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The map label for this gene is lspL [H]

Identifier: 162148305

GI number: 162148305

Start: 2615894

End: 2616892

Strand: Reverse

Name: lspL [H]

Synonym: GDI_2522

Alternate gene names: 162148305

Gene position: 2616892-2615894 (Counterclockwise)

Preceding gene: 162148307

Following gene: 162148301

Centisome position: 66.35

GC content: 67.07

Gene sequence:

>999_bases
TTGCGTATTCTCATGACCGGCACGGCGGGATTCATCGGTTTCCATGTGGCATGCCGGCTGCTGGATGACGGGCATGAGGT
CACGGGCATCGACGGGATCACCGCCTATTACGACGTGGCGCTGAAGCGCGAGCGTCACGACCGCCTTGCCATGCGGCCCG
GTTTCACCCGCCACGAATTCATGCTGGAGGATGCGGTCCGGCTGGCGGAAACCTGCCGCGAGGCGCGCCCGGACATCGTC
ATTCACCTCGCCGCCCAAGCCGGGGTGCGGTACAGCCTGGAAAATCCCGGCGCCTATATCAGCGCCAACATCGTGGGCAC
CCATAACCTGCTGGAAGCGATCAAGACGCTGGGCGTGCGGCATTTCGTCCTGGCCTCGACCTCGTCGGTCTACGGGGCCA
GCGCCGAGAGCCCGTTTACCGAGGACCAGGCCTGCAATCACCCGCTCAGCCTCTACGGCGCGACCAAGAAGGCGTGCGAG
GAGATCGGTCATTCCCATGCCCACCTGTACGGGCTGCCGATCACCGCCTGCCGGTTCTTCACCGTCTACGGCCCATGGGG
GCGGCCGGACATGGCGCTGTTCCGCTTCACCAGCAACATCCTCGGCGGCCGCCCGATCGACGTCTACAATAACGCGCAGA
TGGAACGGGACTTCACCTATATCGACGACGTGGTCGAGGCGCTCTGCCGCCTGCTGCCGCACGCGCCGGCGGTGACGACC
CCCACCCGGCGGGGCGTCAGCCCGGTCGCACCGTTCCGCGTGGTGAATGTCGGCCATGGCCAGCCCGTCGCCCTGGGCGA
TTTCATCGGCGCCATCGAACGGGCGACGGGGCGGACGGCCATCCGTCACAACCTGCCGATGCAGCCCGGCGACGTGCCCC
GGACCTGGGCCGACTGCACGATCCTGGAACATCTGACCGGCTATCGTCCCGCCACCGCGCTGCAGGACGGGATCGACGCC
TTCGTCGCCTGGTACCGCGACTGGTACGACGCCGCCTGA

Upstream 100 bases:

>100_bases
TTGCGATCCGTTCAATCATCCGGACGCTCGCCCGTGTCGGGCGGGGCTTCTCATCGGCCGTCGCGCTCTATATGGGCTGA
AACCGGACGGGGAGGTTCTG

Downstream 100 bases:

>100_bases
CGATTCAGAACGACCCGGTCAGGCTGACATTGAACGACCGGCCCATGCCCTTCAGCGGGCCGAGAACGCCCGTCGCGTCG
TAGTCGCCCAGCGACAATCC

Product: UDP-glucuronate 5'-epimerase (UDP-glucuronic aci epimerase)

Products: NA

Alternate protein names: UDP-glucuronic acid epimerase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MRILMTGTAGFIGFHVACRLLDDGHEVTGIDGITAYYDVALKRERHDRLAMRPGFTRHEFMLEDAVRLAETCREARPDIV
IHLAAQAGVRYSLENPGAYISANIVGTHNLLEAIKTLGVRHFVLASTSSVYGASAESPFTEDQACNHPLSLYGATKKACE
EIGHSHAHLYGLPITACRFFTVYGPWGRPDMALFRFTSNILGGRPIDVYNNAQMERDFTYIDDVVEALCRLLPHAPAVTT
PTRRGVSPVAPFRVVNVGHGQPVALGDFIGAIERATGRTAIRHNLPMQPGDVPRTWADCTILEHLTGYRPATALQDGIDA
FVAWYRDWYDAA

Sequences:

>Translated_332_residues
MRILMTGTAGFIGFHVACRLLDDGHEVTGIDGITAYYDVALKRERHDRLAMRPGFTRHEFMLEDAVRLAETCREARPDIV
IHLAAQAGVRYSLENPGAYISANIVGTHNLLEAIKTLGVRHFVLASTSSVYGASAESPFTEDQACNHPLSLYGATKKACE
EIGHSHAHLYGLPITACRFFTVYGPWGRPDMALFRFTSNILGGRPIDVYNNAQMERDFTYIDDVVEALCRLLPHAPAVTT
PTRRGVSPVAPFRVVNVGHGQPVALGDFIGAIERATGRTAIRHNLPMQPGDVPRTWADCTILEHLTGYRPATALQDGIDA
FVAWYRDWYDAA
>Mature_332_residues
MRILMTGTAGFIGFHVACRLLDDGHEVTGIDGITAYYDVALKRERHDRLAMRPGFTRHEFMLEDAVRLAETCREARPDIV
IHLAAQAGVRYSLENPGAYISANIVGTHNLLEAIKTLGVRHFVLASTSSVYGASAESPFTEDQACNHPLSLYGATKKACE
EIGHSHAHLYGLPITACRFFTVYGPWGRPDMALFRFTSNILGGRPIDVYNNAQMERDFTYIDDVVEALCRLLPHAPAVTT
PTRRGVSPVAPFRVVNVGHGQPVALGDFIGAIERATGRTAIRHNLPMQPGDVPRTWADCTILEHLTGYRPATALQDGIDA
FVAWYRDWYDAA

Specific function: DTDP-L-RHAMNOSE BIOSYNTHESIS WITHIN THE O ANTIGEN BIOSYNTHESIS PATHWAY OF LIPOPOLYSACCHARIDE BIOSYNTHESIS. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=333, Percent_Identity=27.6276276276276, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI7657641, Length=334, Percent_Identity=26.3473053892216, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI56237023, Length=345, Percent_Identity=24.6376811594203, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI56118217, Length=345, Percent_Identity=24.6376811594203, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI189083684, Length=345, Percent_Identity=24.6376811594203, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1788353, Length=346, Percent_Identity=26.5895953757225, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786974, Length=331, Percent_Identity=25.9818731117825, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI48994969, Length=244, Percent_Identity=31.1475409836066, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1788366, Length=352, Percent_Identity=26.7045454545455, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17568069, Length=235, Percent_Identity=32.7659574468085, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71982038, Length=341, Percent_Identity=25.8064516129032, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71982035, Length=340, Percent_Identity=26.1764705882353, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17539532, Length=340, Percent_Identity=27.9411764705882, Blast_Score=97, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6319493, Length=168, Percent_Identity=31.547619047619, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356223, Length=336, Percent_Identity=27.3809523809524, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19923002, Length=342, Percent_Identity=26.3157894736842, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.12 [H]

Molecular weight: Translated: 36620; Mature: 36620

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILMTGTAGFIGFHVACRLLDDGHEVTGIDGITAYYDVALKRERHDRLAMRPGFTRHEF
CEEEEECCCHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
MLEDAVRLAETCREARPDIVIHLAAQAGVRYSLENPGAYISANIVGTHNLLEAIKTLGVR
HHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCEEEEEEECHHHHHHHHHHHCHH
HFVLASTSSVYGASAESPFTEDQACNHPLSLYGATKKACEEIGHSHAHLYGLPITACRFF
HEEEECCCCCCCCCCCCCCCCHHHCCCCHHHHCHHHHHHHHHCCCCEEEECCCHHHEEEE
TVYGPWGRPDMALFRFTSNILGGRPIDVYNNAQMERDFTYIDDVVEALCRLLPHAPAVTT
EEECCCCCCCHHHHHHHHHHCCCCCEECCCCCCHHCCHHHHHHHHHHHHHHCCCCCCCCC
PTRRGVSPVAPFRVVNVGHGQPVALGDFIGAIERATGRTAIRHNLPMQPGDVPRTWADCT
CCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHH
ILEHLTGYRPATALQDGIDAFVAWYRDWYDAA
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRILMTGTAGFIGFHVACRLLDDGHEVTGIDGITAYYDVALKRERHDRLAMRPGFTRHEF
CEEEEECCCHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
MLEDAVRLAETCREARPDIVIHLAAQAGVRYSLENPGAYISANIVGTHNLLEAIKTLGVR
HHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCEEEEEEECHHHHHHHHHHHCHH
HFVLASTSSVYGASAESPFTEDQACNHPLSLYGATKKACEEIGHSHAHLYGLPITACRFF
HEEEECCCCCCCCCCCCCCCCHHHCCCCHHHHCHHHHHHHHHCCCCEEEECCCHHHEEEE
TVYGPWGRPDMALFRFTSNILGGRPIDVYNNAQMERDFTYIDDVVEALCRLLPHAPAVTT
EEECCCCCCCHHHHHHHHHHCCCCCEECCCCCCHHCCHHHHHHHHHHHHHHCCCCCCCCC
PTRRGVSPVAPFRVVNVGHGQPVALGDFIGAIERATGRTAIRHNLPMQPGDVPRTWADCT
CCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHH
ILEHLTGYRPATALQDGIDAFVAWYRDWYDAA
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]