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The map label for this gene is adhC [H]

Identifier: 162148313

GI number: 162148313

Start: 2625366

End: 2626421

Strand: Direct

Name: adhC [H]

Synonym: GDI_2530

Alternate gene names: 162148313

Gene position: 2625366-2626421 (Clockwise)

Preceding gene: 162148311

Following gene: 162148314

Centisome position: 66.56

GC content: 65.81

Gene sequence:

>1056_bases
ATGTTCGCATGCACAGGATATGCGGCCACCGCCGCCGACGCGCGGCTGGCCCCGTTCGCCTTCGAACGTCGCGATACCGG
GCCGGAGGACGTGCGGATCGACATCCATTATTGCGGCGTCTGCCATTCCGACCTGCACCAGGCCCGCAACGAATGGCACA
ACACGATCTACCCCTGCGTTCCCGGGCATGAAATCGTCGGCCGGGTGGCCGAGGTCGGCACCGGTGTCACAAAATTCCGC
GCGGGGGACCTGGTGGGCGTGGGCTGCCTGGTCGATTCCTGCCGCGAATGCCAAAGCTGCCGCGACGGGTACGAGCAATA
TTGCGAAAACGGCTTCGTCGGCACCTATAACGGCCAGGACCGGCACGGGCGCGGCATCACCTTCGGCGGCTATTCCCGTG
CCATCGTGGTCGACCAGGCCTTCGTCCTGAACGTGCCCGAAACCCTGGACCTGGCGGCCGTGGCGCCCCTGCTGTGCGCC
GGAATCACGACCTGGTCCCCGCTGCGCCACTGGAAGGTCGGGCCCGGGCAGCGCGTGGGCATCGTGGGACTGGGCGGCCT
GGGCCATATGGGCGTGAAGTTCGCCCGTGCCTTCGGGGCCGAGGTCGTGCTGTTCACCACGTCGGCCAGCAAGATCGAGG
ACGGGCTGCGCCTGGGCGCGCATGAGGTCGTGCTGTCGCGCGACCCCGATGCCATGGCGCGCGAGGCCGGGCGCTTCGAT
TTCATCCTGGATGCCGTCGCGGCCGACCACGACATCAACGCCTACCTGAACCTGCTGAAGCGCGACGGCACGCTGGTCCA
GGTAGGGGCGCCGGAAAATCCGCTGCCCGTCTCGGTATTCAGCCTGCTGATGAAGCGGCGCAATTTCGCGGGTTCGCTGA
TCGGCGGCATTCCCGAGACCCAGGAAATGCTCGATTTCTGCGGCGAACACGGCATCACCGCCGACATCGAAATGATCCGC
ATGGATGAAATCGAGACCGCCTATGCGCGCATGCTGCGATCCGACGTGAAATATCGCTTCGTGATCGACATGGCGACACT
GCCCGCACAGGCCTGA

Upstream 100 bases:

>100_bases
GTGCAAGAACCAGACAGCATTCCGCATTCAGCCGGCGGGAGCGGCATGGCATGTTCGCCAAGGATATCCTGCCCCGACAT
TTTCAGAAGGATCACACATC

Downstream 100 bases:

>100_bases
TCCTGCCAGGGGCGGCCATGGCGGTCGCCCCTTCGCCGTCCGGGGCCTATTCCTGTTGTCTGGAAACAATGTGCCGCTAT
CCTCGTTCGAGAAACACCTG

Product: NADP-dependent alcohol dehydrogenase C

Products: NA

Alternate protein names: Ms-ADHC 1 [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MFACTGYAATAADARLAPFAFERRDTGPEDVRIDIHYCGVCHSDLHQARNEWHNTIYPCVPGHEIVGRVAEVGTGVTKFR
AGDLVGVGCLVDSCRECQSCRDGYEQYCENGFVGTYNGQDRHGRGITFGGYSRAIVVDQAFVLNVPETLDLAAVAPLLCA
GITTWSPLRHWKVGPGQRVGIVGLGGLGHMGVKFARAFGAEVVLFTTSASKIEDGLRLGAHEVVLSRDPDAMAREAGRFD
FILDAVAADHDINAYLNLLKRDGTLVQVGAPENPLPVSVFSLLMKRRNFAGSLIGGIPETQEMLDFCGEHGITADIEMIR
MDEIETAYARMLRSDVKYRFVIDMATLPAQA

Sequences:

>Translated_351_residues
MFACTGYAATAADARLAPFAFERRDTGPEDVRIDIHYCGVCHSDLHQARNEWHNTIYPCVPGHEIVGRVAEVGTGVTKFR
AGDLVGVGCLVDSCRECQSCRDGYEQYCENGFVGTYNGQDRHGRGITFGGYSRAIVVDQAFVLNVPETLDLAAVAPLLCA
GITTWSPLRHWKVGPGQRVGIVGLGGLGHMGVKFARAFGAEVVLFTTSASKIEDGLRLGAHEVVLSRDPDAMAREAGRFD
FILDAVAADHDINAYLNLLKRDGTLVQVGAPENPLPVSVFSLLMKRRNFAGSLIGGIPETQEMLDFCGEHGITADIEMIR
MDEIETAYARMLRSDVKYRFVIDMATLPAQA
>Mature_351_residues
MFACTGYAATAADARLAPFAFERRDTGPEDVRIDIHYCGVCHSDLHQARNEWHNTIYPCVPGHEIVGRVAEVGTGVTKFR
AGDLVGVGCLVDSCRECQSCRDGYEQYCENGFVGTYNGQDRHGRGITFGGYSRAIVVDQAFVLNVPETLDLAAVAPLLCA
GITTWSPLRHWKVGPGQRVGIVGLGGLGHMGVKFARAFGAEVVLFTTSASKIEDGLRLGAHEVVLSRDPDAMAREAGRFD
FILDAVAADHDINAYLNLLKRDGTLVQVGAPENPLPVSVFSLLMKRRNFAGSLIGGIPETQEMLDFCGEHGITADIEMIR
MDEIETAYARMLRSDVKYRFVIDMATLPAQA

Specific function: Prefers aldehydes over alcohols [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=311, Percent_Identity=27.6527331189711, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI34577061, Length=309, Percent_Identity=27.831715210356, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI4501929, Length=309, Percent_Identity=26.2135922330097, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI71743840, Length=323, Percent_Identity=25.6965944272446, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI262073058, Length=323, Percent_Identity=25.6965944272446, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI156523966, Length=315, Percent_Identity=26.031746031746, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI4501939, Length=315, Percent_Identity=26.031746031746, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI71565154, Length=230, Percent_Identity=27.8260869565217, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1786518, Length=341, Percent_Identity=61.8768328445748, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI87082401, Length=344, Percent_Identity=34.0116279069767, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI87081918, Length=316, Percent_Identity=27.5316455696203, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI226510992, Length=326, Percent_Identity=27.9141104294479, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788075, Length=282, Percent_Identity=25.177304964539, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788073, Length=254, Percent_Identity=25.1968503937008, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790045, Length=287, Percent_Identity=26.8292682926829, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1786552, Length=371, Percent_Identity=25.8760107816712, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=323, Percent_Identity=28.1733746130031, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17562584, Length=325, Percent_Identity=30.7692307692308, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17562582, Length=326, Percent_Identity=29.7546012269939, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI25146526, Length=330, Percent_Identity=28.7878787878788, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=332, Percent_Identity=28.3132530120482, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=352, Percent_Identity=24.7159090909091, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17565904, Length=250, Percent_Identity=30, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562878, Length=187, Percent_Identity=29.4117647058824, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323980, Length=319, Percent_Identity=36.3636363636364, Blast_Score=173, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6319949, Length=329, Percent_Identity=34.9544072948328, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6323729, Length=326, Percent_Identity=29.1411042944785, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6319621, Length=328, Percent_Identity=29.5731707317073, Blast_Score=142, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6323961, Length=326, Percent_Identity=29.7546012269939, Blast_Score=139, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6324486, Length=325, Percent_Identity=28.9230769230769, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319258, Length=301, Percent_Identity=25.2491694352159, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=321, Percent_Identity=23.98753894081, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=331, Percent_Identity=26.8882175226586, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17737895, Length=377, Percent_Identity=26.2599469496021, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.2 [H]

Molecular weight: Translated: 38171; Mature: 38171

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFACTGYAATAADARLAPFAFERRDTGPEDVRIDIHYCGVCHSDLHQARNEWHNTIYPCV
CCEECCCCHHCCCCCCCCCCHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCEECCCC
PGHEIVGRVAEVGTGVTKFRAGDLVGVGCLVDSCRECQSCRDGYEQYCENGFVGTYNGQD
CCHHHHHHHHHHCCCHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCC
RHGRGITFGGYSRAIVVDQAFVLNVPETLDLAAVAPLLCAGITTWSPLRHWKVGPGQRVG
CCCCCEEECCCCEEEEEECEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEE
IVGLGGLGHMGVKFARAFGAEVVLFTTSASKIEDGLRLGAHEVVLSRDPDAMAREAGRFD
EEEECCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCEEEEEECCCHHHHHHCCCHH
FILDAVAADHDINAYLNLLKRDGTLVQVGAPENPLPVSVFSLLMKRRNFAGSLIGGIPET
HHHHHHHCCCCHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCHHHCCCCCH
QEMLDFCGEHGITADIEMIRMDEIETAYARMLRSDVKYRFVIDMATLPAQA
HHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEEEEEECCCCCC
>Mature Secondary Structure
MFACTGYAATAADARLAPFAFERRDTGPEDVRIDIHYCGVCHSDLHQARNEWHNTIYPCV
CCEECCCCHHCCCCCCCCCCHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCEECCCC
PGHEIVGRVAEVGTGVTKFRAGDLVGVGCLVDSCRECQSCRDGYEQYCENGFVGTYNGQD
CCHHHHHHHHHHCCCHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCC
RHGRGITFGGYSRAIVVDQAFVLNVPETLDLAAVAPLLCAGITTWSPLRHWKVGPGQRVG
CCCCCEEECCCCEEEEEECEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEE
IVGLGGLGHMGVKFARAFGAEVVLFTTSASKIEDGLRLGAHEVVLSRDPDAMAREAGRFD
EEEECCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCEEEEEECCCHHHHHHCCCHH
FILDAVAADHDINAYLNLLKRDGTLVQVGAPENPLPVSVFSLLMKRRNFAGSLIGGIPET
HHHHHHHCCCCHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCHHHCCCCCH
QEMLDFCGEHGITADIEMIRMDEIETAYARMLRSDVKYRFVIDMATLPAQA
HHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11257547 [H]