARRAMDTG
EEEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCC
RREGYDVVILDTAGRLSIDEALMDEVRAIRTETTPAETLLVVDAMTGQDAVNTARAFNEA
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHH
VGVTGVVMTRMDGDARGGAALSMRAMTGAPIKLTGSGEKLDALEEFHPERVAGRILGLGD
HCCCEEEEEECCCCCCCCCEEEEEEECCCCEEECCCCCHHHHHHHHCHHHHHHHHHCHHH
IAGLVEKAADTLDHEESEKLALKMMKGQFDLDDYAAQIRQIAKMGSLSGILDMLPGMGKI
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
KQAMGDKDLDTSVLKRHQAIISSMTRAERKTPAIIKASRKKRIAAGSGTSVQDVNRLLKQ
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
FDDMSTMMKRINKLGMKGLMRQGMSALMPKGAKPPGGRPFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MFETLSGKLSGVFDGLAKRGALSEADVAEAMREVRLAMLDADVALPVVKDFVAKVRERAV
CCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
GHEVLGSISPGQAVAKIVNDALIDALGGAGAVPLNLNAVPPVPILMVGLQGSGKTTTSGK
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCEEEEEECCCCCCCCCCE
IALRLATRERKRVLLASLDTQRPAAQLQLQQLAERAGVASLPIVPGQTPVEIARRAMDTG
EEEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCC
RREGYDVVILDTAGRLSIDEALMDEVRAIRTETTPAETLLVVDAMTGQDAVNTARAFNEA
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHH
VGVTGVVMTRMDGDARGGAALSMRAMTGAPIKLTGSGEKLDALEEFHPERVAGRILGLGD
HCCCEEEEEECCCCCCCCCEEEEEEECCCCEEECCCCCHHHHHHHHCHHHHHHHHHCHHH
IAGLVEKAADTLDHEESEKLALKMMKGQFDLDDYAAQIRQIAKMGSLSGILDMLPGMGKI
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
KQAMGDKDLDTSVLKRHQAIISSMTRAERKTPAIIKASRKKRIAAGSGTSVQDVNRLLKQ
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
FDDMSTMMKRINKLGMKGLMRQGMSALMPKGAKPPGGRPFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]