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The map label for this gene is zitB [H]

Identifier: 162148144

GI number: 162148144

Start: 2435193

End: 2436185

Strand: Direct

Name: zitB [H]

Synonym: GDI_2361

Alternate gene names: 162148144

Gene position: 2435193-2436185 (Clockwise)

Preceding gene: 162148141

Following gene: 162148145

Centisome position: 61.74

GC content: 68.38

Gene sequence:

>993_bases
ATGACCACGCGCACGATGATGGACATGATCACGGTCACGATCATGGGCATGAGGGGCACGGACATGGATTCGGCCACCAT
CACGTCCATGCCCCGGCCAGTTTCGGCGCCGCCTTTTGCGTGGGGCATCGCGCTGAACCTGGTCTATGTCGTCGCCGAGG
CGACCTGGGGCGTGCTGTCCCACGCGCTCGCCCTGATGGCGGATGCCGGCCATAACCTGTCCGACGTCCTGGCGCTGGCG
GCGGCGTGGATGGCGCAGCACCTGTCGCGGCGCGCGCCCAGCGCCGATTTCACCTATGGACTGCGCCGCTCGTCCATCCT
GGCCGCGCTGGGCAATGCGGTGGCGCTGCTGCTGGTCACCGGCGGCATCGTGTGGGAGGCGATCCTGCGCCTGATCAACC
CCGCCCCGGTGCCCGGCACCACGATCATGGTGGTGGCGGGGATCGGAATCCTGGTCAACGGGATCACCGCCCTGCTGTTC
GCGCGGGGCGGGGAGGACCTGAACATCCGCGCCGCCTTCCTGCACATGGCGGCCGACACGCTGATGACGGTCGCGGTGGT
GATCGCGGGCGCGATCATCCTCTATACCGGCTGGACGCGCGTGGACCCCATCGTCAGCCTGGTCGTGTCGGTCACGATCG
TCGCCGGCACCTGGTCGCTGCTGCGCGATTCGCTGGACATGGCGCTGGACCGGGTGCCCCGCACGATCGACCGCGCCGGG
GTCGAGGCCTATCTGCGCACCCTGCCGGGGGTGCTGGACCTGCACGACCTGCATATCTGGCCGATCAGTACGACGGACAC
CGCCCTGACCGTGCATCTGGTGCGCGCCGCCTGCCCCGTTCCTCCGGGGGAGGAAGACGCCAGCGAGGACAGCCTGCTGC
GTGACGCGACCGAGGCACTGCGCACGCGCTTTCGCATCGGCCATCCCACCTTCCAGATCGAAACGCTGTCCTATTCCGCA
CGATGTGTCCTGGCGGACGCGAACACGATCTGA

Upstream 100 bases:

>100_bases
CCGGACGAGAACCACGCCGCCATGGCCGACCCGCACGATCAACCGCCCCCGCACCGGCACGATTCCGCCGAGGACCAAGC
GGGAGAGTGTGGCCACGGAC

Downstream 100 bases:

>100_bases
CCCATGCCGCATATCAGCAAGAACGCCCTGGCCTGGACCAGCCTGGGGGTCAGCCTGGTCGCCCTGAGCCTGAAATACGC
CGCCTGGCGCGTCACCGGCT

Product: Zinc transporter zitB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MTTRTMMDMITVTIMGMRGTDMDSATITSMPRPVSAPPFAWGIALNLVYVVAEATWGVLSHALALMADAGHNLSDVLALA
AAWMAQHLSRRAPSADFTYGLRRSSILAALGNAVALLLVTGGIVWEAILRLINPAPVPGTTIMVVAGIGILVNGITALLF
ARGGEDLNIRAAFLHMAADTLMTVAVVIAGAIILYTGWTRVDPIVSLVVSVTIVAGTWSLLRDSLDMALDRVPRTIDRAG
VEAYLRTLPGVLDLHDLHIWPISTTDTALTVHLVRAACPVPPGEEDASEDSLLRDATEALRTRFRIGHPTFQIETLSYSA
RCVLADANTI

Sequences:

>Translated_330_residues
MTTRTMMDMITVTIMGMRGTDMDSATITSMPRPVSAPPFAWGIALNLVYVVAEATWGVLSHALALMADAGHNLSDVLALA
AAWMAQHLSRRAPSADFTYGLRRSSILAALGNAVALLLVTGGIVWEAILRLINPAPVPGTTIMVVAGIGILVNGITALLF
ARGGEDLNIRAAFLHMAADTLMTVAVVIAGAIILYTGWTRVDPIVSLVVSVTIVAGTWSLLRDSLDMALDRVPRTIDRAG
VEAYLRTLPGVLDLHDLHIWPISTTDTALTVHLVRAACPVPPGEEDASEDSLLRDATEALRTRFRIGHPTFQIETLSYSA
RCVLADANTI
>Mature_329_residues
TTRTMMDMITVTIMGMRGTDMDSATITSMPRPVSAPPFAWGIALNLVYVVAEATWGVLSHALALMADAGHNLSDVLALAA
AWMAQHLSRRAPSADFTYGLRRSSILAALGNAVALLLVTGGIVWEAILRLINPAPVPGTTIMVVAGIGILVNGITALLFA
RGGEDLNIRAAFLHMAADTLMTVAVVIAGAIILYTGWTRVDPIVSLVVSVTIVAGTWSLLRDSLDMALDRVPRTIDRAGV
EAYLRTLPGVLDLHDLHIWPISTTDTALTVHLVRAACPVPPGEEDASEDSLLRDATEALRTRFRIGHPTFQIETLSYSAR
CVLADANTI

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=288, Percent_Identity=28.8194444444444, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI289803013, Length=285, Percent_Identity=28.0701754385965, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI289803009, Length=285, Percent_Identity=28.0701754385965, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI289803007, Length=285, Percent_Identity=28.0701754385965, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI289803003, Length=285, Percent_Identity=28.0701754385965, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI64762489, Length=285, Percent_Identity=28.0701754385965, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI21361112, Length=309, Percent_Identity=27.5080906148867, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI21359890, Length=299, Percent_Identity=25.0836120401338, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI14210520, Length=227, Percent_Identity=28.6343612334802, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI20070323, Length=321, Percent_Identity=24.6105919003115, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI52351208, Length=121, Percent_Identity=34.7107438016529, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786966, Length=288, Percent_Identity=37.1527777777778, Blast_Score=145, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI193210990, Length=296, Percent_Identity=30.0675675675676, Blast_Score=144, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17555796, Length=318, Percent_Identity=31.1320754716981, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17555794, Length=300, Percent_Identity=31.3333333333333, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6323899, Length=126, Percent_Identity=37.3015873015873, Blast_Score=82, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320411, Length=167, Percent_Identity=34.7305389221557, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324892, Length=124, Percent_Identity=35.4838709677419, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24583858, Length=311, Percent_Identity=27.0096463022508, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24584409, Length=161, Percent_Identity=30.4347826086957, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28574430, Length=162, Percent_Identity=30.2469135802469, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24585900, Length=176, Percent_Identity=27.2727272727273, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24585898, Length=176, Percent_Identity=27.2727272727273, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24585896, Length=176, Percent_Identity=27.2727272727273, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI19921672, Length=176, Percent_Identity=27.2727272727273, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24656728, Length=290, Percent_Identity=26.8965517241379, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24656724, Length=290, Percent_Identity=26.8965517241379, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24656720, Length=290, Percent_Identity=26.8965517241379, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24656715, Length=290, Percent_Identity=26.8965517241379, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357035, Length=290, Percent_Identity=26.8965517241379, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 35226; Mature: 35094

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRTMMDMITVTIMGMRGTDMDSATITSMPRPVSAPPFAWGIALNLVYVVAEATWGVLS
CCHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
HALALMADAGHNLSDVLALAAAWMAQHLSRRAPSADFTYGLRRSSILAALGNAVALLLVT
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GGIVWEAILRLINPAPVPGTTIMVVAGIGILVNGITALLFARGGEDLNIRAAFLHMAADT
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LMTVAVVIAGAIILYTGWTRVDPIVSLVVSVTIVAGTWSLLRDSLDMALDRVPRTIDRAG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEAYLRTLPGVLDLHDLHIWPISTTDTALTVHLVRAACPVPPGEEDASEDSLLRDATEAL
HHHHHHHCCCCEEEECEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
RTRFRIGHPTFQIETLSYSARCVLADANTI
HHHHHCCCCCEEEEEECCCCEEEEECCCCC
>Mature Secondary Structure 
TTRTMMDMITVTIMGMRGTDMDSATITSMPRPVSAPPFAWGIALNLVYVVAEATWGVLS
CHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
HALALMADAGHNLSDVLALAAAWMAQHLSRRAPSADFTYGLRRSSILAALGNAVALLLVT
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GGIVWEAILRLINPAPVPGTTIMVVAGIGILVNGITALLFARGGEDLNIRAAFLHMAADT
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LMTVAVVIAGAIILYTGWTRVDPIVSLVVSVTIVAGTWSLLRDSLDMALDRVPRTIDRAG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEAYLRTLPGVLDLHDLHIWPISTTDTALTVHLVRAACPVPPGEEDASEDSLLRDATEAL
HHHHHHHCCCCEEEECEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
RTRFRIGHPTFQIETLSYSARCVLADANTI
HHHHHCCCCCEEEEEECCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]