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The map label for this gene is bioF [C]

Identifier: 162147704

GI number: 162147704

Start: 1954473

End: 1955696

Strand: Direct

Name: bioF [C]

Synonym: GDI_1920

Alternate gene names: 162147704

Gene position: 1954473-1955696 (Clockwise)

Preceding gene: 162147701

Following gene: 162147705

Centisome position: 49.55

GC content: 71.41

Gene sequence:

>1224_bases
ATGCGGTCCGGCAGAAAACTTCGCTTCATGACCCGTTTCGATCCCTTTTTCCAGACCGCGCTGGACGACCTGGACCGGCG
TCACCTGAAGCGCGTGCTGTCGCCCGTCGATCGGGACGGACCGGTCATCGTCCGCCGCGATGGCGCAAGCCTGCTGGATT
TCTCGTCCAACGACTATCTCGGCCTGTCCCATCACCCCGCGCTGCGGGCCCGCGCCATCGACTGGACCGAACGCTTCGGC
ATCGGCAGCGGCGCATCCCGCCTCGTCACCGGAACCAGCGAACAGTACCGGCAGGTCGAGGCCAGGCTGGCCCGCTTCAA
GGGCACCGAGGCGGCCCTGCTGCTGGCCTCGGGCTGGCAGGCCAACGCGGCGGTGCTGCCCGCGCTGCTGCGCATTTCGG
CTGCCCAGACCGGCGAACCCGCCCTGGTCTTCACCGACCGGCTGAACCATGCCAGCCTGCATCACGGCTGCCAGGCCGCC
GGCGTGCGGCAGATCCGCTTCGCGCATAACGACCTGGGGCACCTGGAGCATCTGCTGGCCCAGCGGCAGGCGCAGCGCGG
CCTGCGCTTCATCGTGACGGAAAGCGTGTTCAGCATGGACGGCGACCGTGCCGACGTGGCCGGATTGCGGACGCTGGCCG
ACCGGTATGGCGCCTTCCTCTACCTGGACGAAGCCCACGCGACCGGCGTGCTGGGGCCGCAGGGCAGGGGCCTGTCGGCC
GAAGCCGGCGGGGTGGATCTGGCGATGGGCACGTTCAGCAAGGCGCTGGGCGGATTCGGCGCCTATGTCGCGGGATCGCG
CGCCGTCTGCGACTGGCTGGTCAGCACCTGTTCCGGCTTCATCTACACCACGGCGCTGCCGCCCGGGGTGCTGGGGGTAA
TCGACGCGGCACTGGACCTGGTTCCCACGCTGGATGCCGAACGGGCGCATCTGGCCGGCCTGGCCGACCGGATGCGCGCG
GGGGCAGGGGCGCTGGGCTGGTCCACCGGGCCGTCCAGCACGCAGATCGTCCCCGTCATCGTCGGCGCGGCCGATCGGGC
GCTGACCCTGGCGCGGGCGCTGGCGGCGCGGGGCATGCTGGGCACCGCCATCCGGCCGCCGACCGTACCGGCGGGCAGCG
CGCGCATTCGCGTCGCCCTCAGCGCCGCGCATGACGAAACGATGGTCGACCGGCTGCTGTCGGCGCTGGAGGACGCGGCG
CGGGAGCATGGCATTGCCCCCTGA

Upstream 100 bases:

>100_bases
TGCGTGTAGGGCAGCCAGACATGGGGCAGCCCGGCGTCAAACCAGTCCGGTCCGGTCATCGGCGCATCCTTCGAACGAGA
GATGGGAATTGACCGGCCCC

Downstream 100 bases:

>100_bases
GCCCGCCTTCCGTCCCGGCCTGCTGTTTGTCCATGGCTGGGGCTTCACGCCCGATTTCTGGCAACCGGTGCAGGACAGGC
TGGGGCGGCAGGATGCCGTC

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MRSGRKLRFMTRFDPFFQTALDDLDRRHLKRVLSPVDRDGPVIVRRDGASLLDFSSNDYLGLSHHPALRARAIDWTERFG
IGSGASRLVTGTSEQYRQVEARLARFKGTEAALLLASGWQANAAVLPALLRISAAQTGEPALVFTDRLNHASLHHGCQAA
GVRQIRFAHNDLGHLEHLLAQRQAQRGLRFIVTESVFSMDGDRADVAGLRTLADRYGAFLYLDEAHATGVLGPQGRGLSA
EAGGVDLAMGTFSKALGGFGAYVAGSRAVCDWLVSTCSGFIYTTALPPGVLGVIDAALDLVPTLDAERAHLAGLADRMRA
GAGALGWSTGPSSTQIVPVIVGAADRALTLARALAARGMLGTAIRPPTVPAGSARIRVALSAAHDETMVDRLLSALEDAA
REHGIAP

Sequences:

>Translated_407_residues
MRSGRKLRFMTRFDPFFQTALDDLDRRHLKRVLSPVDRDGPVIVRRDGASLLDFSSNDYLGLSHHPALRARAIDWTERFG
IGSGASRLVTGTSEQYRQVEARLARFKGTEAALLLASGWQANAAVLPALLRISAAQTGEPALVFTDRLNHASLHHGCQAA
GVRQIRFAHNDLGHLEHLLAQRQAQRGLRFIVTESVFSMDGDRADVAGLRTLADRYGAFLYLDEAHATGVLGPQGRGLSA
EAGGVDLAMGTFSKALGGFGAYVAGSRAVCDWLVSTCSGFIYTTALPPGVLGVIDAALDLVPTLDAERAHLAGLADRMRA
GAGALGWSTGPSSTQIVPVIVGAADRALTLARALAARGMLGTAIRPPTVPAGSARIRVALSAAHDETMVDRLLSALEDAA
REHGIAP
>Mature_407_residues
MRSGRKLRFMTRFDPFFQTALDDLDRRHLKRVLSPVDRDGPVIVRRDGASLLDFSSNDYLGLSHHPALRARAIDWTERFG
IGSGASRLVTGTSEQYRQVEARLARFKGTEAALLLASGWQANAAVLPALLRISAAQTGEPALVFTDRLNHASLHHGCQAA
GVRQIRFAHNDLGHLEHLLAQRQAQRGLRFIVTESVFSMDGDRADVAGLRTLADRYGAFLYLDEAHATGVLGPQGRGLSA
EAGGVDLAMGTFSKALGGFGAYVAGSRAVCDWLVSTCSGFIYTTALPPGVLGVIDAALDLVPTLDAERAHLAGLADRMRA
GAGALGWSTGPSSTQIVPVIVGAADRALTLARALAARGMLGTAIRPPTVPAGSARIRVALSAAHDETMVDRLLSALEDAA
REHGIAP

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=384, Percent_Identity=37.7604166666667, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI284448556, Length=363, Percent_Identity=37.1900826446281, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI83977440, Length=407, Percent_Identity=31.6953316953317, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI83977442, Length=407, Percent_Identity=31.6953316953317, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI83977444, Length=407, Percent_Identity=31.6953316953317, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI4502025, Length=403, Percent_Identity=31.2655086848635, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI40316939, Length=403, Percent_Identity=31.2655086848635, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI119220554, Length=368, Percent_Identity=29.6195652173913, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI4758668, Length=369, Percent_Identity=28.7262872628726, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI5454084, Length=418, Percent_Identity=26.0765550239234, Blast_Score=119, Evalue=5e-27,
Organism=Escherichia coli, GI1786993, Length=353, Percent_Identity=42.2096317280453, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1790046, Length=402, Percent_Identity=31.8407960199005, Blast_Score=201, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI71994529, Length=367, Percent_Identity=34.3324250681199, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI32566772, Length=378, Percent_Identity=27.5132275132275, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17560912, Length=372, Percent_Identity=26.6129032258064, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17560914, Length=372, Percent_Identity=26.6129032258064, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71982617, Length=309, Percent_Identity=26.2135922330097, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71982625, Length=309, Percent_Identity=26.537216828479, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320438, Length=390, Percent_Identity=33.5897435897436, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6320267, Length=362, Percent_Identity=28.1767955801105, Blast_Score=149, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6323954, Length=309, Percent_Identity=26.537216828479, Blast_Score=106, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24662918, Length=364, Percent_Identity=34.0659340659341, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI17137420, Length=403, Percent_Identity=31.5136476426799, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI17136286, Length=380, Percent_Identity=30.2631578947368, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24653280, Length=269, Percent_Identity=26.3940520446097, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24653276, Length=269, Percent_Identity=26.3940520446097, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24653278, Length=269, Percent_Identity=26.3940520446097, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43221; Mature: 43221

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSGRKLRFMTRFDPFFQTALDDLDRRHLKRVLSPVDRDGPVIVRRDGASLLDFSSNDYL
CCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEECCCCCEE
GLSHHPALRARAIDWTERFGIGSGASRLVTGTSEQYRQVEARLARFKGTEAALLLASGWQ
CCCCCCCHHHHHCCHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCC
ANAAVLPALLRISAAQTGEPALVFTDRLNHASLHHGCQAAGVRQIRFAHNDLGHLEHLLA
CCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHCCHHHCCHHHHHHHHHHHHHHHHHHH
QRQAQRGLRFIVTESVFSMDGDRADVAGLRTLADRYGAFLYLDEAHATGVLGPQGRGLSA
HHHHHCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCC
EAGGVDLAMGTFSKALGGFGAYVAGSRAVCDWLVSTCSGFIYTTALPPGVLGVIDAALDL
CCCCCEEHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHH
VPTLDAERAHLAGLADRMRAGAGALGWSTGPSSTQIVPVIVGAADRALTLARALAARGML
HCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCC
GTAIRPPTVPAGSARIRVALSAAHDETMVDRLLSALEDAAREHGIAP
CCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRSGRKLRFMTRFDPFFQTALDDLDRRHLKRVLSPVDRDGPVIVRRDGASLLDFSSNDYL
CCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEECCCCCEE
GLSHHPALRARAIDWTERFGIGSGASRLVTGTSEQYRQVEARLARFKGTEAALLLASGWQ
CCCCCCCHHHHHCCHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCC
ANAAVLPALLRISAAQTGEPALVFTDRLNHASLHHGCQAAGVRQIRFAHNDLGHLEHLLA
CCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHCCHHHCCHHHHHHHHHHHHHHHHHHH
QRQAQRGLRFIVTESVFSMDGDRADVAGLRTLADRYGAFLYLDEAHATGVLGPQGRGLSA
HHHHHCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCC
EAGGVDLAMGTFSKALGGFGAYVAGSRAVCDWLVSTCSGFIYTTALPPGVLGVIDAALDL
CCCCCEEHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHH
VPTLDAERAHLAGLADRMRAGAGALGWSTGPSSTQIVPVIVGAADRALTLARALAARGML
HCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCC
GTAIRPPTVPAGSARIRVALSAAHDETMVDRLLSALEDAAREHGIAP
CCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA