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The map label for this gene is nuoCD

Identifier: 162148252

GI number: 162148252

Start: 2559709

End: 2561514

Strand: Reverse

Name: nuoCD

Synonym: GDI_2469

Alternate gene names: 162148252

Gene position: 2561514-2559709 (Counterclockwise)

Preceding gene: 162148253

Following gene: 162148251

Centisome position: 64.94

GC content: 66.0

Gene sequence:

>1806_bases
ATGATCGTGCCCGACCTGGTGGCGGACGCCATGACCGCAGGACCGCCCGCCGCGAAAAGCGGAGACGGCGCCACCATGTT
CGGGCAGGTCTCCGACCTGGGGCCGGGAACGGTGCTGGCGGTCGAGACGGCGCGCGACGGAGTGCCCACGGCCTGGATCG
CGCCGACTTCCCTGCGCGCGGTCGTCGGCATGCTGCGCGAACCGGCGGCGGCGCTGCGGATGCTGTTCGACCTGACGGCG
ATCGACGAACGGCAGCGCGCGCACCGCGTCGGACAGCCGGATTGCGCCTTTACCCTGGTCTGCCATTTCATGGCCCTGGG
GGGTGCGGGCGACGCACTGCGCCTGAAGGTGCCGTTGCCCGCCGAGGCGCCGCGGGTGCCGTCGATCGCGGACTTTTGGC
CCAACGCGAACTGGTACGAGCGCGAGGTCTGGGACCTGTTCGGCATCACGTTCGAGGGCCACCCGTTCCTGCGGCGCATC
CTGACCCCGCCCACCTGGACCGGGCACCCGCTGCGCAAGGACCATTACGCCCGCGCCACCGAAATGCCGCCCTACAGTCT
GACCGAAGACCAGGAAATGGCCGAACAGCAGGCCCTGCGCTTCGACCCCGGCGCGTGGGGCATGGCGCGGCATTCGGCGC
ATAGCGACTTCATGTTCCTCAATCTGGGGCCGAACCATCCCAGCGTGCATGGGGTGTTTCGCATCGTCTTGCAACTGGAG
GGCGAGCGGATCGTCGATGCGGTGCCCGATATCGGTTTTCACCATCGTGGCGCCGAGAAGATGGGCGAGCGCCAGTCCTG
GCACAGCTTCATTCCCTATACCGACCGGGTCGATTACCTGGGCGGCGTCATGAACAATTTCCCCTATGTCATGGCGGTGG
AAAAATTGGCCGGCATCACGGTGCCGCCCCGGGCGCAGATGATCCGGGTCATGCTGGCCGAACTGTTCCGTGTGGCCAGC
CACCTGGTGTTCTACGGCACCATGACGCAGGATGTCGGGCAGTTGTCGCCGGTCTTCTACATGTTCAGCGACCGCGAGCG
GGTTTTCGAAATCATCGAGGCCATCTGCGGTTTTCGCATGCATCCCGCCTGGTTCCGCATCGGCGGCGTGGCGATGGACC
TGCCGCGCGGCTGGGACGGGCTGATCCGTGATTTCCTGGACTATCTGCCGCCGCGCCTGGACGAGTACGAAAAGATGGTG
ATGCGCAATCCCATCTTCCGGGCACGGACCATCGGCGTCGGCGCCTACGACGTATCGGAAGCCATTGCCTGGGGGGTGAC
GGGGCCGGGCCTGCGGGCCTGCGGCCTGGAATGGGACCTGCGGCGCAAGGTCCCCTATTCGGGATACGACCAGCTGGAGT
TCGATATTCCGACGGCGCAGAACGGCGATTGCTACGACCGGGTGCGCGTCCATATCGCGGAAATCCGCCAGAGCCTGCGC
ATCATCCGGCAATGTCTGGACGGCATGCCCGCGGGCGCGATCAAGGCGGAACACAGGCTGACCACGCCGCCGCCGCGGGC
GCGGACGATGCATGACATCGAAACCCTGATCCATCATTTCCTGTCCGTCAGCTGGGGGCCGGTCATTCCGCCCGGCGAGG
CCCATGCCTGCGTCGAGGCGACGAAGGGGCTCAATTCCTATCACCTGATCAGCGACGGGGGGACGATGTCCTATCGCACG
CGCATCCGTACCCCGTCCTTTCCCCATCTGCAGATGATCCCGCTGATCAGCCGGGGCGGGATGATCGCCGACCTGATCGC
GATCATCGGCAGCATCGATTTCGTGATGGCCGATGTCGACCGCTGA

Upstream 100 bases:

>100_bases
CGAACGGGTCACGCCGCCCAGCCTGCGTGATGCGAAGCGCGACCAGCGCCGCGCCGCGCAGACCCTGCGCAGCCCCGACA
CGATCTGACGGGGCCGCGCG

Downstream 100 bases:

>100_bases
CCCGCCCCTGCCGCCCGACCTGAAGGCCGAGATCGCGGCCATGGTGCGGGCCGCCGATTACCCGCGCGCGGTGTCGGTGG
GCGCGCTGGCCGCCGTGCAG

Product: bifunctional NADH:ubiquinone oxidoreductase subunit C/D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit C/D; NDH-1 subunit C/D

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MIVPDLVADAMTAGPPAAKSGDGATMFGQVSDLGPGTVLAVETARDGVPTAWIAPTSLRAVVGMLREPAAALRMLFDLTA
IDERQRAHRVGQPDCAFTLVCHFMALGGAGDALRLKVPLPAEAPRVPSIADFWPNANWYEREVWDLFGITFEGHPFLRRI
LTPPTWTGHPLRKDHYARATEMPPYSLTEDQEMAEQQALRFDPGAWGMARHSAHSDFMFLNLGPNHPSVHGVFRIVLQLE
GERIVDAVPDIGFHHRGAEKMGERQSWHSFIPYTDRVDYLGGVMNNFPYVMAVEKLAGITVPPRAQMIRVMLAELFRVAS
HLVFYGTMTQDVGQLSPVFYMFSDRERVFEIIEAICGFRMHPAWFRIGGVAMDLPRGWDGLIRDFLDYLPPRLDEYEKMV
MRNPIFRARTIGVGAYDVSEAIAWGVTGPGLRACGLEWDLRRKVPYSGYDQLEFDIPTAQNGDCYDRVRVHIAEIRQSLR
IIRQCLDGMPAGAIKAEHRLTTPPPRARTMHDIETLIHHFLSVSWGPVIPPGEAHACVEATKGLNSYHLISDGGTMSYRT
RIRTPSFPHLQMIPLISRGGMIADLIAIIGSIDFVMADVDR

Sequences:

>Translated_601_residues
MIVPDLVADAMTAGPPAAKSGDGATMFGQVSDLGPGTVLAVETARDGVPTAWIAPTSLRAVVGMLREPAAALRMLFDLTA
IDERQRAHRVGQPDCAFTLVCHFMALGGAGDALRLKVPLPAEAPRVPSIADFWPNANWYEREVWDLFGITFEGHPFLRRI
LTPPTWTGHPLRKDHYARATEMPPYSLTEDQEMAEQQALRFDPGAWGMARHSAHSDFMFLNLGPNHPSVHGVFRIVLQLE
GERIVDAVPDIGFHHRGAEKMGERQSWHSFIPYTDRVDYLGGVMNNFPYVMAVEKLAGITVPPRAQMIRVMLAELFRVAS
HLVFYGTMTQDVGQLSPVFYMFSDRERVFEIIEAICGFRMHPAWFRIGGVAMDLPRGWDGLIRDFLDYLPPRLDEYEKMV
MRNPIFRARTIGVGAYDVSEAIAWGVTGPGLRACGLEWDLRRKVPYSGYDQLEFDIPTAQNGDCYDRVRVHIAEIRQSLR
IIRQCLDGMPAGAIKAEHRLTTPPPRARTMHDIETLIHHFLSVSWGPVIPPGEAHACVEATKGLNSYHLISDGGTMSYRT
RIRTPSFPHLQMIPLISRGGMIADLIAIIGSIDFVMADVDR
>Mature_601_residues
MIVPDLVADAMTAGPPAAKSGDGATMFGQVSDLGPGTVLAVETARDGVPTAWIAPTSLRAVVGMLREPAAALRMLFDLTA
IDERQRAHRVGQPDCAFTLVCHFMALGGAGDALRLKVPLPAEAPRVPSIADFWPNANWYEREVWDLFGITFEGHPFLRRI
LTPPTWTGHPLRKDHYARATEMPPYSLTEDQEMAEQQALRFDPGAWGMARHSAHSDFMFLNLGPNHPSVHGVFRIVLQLE
GERIVDAVPDIGFHHRGAEKMGERQSWHSFIPYTDRVDYLGGVMNNFPYVMAVEKLAGITVPPRAQMIRVMLAELFRVAS
HLVFYGTMTQDVGQLSPVFYMFSDRERVFEIIEAICGFRMHPAWFRIGGVAMDLPRGWDGLIRDFLDYLPPRLDEYEKMV
MRNPIFRARTIGVGAYDVSEAIAWGVTGPGLRACGLEWDLRRKVPYSGYDQLEFDIPTAQNGDCYDRVRVHIAEIRQSLR
IIRQCLDGMPAGAIKAEHRLTTPPPRARTMHDIETLIHHFLSVSWGPVIPPGEAHACVEATKGLNSYHLISDGGTMSYRT
RIRTPSFPHLQMIPLISRGGMIADLIAIIGSIDFVMADVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=382, Percent_Identity=44.7643979057592, Blast_Score=339, Evalue=5e-93,
Organism=Homo sapiens, GI260898743, Length=372, Percent_Identity=44.6236559139785, Blast_Score=330, Evalue=3e-90,
Organism=Homo sapiens, GI4758788, Length=152, Percent_Identity=34.8684210526316, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI145693162, Length=594, Percent_Identity=57.2390572390572, Blast_Score=719, Evalue=0.0,
Organism=Escherichia coli, GI1789076, Length=492, Percent_Identity=27.6422764227642, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1788832, Length=506, Percent_Identity=26.2845849802372, Blast_Score=138, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17555284, Length=384, Percent_Identity=43.75, Blast_Score=353, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI17568379, Length=384, Percent_Identity=44.0104166666667, Blast_Score=351, Evalue=6e-97,
Organism=Drosophila melanogaster, GI221459469, Length=383, Percent_Identity=42.2976501305483, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24638644, Length=384, Percent_Identity=43.4895833333333, Blast_Score=350, Evalue=2e-96,
Organism=Drosophila melanogaster, GI24656494, Length=169, Percent_Identity=31.3609467455621, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOCD_GLUDA (A9HN95)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001602713.1
- RefSeq:   YP_002275121.1
- ProteinModelPortal:   A9HN95
- GeneID:   5789119
- GeneID:   6974113
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_0716
- HOGENOM:   HBG459705
- OMA:   FRARTIG
- ProtClustDB:   PRK11742
- GO:   GO:0006810
- HAMAP:   MF_01359
- InterPro:   IPR010219
- InterPro:   IPR023062
- InterPro:   IPR001135
- InterPro:   IPR001268
- InterPro:   IPR014029
- InterPro:   IPR020396
- InterPro:   IPR022885
- ProDom:   PD001581
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00329 Complex1_30kDa; PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 67085; Mature: 67085

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00542 COMPLEX1_30K; PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVPDLVADAMTAGPPAAKSGDGATMFGQVSDLGPGTVLAVETARDGVPTAWIAPTSLRA
CCCHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCEEEECCHHHHH
VVGMLREPAAALRMLFDLTAIDERQRAHRVGQPDCAFTLVCHFMALGGAGDALRLKVPLP
HHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCC
AEAPRVPSIADFWPNANWYEREVWDLFGITFEGHPFLRRILTPPTWTGHPLRKDHYARAT
CCCCCCCCHHHHCCCCCCHHHHHHHHHCEEECCCHHHHHHCCCCCCCCCCCCCCHHHHHC
EMPPYSLTEDQEMAEQQALRFDPGAWGMARHSAHSDFMFLNLGPNHPSVHGVFRIVLQLE
CCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCC
GERIVDAVPDIGFHHRGAEKMGERQSWHSFIPYTDRVDYLGGVMNNFPYVMAVEKLAGIT
CCHHHHHCCCCCCCCCCHHHHCCHHHHHCCCCCCCHHHHHHHHHHCCCHHEEHHHHHCCC
VPPRAQMIRVMLAELFRVASHLVFYGTMTQDVGQLSPVFYMFSDRERVFEIIEAICGFRM
CCCHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCC
HPAWFRIGGVAMDLPRGWDGLIRDFLDYLPPRLDEYEKMVMRNPIFRARTIGVGAYDVSE
CCHHEEECCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHEEECCCCHHHHH
AIAWGVTGPGLRACGLEWDLRRKVPYSGYDQLEFDIPTAQNGDCYDRVRVHIAEIRQSLR
HHCCCCCCCCCEECCCCCHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHH
IIRQCLDGMPAGAIKAEHRLTTPPPRARTMHDIETLIHHFLSVSWGPVIPPGEAHACVEA
HHHHHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
TKGLNSYHLISDGGTMSYRTRIRTPSFPHLQMIPLISRGGMIADLIAIIGSIDFVMADVD
HCCCCCEEEEECCCCEEEEEEECCCCCCCEEEEHHHHCCCHHHHHHHHHCCHHHHEECCC
R
C
>Mature Secondary Structure
MIVPDLVADAMTAGPPAAKSGDGATMFGQVSDLGPGTVLAVETARDGVPTAWIAPTSLRA
CCCHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCEEEECCHHHHH
VVGMLREPAAALRMLFDLTAIDERQRAHRVGQPDCAFTLVCHFMALGGAGDALRLKVPLP
HHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCC
AEAPRVPSIADFWPNANWYEREVWDLFGITFEGHPFLRRILTPPTWTGHPLRKDHYARAT
CCCCCCCCHHHHCCCCCCHHHHHHHHHCEEECCCHHHHHHCCCCCCCCCCCCCCHHHHHC
EMPPYSLTEDQEMAEQQALRFDPGAWGMARHSAHSDFMFLNLGPNHPSVHGVFRIVLQLE
CCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCC
GERIVDAVPDIGFHHRGAEKMGERQSWHSFIPYTDRVDYLGGVMNNFPYVMAVEKLAGIT
CCHHHHHCCCCCCCCCCHHHHCCHHHHHCCCCCCCHHHHHHHHHHCCCHHEEHHHHHCCC
VPPRAQMIRVMLAELFRVASHLVFYGTMTQDVGQLSPVFYMFSDRERVFEIIEAICGFRM
CCCHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCC
HPAWFRIGGVAMDLPRGWDGLIRDFLDYLPPRLDEYEKMVMRNPIFRARTIGVGAYDVSE
CCHHEEECCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHEEECCCCHHHHH
AIAWGVTGPGLRACGLEWDLRRKVPYSGYDQLEFDIPTAQNGDCYDRVRVHIAEIRQSLR
HHCCCCCCCCCEECCCCCHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHH
IIRQCLDGMPAGAIKAEHRLTTPPPRARTMHDIETLIHHFLSVSWGPVIPPGEAHACVEA
HHHHHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
TKGLNSYHLISDGGTMSYRTRIRTPSFPHLQMIPLISRGGMIADLIAIIGSIDFVMADVD
HCCCCCEEEEECCCCEEEEEEECCCCCCCEEEEHHHHCCCHHHHHHHHHCCHHHHEECCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA