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The map label for this gene is msrA [H]

Identifier: 162148540

GI number: 162148540

Start: 2853624

End: 2854331

Strand: Direct

Name: msrA [H]

Synonym: GDI_2764

Alternate gene names: 162148540

Gene position: 2853624-2854331 (Clockwise)

Preceding gene: 162148539

Following gene: 162148541

Centisome position: 72.35

GC content: 63.42

Gene sequence:

>708_bases
ATGACACGAGCAGGACTTTTCGGCGTTTCCCTGGTGGCGCTGACCACATTCGGTGTCGCCTGCCACACGGCAATGGGCGA
GCCCGGCCCCCGTATTCTTCCGGCGCCCGTTCTGGCGGAACCGGCGCCTGCGACGCACCATGCAAGTACCGTTTTCGCAG
GTGGTTGCTTCTGGGGCGTGCAGAGCGTGTTCGAACATATTCGTGGCGTGACCGCGACCCGCGCGGGTTTCGACGGCGGT
GCGCGCGACACGGCGGATTATGAGACCGTCAGCAGCGGCGATACGGAACACGCAGAGTCGGTTGAAGTCGACTTTGATCC
GACGCAGGTCAGCTACGGCACGCTGATGCGCATCTTCTTTTCTGTTGCGCTCGACCCGACACAGGTGAACCGCCAGTTCC
CGGATGACGGCACGCAATATCGCTCCGTGCTCTACACCCGATCCGCGCAGCAGGCTCGGGAAGCGCATGCCTATATCGCG
CAGCTCGACGCGGCGCATGTCTTCACGCGCCCCATCGCAACGCAGGTGGCGCCGGATCACGGATTCTACCCAGCCGAGGC
AGATCACCAAAATTTCGCGGCCCGCTATCCGGATCATCCGTATATCGCTACATATGACGCACCACGGATCGAGGCGCTGC
ACGCGTTGTTCGCATCGTCCTGGCGCGCGCAGCCTGTGCTGACGCTGGCCGACGATGGCGGGAGCTGA

Upstream 100 bases:

>100_bases
CTCGGCCACGTGTTCGATGACGGACCGCAGCCAACGGGCCTGCGCTACTGCATGAACGGCGTGGCACTTTCATTCCATAC
GGCCTGAAGGAACTGGAAAC

Downstream 100 bases:

>100_bases
CTCTCGCCGTAACCAGGGACGGAGGGTTCGTGACGGAAGCGGATTGGAGCCGCTGGATGGCGGCGGCTCAGGCGGGCGAC
GCCGATGCCTATCGCCACGT

Product: peptide methionine sulfoxide reductase msrA

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MTRAGLFGVSLVALTTFGVACHTAMGEPGPRILPAPVLAEPAPATHHASTVFAGGCFWGVQSVFEHIRGVTATRAGFDGG
ARDTADYETVSSGDTEHAESVEVDFDPTQVSYGTLMRIFFSVALDPTQVNRQFPDDGTQYRSVLYTRSAQQAREAHAYIA
QLDAAHVFTRPIATQVAPDHGFYPAEADHQNFAARYPDHPYIATYDAPRIEALHALFASSWRAQPVLTLADDGGS

Sequences:

>Translated_235_residues
MTRAGLFGVSLVALTTFGVACHTAMGEPGPRILPAPVLAEPAPATHHASTVFAGGCFWGVQSVFEHIRGVTATRAGFDGG
ARDTADYETVSSGDTEHAESVEVDFDPTQVSYGTLMRIFFSVALDPTQVNRQFPDDGTQYRSVLYTRSAQQAREAHAYIA
QLDAAHVFTRPIATQVAPDHGFYPAEADHQNFAARYPDHPYIATYDAPRIEALHALFASSWRAQPVLTLADDGGS
>Mature_234_residues
TRAGLFGVSLVALTTFGVACHTAMGEPGPRILPAPVLAEPAPATHHASTVFAGGCFWGVQSVFEHIRGVTATRAGFDGGA
RDTADYETVSSGDTEHAESVEVDFDPTQVSYGTLMRIFFSVALDPTQVNRQFPDDGTQYRSVLYTRSAQQAREAHAYIAQ
LDAAHVFTRPIATQVAPDHGFYPAEADHQNFAARYPDHPYIATYDAPRIEALHALFASSWRAQPVLTLADDGGS

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=183, Percent_Identity=34.9726775956284, Blast_Score=101, Evalue=5e-22,
Organism=Homo sapiens, GI208609995, Length=151, Percent_Identity=38.4105960264901, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1790665, Length=150, Percent_Identity=41.3333333333333, Blast_Score=111, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6320881, Length=154, Percent_Identity=31.1688311688312, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24664627, Length=149, Percent_Identity=34.2281879194631, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24664631, Length=149, Percent_Identity=33.5570469798658, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45553131, Length=142, Percent_Identity=34.5070422535211, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 25326; Mature: 25195

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRAGLFGVSLVALTTFGVACHTAMGEPGPRILPAPVLAEPAPATHHASTVFAGGCFWGV
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEECHHHHHH
QSVFEHIRGVTATRAGFDGGARDTADYETVSSGDTEHAESVEVDFDPTQVSYGTLMRIFF
HHHHHHHCCCHHHCCCCCCCCCCCCCCHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHH
SVALDPTQVNRQFPDDGTQYRSVLYTRSAQQAREAHAYIAQLDAAHVFTRPIATQVAPDH
HHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GFYPAEADHQNFAARYPDHPYIATYDAPRIEALHALFASSWRAQPVLTLADDGGS
CCCCCCCCCCCCHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCC
>Mature Secondary Structure 
TRAGLFGVSLVALTTFGVACHTAMGEPGPRILPAPVLAEPAPATHHASTVFAGGCFWGV
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEECHHHHHH
QSVFEHIRGVTATRAGFDGGARDTADYETVSSGDTEHAESVEVDFDPTQVSYGTLMRIFF
HHHHHHHCCCHHHCCCCCCCCCCCCCCHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHH
SVALDPTQVNRQFPDDGTQYRSVLYTRSAQQAREAHAYIAQLDAAHVFTRPIATQVAPDH
HHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GFYPAEADHQNFAARYPDHPYIATYDAPRIEALHALFASSWRAQPVLTLADDGGS
CCCCCCCCCCCCHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]