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The map label for this gene is norM [H]

Identifier: 162147982

GI number: 162147982

Start: 2249646

End: 2251046

Strand: Reverse

Name: norM [H]

Synonym: GDI_2198

Alternate gene names: 162147982

Gene position: 2251046-2249646 (Counterclockwise)

Preceding gene: 162147984

Following gene: 162147979

Centisome position: 57.07

GC content: 72.02

Gene sequence:

>1401_bases
ATGCCCGATCCAGCCTGTCCCGATTCATCCTCTCCCCCGGGGGAACTTCGCCTGTTGCTGCGCATCGCGGCCCCGATCGC
CCTGGCGCAGATCGCGCAGATGGCCATGGGCGTCACCGACAGCGTGCTGCTGGGCGGGCTGGGGGCCGACGCGCTGGCCA
TCGGCGGCCTGTCGACCATGCTGTTCTTCACGCTGCTGGTGATGCTGCAGGCCAATCTGGGGGCGGGCGGGGTGCTGATC
GCCCAGGCGCGTGGCAGCGGGGATGAGGGGCGCATCGCCTCGATCCACGCCATGCTGCTGGTCGTGGCGCTGCTGCTGTG
CGTACCCTTCCTGGCGCTGCTGACGCAGGCCGGCCCCCTGTTGCGGCTGATGCATCAGCCCGCGACGCTGGTCGGCCCGG
TCACGTCCTTCCTGCATATCCTGATGTGGGGCGTGCCGCCGGCGCTGATCGGCACGGGGGTGGTGGAAGTGGTGCTGCCG
GCGCTGGACGCGCAGGGTGTCCTGCTGCGGGTGATGCCGGTCGTGGCGGTGGTGAACGGCGTGCTGAACGCGGGGCTGAT
TCACGGATGGTTCGGCCTGCCGGCAATGGGGCTGCGCGGTTCGGCCCTGGCCACCACCCTGACCATGTGGGGCGCGGCGC
TGGTCCTGCTGGCGATGGTGCATTCCCGGCCGCATCTGCGCCTGCTGCTGTGGCCGCCGCGACCGCGGGCCGCCGACATG
GCGGTACTGCTGCGCCTGGGGGTGCCGATGATGATGGCGACGGGGGCCGAGATCATGCTGTTCCAGGTCACGGCGCTGCA
GGCGGCGACCCTGGGCCCCCATGCCCTGGCGGCGCACCAGATCGTACTGAACCTGACCGCGACCACCTACATGGCGATCA
TGGCGCTGGGACAGGCCGCGAACGTGCGGGTGGCCTACTGGACCGGGGCGGCGCGGCCGGCGCGGGCACGCCACGCGGCA
TGGGTGGCGGTCGGGACCGCGATCGCCGGCATGGTGGCCAGCGGCTGCCTGATCTACCTGTTCCGCGCGCGGCTGGTGGC
CTTCTATCTGGACCCGTCGGTGCCGGCCAATGCGGAGAGCACGCATATCGCCATGGCGGCGCTGCTGCTGGCGGCCGTGT
TCCAGGTGGCGGACGGCACGCAGGCGGTGCTGGTGGGTGCGCTGCGGGGACGCGGCGATGCGATCGTGCCGATGGTCCTG
GCCGTGCTGGGCTATTGGGGGATCGGCTTTCCGCTGGGCACGTGGCTGGCGTTCCGATGCGGCCTGGGCGTCGTCGGCCT
GTGGGGCGGCGTGGCGTGCGCGCTGGTGGCGGTGGCGCTGATGCTGGGGGTGCGGGCCGCGCGGACGCTGGGCGATCGCG
GGCCCGCGGCGGTCAGCGTGTCTCGATGCCGATCTGCTTGA

Upstream 100 bases:

>100_bases
CGGGGCGGACGCAACACCCTTGTGCGGCGGCAGGGACGAAAGGGGGGCATGGTCCCGCCGCGTCTGGTCTTTGCGGGGGC
GATCTGCTTTGGATGCGGGC

Downstream 100 bases:

>100_bases
TGTCGTGGAATGACAGGTCGAGGTTCATCTCGGCCGTGCGACGCATCATGAAGGCCGATCCGGCCAGGAAGACCGGATCG
CCGTCCAGGTCGTCCGCCAT

Product: multidrug ABC transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MPDPACPDSSSPPGELRLLLRIAAPIALAQIAQMAMGVTDSVLLGGLGADALAIGGLSTMLFFTLLVMLQANLGAGGVLI
AQARGSGDEGRIASIHAMLLVVALLLCVPFLALLTQAGPLLRLMHQPATLVGPVTSFLHILMWGVPPALIGTGVVEVVLP
ALDAQGVLLRVMPVVAVVNGVLNAGLIHGWFGLPAMGLRGSALATTLTMWGAALVLLAMVHSRPHLRLLLWPPRPRAADM
AVLLRLGVPMMMATGAEIMLFQVTALQAATLGPHALAAHQIVLNLTATTYMAIMALGQAANVRVAYWTGAARPARARHAA
WVAVGTAIAGMVASGCLIYLFRARLVAFYLDPSVPANAESTHIAMAALLLAAVFQVADGTQAVLVGALRGRGDAIVPMVL
AVLGYWGIGFPLGTWLAFRCGLGVVGLWGGVACALVAVALMLGVRAARTLGDRGPAAVSVSRCRSA

Sequences:

>Translated_466_residues
MPDPACPDSSSPPGELRLLLRIAAPIALAQIAQMAMGVTDSVLLGGLGADALAIGGLSTMLFFTLLVMLQANLGAGGVLI
AQARGSGDEGRIASIHAMLLVVALLLCVPFLALLTQAGPLLRLMHQPATLVGPVTSFLHILMWGVPPALIGTGVVEVVLP
ALDAQGVLLRVMPVVAVVNGVLNAGLIHGWFGLPAMGLRGSALATTLTMWGAALVLLAMVHSRPHLRLLLWPPRPRAADM
AVLLRLGVPMMMATGAEIMLFQVTALQAATLGPHALAAHQIVLNLTATTYMAIMALGQAANVRVAYWTGAARPARARHAA
WVAVGTAIAGMVASGCLIYLFRARLVAFYLDPSVPANAESTHIAMAALLLAAVFQVADGTQAVLVGALRGRGDAIVPMVL
AVLGYWGIGFPLGTWLAFRCGLGVVGLWGGVACALVAVALMLGVRAARTLGDRGPAAVSVSRCRSA
>Mature_465_residues
PDPACPDSSSPPGELRLLLRIAAPIALAQIAQMAMGVTDSVLLGGLGADALAIGGLSTMLFFTLLVMLQANLGAGGVLIA
QARGSGDEGRIASIHAMLLVVALLLCVPFLALLTQAGPLLRLMHQPATLVGPVTSFLHILMWGVPPALIGTGVVEVVLPA
LDAQGVLLRVMPVVAVVNGVLNAGLIHGWFGLPAMGLRGSALATTLTMWGAALVLLAMVHSRPHLRLLLWPPRPRAADMA
VLLRLGVPMMMATGAEIMLFQVTALQAATLGPHALAAHQIVLNLTATTYMAIMALGQAANVRVAYWTGAARPARARHAAW
VAVGTAIAGMVASGCLIYLFRARLVAFYLDPSVPANAESTHIAMAALLLAAVFQVADGTQAVLVGALRGRGDAIVPMVLA
VLGYWGIGFPLGTWLAFRCGLGVVGLWGGVACALVAVALMLGVRAARTLGDRGPAAVSVSRCRSA

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=445, Percent_Identity=26.7415730337079, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI153792564, Length=452, Percent_Identity=25.4424778761062, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI38261960, Length=266, Percent_Identity=27.4436090225564, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI48994890, Length=463, Percent_Identity=30.2375809935205, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI226510954, Length=435, Percent_Identity=24.8275862068966, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320545, Length=446, Percent_Identity=24.8878923766816, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47988; Mature: 47857

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDPACPDSSSPPGELRLLLRIAAPIALAQIAQMAMGVTDSVLLGGLGADALAIGGLSTM
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHH
LFFTLLVMLQANLGAGGVLIAQARGSGDEGRIASIHAMLLVVALLLCVPFLALLTQAGPL
HHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LRLMHQPATLVGPVTSFLHILMWGVPPALIGTGVVEVVLPALDAQGVLLRVMPVVAVVNG
HHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VLNAGLIHGWFGLPAMGLRGSALATTLTMWGAALVLLAMVHSRPHLRLLLWPPRPRAADM
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHH
AVLLRLGVPMMMATGAEIMLFQVTALQAATLGPHALAAHQIVLNLTATTYMAIMALGQAA
HHHHHHCCHHHHHCCCCEEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NVRVAYWTGAARPARARHAAWVAVGTAIAGMVASGCLIYLFRARLVAFYLDPSVPANAES
CEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCH
THIAMAALLLAAVFQVADGTQAVLVGALRGRGDAIVPMVLAVLGYWGIGFPLGTWLAFRC
HHHHHHHHHHHHHHHHCCCCHHHHEEHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHH
GLGVVGLWGGVACALVAVALMLGVRAARTLGDRGPAAVSVSRCRSA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHCCC
>Mature Secondary Structure 
PDPACPDSSSPPGELRLLLRIAAPIALAQIAQMAMGVTDSVLLGGLGADALAIGGLSTM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHH
LFFTLLVMLQANLGAGGVLIAQARGSGDEGRIASIHAMLLVVALLLCVPFLALLTQAGPL
HHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LRLMHQPATLVGPVTSFLHILMWGVPPALIGTGVVEVVLPALDAQGVLLRVMPVVAVVNG
HHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VLNAGLIHGWFGLPAMGLRGSALATTLTMWGAALVLLAMVHSRPHLRLLLWPPRPRAADM
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHH
AVLLRLGVPMMMATGAEIMLFQVTALQAATLGPHALAAHQIVLNLTATTYMAIMALGQAA
HHHHHHCCHHHHHCCCCEEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NVRVAYWTGAARPARARHAAWVAVGTAIAGMVASGCLIYLFRARLVAFYLDPSVPANAES
CEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCH
THIAMAALLLAAVFQVADGTQAVLVGALRGRGDAIVPMVLAVLGYWGIGFPLGTWLAFRC
HHHHHHHHHHHHHHHHCCCCHHHHEEHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHH
GLGVVGLWGGVACALVAVALMLGVRAARTLGDRGPAAVSVSRCRSA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA