Click here to switch to the map view.

The map label for this gene is gabP [H]

Identifier: 162148014

GI number: 162148014

Start: 2284790

End: 2286160

Strand: Reverse

Name: gabP [H]

Synonym: GDI_2230

Alternate gene names: 162148014

Gene position: 2286160-2284790 (Counterclockwise)

Preceding gene: 162148015

Following gene: 162148013

Centisome position: 57.96

GC content: 68.27

Gene sequence:

>1371_bases
ATGCTGAAGGCTGCTCCCACGGGGGGCGGCCTGGCCCATTCGTTGCGCAGCCGCCACGTTTCGATGATCGCGATCGGCGG
GATGATCGGCGCCGGACTGTTCGTGAACACCTCGGTGATGATCCAGGGCGCGGGGCCGCTGGTGCTGCTGTCCTACCTGC
TGGCCGGGCTGATGGTGTTCCTGGTCATGCGCATGCTGGGTGAAATGGCGATCGACTGCCCCGATGCCGGGTCGTTCGTG
GGCCATGTCCGGCGCGGCCTGGGCCATCGGGCGGCCTTCGTCACAGGCTGGTCGTACTGGCTGTTCTGGGTTGTCGTGGC
GTCGGTCGAGGCCAAGGCGGCGGGCATGGTCGCGGGGCCGATGCTGGGGGTGCCGCCCCTGGGCGTGGCGCTGGGGCTGA
CGGCGGTCATGACCGGCGTGAACATGGGCTCGGTCCGGGGCTATGGCGAGTTCGAATTCTGGTTCTCGCTGATGAAGATC
ACGGCGATCGGCGTGTTCACGGTCATTGCCGGGCTGGCGCTGTTCGGGGTGATCGGGCCGCCGCTGCATGGCGGGCTTGC
GCATCTGTGGGACCAGGGCGGGTTCATGCCGCATGGCTTCAGCGCGTCGCTGTCCCTGCTGCCGGCGATCCTGTTCACCT
TCGCGGGGGCGGAAATCGCCACCGTCGCGGCGGCGGAAACCGACGACCCCGGCCGCAACATCGTCCAGGCCATCCGTACC
GTCGTGATCCGGGTGATGCTGTTCTACATGGCGTCGCTGGGCGTCATCCTGTGCCTGGTTCCGTGGAACCAGGTGCAGCC
CGGCCATTCCCCGTTCCTCGAGGTGCTGCACCGCATCGGCATTCCGGGGGCCGAGGGCGCGATGACGCTGGTGGTGCTGG
TCGCGATCGCCTCGTGCCTGAATTCCACCCTCTATGTCACCTCGCGCATCCTGTTCGAAATGGCGGCGCATGGCGACGCG
CCGGGCTGGCTGGTCCGAACCGGTCCCAGCGGCGCGCCGCGCCGGGCCATTTCCACTGGGGCGCTGGTGGCGTCCGTGCT
GACGGTGGTGGCCTCGACCTTCCCGGGCGAAGTCTTCGGCTTCCTGCTCAACGCCTCGGGCGCGGTGATCCTGTTCGACT
ACCTGATGGTGGTGTTCGCCCAGATCAGCCTGCGCCGCCAGATGAAGCGCGCGGGGCGCCATCCGGCCTTTCCGATGCTG
CTGTTTCCGTATCTGTCATGGCTGACGGTCGCCGCCATCCTGCTGGTGATGGTGACGATGATGCTGACCCCCGACACCCG
GGTGCAGATCGAACTGGGCAGCGTGACCCTGGCGCTGATCCTGGTCCTGGGGCTGGCCACCTCGCGCCGGGGCGGCCGCC
CGACGCTCTGA

Upstream 100 bases:

>100_bases
ACTTCGCCAACGGCGTGTCCGACCGGCTGGATATGGATTTCGGAGATTTTCGCATGCAAGGCACCTTGCGCAGCTTCACG
CCGGTGACGGCGGCCCGTCG

Downstream 100 bases:

>100_bases
CGGGTTCTTGTTACATACGGCCATCTTTCGCCATTCCGCCGCCACGATAATCGGACCACAATGCATTGACGGAGCGGCAG
GAATACCCGCCCGCATGCAG

Product: GABA permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MLKAAPTGGGLAHSLRSRHVSMIAIGGMIGAGLFVNTSVMIQGAGPLVLLSYLLAGLMVFLVMRMLGEMAIDCPDAGSFV
GHVRRGLGHRAAFVTGWSYWLFWVVVASVEAKAAGMVAGPMLGVPPLGVALGLTAVMTGVNMGSVRGYGEFEFWFSLMKI
TAIGVFTVIAGLALFGVIGPPLHGGLAHLWDQGGFMPHGFSASLSLLPAILFTFAGAEIATVAAAETDDPGRNIVQAIRT
VVIRVMLFYMASLGVILCLVPWNQVQPGHSPFLEVLHRIGIPGAEGAMTLVVLVAIASCLNSTLYVTSRILFEMAAHGDA
PGWLVRTGPSGAPRRAISTGALVASVLTVVASTFPGEVFGFLLNASGAVILFDYLMVVFAQISLRRQMKRAGRHPAFPML
LFPYLSWLTVAAILLVMVTMMLTPDTRVQIELGSVTLALILVLGLATSRRGGRPTL

Sequences:

>Translated_456_residues
MLKAAPTGGGLAHSLRSRHVSMIAIGGMIGAGLFVNTSVMIQGAGPLVLLSYLLAGLMVFLVMRMLGEMAIDCPDAGSFV
GHVRRGLGHRAAFVTGWSYWLFWVVVASVEAKAAGMVAGPMLGVPPLGVALGLTAVMTGVNMGSVRGYGEFEFWFSLMKI
TAIGVFTVIAGLALFGVIGPPLHGGLAHLWDQGGFMPHGFSASLSLLPAILFTFAGAEIATVAAAETDDPGRNIVQAIRT
VVIRVMLFYMASLGVILCLVPWNQVQPGHSPFLEVLHRIGIPGAEGAMTLVVLVAIASCLNSTLYVTSRILFEMAAHGDA
PGWLVRTGPSGAPRRAISTGALVASVLTVVASTFPGEVFGFLLNASGAVILFDYLMVVFAQISLRRQMKRAGRHPAFPML
LFPYLSWLTVAAILLVMVTMMLTPDTRVQIELGSVTLALILVLGLATSRRGGRPTL
>Mature_456_residues
MLKAAPTGGGLAHSLRSRHVSMIAIGGMIGAGLFVNTSVMIQGAGPLVLLSYLLAGLMVFLVMRMLGEMAIDCPDAGSFV
GHVRRGLGHRAAFVTGWSYWLFWVVVASVEAKAAGMVAGPMLGVPPLGVALGLTAVMTGVNMGSVRGYGEFEFWFSLMKI
TAIGVFTVIAGLALFGVIGPPLHGGLAHLWDQGGFMPHGFSASLSLLPAILFTFAGAEIATVAAAETDDPGRNIVQAIRT
VVIRVMLFYMASLGVILCLVPWNQVQPGHSPFLEVLHRIGIPGAEGAMTLVVLVAIASCLNSTLYVTSRILFEMAAHGDA
PGWLVRTGPSGAPRRAISTGALVASVLTVVASTFPGEVFGFLLNASGAVILFDYLMVVFAQISLRRQMKRAGRHPAFPML
LFPYLSWLTVAAILLVMVTMMLTPDTRVQIELGSVTLALILVLGLATSRRGGRPTL

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=340, Percent_Identity=25, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1789017, Length=430, Percent_Identity=42.093023255814, Blast_Score=337, Evalue=1e-93,
Organism=Escherichia coli, GI1786302, Length=446, Percent_Identity=35.4260089686099, Blast_Score=292, Evalue=3e-80,
Organism=Escherichia coli, GI1786789, Length=451, Percent_Identity=35.4767184035477, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI87081915, Length=405, Percent_Identity=36.0493827160494, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1790653, Length=433, Percent_Identity=31.4087759815243, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI48994972, Length=453, Percent_Identity=32.2295805739514, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI87081708, Length=470, Percent_Identity=31.7021276595745, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI1788480, Length=390, Percent_Identity=35.1282051282051, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1786602, Length=456, Percent_Identity=30.9210526315789, Blast_Score=197, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17532491, Length=367, Percent_Identity=25.3405994550409, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320772, Length=405, Percent_Identity=31.6049382716049, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6324061, Length=417, Percent_Identity=29.9760191846523, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6324924, Length=454, Percent_Identity=28.8546255506608, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6322892, Length=402, Percent_Identity=32.089552238806, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324553, Length=393, Percent_Identity=31.2977099236641, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6324990, Length=418, Percent_Identity=25.5980861244019, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321629, Length=403, Percent_Identity=29.0322580645161, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6324059, Length=400, Percent_Identity=28.25, Blast_Score=136, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6320717, Length=403, Percent_Identity=26.7990074441687, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319543, Length=402, Percent_Identity=25.8706467661692, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6319824, Length=398, Percent_Identity=26.6331658291457, Blast_Score=123, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6321053, Length=422, Percent_Identity=26.0663507109005, Blast_Score=123, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6319542, Length=407, Percent_Identity=24.8157248157248, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322967, Length=395, Percent_Identity=26.3291139240506, Blast_Score=116, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6320251, Length=409, Percent_Identity=25.6723716381418, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324981, Length=395, Percent_Identity=28.3544303797468, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319608, Length=432, Percent_Identity=23.8425925925926, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24667468, Length=340, Percent_Identity=22.6470588235294, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48051; Mature: 48051

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure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HHCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8297211; 9205837; 9278503 [H]