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The map label for this gene is gppA [H]

Identifier: 162147793

GI number: 162147793

Start: 2048097

End: 2049605

Strand: Reverse

Name: gppA [H]

Synonym: GDI_2009

Alternate gene names: 162147793

Gene position: 2049605-2048097 (Counterclockwise)

Preceding gene: 162147794

Following gene: 162147792

Centisome position: 51.97

GC content: 70.11

Gene sequence:

>1509_bases
GTGCGGGGCCCGATGACCCGGGCCGGCAGCACCCATCGCCGGTCGGCCGTCGTCGATCTGGGGTCGAATTCCGTCCGGCT
GGTCGTCTTCGACGGTATCACCCGCAATCCGATTCCCATCTTCAACGAAAAGGCCGTGCTGCGCCTGGGGCGCGGGCTGA
ACGCCACCGGACGCCTGAACGAGGAAGGCGTCGGCGCGGCCATACAGGTCATGGACCGGTTCTATGCCATTGCCCGGGGC
ATGGATGCCGATCCGTTCGAAATCCTGTCCACGGCGGCCGTCCGCGATGCCTCCAACGGGGGGGAATTCGTCGAGACCCT
GCGCGCGCGGATGCCGGGCGTGCCGATCCGCATCCTGTCGGGCGAGGAAGAAGCCGATTATTCCGCCACCGGCGTGCTGT
GCGGCCTGCCGGAGGCCGACGGGCTGGTGGCCGATATCGGTGGCGGCTCGCTGGAACTGATCCGCCTGTCCGGCGGGCAG
AAGCTGGATGCCTGCACCCTGCGCCTGGGCGTGATCCGGCTGAACGACCGGTCCGAGAACGATCTGGCGAAGGCGCGTGC
CATCGCGGATGCCGACATCGCGCAGGTCGGATGGCTGGACGACATGCAGGGGCGGCCGCTCTACCTGGTCGGCGGCGCCT
TCCGCGCGCTGGCCCGGCTGCAGATCGCCCGCACCAATTACCCGCTGAATATCGTGCATCTTTATACGATGTCGGGCGAC
GGCGCGAAGGACATGGCCGACTGGGCCGCCAGCACGCCGCGCCGCACGCTGGAACGCCTGCCCGGCGCGCCGCGCAAGCG
GCTGGACGACGTTCCGTTCGCCGCCACCGTGCTGCGCCGCCTGATCCGCCGCGTCCAGCCGACCTGCGTGGTGGTTTCGG
TCGATGGCCTGCGCGAGGGCTGGTACATGCGCCGCGTCGCCGCATCGGTGAAGGCGCTGGACCCGCAGGAAGCCGTGGCG
CATGAGATGTGTACCCGCCTGGGACGCAGCGAGACCCTGCCCGACCGGCTGATGACATGGACCGCGCCGCTGTTCGCCGA
CGAAGACCCGTCGATGCGCCGCCTGCGCCGTGCCGCCTGCCTGATGTCCGATATCGGTTCGTACGATCACCCGGAATATC
GGGCTGAACAGACTTATCTGCGCGTGCTGCGCATGCAGGGGGTGGGGTTCGACCACCCGGCCCGCGCCTTCGTCGCCCTG
ACCCTGGCCGTGCGGTACGAGGCCGAACTGGGGCAGGAGTTCCTGCAGCCGTCGCGCCTTCTGCTGCCGCCCGAACAGTA
CGGGCGCGCGGTGGTGCTGGGGCTGGCGCTGCGCCTGGCCTATACGGTCTGCGGCGGGACCGAGGAACTGCTCGACGGAA
CCTGGGTGGGCATGTCGAAGCAGGGCCTGGCACTGCACCTGTCGGCCGGCCGTGGCGTGGTGCGGGGCGAGAGCGTACGC
CGCCGCCTGGACCGGCTGGCCGACGCCCTGTCGCTGCCCGCCCGGATCGAGGAGGCCGCCACGGCATGA

Upstream 100 bases:

>100_bases
CCAGGACCGGATTCTCGATGATTGAGGATGTCGCCATGACGCAGTTCCCGCATCAGGCCAGTTCCCTGCCGCCCGCCCCT
CCGTCACCCGCCGCGCGCGC

Downstream 100 bases:

>100_bases
AGCGCGTCCTTCTGGGTGCCGCCGTTCCGGCCATGCTGGCGGCGGGCATCCTGCTGACGGTGGCCAGGGCCAGCGGTCCC
GCACGGCTGAACAATGATCC

Product: guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MRGPMTRAGSTHRRSAVVDLGSNSVRLVVFDGITRNPIPIFNEKAVLRLGRGLNATGRLNEEGVGAAIQVMDRFYAIARG
MDADPFEILSTAAVRDASNGGEFVETLRARMPGVPIRILSGEEEADYSATGVLCGLPEADGLVADIGGGSLELIRLSGGQ
KLDACTLRLGVIRLNDRSENDLAKARAIADADIAQVGWLDDMQGRPLYLVGGAFRALARLQIARTNYPLNIVHLYTMSGD
GAKDMADWAASTPRRTLERLPGAPRKRLDDVPFAATVLRRLIRRVQPTCVVVSVDGLREGWYMRRVAASVKALDPQEAVA
HEMCTRLGRSETLPDRLMTWTAPLFADEDPSMRRLRRAACLMSDIGSYDHPEYRAEQTYLRVLRMQGVGFDHPARAFVAL
TLAVRYEAELGQEFLQPSRLLLPPEQYGRAVVLGLALRLAYTVCGGTEELLDGTWVGMSKQGLALHLSAGRGVVRGESVR
RRLDRLADALSLPARIEEAATA

Sequences:

>Translated_502_residues
MRGPMTRAGSTHRRSAVVDLGSNSVRLVVFDGITRNPIPIFNEKAVLRLGRGLNATGRLNEEGVGAAIQVMDRFYAIARG
MDADPFEILSTAAVRDASNGGEFVETLRARMPGVPIRILSGEEEADYSATGVLCGLPEADGLVADIGGGSLELIRLSGGQ
KLDACTLRLGVIRLNDRSENDLAKARAIADADIAQVGWLDDMQGRPLYLVGGAFRALARLQIARTNYPLNIVHLYTMSGD
GAKDMADWAASTPRRTLERLPGAPRKRLDDVPFAATVLRRLIRRVQPTCVVVSVDGLREGWYMRRVAASVKALDPQEAVA
HEMCTRLGRSETLPDRLMTWTAPLFADEDPSMRRLRRAACLMSDIGSYDHPEYRAEQTYLRVLRMQGVGFDHPARAFVAL
TLAVRYEAELGQEFLQPSRLLLPPEQYGRAVVLGLALRLAYTVCGGTEELLDGTWVGMSKQGLALHLSAGRGVVRGESVR
RRLDRLADALSLPARIEEAATA
>Mature_502_residues
MRGPMTRAGSTHRRSAVVDLGSNSVRLVVFDGITRNPIPIFNEKAVLRLGRGLNATGRLNEEGVGAAIQVMDRFYAIARG
MDADPFEILSTAAVRDASNGGEFVETLRARMPGVPIRILSGEEEADYSATGVLCGLPEADGLVADIGGGSLELIRLSGGQ
KLDACTLRLGVIRLNDRSENDLAKARAIADADIAQVGWLDDMQGRPLYLVGGAFRALARLQIARTNYPLNIVHLYTMSGD
GAKDMADWAASTPRRTLERLPGAPRKRLDDVPFAATVLRRLIRRVQPTCVVVSVDGLREGWYMRRVAASVKALDPQEAVA
HEMCTRLGRSETLPDRLMTWTAPLFADEDPSMRRLRRAACLMSDIGSYDHPEYRAEQTYLRVLRMQGVGFDHPARAFVAL
TLAVRYEAELGQEFLQPSRLLLPPEQYGRAVVLGLALRLAYTVCGGTEELLDGTWVGMSKQGLALHLSAGRGVVRGESVR
RRLDRLADALSLPARIEEAATA

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=174, Percent_Identity=31.6091954022989, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788848, Length=197, Percent_Identity=28.4263959390863, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 54811; Mature: 54811

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGPMTRAGSTHRRSAVVDLGSNSVRLVVFDGITRNPIPIFNEKAVLRLGRGLNATGRLN
CCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCC
EEGVGAAIQVMDRFYAIARGMDADPFEILSTAAVRDASNGGEFVETLRARMPGVPIRILS
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEC
GEEEADYSATGVLCGLPEADGLVADIGGGSLELIRLSGGQKLDACTLRLGVIRLNDRSEN
CCCCCCCCCCEEEECCCCCCCEEEECCCCCEEEEEECCCCEEEEEEEEEEEEEECCCCCH
DLAKARAIADADIAQVGWLDDMQGRPLYLVGGAFRALARLQIARTNYPLNIVHLYTMSGD
HHHHHHHHHCCCHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHCCCCEEEEEEEEECCC
GAKDMADWAASTPRRTLERLPGAPRKRLDDVPFAATVLRRLIRRVQPTCVVVSVDGLREG
CCHHHHHHHCCCHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCH
WYMRRVAASVKALDPQEAVAHEMCTRLGRSETLPDRLMTWTAPLFADEDPSMRRLRRAAC
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHH
LMSDIGSYDHPEYRAEQTYLRVLRMQGVGFDHPARAFVALTLAVRYEAELGQEFLQPSRL
HHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LLPPEQYGRAVVLGLALRLAYTVCGGTEELLDGTWVGMSKQGLALHLSAGRGVVRGESVR
ECCHHHHCHHHHHHHHHHHHHHHCCCCHHHHCCEECCCCCCCEEEEEECCCCCCCCHHHH
RRLDRLADALSLPARIEEAATA
HHHHHHHHHHCCCHHHHHHCCC
>Mature Secondary Structure
MRGPMTRAGSTHRRSAVVDLGSNSVRLVVFDGITRNPIPIFNEKAVLRLGRGLNATGRLN
CCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCC
EEGVGAAIQVMDRFYAIARGMDADPFEILSTAAVRDASNGGEFVETLRARMPGVPIRILS
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEC
GEEEADYSATGVLCGLPEADGLVADIGGGSLELIRLSGGQKLDACTLRLGVIRLNDRSEN
CCCCCCCCCCEEEECCCCCCCEEEECCCCCEEEEEECCCCEEEEEEEEEEEEEECCCCCH
DLAKARAIADADIAQVGWLDDMQGRPLYLVGGAFRALARLQIARTNYPLNIVHLYTMSGD
HHHHHHHHHCCCHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHCCCCEEEEEEEEECCC
GAKDMADWAASTPRRTLERLPGAPRKRLDDVPFAATVLRRLIRRVQPTCVVVSVDGLREG
CCHHHHHHHCCCHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCH
WYMRRVAASVKALDPQEAVAHEMCTRLGRSETLPDRLMTWTAPLFADEDPSMRRLRRAAC
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHH
LMSDIGSYDHPEYRAEQTYLRVLRMQGVGFDHPARAFVALTLAVRYEAELGQEFLQPSRL
HHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LLPPEQYGRAVVLGLALRLAYTVCGGTEELLDGTWVGMSKQGLALHLSAGRGVVRGESVR
ECCHHHHCHHHHHHHHHHHHHHHCCCCHHHHCCEECCCCCCCEEEEEECCCCCCCCHHHH
RRLDRLADALSLPARIEEAATA
HHHHHHHHHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA