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The map label for this gene is kbl [H]

Identifier: 162148700

GI number: 162148700

Start: 3017127

End: 3018329

Strand: Direct

Name: kbl [H]

Synonym: GDI_2928

Alternate gene names: 162148700

Gene position: 3017127-3018329 (Clockwise)

Preceding gene: 162148699

Following gene: 162148703

Centisome position: 76.5

GC content: 67.5

Gene sequence:

>1203_bases
ATGTCGATCTTCAGCAAATATGATGGGCTGTCCCGGTCGCTCGCGGCCGTGACGGCGGGAGGAGGCCGGAATCCATTTTC
CGTCGTCATCGACCGTCCCCTGTCCTCGACCGTGGGGCTGATTGAGGGACGGGAGACGCTGCTGTTCGGCACCAACAACT
ATCTGGGCCTCAGCCAGTCCGAAGCGGCGATCGAGGCCGCGATCGAGACATTGCGGACCCATGGGGTCGGCACCACCGGA
TCGCGGATCGCCAACGGAACCCAGGGACTGCACCGCCAGTTGGAGGAGCGTATCGCCGGCTTCTTCCGGCGCCGCCACTG
CATGGTGTTTTCGACCGGGTACCAGGCCAATCTGGGCACGATCTCGGCCCTGGCCGGCAAGGACGATTACCTGCTGCTGG
ATGCCGACAGCCATGCCAGCATCTATGACGGCAGCCGGCTGAGCCAGGCGCAGGTCATCCGTTTCCGTCACAACGACCCC
GACGACCTGCACAAGCGCCTGCGCCGCCTGGACGGCACGCCCGGCGCCAAGCTGATCGTCGTCGAAGGCATCTATTCCAT
GATGGGCGACGTGGTCCCGATGGCCGAATTCGCCGCCGTGAAGCGCGAGACCGGGGCGTGGCTGCTGGCGGACGAAGCCC
ATTCGTTCGGCGTCATGGGCGCGCATGGCCGCGGAGTGGCCGAGTCCGACGGGGTCGAAAGCGACATCGACTTCGTGGTC
GGCACCTTCTCCAAGAGCCTGGGCACGGTCGGCGGCTATTGCGTGTCGGACCATGACGGGCTGGACCTGATCCGCCTGTG
CTCGCGGCCGTATATGTTCACAGCCTCGCTGCCGCCGGACGTCATCGCGGCCACCATGGCGGCGCTGGACGAACTGGAGC
GGCGGCCGGAACTGCGGCACGCGCTGATGGACAATGCCAGGCGCCTGCATGCCGGACTGAATGCCGCCGGATTGCGCACC
GGCCCGCAGGCCAGCCCGGTCGTGTCGGTGGTGCTGGACGAGGTCGGCCAGGCGGTCCATTTCTGGAACCGGCTGCTGGA
CCTGGGCGTGTACGTGAATCTCAGCCTGCCGCCGGCCACCCCGGACCAGCACCCGCTGCTGCGCACGTCGGTCATGGCGA
CGCACAGCCCGGCGCAGGTCGATCGTGCCGTGGAGATCTTCGCCACCGTGGCCGGGGAAATGGGCCTGCGCGCGGCCGGG
TAG

Upstream 100 bases:

>100_bases
TTCGCTCGACGTGTCCGTCCCGCTCGACCGGCTTGCCGACATTCGCACCATCGACGACCTGGCCGCCTGCATCGTGTCCC
TGAAACAGGCCGGCTGAGCC

Downstream 100 bases:

>100_bases
CGCGTTACCGCCGTGTAAAGATGCCTGCCTGCCGCAGCTTCCACAACAGCCACGGCAGGCAGAGCAGCGGATGCCGCGCC
GCGAAGGGCGGAATTTTCAG

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MSIFSKYDGLSRSLAAVTAGGGRNPFSVVIDRPLSSTVGLIEGRETLLFGTNNYLGLSQSEAAIEAAIETLRTHGVGTTG
SRIANGTQGLHRQLEERIAGFFRRRHCMVFSTGYQANLGTISALAGKDDYLLLDADSHASIYDGSRLSQAQVIRFRHNDP
DDLHKRLRRLDGTPGAKLIVVEGIYSMMGDVVPMAEFAAVKRETGAWLLADEAHSFGVMGAHGRGVAESDGVESDIDFVV
GTFSKSLGTVGGYCVSDHDGLDLIRLCSRPYMFTASLPPDVIAATMAALDELERRPELRHALMDNARRLHAGLNAAGLRT
GPQASPVVSVVLDEVGQAVHFWNRLLDLGVYVNLSLPPATPDQHPLLRTSVMATHSPAQVDRAVEIFATVAGEMGLRAAG

Sequences:

