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The map label for this gene is purL [H]

Identifier: 162147744

GI number: 162147744

Start: 1994308

End: 1996521

Strand: Direct

Name: purL [H]

Synonym: GDI_1960

Alternate gene names: 162147744

Gene position: 1994308-1996521 (Clockwise)

Preceding gene: 162147743

Following gene: 162147745

Centisome position: 50.56

GC content: 68.52

Gene sequence:

>2214_bases
ATGAGCAGCGAAAAGGGACAGCGACCTGTCGATCAGGACCTGGCGAAGGAATTCGGGCTGACCGCGGAAGAATACGGCAA
CGTCCTGTCGATCATGGGCCGCACGCCCTCGCTGACCGAACTGGGCATCTTTTCGGTCATGTGGTCGGAGCATTGTTCGT
ACAAATCGTCGCGCGTATGGCTGAAGACGCTGCCGACCACGGCGCCGTGGGTGATCCACGGACCGGGCGAGAATGCCGGC
GTCGTCGATATCGGCCAGGGCCTGGCAGCCATCTTCAAGATGGAAAGCCATAACCATCCGTCGTTCATCGAACCCTACCA
GGGGGCGGCGACCGGCGTGGGCGGCATCCTGCGCGACGTGTTCACCATGGGCGCGCGGCCGGTGGCGAACCTGAACGCCC
TGCGCTTCGGCAGTCCCGAAAACCCGCAGACCCGTCGCATCGTCGACGGCGTGGTGCGCGGCGTGGGCGGATACGGCAAT
TGCGTCGGGGTGCCGACCGTGGGCGGGGAAATCAATTTCCACCCGTCCTATGACGGCAATCCGCTGGTCAACGCCATGAC
GGTGGGCATCGCCCGCCAGGACCGGATCTTCCTTTCCGCCGCGGCGGGGGTGGGCAATCCGGTGATCTATGTCGGGTCCA
AGACCGGGCGCGACGGCATCCATGGCGCCACCATGTCCTCGTCCGAATTCGACGAGGACGCGCTGGCCAAGCGCCCCACC
GTGCAGGTCGGCGACCCGTTCGTGGAAAAGTTGCTGATCGAGGCCTGCCTGGAACTGATGGCCACCGACGCCATCGTGGC
GATCCAGGACATGGGCGCCGCCGGCCTGACCTCGTCTTCGGTCGAGATGGCGGGCAAGGGCGGGGTCGGCATCGACCTGG
ACCTGGATGCCGTGCCGCAGCGCGAACGCGGCATGACGGCGTACGAGATGATGCTCTCGGAAAGCCAGGAGCGCATGCTG
ATCGTCATCCGTCCCGACCGGACGGACGTCGCGCGCGCGATCTTCGAGAAGTGGGAACTGGATTTCGCGGTCATCGGCCA
CCTGACCGAGACCGGCCATATCGTCGTGCGCCACCAGGGCCGCGTCGAGGCCGATATTCCGCTGGACCCGCTGGCGGACC
AGGCGCCGATCTATCGCCGCCCGACCGCCCCCGCGCCCGTCCCGGCGCCGCTGGGCCCGCTGACCGACCCTGTCGGGATC
GAGCAGGCGCTGATCCGGCTGATCGGCTGCCCGGACCTGGCCTCGCGCGCGTGGGTGTGGAACCAGTACGACAGCACGGT
GGGCGGCCAGACCGTCAAGCGCCCCGGCGGGGCCGACGCCGCGATCGTCAAGATCGAGGACACGTCGCTGGGCCTGGCGC
TGACCACCGACTGTACTCCGCGCTATTGCCGCGCCGACGCCCGCCTGGGCGGGGCGCAGGCGGTGGCCGAGGCCTGGCGC
AACATCGTCGCGACCGGCGCGCGCCCCCTGGCGGTGACCGACAACCTCAATTTCGGATCACCCGAGAAGCCCGAGGTCAT
GGGCCAGTTCGTCGCGGCGATCGAGGGGATGGGCGAGGCCTGCCGCGCGCTGGACTTCCCGGTCGTCAGCGGCAACGTCT
CGCTCTACAACGAAACCCGCGCGCCGGACGGGTCCTCGGTCTCGATCCTGCCCACGCCCGCCATCGGCGGCCTGGGGGTG
CTCGAGGACGTGGCGAAGGCCGTCGGGCTGGCGATGCCGGCGGACTGCACCCTGGTCCTGGTCGGCGCCACGCGGGGCGA
GATGGGCCAGTCGCTGTGGCTGCGCGAGATCCATGGCCGCGAGGACGGGCCGCCGCCGGCGCTGGACCTGGCCGCGGAAC
GGCGGAATGGCGATTTCGTCCGCGGGCAGATCCAGGACGGCCATGTCGTGGCCTGTCATGACGTCGCGGATGGCGGCCTG
CTGGTCACGCTGGCCGAGATGGTCATGGCCGGCGATGTCGGCTGCGTCCTGTCGGCGCCGCAATCGGGCATCCGCCCCGA
GGCCTTCTGGTTCGGCGAGGATCAGTCACGATATGTTGTGGCGGTTCGCGATGCCGACGCCTTTACCCTTGCCGCCACGG
GGGCAGGGGTCGAAACGCGGGTGCTGGGCCGGTCGGGCGGCGACGGTTTGACTTTGCCCAGTGGCGCCACAATATCGACA
GCGCGGTTGAATGCAGTCAATTCGGCGTTCTTTCCTGCCTTGATGGACCGCTAG

Upstream 100 bases:

>100_bases
TCTGCGGCATGATGCCGCACCCCGAGGACCTGGTGGACCCGCTGATGGGCGGCGAGGACGGAAAACCCCTGTTCGAGGGG
CTGGTGGAGGCTCTGGTCCG

Downstream 100 bases:

>100_bases
AACTAACGCGCACAGGAGTACTGCCGATGGCGATGACGGCACAGGAAATAGAGACCTATATCCGGACGGCCCTGCCGGAT
GCCTCGATCAGCATAGAGGA

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 737; Mature: 736

Protein sequence:

>737_residues
MSSEKGQRPVDQDLAKEFGLTAEEYGNVLSIMGRTPSLTELGIFSVMWSEHCSYKSSRVWLKTLPTTAPWVIHGPGENAG
VVDIGQGLAAIFKMESHNHPSFIEPYQGAATGVGGILRDVFTMGARPVANLNALRFGSPENPQTRRIVDGVVRGVGGYGN
CVGVPTVGGEINFHPSYDGNPLVNAMTVGIARQDRIFLSAAAGVGNPVIYVGSKTGRDGIHGATMSSSEFDEDALAKRPT
VQVGDPFVEKLLIEACLELMATDAIVAIQDMGAAGLTSSSVEMAGKGGVGIDLDLDAVPQRERGMTAYEMMLSESQERML
IVIRPDRTDVARAIFEKWELDFAVIGHLTETGHIVVRHQGRVEADIPLDPLADQAPIYRRPTAPAPVPAPLGPLTDPVGI
EQALIRLIGCPDLASRAWVWNQYDSTVGGQTVKRPGGADAAIVKIEDTSLGLALTTDCTPRYCRADARLGGAQAVAEAWR
NIVATGARPLAVTDNLNFGSPEKPEVMGQFVAAIEGMGEACRALDFPVVSGNVSLYNETRAPDGSSVSILPTPAIGGLGV
LEDVAKAVGLAMPADCTLVLVGATRGEMGQSLWLREIHGREDGPPPALDLAAERRNGDFVRGQIQDGHVVACHDVADGGL
LVTLAEMVMAGDVGCVLSAPQSGIRPEAFWFGEDQSRYVVAVRDADAFTLAATGAGVETRVLGRSGGDGLTLPSGATIST
ARLNAVNSAFFPALMDR

Sequences:

