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The map label for this gene is pepA [H]

Identifier: 162147812

GI number: 162147812

Start: 2070293

End: 2071738

Strand: Reverse

Name: pepA [H]

Synonym: GDI_2028

Alternate gene names: 162147812

Gene position: 2071738-2070293 (Counterclockwise)

Preceding gene: 162147816

Following gene: 162147811

Centisome position: 52.53

GC content: 69.92

Gene sequence:

>1446_bases
ATGTCTATCGAGGAATTTCCCTGCCTGTTGCCCCCGACGCGGGGCCGCCGCGCCGGCGTGCGGACGATTCACGCCCTGCC
GCAGGCCGAACTGGGCACCCTGGGCGAGCGAATCGGGGCAACGGGCGCCGCCTTCGCGCGGGATACCGGCTTTCAGGCCC
GTCCCGGAGAACTGGCGCTGATTCCCGGTGCCAACGGCGTGGCGGCGGCGGTGCTGGGTGTGCGCACGGGGGCGGACGGC
GGGGCGGCCGATCCGTTCCAGTTCGGCGGTCTGGCCGGGTCGCTGCCGCCCGGGGCGTGGAAGATCGCGCTGCCCGATGG
TGTGGCGCCCGCGACGGCGGTCCTGGGCTTCTGCCTGGGGGCCTATCGCATGCCGGCCTTCGGACGGGCTGAGGCGTCGC
CGCCGGGCAAGGACATCGCCCGCCTGATCGTGCCGGCGGGCGGCGGGGCAGGGGCCGAAGTGGCCCATGCGATCCGGCTG
GGCAGGGACCTGATCAACACGCCGCCCAACCTGATGGGCCCGGCCGAACTGGCCCGCGCCGCCCGCCATATGCTGAATCC
GCTGGGCGCGCGGGTCGAAACGGTCAAGGGGCGTGACCTGGCCCGCGCCTATCCCACCATCGCGCATGTCGGCGCCGGAT
CGGCCCGGGCACCGAAGGTCGTCATCGCGCGTTGGCAGGGCAGCGCCGCCGGTCCCGATGCCCCCCTGCTGTCGCTGGTG
GGCAAGGGCGTGTGCTTCGATACCGGCGGGTACGACCTGAAGCAGCCATCGGGGATGCTGCGCATGAAGAAGGACATGGG
CGGTGCGGCGGTGATGCTGTCGCTGGCGCACCTGATCCTGACCCGCGACCTGCCGATCCGCCTGGAACTGCGGCTGGGCT
GCGTGGAAAACAGCGTGTCGGGCGAGGCGATGCGGCCCTCGGACGTGGTCGTGACCCGCTCGGGCCTGACGGTGGAAATC
GGTAACACCGATGCCGAAGGGCGCCTGGTCCTGTGCGACCTGCTGACCGATGCCTGTGCCGCCGCCCCGGACCTGCTGAT
CGACGCGGCCACCCTGACCGGCGCCGCGCGGGTGGCGCTGGGTCCGGACCTGCCGGCCCTGTTCAGCCCCGACGACGCCG
TCGCCCAGGCGATCCTGGAAGCCGGCACGGCCCAGTGCGATCCGCTGTGGCGGCTGCCGCTATGGGACGGATACGCCGAC
TGGCTGCGGAGTCCGGTGGCCGACCTGAACAACGTATCGGCCAAGCCGATGGCCGGATCCGTCACGGCGGCGCTTTTTTT
GCGAAATTTTGTCAAAACAGACGTGCGCTGGGCACATATCGACCTCTACGGCTGGAACGATCATTACAAGCCCGGACGGC
CCGAAGGAGGGGAAACGCCTATTTTGCGGGCAGTTTATGCCTCATTGTTGCGAATCCTTAATGTCGCGGACAGGGTGTCA
CACTAA

Upstream 100 bases:

>100_bases
CAAGCAAAACCCGCATGGGAAACGTGGAATTGCGCGCCGGCGGTTGCGTTGCCGCCGCCAGGGACGCACGCTGGCGGCCA
CTGGATCGCGGAGATCGCTG

Downstream 100 bases:

>100_bases
AGTAACGATTTAGGGAATGAACTATATGGCGGCTCGGACTTATATATGCCGCATTCTGAAACTATATAGAGCATTGGAAT
GACTGAGGGGCTCCGGCAGC

Product: cytosol aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MSIEEFPCLLPPTRGRRAGVRTIHALPQAELGTLGERIGATGAAFARDTGFQARPGELALIPGANGVAAAVLGVRTGADG
GAADPFQFGGLAGSLPPGAWKIALPDGVAPATAVLGFCLGAYRMPAFGRAEASPPGKDIARLIVPAGGGAGAEVAHAIRL
GRDLINTPPNLMGPAELARAARHMLNPLGARVETVKGRDLARAYPTIAHVGAGSARAPKVVIARWQGSAAGPDAPLLSLV
GKGVCFDTGGYDLKQPSGMLRMKKDMGGAAVMLSLAHLILTRDLPIRLELRLGCVENSVSGEAMRPSDVVVTRSGLTVEI
GNTDAEGRLVLCDLLTDACAAAPDLLIDAATLTGAARVALGPDLPALFSPDDAVAQAILEAGTAQCDPLWRLPLWDGYAD
WLRSPVADLNNVSAKPMAGSVTAALFLRNFVKTDVRWAHIDLYGWNDHYKPGRPEGGETPILRAVYASLLRILNVADRVS
H

Sequences:

>Translated_481_residues
MSIEEFPCLLPPTRGRRAGVRTIHALPQAELGTLGERIGATGAAFARDTGFQARPGELALIPGANGVAAAVLGVRTGADG
GAADPFQFGGLAGSLPPGAWKIALPDGVAPATAVLGFCLGAYRMPAFGRAEASPPGKDIARLIVPAGGGAGAEVAHAIRL
GRDLINTPPNLMGPAELARAARHMLNPLGARVETVKGRDLARAYPTIAHVGAGSARAPKVVIARWQGSAAGPDAPLLSLV
GKGVCFDTGGYDLKQPSGMLRMKKDMGGAAVMLSLAHLILTRDLPIRLELRLGCVENSVSGEAMRPSDVVVTRSGLTVEI
GNTDAEGRLVLCDLLTDACAAAPDLLIDAATLTGAARVALGPDLPALFSPDDAVAQAILEAGTAQCDPLWRLPLWDGYAD
WLRSPVADLNNVSAKPMAGSVTAALFLRNFVKTDVRWAHIDLYGWNDHYKPGRPEGGETPILRAVYASLLRILNVADRVS
H
>Mature_480_residues
SIEEFPCLLPPTRGRRAGVRTIHALPQAELGTLGERIGATGAAFARDTGFQARPGELALIPGANGVAAAVLGVRTGADGG
AADPFQFGGLAGSLPPGAWKIALPDGVAPATAVLGFCLGAYRMPAFGRAEASPPGKDIARLIVPAGGGAGAEVAHAIRLG
RDLINTPPNLMGPAELARAARHMLNPLGARVETVKGRDLARAYPTIAHVGAGSARAPKVVIARWQGSAAGPDAPLLSLVG
KGVCFDTGGYDLKQPSGMLRMKKDMGGAAVMLSLAHLILTRDLPIRLELRLGCVENSVSGEAMRPSDVVVTRSGLTVEIG
NTDAEGRLVLCDLLTDACAAAPDLLIDAATLTGAARVALGPDLPALFSPDDAVAQAILEAGTAQCDPLWRLPLWDGYADW
LRSPVADLNNVSAKPMAGSVTAALFLRNFVKTDVRWAHIDLYGWNDHYKPGRPEGGETPILRAVYASLLRILNVADRVSH

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=298, Percent_Identity=35.9060402684564, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI47155554, Length=299, Percent_Identity=31.438127090301, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI87082123, Length=287, Percent_Identity=45.993031358885, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1790710, Length=285, Percent_Identity=40, Blast_Score=185, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=302, Percent_Identity=34.1059602649007, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17565172, Length=317, Percent_Identity=27.7602523659306, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355725, Length=293, Percent_Identity=31.740614334471, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24661038, Length=293, Percent_Identity=31.740614334471, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI20129969, Length=294, Percent_Identity=32.6530612244898, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI221379063, Length=301, Percent_Identity=32.5581395348837, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI221379062, Length=301, Percent_Identity=32.5581395348837, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI21357381, Length=301, Percent_Identity=32.5581395348837, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24662227, Length=298, Percent_Identity=30.8724832214765, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21355645, Length=293, Percent_Identity=30.0341296928328, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24662223, Length=293, Percent_Identity=30.0341296928328, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI161077148, Length=435, Percent_Identity=28.0459770114943, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI20130057, Length=435, Percent_Identity=28.0459770114943, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI20129963, Length=294, Percent_Identity=33.6734693877551, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI19922386, Length=304, Percent_Identity=29.9342105263158, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24646701, Length=216, Percent_Identity=31.4814814814815, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646703, Length=216, Percent_Identity=31.4814814814815, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21358201, Length=216, Percent_Identity=31.4814814814815, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 49969; Mature: 49838

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIEEFPCLLPPTRGRRAGVRTIHALPQAELGTLGERIGATGAAFARDTGFQARPGELAL
CCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCHHHHCCCCCCCCCCEEE
IPGANGVAAAVLGVRTGADGGAADPFQFGGLAGSLPPGAWKIALPDGVAPATAVLGFCLG
EECCCCHHHHHHHEEECCCCCCCCCHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHH
AYRMPAFGRAEASPPGKDIARLIVPAGGGAGAEVAHAIRLGRDLINTPPNLMGPAELARA
HHCCCCCCCCCCCCCHHHEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
ARHMLNPLGARVETVKGRDLARAYPTIAHVGAGSARAPKVVIARWQGSAAGPDAPLLSLV
HHHHHHHHCCCEEECCCCHHHHHCCHHHCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHH
GKGVCFDTGGYDLKQPSGMLRMKKDMGGAAVMLSLAHLILTRDLPIRLELRLGCVENSVS
CCCCEEECCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCC
GEAMRPSDVVVTRSGLTVEIGNTDAEGRLVLCDLLTDACAAAPDLLIDAATLTGAARVAL
CCCCCCCCEEEEECCCEEEECCCCCCCCEEEHHHHHHHHHCCCHHHEEHHHHCCCEEEEE
GPDLPALFSPDDAVAQAILEAGTAQCDPLWRLPLWDGYADWLRSPVADLNNVSAKPMAGS
CCCCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHCHHHHHHCCCCCCCCCH
VTAALFLRNFVKTDVRWAHIDLYGWNDHYKPGRPEGGETPILRAVYASLLRILNVADRVS
HHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
H
C
>Mature Secondary Structure 
SIEEFPCLLPPTRGRRAGVRTIHALPQAELGTLGERIGATGAAFARDTGFQARPGELAL
CCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCHHHHCCCCCCCCCCEEE
IPGANGVAAAVLGVRTGADGGAADPFQFGGLAGSLPPGAWKIALPDGVAPATAVLGFCLG
EECCCCHHHHHHHEEECCCCCCCCCHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHH
AYRMPAFGRAEASPPGKDIARLIVPAGGGAGAEVAHAIRLGRDLINTPPNLMGPAELARA
HHCCCCCCCCCCCCCHHHEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
ARHMLNPLGARVETVKGRDLARAYPTIAHVGAGSARAPKVVIARWQGSAAGPDAPLLSLV
HHHHHHHHCCCEEECCCCHHHHHCCHHHCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHH
GKGVCFDTGGYDLKQPSGMLRMKKDMGGAAVMLSLAHLILTRDLPIRLELRLGCVENSVS
CCCCEEECCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCC
GEAMRPSDVVVTRSGLTVEIGNTDAEGRLVLCDLLTDACAAAPDLLIDAATLTGAARVAL
CCCCCCCCEEEEECCCEEEECCCCCCCCEEEHHHHHHHHHCCCHHHEEHHHHCCCEEEEE
GPDLPALFSPDDAVAQAILEAGTAQCDPLWRLPLWDGYADWLRSPVADLNNVSAKPMAGS
CCCCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHCHHHHHHCCCCCCCCCH
VTAALFLRNFVKTDVRWAHIDLYGWNDHYKPGRPEGGETPILRAVYASLLRILNVADRVS
HHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
H
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]