>Translated_400_residues
MSIFSKYDGLSRSLAAVTAGGGRNPFSVVIDRPLSSTVGLIEGRETLLFGTNNYLGLSQSEAAIEAAIETLRTHGVGTTG
SRIANGTQGLHRQLEERIAGFFRRRHCMVFSTGYQANLGTISALAGKDDYLLLDADSHASIYDGSRLSQAQVIRFRHNDP
DDLHKRLRRLDGTPGAKLIVVEGIYSMMGDVVPMAEFAAVKRETGAWLLADEAHSFGVMGAHGRGVAESDGVESDIDFVV
GTFSKSLGTVGGYCVSDHDGLDLIRLCSRPYMFTASLPPDVIAATMAALDELERRPELRHALMDNARRLHAGLNAAGLRT
GPQASPVVSVVLDEVGQAVHFWNRLLDLGVYVNLSLPPATPDQHPLLRTSVMATHSPAQVDRAVEIFATVAGEMGLRAAG
>Mature_399_residues
SIFSKYDGLSRSLAAVTAGGGRNPFSVVIDRPLSSTVGLIEGRETLLFGTNNYLGLSQSEAAIEAAIETLRTHGVGTTGS
RIANGTQGLHRQLEERIAGFFRRRHCMVFSTGYQANLGTISALAGKDDYLLLDADSHASIYDGSRLSQAQVIRFRHNDPD
DLHKRLRRLDGTPGAKLIVVEGIYSMMGDVVPMAEFAAVKRETGAWLLADEAHSFGVMGAHGRGVAESDGVESDIDFVVG
TFSKSLGTVGGYCVSDHDGLDLIRLCSRPYMFTASLPPDVIAATMAALDELERRPELRHALMDNARRLHAGLNAAGLRTG
PQASPVVSVVLDEVGQAVHFWNRLLDLGVYVNLSLPPATPDQHPLLRTSVMATHSPAQVDRAVEIFATVAGEMGLRAAG

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI284448556, Length=359, Percent_Identity=33.1476323119777, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI7657118, Length=345, Percent_Identity=33.6231884057971, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI83977444, Length=367, Percent_Identity=32.9700272479564, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI83977442, Length=367, Percent_Identity=32.9700272479564, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI83977440, Length=367, Percent_Identity=32.9700272479564, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI4758668, Length=353, Percent_Identity=33.1444759206799, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI5454084, Length=389, Percent_Identity=29.305912596401, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI119220554, Length=359, Percent_Identity=31.1977715877437, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI4502025, Length=366, Percent_Identity=30.8743169398907, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI40316939, Length=366, Percent_Identity=30.8743169398907, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1790046, Length=373, Percent_Identity=32.4396782841823, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI1786993, Length=349, Percent_Identity=30.6590257879656, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71994529, Length=372, Percent_Identity=32.258064516129, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI32566772, Length=368, Percent_Identity=33.1521739130435, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17560914, Length=353, Percent_Identity=28.8951841359773, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17560912, Length=353, Percent_Identity=28.8951841359773, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71982617, Length=266, Percent_Identity=30.4511278195489, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71982625, Length=266, Percent_Identity=30.4511278195489, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320267, Length=363, Percent_Identity=31.404958677686, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6320438, Length=315, Percent_Identity=28.2539682539683, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323954, Length=300, Percent_Identity=27.3333333333333, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24662918, Length=348, Percent_Identity=33.6206896551724, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24653280, Length=387, Percent_Identity=29.9741602067183, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24653276, Length=387, Percent_Identity=29.9741602067183, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24653278, Length=387, Percent_Identity=29.9741602067183, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI17137420, Length=310, Percent_Identity=31.9354838709677, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI17136286, Length=378, Percent_Identity=31.2169312169312, Blast_Score=156, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 42890; Mature: 42759

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIFSKYDGLSRSLAAVTAGGGRNPFSVVIDRPLSSTVGLIEGRETLLFGTNNYLGLSQS
CCCCHHHCCCHHHHHHEECCCCCCCEEEEEECCCHHHHHHCCCCEEEEEECCCCCCCCCH
EAAIEAAIETLRTHGVGTTGSRIANGTQGLHRQLEERIAGFFRRRHCMVFSTGYQANLGT
HHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCC
ISALAGKDDYLLLDADSHASIYDGSRLSQAQVIRFRHNDPDDLHKRLRRLDGTPGAKLIV
EEEECCCCCEEEEECCCCCCCCCCCCCCHHHEEEECCCCHHHHHHHHHHHCCCCCCEEEE
VEGIYSMMGDVVPMAEFAAVKRETGAWLLADEAHSFGVMGAHGRGVAESDGVESDIDFVV
HHHHHHHHCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
GTFSKSLGTVGGYCVSDHDGLDLIRLCSRPYMFTASLPPDVIAATMAALDELERRPELRH
HHHHHHHCCCCCEEECCCCCHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCHHHHH
ALMDNARRLHAGLNAAGLRTGPQASPVVSVVLDEVGQAVHFWNRLLDLGVYVNLSLPPAT
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCC
PDQHPLLRTSVMATHSPAQVDRAVEIFATVAGEMGLRAAG
CCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SIFSKYDGLSRSLAAVTAGGGRNPFSVVIDRPLSSTVGLIEGRETLLFGTNNYLGLSQS
CCCHHHCCCHHHHHHEECCCCCCCEEEEEECCCHHHHHHCCCCEEEEEECCCCCCCCCH
EAAIEAAIETLRTHGVGTTGSRIANGTQGLHRQLEERIAGFFRRRHCMVFSTGYQANLGT
HHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCC
ISALAGKDDYLLLDADSHASIYDGSRLSQAQVIRFRHNDPDDLHKRLRRLDGTPGAKLIV
EEEECCCCCEEEEECCCCCCCCCCCCCCHHHEEEECCCCHHHHHHHHHHHCCCCCCEEEE
VEGIYSMMGDVVPMAEFAAVKRETGAWLLADEAHSFGVMGAHGRGVAESDGVESDIDFVV
HHHHHHHHCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
GTFSKSLGTVGGYCVSDHDGLDLIRLCSRPYMFTASLPPDVIAATMAALDELERRPELRH
HHHHHHHCCCCCEEECCCCCHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCHHHHH
ALMDNARRLHAGLNAAGLRTGPQASPVVSVVLDEVGQAVHFWNRLLDLGVYVNLSLPPAT
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCC
PDQHPLLRTSVMATHSPAQVDRAVEIFATVAGEMGLRAAG
CCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA