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The map label for this gene is trpC [H]

Identifier: 162147721

GI number: 162147721

Start: 1972060

End: 1972911

Strand: Direct

Name: trpC [H]

Synonym: GDI_1937

Alternate gene names: 162147721

Gene position: 1972060-1972911 (Clockwise)

Preceding gene: 162147720

Following gene: 162147722

Centisome position: 50.0

GC content: 66.31

Gene sequence:

>852_bases
ATGCCGACAAGCCAGGCGCCGATCGATTGCGGTAACACGCCCGGCCAGGACGGGATTCCCGATGTCCTGGCGCGGATTTG
TGCCCGCACCCGCGTGGATGTCGCCCAGCGGGCGACGATCACCCCGCTGAAGGACATCACCGCCCGCGCGCGCGAGGTCG
ACTCTCCCACCCGGGGGTTCGGCCAGGCGCTGAAGCAACGCACGGCGGACCGGCAGATCGGCCTGATCGCGGAGATCAAG
AAGGCATCGCCATCCGCGGGCATCCTGCGCCCGGACTACGATCCGGCCGGCATCGCCGTGCAATATGAAACGGCGGGCGC
CGCCTGTATCTCGGTGCTGACCGAAGGGTCCTGCTTCCACGGCTGCGCCGAGGACCTGCAACGGGTTCGCAAGGCATGCA
GCCTGCCGATCCTGCGCAAGGATTTCATCCTGGACCCGTGGCAGGTCCATGAAAGCCGGCTGATCGGTGCGGACTGCATC
CTGCTGATCCTGGCCGCCCTGACGGATACCGAGGCATCGGAGCTGCTGGACATCGCGCGCGGACTGGACATGGACGTGCT
GGTGGAAGTGCATGACGAGGGCGAACTGAACCGCGCCCTGGCGCTGGATACGTCCCTGATTGGCATTAATAACCGAAATC
TCAAGACCTTGAAGACCGATCTTGAGACAACCATCCAACTGACCCCCCTGGTGCCGCCGGACCGGATCGTGGTGTCGGAG
AGTGGCATCAGCACGCACGCGGACATCGTCCGGCTGAGCGAGATCGGCGCCAGCGGCTTCCTGGTCGGCGAGAGCCTGCT
GCGCCACGATGTCCCCGGCGACGCGGCCCGCGTGCTGCTGGGCACGGTCTGA

Upstream 100 bases:

>100_bases
GCGTGCTGGATGACGGATCGGCCCTGGCCATGCTGAATTCCGCGCGCCGTCGCCACATGGATACGCCGGAGGGGATTACA
CAAAGCTTATGATGAACGAC

Downstream 100 bases:

>100_bases
ACATGGCGACTGCCGGCGGATTGTCTCACCTGGACGCCAACGGCCATGCCGTCATGGTCGATGTGTCCACCAAGCCGGCC
ACGGCGCGGCAGGCCGTCGC

Product: indole-3-glycerol phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MPTSQAPIDCGNTPGQDGIPDVLARICARTRVDVAQRATITPLKDITARAREVDSPTRGFGQALKQRTADRQIGLIAEIK
KASPSAGILRPDYDPAGIAVQYETAGAACISVLTEGSCFHGCAEDLQRVRKACSLPILRKDFILDPWQVHESRLIGADCI
LLILAALTDTEASELLDIARGLDMDVLVEVHDEGELNRALALDTSLIGINNRNLKTLKTDLETTIQLTPLVPPDRIVVSE
SGISTHADIVRLSEIGASGFLVGESLLRHDVPGDAARVLLGTV

Sequences:

>Translated_283_residues
MPTSQAPIDCGNTPGQDGIPDVLARICARTRVDVAQRATITPLKDITARAREVDSPTRGFGQALKQRTADRQIGLIAEIK
KASPSAGILRPDYDPAGIAVQYETAGAACISVLTEGSCFHGCAEDLQRVRKACSLPILRKDFILDPWQVHESRLIGADCI
LLILAALTDTEASELLDIARGLDMDVLVEVHDEGELNRALALDTSLIGINNRNLKTLKTDLETTIQLTPLVPPDRIVVSE
SGISTHADIVRLSEIGASGFLVGESLLRHDVPGDAARVLLGTV
>Mature_282_residues
PTSQAPIDCGNTPGQDGIPDVLARICARTRVDVAQRATITPLKDITARAREVDSPTRGFGQALKQRTADRQIGLIAEIKK
ASPSAGILRPDYDPAGIAVQYETAGAACISVLTEGSCFHGCAEDLQRVRKACSLPILRKDFILDPWQVHESRLIGADCIL
LILAALTDTEASELLDIARGLDMDVLVEVHDEGELNRALALDTSLIGINNRNLKTLKTDLETTIQLTPLVPPDRIVVSES
GISTHADIVRLSEIGASGFLVGESLLRHDVPGDAARVLLGTV

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=262, Percent_Identity=43.1297709923664, Blast_Score=176, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6322638, Length=258, Percent_Identity=36.8217054263566, Blast_Score=159, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 30295; Mature: 30164

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTSQAPIDCGNTPGQDGIPDVLARICARTRVDVAQRATITPLKDITARAREVDSPTRGF
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHH
GQALKQRTADRQIGLIAEIKKASPSAGILRPDYDPAGIAVQYETAGAACISVLTEGSCFH
HHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHCCCHHH
GCAEDLQRVRKACSLPILRKDFILDPWQVHESRLIGADCILLILAALTDTEASELLDIAR
HHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHH
GLDMDVLVEVHDEGELNRALALDTSLIGINNRNLKTLKTDLETTIQLTPLVPPDRIVVSE
CCCEEEEEEECCCCCCCCEEEECCEEEECCCCCHHHHHHCCHHEEEEECCCCCCEEEEEC
SGISTHADIVRLSEIGASGFLVGESLLRHDVPGDAARVLLGTV
CCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHCCC
>Mature Secondary Structure 
PTSQAPIDCGNTPGQDGIPDVLARICARTRVDVAQRATITPLKDITARAREVDSPTRGF
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHH
GQALKQRTADRQIGLIAEIKKASPSAGILRPDYDPAGIAVQYETAGAACISVLTEGSCFH
HHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHCCCHHH
GCAEDLQRVRKACSLPILRKDFILDPWQVHESRLIGADCILLILAALTDTEASELLDIAR
HHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHH
GLDMDVLVEVHDEGELNRALALDTSLIGINNRNLKTLKTDLETTIQLTPLVPPDRIVVSE
CCCEEEEEEECCCCCCCCEEEECCEEEECCCCCHHHHHHCCHHEEEEECCCCCCEEEEEC
SGISTHADIVRLSEIGASGFLVGESLLRHDVPGDAARVLLGTV
CCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA