Click here to switch to the map view.

The map label for this gene is trpE [H]

Identifier: 162147718

GI number: 162147718

Start: 1968628

End: 1970196

Strand: Direct

Name: trpE [H]

Synonym: GDI_1934

Alternate gene names: 162147718

Gene position: 1968628-1970196 (Clockwise)

Preceding gene: 162147717

Following gene: 162147719

Centisome position: 49.91

GC content: 70.87

Gene sequence:

>1569_bases
GTGAGCATCCCCTCCGCCTCCGCCGCCCCGGTTCCGGCCGGGCGCGACGACGTGCTGGCCACGCTCCGGCAGGGACAGGG
CGCGGTGGTCTGGAGCATCGAGGCCGCGGACCTGCTGACCCCGGTCGCCGCCTATATGCGCCTGTCGCGCCTGGCCGGGG
CCAGCGACACGGCGCCCCCGCGCAACGCGTTCCTGCTGGAAAGCGTCGAGGGCGGGGTGGCGCGCGGCCGGTATTCGGTG
ATCGGCCTGCTGCCCGACCTGATCTGGCGCTGCCATGGCGGCGCGGCCACGATCAACACCGACGCGGCGCGGGACCCGGC
CGCGTTCGTGCCGGCCGGGGTGCCGCCGCTGGATTCGCTGCGCGCCGTGATCCGCGCCAGCCAGATGACGTTGCCGTCCG
GCCTGCCGCCCATGGTGGCCGGGCTGTTCGGCTATCTGGGCTATGACATGGTCCGGCAGATGGAGCATCTGCCGGACATG
CCGGCTGACGACCTGGACCTGCCCGAAGGGGTGATGATCCGCCCCGGGCTGTTCGCGATCTTCGATACGGTGCGCGACGA
GCTGATCCTGGCGGCGCCCGTGCGCCCCCGAAGCGACCGCACGCCCGAAGCGGCATGGCAGGCGGCGCAGGACCTGCTGG
CCACGGCGCGGCGCACCCTGTCCGAGCCGCTGCAACTGCACGAGATCACGCCGGATTATACCGGGCCGCTCGAGGCGCCG
CGCTCGACCTTCACGCGTGAGGGTTTCTGCGCCATGGTCCGGCGCATCCAGGACTACATCGCGGCGGGCGATGCCTTCCA
GGTCGTGCCCAGCCAGCGTTTCTCGACCGCCTTCACGCTGCCGCCGCTGGCGCTGTACCGGGCGCTGCGCCGCATCAATC
CGGCGCCGTTCCTGTTCAACCTGGCGTTCGACGGATTCAGCCTGGTGGGCTCGTCGCCCGAAATCCTGGTCCGGCTGCGC
GACGGGCAGATGACGGTGCGCCCGCTGGCCGGCACCCGCCCGCGCGGCCGGACGGACGAGGAGGATCTGGCGCTGGAGCG
GGACCTGCTGGCCGACCCCAAGGAACTGGCCGAGCACCTGATGCTGATCGATCTGGGGCGCAACGATATCGGGCGGGCCT
GTACCGTGGGTTCGGTCCAGGTGACCGAGAAATTCGTCATCGAGCGCTTCAGCCACGTCATGCACATTTCCTCGAACGTC
GAGGGGCAGTTGCGGCCGGGGCTGGAGGCGCTGGATGCCCTGATCGCGGGCTTTCCCGCCGGGACCCTGACCGGCGCGCC
GAAGATCCGTGCGATGGAGATCATCGACGAGGTCGAGCCGACCCGCCGCGCCACCTACGCCGGATGCATCGGCTATTTCG
GGGCGAACGGCGCCATGGATACCTGCATCGGCCTGCGCATGGCCGTGGTCAAGGACGGGCAGATGCACGTGCAGGCCGGC
TGCGGCGTGGTGGCCGACAGCGTGCCCGACCTGGAATACGAGGAAACCCGGCACAAGGCGCGTGCCCTGTTCCGCGCGGC
CGAGGACGCTGTGCAGTTCGCCCGCGGGCAGAACACGGCGGGATCATAA

Upstream 100 bases:

>100_bases
CAACGCTGCAGCAGGCCGTCAAGCCCAAGACCAACATGGGCGCGCTGCAATCCGCCCTGTCGTCGGTGACCGGCAGCCCC
GCCGCCGGAGAATCCAGCCC

Downstream 100 bases:

>100_bases
AATTGCGCCGTTCTTAACGAGTGGCGCAATAAAATCCCCATTTTTGAACGCCAGACATTATTTTGATTAATTTCTGATCT
GTTGTTTGACCGGGCCGAAA

Product: anthranilate synthase component 1

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MSIPSASAAPVPAGRDDVLATLRQGQGAVVWSIEAADLLTPVAAYMRLSRLAGASDTAPPRNAFLLESVEGGVARGRYSV
IGLLPDLIWRCHGGAATINTDAARDPAAFVPAGVPPLDSLRAVIRASQMTLPSGLPPMVAGLFGYLGYDMVRQMEHLPDM
PADDLDLPEGVMIRPGLFAIFDTVRDELILAAPVRPRSDRTPEAAWQAAQDLLATARRTLSEPLQLHEITPDYTGPLEAP
RSTFTREGFCAMVRRIQDYIAAGDAFQVVPSQRFSTAFTLPPLALYRALRRINPAPFLFNLAFDGFSLVGSSPEILVRLR
DGQMTVRPLAGTRPRGRTDEEDLALERDLLADPKELAEHLMLIDLGRNDIGRACTVGSVQVTEKFVIERFSHVMHISSNV
EGQLRPGLEALDALIAGFPAGTLTGAPKIRAMEIIDEVEPTRRATYAGCIGYFGANGAMDTCIGLRMAVVKDGQMHVQAG
CGVVADSVPDLEYEETRHKARALFRAAEDAVQFARGQNTAGS

Sequences:

>Translated_522_residues
MSIPSASAAPVPAGRDDVLATLRQGQGAVVWSIEAADLLTPVAAYMRLSRLAGASDTAPPRNAFLLESVEGGVARGRYSV
IGLLPDLIWRCHGGAATINTDAARDPAAFVPAGVPPLDSLRAVIRASQMTLPSGLPPMVAGLFGYLGYDMVRQMEHLPDM
PADDLDLPEGVMIRPGLFAIFDTVRDELILAAPVRPRSDRTPEAAWQAAQDLLATARRTLSEPLQLHEITPDYTGPLEAP
RSTFTREGFCAMVRRIQDYIAAGDAFQVVPSQRFSTAFTLPPLALYRALRRINPAPFLFNLAFDGFSLVGSSPEILVRLR
DGQMTVRPLAGTRPRGRTDEEDLALERDLLADPKELAEHLMLIDLGRNDIGRACTVGSVQVTEKFVIERFSHVMHISSNV
EGQLRPGLEALDALIAGFPAGTLTGAPKIRAMEIIDEVEPTRRATYAGCIGYFGANGAMDTCIGLRMAVVKDGQMHVQAG
CGVVADSVPDLEYEETRHKARALFRAAEDAVQFARGQNTAGS
>Mature_521_residues
SIPSASAAPVPAGRDDVLATLRQGQGAVVWSIEAADLLTPVAAYMRLSRLAGASDTAPPRNAFLLESVEGGVARGRYSVI
GLLPDLIWRCHGGAATINTDAARDPAAFVPAGVPPLDSLRAVIRASQMTLPSGLPPMVAGLFGYLGYDMVRQMEHLPDMP
ADDLDLPEGVMIRPGLFAIFDTVRDELILAAPVRPRSDRTPEAAWQAAQDLLATARRTLSEPLQLHEITPDYTGPLEAPR
STFTREGFCAMVRRIQDYIAAGDAFQVVPSQRFSTAFTLPPLALYRALRRINPAPFLFNLAFDGFSLVGSSPEILVRLRD
GQMTVRPLAGTRPRGRTDEEDLALERDLLADPKELAEHLMLIDLGRNDIGRACTVGSVQVTEKFVIERFSHVMHISSNVE
GQLRPGLEALDALIAGFPAGTLTGAPKIRAMEIIDEVEPTRRATYAGCIGYFGANGAMDTCIGLRMAVVKDGQMHVQAGC
GVVADSVPDLEYEETRHKARALFRAAEDAVQFARGQNTAGS

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=380, Percent_Identity=41.3157894736842, Blast_Score=245, Evalue=6e-66,
Organism=Escherichia coli, GI1788114, Length=372, Percent_Identity=35.752688172043, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI87082077, Length=280, Percent_Identity=28.9285714285714, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786809, Length=312, Percent_Identity=26.9230769230769, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6320935, Length=472, Percent_Identity=36.6525423728814, Blast_Score=263, Evalue=4e-71,
Organism=Saccharomyces cerevisiae, GI6324361, Length=284, Percent_Identity=25, Blast_Score=94, Evalue=7e-20,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 56260; Mature: 56129

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPSASAAPVPAGRDDVLATLRQGQGAVVWSIEAADLLTPVAAYMRLSRLAGASDTAPP
CCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCC
RNAFLLESVEGGVARGRYSVIGLLPDLIWRCHGGAATINTDAARDPAAFVPAGVPPLDSL
CCCEEHEHHCCCHHCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCHHHH
RAVIRASQMTLPSGLPPMVAGLFGYLGYDMVRQMEHLPDMPADDLDLPEGVMIRPGLFAI
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHHH
FDTVRDELILAAPVRPRSDRTPEAAWQAAQDLLATARRTLSEPLQLHEITPDYTGPLEAP
HHHHHHCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCC
RSTFTREGFCAMVRRIQDYIAAGDAFQVVPSQRFSTAFTLPPLALYRALRRINPAPFLFN
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEE
LAFDGFSLVGSSPEILVRLRDGQMTVRPLAGTRPRGRTDEEDLALERDLLADPKELAEHL
EECCCHHHCCCCCEEEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHH
MLIDLGRNDIGRACTVGSVQVTEKFVIERFSHVMHISSNVEGQLRPGLEALDALIAGFPA
EEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCC
GTLTGAPKIRAMEIIDEVEPTRRATYAGCIGYFGANGAMDTCIGLRMAVVKDGQMHVQAG
CCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEECCCCEEEECC
CGVVADSVPDLEYEETRHKARALFRAAEDAVQFARGQNTAGS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SIPSASAAPVPAGRDDVLATLRQGQGAVVWSIEAADLLTPVAAYMRLSRLAGASDTAPP
CCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCC
RNAFLLESVEGGVARGRYSVIGLLPDLIWRCHGGAATINTDAARDPAAFVPAGVPPLDSL
CCCEEHEHHCCCHHCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCHHHH
RAVIRASQMTLPSGLPPMVAGLFGYLGYDMVRQMEHLPDMPADDLDLPEGVMIRPGLFAI
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHHH
FDTVRDELILAAPVRPRSDRTPEAAWQAAQDLLATARRTLSEPLQLHEITPDYTGPLEAP
HHHHHHCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCC
RSTFTREGFCAMVRRIQDYIAAGDAFQVVPSQRFSTAFTLPPLALYRALRRINPAPFLFN
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEE
LAFDGFSLVGSSPEILVRLRDGQMTVRPLAGTRPRGRTDEEDLALERDLLADPKELAEHL
EECCCHHHCCCCCEEEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHH
MLIDLGRNDIGRACTVGSVQVTEKFVIERFSHVMHISSNVEGQLRPGLEALDALIAGFPA
EEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCC
GTLTGAPKIRAMEIIDEVEPTRRATYAGCIGYFGANGAMDTCIGLRMAVVKDGQMHVQAG
CCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEECCCCEEEECC
CGVVADSVPDLEYEETRHKARALFRAAEDAVQFARGQNTAGS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA