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The map label for this gene is ubiB [C]

Identifier: 162147893

GI number: 162147893

Start: 2157952

End: 2159316

Strand: Reverse

Name: ubiB [C]

Synonym: GDI_2109

Alternate gene names: 162147893

Gene position: 2159316-2157952 (Counterclockwise)

Preceding gene: 162147894

Following gene: 162147892

Centisome position: 54.75

GC content: 67.18

Gene sequence:

>1365_bases
GTGGCGGAAGAACGGGATCTCGACAATACCGGGCTGTTCGGCGAATTCCGCCGGATGGTGCGGACCTCGGGCGCCGTCGG
CGGCATCGCGGCGCGGATCGCGGGGCACAAGATGGGCATCCGGACCGACCGGACGGCCCATGCCGGCGACCTGAAATCCA
TCCTTGGCGGGCTGAAGGGGCCGCTGATGAAGGGCGCGCAACTGCTGTCCACCATTCCCGGTGCCCTGCCCGAGGAATAT
GCCGTGGAACTGGCGCAGCTCCAGGCCAATGCCCCCGCGATGGGATGGAGCTTCGTGCGCCGGCGCATGGCCAGCGAACT
GGGCCGCGACTGGGAACGGCGCTTCCGCACCTTCGAGCACGAGGCCGCGGCCGCCGCCAGCCTGGGCCAGGTGCATCGGG
CCGTCCTGCCCGACGGGCGGCTGGTGGCGTGCAAGCTGCAATATCCCGACATGCAGGCCACGGTGGATTCCGACCTGCGG
CAGTTCCGCATGGCGGTGGGCCTGTATTACCGGATCGACAGTACCATCCAGCAGGATGACGTGCTGGTGGAACTGGAAGC
GCGCCTGCGCGAGGAACTGGATTACCTGCGCGAGGCCGCGAACCTGCGGCTCTATCGCCTGATGCTGGCCGATCGGCCCG
ATGTCAGCGTGCCCGCCCCGGTCGAGGACATGACGACCCGGCGGCTGCTGGTCATGGACTGGCTGGAGGGCCGCGGGGTG
CAGAAGGTCCTGGACACCAACCCGTCGCAGGACCAGCGCAATGCCATGGCGCGCGCGCTGTTCCATGCGTGGTACGTGCC
GCTGTACCGTTACGGCGTCATCCATGGCGACCCGCACATGGGCAATTTCACCGTGCGGGGCGATTACGGGCTGAACCTGC
TGGACCTGGGCGCGATCCGGATCTTCCCGGCTAGGTTCGTGCAGGGCATCATCGACCTGTACCGCGCGCTGGAACGCAAT
GACGAGGACCTGGCCTATCACGCCTATCAGGCCTGGGGCTTTACCAACATGTCGCGCGAGACGATGCGGATCCTCAATGA
ATGGGCCCGCTTCATCTACGAACCGCTGATGCAGGACCGGGTGCGTCCCATCCAGGAAAATGACGACCCGCAATTCGGCC
GCGCGGTGGCCGAACGCGTCTATGCCGGACTGAAGCGCACGGGCGGGGTGCGCCCGCCGCGCGAATTCGTGCTGGTGGAC
CGCTCCGCCATCGGGTTGGGCAGCGTGTTCCTGCGCCTGGGCGCGAAATTGAACTGGTACCGGCTGTTCCAGGAACTGAT
CGCCGATTTCGACGCGGCGCAACTGGCGGCCCGGCAGGCGGAGGCTATTCGGGTTGCCGGAGTGCCGACGCCGATCGAGG
CCTGA

Upstream 100 bases:

>100_bases
TTGCTGGCGCCGTTCGGGCTGGATGCGGCCGATCCCGGATTCTGGCGCAAGGGGCTGGATGTGATTGCCGGATTTATCGA
CGAGCTGGAGCGTGCCTGAC

Downstream 100 bases:

>100_bases
TCCGCATGAATGAAACGTCCGACGCGGACAGGGAGCCGTTGTCGCCGCCACTTTCCCGGCCGCTCTCCGGATGGACCAGG
GAGCGCCGGGCGATCGTCTT

Product: ubiquinone biosynthesis protein ubiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MAEERDLDNTGLFGEFRRMVRTSGAVGGIAARIAGHKMGIRTDRTAHAGDLKSILGGLKGPLMKGAQLLSTIPGALPEEY
AVELAQLQANAPAMGWSFVRRRMASELGRDWERRFRTFEHEAAAAASLGQVHRAVLPDGRLVACKLQYPDMQATVDSDLR
QFRMAVGLYYRIDSTIQQDDVLVELEARLREELDYLREAANLRLYRLMLADRPDVSVPAPVEDMTTRRLLVMDWLEGRGV
QKVLDTNPSQDQRNAMARALFHAWYVPLYRYGVIHGDPHMGNFTVRGDYGLNLLDLGAIRIFPARFVQGIIDLYRALERN
DEDLAYHAYQAWGFTNMSRETMRILNEWARFIYEPLMQDRVRPIQENDDPQFGRAVAERVYAGLKRTGGVRPPREFVLVD
RSAIGLGSVFLRLGAKLNWYRLFQELIADFDAAQLAARQAEAIRVAGVPTPIEA

Sequences:

>Translated_454_residues
MAEERDLDNTGLFGEFRRMVRTSGAVGGIAARIAGHKMGIRTDRTAHAGDLKSILGGLKGPLMKGAQLLSTIPGALPEEY
AVELAQLQANAPAMGWSFVRRRMASELGRDWERRFRTFEHEAAAAASLGQVHRAVLPDGRLVACKLQYPDMQATVDSDLR
QFRMAVGLYYRIDSTIQQDDVLVELEARLREELDYLREAANLRLYRLMLADRPDVSVPAPVEDMTTRRLLVMDWLEGRGV
QKVLDTNPSQDQRNAMARALFHAWYVPLYRYGVIHGDPHMGNFTVRGDYGLNLLDLGAIRIFPARFVQGIIDLYRALERN
DEDLAYHAYQAWGFTNMSRETMRILNEWARFIYEPLMQDRVRPIQENDDPQFGRAVAERVYAGLKRTGGVRPPREFVLVD
RSAIGLGSVFLRLGAKLNWYRLFQELIADFDAAQLAARQAEAIRVAGVPTPIEA
>Mature_453_residues
AEERDLDNTGLFGEFRRMVRTSGAVGGIAARIAGHKMGIRTDRTAHAGDLKSILGGLKGPLMKGAQLLSTIPGALPEEYA
VELAQLQANAPAMGWSFVRRRMASELGRDWERRFRTFEHEAAAAASLGQVHRAVLPDGRLVACKLQYPDMQATVDSDLRQ
FRMAVGLYYRIDSTIQQDDVLVELEARLREELDYLREAANLRLYRLMLADRPDVSVPAPVEDMTTRRLLVMDWLEGRGVQ
KVLDTNPSQDQRNAMARALFHAWYVPLYRYGVIHGDPHMGNFTVRGDYGLNLLDLGAIRIFPARFVQGIIDLYRALERND
EDLAYHAYQAWGFTNMSRETMRILNEWARFIYEPLMQDRVRPIQENDDPQFGRAVAERVYAGLKRTGGVRPPREFVLVDR
SAIGLGSVFLRLGAKLNWYRLFQELIADFDAAQLAARQAEAIRVAGVPTPIEA

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI27363457, Length=364, Percent_Identity=27.4725274725275, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI217416386, Length=364, Percent_Identity=27.4725274725275, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI40254938, Length=276, Percent_Identity=28.6231884057971, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI34147522, Length=399, Percent_Identity=23.8095238095238, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI41393593, Length=267, Percent_Identity=30.7116104868914, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI217035081, Length=212, Percent_Identity=29.2452830188679, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI2367309, Length=239, Percent_Identity=27.6150627615063, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI32565180, Length=299, Percent_Identity=27.7591973244147, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17559152, Length=256, Percent_Identity=26.953125, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321319, Length=381, Percent_Identity=27.5590551181102, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323282, Length=308, Percent_Identity=23.3766233766234, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI18859849, Length=392, Percent_Identity=27.2959183673469, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI22024280, Length=228, Percent_Identity=28.9473684210526, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24662575, Length=311, Percent_Identity=26.6881028938907, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 51320; Mature: 51188

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEERDLDNTGLFGEFRRMVRTSGAVGGIAARIAGHKMGIRTDRTAHAGDLKSILGGLKG
CCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCC
PLMKGAQLLSTIPGALPEEYAVELAQLQANAPAMGWSFVRRRMASELGRDWERRFRTFEH
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHH
EAAAAASLGQVHRAVLPDGRLVACKLQYPDMQATVDSDLRQFRMAVGLYYRIDSTIQQDD
HHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCC
VLVELEARLREELDYLREAANLRLYRLMLADRPDVSVPAPVEDMTTRRLLVMDWLEGRGV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCH
QKVLDTNPSQDQRNAMARALFHAWYVPLYRYGVIHGDPHMGNFTVRGDYGLNLLDLGAIR
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCEEEECCCCCCHHHHHHHH
IFPARFVQGIIDLYRALERNDEDLAYHAYQAWGFTNMSRETMRILNEWARFIYEPLMQDR
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VRPIQENDDPQFGRAVAERVYAGLKRTGGVRPPREFVLVDRSAIGLGSVFLRLGAKLNWY
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHEEEECCCHHHHHHHHHHHCCCCHHH
RLFQELIADFDAAQLAARQAEAIRVAGVPTPIEA
HHHHHHHHCCCHHHHHHHHHHHEEECCCCCCCCC
>Mature Secondary Structure 
AEERDLDNTGLFGEFRRMVRTSGAVGGIAARIAGHKMGIRTDRTAHAGDLKSILGGLKG
CCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCC
PLMKGAQLLSTIPGALPEEYAVELAQLQANAPAMGWSFVRRRMASELGRDWERRFRTFEH
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHH
EAAAAASLGQVHRAVLPDGRLVACKLQYPDMQATVDSDLRQFRMAVGLYYRIDSTIQQDD
HHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCC
VLVELEARLREELDYLREAANLRLYRLMLADRPDVSVPAPVEDMTTRRLLVMDWLEGRGV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCH
QKVLDTNPSQDQRNAMARALFHAWYVPLYRYGVIHGDPHMGNFTVRGDYGLNLLDLGAIR
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCEEEECCCCCCHHHHHHHH
IFPARFVQGIIDLYRALERNDEDLAYHAYQAWGFTNMSRETMRILNEWARFIYEPLMQDR
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VRPIQENDDPQFGRAVAERVYAGLKRTGGVRPPREFVLVDRSAIGLGSVFLRLGAKLNWY
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHEEEECCCHHHHHHHHHHHCCCCHHH
RLFQELIADFDAAQLAARQAEAIRVAGVPTPIEA
HHHHHHHHCCCHHHHHHHHHHHEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]