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The map label for this gene is argH

Identifier: 162148741

GI number: 162148741

Start: 3055633

End: 3057063

Strand: Direct

Name: argH

Synonym: GDI_2969

Alternate gene names: 162148741

Gene position: 3055633-3057063 (Clockwise)

Preceding gene: 162148729

Following gene: 162148742

Centisome position: 77.47

GC content: 68.9

Gene sequence:

>1431_bases
ATGTCTGTGAACGAAGAAAATGGTGCGGGCAAGGACGCGTCACGGGCGAACGCCCAGTGGGGCGGCCGGTTCGCGGGCGG
CCCTTCGGCCATCATGCAGGACATCAATGCCTCGATCGGCTTCGATCATGTGCTGTGGAGGCAGGATATCGCCGGGTCGC
TGGCTCACGCCGCCATGCTGGCCAGGACCGGCATCATCAGCGCGGACGATGAAGCCGCGATCCGCCGGGGCCTGACCGAA
ATCGGGGCGGAGATCGAAGCCGGGCGCTTCGATTTCAGCACCGCCCTGGAAGACATCCACATGAATATCGAGGCCCGCCT
GTCCGACCGGATCGGCGAGGCCGGCAAGCGCCTGCACACCGCACGGTCGCGCAACGACCAGGTCGCCACCGATTTCCGCC
TGTGGGTACGCGACGCCATCGACGGACTGGACGCGCAGGCGGCGTCGCTGATGCGCGCGCTGTGCCGCCGTGCAGAGCAG
CACGCGGCCGACCCCATGCCCGGCTTCACGCATCTTCAGACGGCCCAGCCCGTGACCTTCGGCCATCACCTGATGGCGTA
TGTGGAAATGCTGGGGCGCGACCGGGGGCGGCTGGCCGATGCGCGCCGCCGCCTGAACGAATGCCCGCTGGGATCGGCCG
CGCTGGCCGGCACGTCCTTCCCCATCGACCGGCGGATGACGGCGGCGGCGCTGGGCTTCGACCGGCCCACCGCCAATTCG
CTGGACGCCGTGTCGGATCGCGATTTCGCCCTGGAATACCTGTCGGCGCTGTCGATCATGGCCATGCACCTGTCGCGCCT
GTCCGAGGAAATCGTGATCTGGTGTTCGGCCCCGTTCGCGTTCGTCCGCCTGTCGGACGCGTTCACCACCGGGTCGTCGA
TCATGCCGCAGAAGCGCAACCCGGACGCCGCCGAACTGGTGCGGGCCAAGATCGGCCGCGTCACCGGGGCGCTGGTCGGG
TTGCTGACCGTCATGAAGGGCCTGCCGCTGGCCTATGCCAAGGACATGCAGGAGGACAAGGAGCCGGTCTTCGCCGCGAC
CGATGCCGCCGCCCTGTCGCTGGCGGCATGCGACGGCATGATCCGCGACCTGACCGCCAATACCGACCGGATGCGGGCCT
ATGCCGGATCGGGCTTTTCCACGGCGACCGACCTGGCGGACTGGCTGGTGCGGGTGCTGAAGCTGCCGTTCCGCACCGCG
CACCACGTCACCGGCCGGCTGGTGGGCCTGGCGGAAAGCCGGGGGGTCGATCTGTCCGACCTGTCACTGGCGGACATGCA
GGCCGAGGAAGCCGGCATCACCCAGGACATCTTCTCGGTCCTCACCGTCGAATCCTCGATCGCCTCGCGCACCAGCGAGG
GGGGGACCGCGCCGGACAATGTCCGCGCCCAGGCCGCCCGCTGGCTGGCCGTGCTGGAGAACGGGGCATGA

Upstream 100 bases:

>100_bases
ACCCGAGCCATGCGGCCAGTAGGGTGCCGCCATTCGCAAGCAGGGCGCGGCGATCGACGGGTTCCGTCAGAACGCGTTTC
GTCAGGATCTGGGGCATGGA

Downstream 100 bases:

>100_bases
GGCGCGCGATCGGCCTGCTGGGTGCCGTACTGCTGCTGGGCGCGCTGGCCGGCAGCCTTGCGGCCTGCGGCAAGAAGGGC
GCCCCCGAGGCCCCCGGCCC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MSVNEENGAGKDASRANAQWGGRFAGGPSAIMQDINASIGFDHVLWRQDIAGSLAHAAMLARTGIISADDEAAIRRGLTE
IGAEIEAGRFDFSTALEDIHMNIEARLSDRIGEAGKRLHTARSRNDQVATDFRLWVRDAIDGLDAQAASLMRALCRRAEQ
HAADPMPGFTHLQTAQPVTFGHHLMAYVEMLGRDRGRLADARRRLNECPLGSAALAGTSFPIDRRMTAAALGFDRPTANS
LDAVSDRDFALEYLSALSIMAMHLSRLSEEIVIWCSAPFAFVRLSDAFTTGSSIMPQKRNPDAAELVRAKIGRVTGALVG
LLTVMKGLPLAYAKDMQEDKEPVFAATDAAALSLAACDGMIRDLTANTDRMRAYAGSGFSTATDLADWLVRVLKLPFRTA
HHVTGRLVGLAESRGVDLSDLSLADMQAEEAGITQDIFSVLTVESSIASRTSEGGTAPDNVRAQAARWLAVLENGA

Sequences:

>Translated_476_residues
MSVNEENGAGKDASRANAQWGGRFAGGPSAIMQDINASIGFDHVLWRQDIAGSLAHAAMLARTGIISADDEAAIRRGLTE
IGAEIEAGRFDFSTALEDIHMNIEARLSDRIGEAGKRLHTARSRNDQVATDFRLWVRDAIDGLDAQAASLMRALCRRAEQ
HAADPMPGFTHLQTAQPVTFGHHLMAYVEMLGRDRGRLADARRRLNECPLGSAALAGTSFPIDRRMTAAALGFDRPTANS
LDAVSDRDFALEYLSALSIMAMHLSRLSEEIVIWCSAPFAFVRLSDAFTTGSSIMPQKRNPDAAELVRAKIGRVTGALVG
LLTVMKGLPLAYAKDMQEDKEPVFAATDAAALSLAACDGMIRDLTANTDRMRAYAGSGFSTATDLADWLVRVLKLPFRTA
HHVTGRLVGLAESRGVDLSDLSLADMQAEEAGITQDIFSVLTVESSIASRTSEGGTAPDNVRAQAARWLAVLENGA
>Mature_475_residues
SVNEENGAGKDASRANAQWGGRFAGGPSAIMQDINASIGFDHVLWRQDIAGSLAHAAMLARTGIISADDEAAIRRGLTEI
GAEIEAGRFDFSTALEDIHMNIEARLSDRIGEAGKRLHTARSRNDQVATDFRLWVRDAIDGLDAQAASLMRALCRRAEQH
AADPMPGFTHLQTAQPVTFGHHLMAYVEMLGRDRGRLADARRRLNECPLGSAALAGTSFPIDRRMTAAALGFDRPTANSL
DAVSDRDFALEYLSALSIMAMHLSRLSEEIVIWCSAPFAFVRLSDAFTTGSSIMPQKRNPDAAELVRAKIGRVTGALVGL
LTVMKGLPLAYAKDMQEDKEPVFAATDAAALSLAACDGMIRDLTANTDRMRAYAGSGFSTATDLADWLVRVLKLPFRTAH
HVTGRLVGLAESRGVDLSDLSLADMQAEEAGITQDIFSVLTVESSIASRTSEGGTAPDNVRAQAARWLAVLENGA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=461, Percent_Identity=42.0824295010846, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI68303542, Length=461, Percent_Identity=42.0824295010846, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI68303547, Length=461, Percent_Identity=39.6963123644252, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI68303549, Length=461, Percent_Identity=39.6963123644252, Blast_Score=328, Evalue=7e-90,
Organism=Escherichia coli, GI1790398, Length=449, Percent_Identity=44.988864142539, Blast_Score=381, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6321806, Length=456, Percent_Identity=42.5438596491228, Blast_Score=353, Evalue=2e-98,
Organism=Drosophila melanogaster, GI221473854, Length=445, Percent_Identity=40.2247191011236, Blast_Score=334, Evalue=9e-92,
Organism=Drosophila melanogaster, GI78706858, Length=445, Percent_Identity=40.2247191011236, Blast_Score=334, Evalue=9e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_GLUDA (A9HRH6)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001603202.1
- RefSeq:   YP_002277722.1
- ProteinModelPortal:   A9HRH6
- SMR:   A9HRH6
- GeneID:   5791791
- GeneID:   6976827
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_3381
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   PRK00855
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51137; Mature: 51006

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVNEENGAGKDASRANAQWGGRFAGGPSAIMQDINASIGFDHVLWRQDIAGSLAHAAML
CCCCCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ARTGIISADDEAAIRRGLTEIGAEIEAGRFDFSTALEDIHMNIEARLSDRIGEAGKRLHT
HHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ARSRNDQVATDFRLWVRDAIDGLDAQAASLMRALCRRAEQHAADPMPGFTHLQTAQPVTF
HHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
GHHLMAYVEMLGRDRGRLADARRRLNECPLGSAALAGTSFPIDRRMTAAALGFDRPTANS
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHCCCCCCCCC
LDAVSDRDFALEYLSALSIMAMHLSRLSEEIVIWCSAPFAFVRLSDAFTTGSSIMPQKRN
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEHHHHCCCCCCCCCCCC
PDAAELVRAKIGRVTGALVGLLTVMKGLPLAYAKDMQEDKEPVFAATDAAALSLAACDGM
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECHHHHHHHHHHHHH
IRDLTANTDRMRAYAGSGFSTATDLADWLVRVLKLPFRTAHHVTGRLVGLAESRGVDLSD
HHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHEEEHHCCCCCHHH
LSLADMQAEEAGITQDIFSVLTVESSIASRTSEGGTAPDNVRAQAARWLAVLENGA
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SVNEENGAGKDASRANAQWGGRFAGGPSAIMQDINASIGFDHVLWRQDIAGSLAHAAML
CCCCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ARTGIISADDEAAIRRGLTEIGAEIEAGRFDFSTALEDIHMNIEARLSDRIGEAGKRLHT
HHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ARSRNDQVATDFRLWVRDAIDGLDAQAASLMRALCRRAEQHAADPMPGFTHLQTAQPVTF
HHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
GHHLMAYVEMLGRDRGRLADARRRLNECPLGSAALAGTSFPIDRRMTAAALGFDRPTANS
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHCCCCCCCCC
LDAVSDRDFALEYLSALSIMAMHLSRLSEEIVIWCSAPFAFVRLSDAFTTGSSIMPQKRN
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEHHHHCCCCCCCCCCCC
PDAAELVRAKIGRVTGALVGLLTVMKGLPLAYAKDMQEDKEPVFAATDAAALSLAACDGM
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECHHHHHHHHHHHHH
IRDLTANTDRMRAYAGSGFSTATDLADWLVRVLKLPFRTAHHVTGRLVGLAESRGVDLSD
HHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHEEEHHCCCCCHHH
LSLADMQAEEAGITQDIFSVLTVESSIASRTSEGGTAPDNVRAQAARWLAVLENGA
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA