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The map label for this gene is bioA [H]

Identifier: 162147703

GI number: 162147703

Start: 1953166

End: 1954431

Strand: Reverse

Name: bioA [H]

Synonym: GDI_1919

Alternate gene names: 162147703

Gene position: 1954431-1953166 (Counterclockwise)

Preceding gene: 162147707

Following gene: 162147702

Centisome position: 49.55

GC content: 68.25

Gene sequence:

>1266_bases
ATGACCGGACCGGACTGGTTTGACGCCGGGCTGCCCCATGTCTGGCTGCCCTACACGCAGATGCACACGGCATCGCCCCC
CCTGCCCGCGACGGCTACCGACGGGTGCCGCATCCGTCTGTCGGACGGGCGGGAACTGATCGACGGCATCGCGTCGTGGT
GGACGGCCTGCCATGGCTATAACCACCCCCACATTCGCCAGGCGGCGACCGACCAGCTTGCGCGCATGCCGCATGTCATG
TTCGGCGGCCTGGTGCATGAACCGGCGCTGCGCCTGGCGCGGCGGCTGACCGACCTGCTGCCGGGCGACCTGGAGCGCGT
GTTCTTCTCGGATTCCGGGTCGGTCGCGGTCGAGGTCGCGATGAAGATGGCCGTGCAATACTGGCTGAACCGGGGCCAGT
CCGGACGGACCCGGCTGGTCGCGTTTCGTGGCGGCTATCATGGGGACACGCTGGCGACCATGGCGGTGTGCGATCCGGAA
GAAGGGATGCACAGCCTGTTCGCCGGTGTCCTGCCCCAACATGTCATCACCGACCTGCCGTGCGACGCGGCATCGTGCGC
CGCCCTGGACCATCTGATGGAGACCGAAGGCCAACACGTGGCGGCAATCCTGGTCGAACCGCTGGTCCAGGGCGCGGGCG
GAATGCTCTTCCACGACCCGGCGACCCTGCGCGCGCTGCGCGAGATCGCCGACCGGCACGGGGTGCTGCTGATCCTGGAC
GAAATCTTTACCGGCTTCGGACGAACGGGCAGCCTGTTCGCCTGCCAGCAGGCCGGCATCGTCCCCGACATCATCACGCT
GTCCAAGGCGCTGTCGGGGGGAACGGTCCCGCTGGCCGCGACGGTGGCGCGGCGCCACGTCTTCCAGGCGTTCCTGTCCG
ACGACCCGACGCATGCCCTGATGCACGGGCCCACCTTCATGGCCAACCCGCTGGCCTGTGCCTGCGCCAACGCGTCGCTG
GACCTGTTCGAGCGCGAACCGCGCCTGGAACAGGTTGCCGCCATCGGCGCGCAGATGCGCGACGAACTGGAAGCCTGCCG
CCACCTGCCCGCCGTGCGCGACGTACGAACCATGGGGGCGATCGGCGTGGTGGAACTGGAGCGGATCCGCGACATGAACC
GCCTGAAGGCCCGTCTGGTCGATCAAGGCGTATGGGTGCGGCCATTCCGGACGATCGTCTACCTGACGCCGGCCTTTACC
ATCGCGCCGAAAGAACTGGCGCACCTGACGCAGGCCATTCGGACGGTCCTGTCCGATCCGCCATAG

Upstream 100 bases:

>100_bases
GCGGTCTGGAAAAAGGGATCGAAACGGGTCATGAAGCGAAGTTTTCTGCCGGACCGCATGGGGCCGGTCAATTCCCATCT
CTCGTTCGAAGGATGCGCCG

Downstream 100 bases:

>100_bases
AACGCGCGCCGGATAAACGCCGGCGCGCATTCGTCAGCACATGATCAGGCTTCGGCCGGGGCGAGTTCCACATCCGGCTT
GCCTTTTTCGGCCGGTTCCT

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MTGPDWFDAGLPHVWLPYTQMHTASPPLPATATDGCRIRLSDGRELIDGIASWWTACHGYNHPHIRQAATDQLARMPHVM
FGGLVHEPALRLARRLTDLLPGDLERVFFSDSGSVAVEVAMKMAVQYWLNRGQSGRTRLVAFRGGYHGDTLATMAVCDPE
EGMHSLFAGVLPQHVITDLPCDAASCAALDHLMETEGQHVAAILVEPLVQGAGGMLFHDPATLRALREIADRHGVLLILD
EIFTGFGRTGSLFACQQAGIVPDIITLSKALSGGTVPLAATVARRHVFQAFLSDDPTHALMHGPTFMANPLACACANASL
DLFEREPRLEQVAAIGAQMRDELEACRHLPAVRDVRTMGAIGVVELERIRDMNRLKARLVDQGVWVRPFRTIVYLTPAFT
IAPKELAHLTQAIRTVLSDPP

Sequences:

>Translated_421_residues
MTGPDWFDAGLPHVWLPYTQMHTASPPLPATATDGCRIRLSDGRELIDGIASWWTACHGYNHPHIRQAATDQLARMPHVM
FGGLVHEPALRLARRLTDLLPGDLERVFFSDSGSVAVEVAMKMAVQYWLNRGQSGRTRLVAFRGGYHGDTLATMAVCDPE
EGMHSLFAGVLPQHVITDLPCDAASCAALDHLMETEGQHVAAILVEPLVQGAGGMLFHDPATLRALREIADRHGVLLILD
EIFTGFGRTGSLFACQQAGIVPDIITLSKALSGGTVPLAATVARRHVFQAFLSDDPTHALMHGPTFMANPLACACANASL
DLFEREPRLEQVAAIGAQMRDELEACRHLPAVRDVRTMGAIGVVELERIRDMNRLKARLVDQGVWVRPFRTIVYLTPAFT
IAPKELAHLTQAIRTVLSDPP
>Mature_420_residues
TGPDWFDAGLPHVWLPYTQMHTASPPLPATATDGCRIRLSDGRELIDGIASWWTACHGYNHPHIRQAATDQLARMPHVMF
GGLVHEPALRLARRLTDLLPGDLERVFFSDSGSVAVEVAMKMAVQYWLNRGQSGRTRLVAFRGGYHGDTLATMAVCDPEE
GMHSLFAGVLPQHVITDLPCDAASCAALDHLMETEGQHVAAILVEPLVQGAGGMLFHDPATLRALREIADRHGVLLILDE
IFTGFGRTGSLFACQQAGIVPDIITLSKALSGGTVPLAATVARRHVFQAFLSDDPTHALMHGPTFMANPLACACANASLD
LFEREPRLEQVAAIGAQMRDELEACRHLPAVRDVRTMGAIGVVELERIRDMNRLKARLVDQGVWVRPFRTIVYLTPAFTI
APKELAHLTQAIRTVLSDPP

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=409, Percent_Identity=30.8068459657702, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI13994255, Length=429, Percent_Identity=25.8741258741259, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI284507298, Length=320, Percent_Identity=32.5, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI37574042, Length=362, Percent_Identity=25.414364640884, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI226442709, Length=320, Percent_Identity=26.25, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI24119277, Length=423, Percent_Identity=24.3498817966903, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI226442705, Length=295, Percent_Identity=26.4406779661017, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI1786991, Length=414, Percent_Identity=49.0338164251208, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1789016, Length=368, Percent_Identity=34.7826086956522, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI145693181, Length=334, Percent_Identity=33.5329341317365, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1789759, Length=344, Percent_Identity=34.0116279069767, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI1788044, Length=387, Percent_Identity=31.266149870801, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1787560, Length=350, Percent_Identity=31.4285714285714, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1786349, Length=408, Percent_Identity=28.921568627451, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25144271, Length=408, Percent_Identity=25.4901960784314, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32564660, Length=361, Percent_Identity=27.9778393351801, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=225, Percent_Identity=29.3333333333333, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17541228, Length=358, Percent_Identity=24.0223463687151, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71992977, Length=350, Percent_Identity=24.8571428571429, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324386, Length=459, Percent_Identity=33.7690631808279, Blast_Score=285, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6324432, Length=406, Percent_Identity=27.8325123152709, Blast_Score=123, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6323470, Length=408, Percent_Identity=25.7352941176471, Blast_Score=122, Evalue=9e-29,
Organism=Drosophila melanogaster, GI21357415, Length=404, Percent_Identity=27.970297029703, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI28574759, Length=363, Percent_Identity=28.9256198347107, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI161085790, Length=363, Percent_Identity=28.9256198347107, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21356575, Length=392, Percent_Identity=26.0204081632653, Blast_Score=101, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 45937; Mature: 45805

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGPDWFDAGLPHVWLPYTQMHTASPPLPATATDGCRIRLSDGRELIDGIASWWTACHGY
CCCCCCHHCCCCCEECCHHHHCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCC
NHPHIRQAATDQLARMPHVMFGGLVHEPALRLARRLTDLLPGDLERVFFSDSGSVAVEVA
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCHHHHHH
MKMAVQYWLNRGQSGRTRLVAFRGGYHGDTLATMAVCDPEEGMHSLFAGVLPQHVITDLP
HHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCC
CDAASCAALDHLMETEGQHVAAILVEPLVQGAGGMLFHDPATLRALREIADRHGVLLILD
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHCCEEEEHH
EIFTGFGRTGSLFACQQAGIVPDIITLSKALSGGTVPLAATVARRHVFQAFLSDDPTHAL
HHHHCCCCCCCEEEEHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHH
MHGPTFMANPLACACANASLDLFEREPRLEQVAAIGAQMRDELEACRHLPAVRDVRTMGA
HCCCCHHCCCHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
IGVVELERIRDMNRLKARLVDQGVWVRPFRTIVYLTPAFTIAPKELAHLTQAIRTVLSDP
CHHHHHHHHHHHHHHHHHHHHCCCEECCHHEEEEECCCCEECHHHHHHHHHHHHHHHCCC
P
C
>Mature Secondary Structure 
TGPDWFDAGLPHVWLPYTQMHTASPPLPATATDGCRIRLSDGRELIDGIASWWTACHGY
CCCCCHHCCCCCEECCHHHHCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCC
NHPHIRQAATDQLARMPHVMFGGLVHEPALRLARRLTDLLPGDLERVFFSDSGSVAVEVA
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCHHHHHH
MKMAVQYWLNRGQSGRTRLVAFRGGYHGDTLATMAVCDPEEGMHSLFAGVLPQHVITDLP
HHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCC
CDAASCAALDHLMETEGQHVAAILVEPLVQGAGGMLFHDPATLRALREIADRHGVLLILD
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHCCEEEEHH
EIFTGFGRTGSLFACQQAGIVPDIITLSKALSGGTVPLAATVARRHVFQAFLSDDPTHAL
HHHHCCCCCCCEEEEHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHH
MHGPTFMANPLACACANASLDLFEREPRLEQVAAIGAQMRDELEACRHLPAVRDVRTMGA
HCCCCHHCCCHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
IGVVELERIRDMNRLKARLVDQGVWVRPFRTIVYLTPAFTIAPKELAHLTQAIRTVLSDP
CHHHHHHHHHHHHHHHHHHHHCCCEECCHHEEEEECCCCEECHHHHHHHHHHHHHHHCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8890743 [H]