>Translated_737_residues
MSSEKGQRPVDQDLAKEFGLTAEEYGNVLSIMGRTPSLTELGIFSVMWSEHCSYKSSRVWLKTLPTTAPWVIHGPGENAG
VVDIGQGLAAIFKMESHNHPSFIEPYQGAATGVGGILRDVFTMGARPVANLNALRFGSPENPQTRRIVDGVVRGVGGYGN
CVGVPTVGGEINFHPSYDGNPLVNAMTVGIARQDRIFLSAAAGVGNPVIYVGSKTGRDGIHGATMSSSEFDEDALAKRPT
VQVGDPFVEKLLIEACLELMATDAIVAIQDMGAAGLTSSSVEMAGKGGVGIDLDLDAVPQRERGMTAYEMMLSESQERML
IVIRPDRTDVARAIFEKWELDFAVIGHLTETGHIVVRHQGRVEADIPLDPLADQAPIYRRPTAPAPVPAPLGPLTDPVGI
EQALIRLIGCPDLASRAWVWNQYDSTVGGQTVKRPGGADAAIVKIEDTSLGLALTTDCTPRYCRADARLGGAQAVAEAWR
NIVATGARPLAVTDNLNFGSPEKPEVMGQFVAAIEGMGEACRALDFPVVSGNVSLYNETRAPDGSSVSILPTPAIGGLGV
LEDVAKAVGLAMPADCTLVLVGATRGEMGQSLWLREIHGREDGPPPALDLAAERRNGDFVRGQIQDGHVVACHDVADGGL
LVTLAEMVMAGDVGCVLSAPQSGIRPEAFWFGEDQSRYVVAVRDADAFTLAATGAGVETRVLGRSGGDGLTLPSGATIST
ARLNAVNSAFFPALMDR
>Mature_736_residues
SSEKGQRPVDQDLAKEFGLTAEEYGNVLSIMGRTPSLTELGIFSVMWSEHCSYKSSRVWLKTLPTTAPWVIHGPGENAGV
VDIGQGLAAIFKMESHNHPSFIEPYQGAATGVGGILRDVFTMGARPVANLNALRFGSPENPQTRRIVDGVVRGVGGYGNC
VGVPTVGGEINFHPSYDGNPLVNAMTVGIARQDRIFLSAAAGVGNPVIYVGSKTGRDGIHGATMSSSEFDEDALAKRPTV
QVGDPFVEKLLIEACLELMATDAIVAIQDMGAAGLTSSSVEMAGKGGVGIDLDLDAVPQRERGMTAYEMMLSESQERMLI
VIRPDRTDVARAIFEKWELDFAVIGHLTETGHIVVRHQGRVEADIPLDPLADQAPIYRRPTAPAPVPAPLGPLTDPVGIE
QALIRLIGCPDLASRAWVWNQYDSTVGGQTVKRPGGADAAIVKIEDTSLGLALTTDCTPRYCRADARLGGAQAVAEAWRN
IVATGARPLAVTDNLNFGSPEKPEVMGQFVAAIEGMGEACRALDFPVVSGNVSLYNETRAPDGSSVSILPTPAIGGLGVL
EDVAKAVGLAMPADCTLVLVGATRGEMGQSLWLREIHGREDGPPPALDLAAERRNGDFVRGQIQDGHVVACHDVADGGLL
VTLAEMVMAGDVGCVLSAPQSGIRPEAFWFGEDQSRYVVAVRDADAFTLAATGAGVETRVLGRSGGDGLTLPSGATISTA
RLNAVNSAFFPALMDR

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=646, Percent_Identity=26.0061919504644, Blast_Score=103, Evalue=6e-22,
Organism=Escherichia coli, GI48994899, Length=773, Percent_Identity=26.0025873221216, Blast_Score=158, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17553022, Length=699, Percent_Identity=20.8869814020029, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321498, Length=726, Percent_Identity=23.8292011019284, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24582111, Length=723, Percent_Identity=24.6196403872752, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24582109, Length=723, Percent_Identity=24.6196403872752, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17137292, Length=723, Percent_Identity=24.6196403872752, Blast_Score=94, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 77705; Mature: 77574

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSEKGQRPVDQDLAKEFGLTAEEYGNVLSIMGRTPSLTELGIFSVMWSEHCSYKSSRVW
CCCCCCCCCHHHHHHHHHCCCHHHHCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEE
LKTLPTTAPWVIHGPGENAGVVDIGQGLAAIFKMESHNHPSFIEPYQGAATGVGGILRDV
EEECCCCCCEEEECCCCCCCEEECCCCCEEHHEECCCCCCCCCCCCCCCHHHHHHHHHHH
FTMGARPVANLNALRFGSPENPQTRRIVDGVVRGVGGYGNCVGVPTVGGEINFHPSYDGN
HHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCEEEECCCCCCC
PLVNAMTVGIARQDRIFLSAAAGVGNPVIYVGSKTGRDGIHGATMSSSEFDEDALAKRPT
CCEEEEEEEEECCCEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCC
VQVGDPFVEKLLIEACLELMATDAIVAIQDMGAAGLTSSSVEMAGKGGVGIDLDLDAVPQ
EECCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHCCCCCCCEEEECCCCCCC
RERGMTAYEMMLSESQERMLIVIRPDRTDVARAIFEKWELDFAVIGHLTETGHIVVRHQG
HHCCCHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECC
RVEADIPLDPLADQAPIYRRPTAPAPVPAPLGPLTDPVGIEQALIRLIGCPDLASRAWVW
CEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHCCEEE
NQYDSTVGGQTVKRPGGADAAIVKIEDTSLGLALTTDCTPRYCRADARLGGAQAVAEAWR
CCCCCCCCCCEECCCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHCCCCHHHHHHHHHH
NIVATGARPLAVTDNLNFGSPEKPEVMGQFVAAIEGMGEACRALDFPVVSGNVSLYNETR
HHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEECCC
APDGSSVSILPTPAIGGLGVLEDVAKAVGLAMPADCTLVLVGATRGEMGQSLWLREIHGR
CCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCC
EDGPPPALDLAAERRNGDFVRGQIQDGHVVACHDVADGGLLVTLAEMVMAGDVGCVLSAP
CCCCCCHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECC
QSGIRPEAFWFGEDQSRYVVAVRDADAFTLAATGAGVETRVLGRSGGDGLTLPSGATIST
CCCCCCCEEEECCCCCEEEEEEECCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCEEEH
ARLNAVNSAFFPALMDR
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSEKGQRPVDQDLAKEFGLTAEEYGNVLSIMGRTPSLTELGIFSVMWSEHCSYKSSRVW
CCCCCCCCHHHHHHHHHCCCHHHHCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEE
LKTLPTTAPWVIHGPGENAGVVDIGQGLAAIFKMESHNHPSFIEPYQGAATGVGGILRDV
EEECCCCCCEEEECCCCCCCEEECCCCCEEHHEECCCCCCCCCCCCCCCHHHHHHHHHHH
FTMGARPVANLNALRFGSPENPQTRRIVDGVVRGVGGYGNCVGVPTVGGEINFHPSYDGN
HHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCEEEECCCCCCC
PLVNAMTVGIARQDRIFLSAAAGVGNPVIYVGSKTGRDGIHGATMSSSEFDEDALAKRPT
CCEEEEEEEEECCCEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCC
VQVGDPFVEKLLIEACLELMATDAIVAIQDMGAAGLTSSSVEMAGKGGVGIDLDLDAVPQ
EECCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHCCCCCCCEEEECCCCCCC
RERGMTAYEMMLSESQERMLIVIRPDRTDVARAIFEKWELDFAVIGHLTETGHIVVRHQG
HHCCCHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECC
RVEADIPLDPLADQAPIYRRPTAPAPVPAPLGPLTDPVGIEQALIRLIGCPDLASRAWVW
CEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHCCEEE
NQYDSTVGGQTVKRPGGADAAIVKIEDTSLGLALTTDCTPRYCRADARLGGAQAVAEAWR
CCCCCCCCCCEECCCCCCCEEEEEEECCCCCEEEECCCCHHHHHHHCCCCHHHHHHHHHH
NIVATGARPLAVTDNLNFGSPEKPEVMGQFVAAIEGMGEACRALDFPVVSGNVSLYNETR
HHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEECCC
APDGSSVSILPTPAIGGLGVLEDVAKAVGLAMPADCTLVLVGATRGEMGQSLWLREIHGR
CCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCC
EDGPPPALDLAAERRNGDFVRGQIQDGHVVACHDVADGGLLVTLAEMVMAGDVGCVLSAP
CCCCCCHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECC
QSGIRPEAFWFGEDQSRYVVAVRDADAFTLAATGAGVETRVLGRSGGDGLTLPSGATIST
CCCCCCCEEEECCCCCEEEEEEECCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCEEEH
ARLNAVNSAFFPALMDR
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA