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The map label for this gene is cat1 [H]

Identifier: 162147620

GI number: 162147620

Start: 1866249

End: 1867769

Strand: Direct

Name: cat1 [H]

Synonym: GDI_1836

Alternate gene names: 162147620

Gene position: 1866249-1867769 (Clockwise)

Preceding gene: 162147613

Following gene: 162147628

Centisome position: 47.32

GC content: 64.63

Gene sequence:

>1521_bases
ATGATCGATCATAACCGAATCCGGAATGCGGCCTTCCGGGCAAAAGTCACGACTGCCGAGGAAGCTGCCTACTACATCCG
TCCCGGTTCCATGGTCGGCATGAGCGGCTTTACCGGTTCGGGCTATCCGAAAGCCGTGCCGCAGGCACTGGCCGCGATCA
TGGAAGCCGAGAAGGCGAAGGGAAATTCGTTCCGCATCCGCCTGTTCACGGGCGCGTCCACCGGTCCGGAACTGGATGGC
GCGCTGGCCAAGGCGGACGGCATCGCGTTCCGCATGCCCTATAATTCCGACGCCACGCTGCGCGGCCGGATCAACAAGGG
CGAAACCGAATATCTGGACATGCATCTGAGCCACGTGGCGCCGATGGTGTGGCAGGGCTTCTTCGGCGAGATGGACACCG
CGGTCATCGAGGCCGTGGCGATCCGCGAGGACGGCACGATCGTCCCGTCCTCGTCCGTCGGCAACAACAAGACGTGGCTG
GAATCGGCACGCCAGGTCATCATCGAGGTCAATAGCTGGCAGGACGCGGCGCTGGAGGGGATGCACGACATCTGGTACGG
CGCGGCCCTGCCGCCCGAGCGCCAGCCCATTCCCCTGCTGCGCCCGGATGACAGGATCGGCCAGGCGACCCTGCGCGTCG
ATCCGTCCAAGGTCGTGGCGGTGGTCGAAACCCATGCGCCGGACCGCAACGCCCCGTTCACGCCGCCCGATGCCTCGGCC
AAGGCCATTGCCGGCCACCTGATGGAATTCTTCCGCCACGAGGTCGCGCGCGGCCGCCTGCCGCAATCGCTGCTGCCGCT
GCAGTCCGGCGTGGGCAATGTAGCCAACGCGGTCATGAGCGGCCTGGAAGAGGGTCCGTTCGAGGACCTGACCGCCTTCA
CCGAAGTGATCCAGGACGGCATGCTGGGCATGCTGGAATCCGGCAAGATGCGCGTCGCGTCGGCCACGGCGTTCTCGCTG
AGCCCCGAGGCCGCGGAATCGCTGAATGCCCGGATGGCCGAATTCCGGTCCAAGATCATCCTGCGGCCGCAGGATATCAG
CAACCATCCCGAACTGATCCGCCGCCTGGGCTGCATCGCGATGAACGGGCTGATCGAATCCGACATCTACGGCAACGTCA
ATTCGACCCAGATCATGGGCTCGCGCATCCAGAACGGCATCGGCGGTTCGGGCGATTTCGCGCGCAACGCCTATATCTCG
GTCTTCATGACGCCTTCGACGGCCAAGGGCGGCAAGATCTCGGCCATCGTGCCGATGGCGTCGCACGTCGATCACATCAC
GCAGGATTCGCAGGTGCTGGTGACGGAACAGGGCCTGGCCGACCTGCGCGGCCTGTCGCCCAAGCAGCGCGCCGAAGTGA
TCATCAAGAACTGCGCGCATCCGGATTACCGTCCGGGGCTGCAGGATTACTTCAAGCGGGCGAAGGAAGGGTCCTACGGC
CTGCAATCGCCGCATCTGCTGACCGAATCGCTGTCCTGGCATCAGCGCTTCATCGAAACCGGCTCGATGCTGCCGACCTG
A

Upstream 100 bases:

>100_bases
GGAAAGAGAAGAGATGGCGTATCGGGATCGGCCTGTGGCGACCGGCCGGTATGAACGAACCCGCGACACAAGATAATGAG
AAGACACGAGGAAAGGTTCC

Downstream 100 bases:

>100_bases
TCGTCTCGGATCGTCACGGAAGGCCGGGCATCGTCCCGGCCTTCTTTTTTCAGACTGTTTCAGCGCGGAACTGACCCGCC
ATCGTCGCGGCGTGGTCCAG

Product: acetyl-CoA hydrolase

Products: propionate; succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MIDHNRIRNAAFRAKVTTAEEAAYYIRPGSMVGMSGFTGSGYPKAVPQALAAIMEAEKAKGNSFRIRLFTGASTGPELDG
ALAKADGIAFRMPYNSDATLRGRINKGETEYLDMHLSHVAPMVWQGFFGEMDTAVIEAVAIREDGTIVPSSSVGNNKTWL
ESARQVIIEVNSWQDAALEGMHDIWYGAALPPERQPIPLLRPDDRIGQATLRVDPSKVVAVVETHAPDRNAPFTPPDASA
KAIAGHLMEFFRHEVARGRLPQSLLPLQSGVGNVANAVMSGLEEGPFEDLTAFTEVIQDGMLGMLESGKMRVASATAFSL
SPEAAESLNARMAEFRSKIILRPQDISNHPELIRRLGCIAMNGLIESDIYGNVNSTQIMGSRIQNGIGGSGDFARNAYIS
VFMTPSTAKGGKISAIVPMASHVDHITQDSQVLVTEQGLADLRGLSPKQRAEVIIKNCAHPDYRPGLQDYFKRAKEGSYG
LQSPHLLTESLSWHQRFIETGSMLPT

Sequences:

>Translated_506_residues
MIDHNRIRNAAFRAKVTTAEEAAYYIRPGSMVGMSGFTGSGYPKAVPQALAAIMEAEKAKGNSFRIRLFTGASTGPELDG
ALAKADGIAFRMPYNSDATLRGRINKGETEYLDMHLSHVAPMVWQGFFGEMDTAVIEAVAIREDGTIVPSSSVGNNKTWL
ESARQVIIEVNSWQDAALEGMHDIWYGAALPPERQPIPLLRPDDRIGQATLRVDPSKVVAVVETHAPDRNAPFTPPDASA
KAIAGHLMEFFRHEVARGRLPQSLLPLQSGVGNVANAVMSGLEEGPFEDLTAFTEVIQDGMLGMLESGKMRVASATAFSL
SPEAAESLNARMAEFRSKIILRPQDISNHPELIRRLGCIAMNGLIESDIYGNVNSTQIMGSRIQNGIGGSGDFARNAYIS
VFMTPSTAKGGKISAIVPMASHVDHITQDSQVLVTEQGLADLRGLSPKQRAEVIIKNCAHPDYRPGLQDYFKRAKEGSYG
LQSPHLLTESLSWHQRFIETGSMLPT
>Mature_506_residues
MIDHNRIRNAAFRAKVTTAEEAAYYIRPGSMVGMSGFTGSGYPKAVPQALAAIMEAEKAKGNSFRIRLFTGASTGPELDG
ALAKADGIAFRMPYNSDATLRGRINKGETEYLDMHLSHVAPMVWQGFFGEMDTAVIEAVAIREDGTIVPSSSVGNNKTWL
ESARQVIIEVNSWQDAALEGMHDIWYGAALPPERQPIPLLRPDDRIGQATLRVDPSKVVAVVETHAPDRNAPFTPPDASA
KAIAGHLMEFFRHEVARGRLPQSLLPLQSGVGNVANAVMSGLEEGPFEDLTAFTEVIQDGMLGMLESGKMRVASATAFSL
SPEAAESLNARMAEFRSKIILRPQDISNHPELIRRLGCIAMNGLIESDIYGNVNSTQIMGSRIQNGIGGSGDFARNAYIS
VFMTPSTAKGGKISAIVPMASHVDHITQDSQVLVTEQGLADLRGLSPKQRAEVIIKNCAHPDYRPGLQDYFKRAKEGSYG
LQSPHLLTESLSWHQRFIETGSMLPT

Specific function: Forms succinyl-CoA from succinate and acetyl-CoA [H]

COG id: COG0427

COG function: function code C; Acetyl-CoA hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetyl-CoA hydrolase/transferase family [H]

Homologues:

Organism=Escherichia coli, GI1789287, Length=488, Percent_Identity=46.7213114754098, Blast_Score=441, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17538151, Length=226, Percent_Identity=29.2035398230088, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319456, Length=513, Percent_Identity=46.0038986354776, Blast_Score=428, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003702
- InterPro:   IPR006472
- InterPro:   IPR017821 [H]

Pfam domain/function: PF02550 AcetylCoA_hydro; PF04223 CitF [H]

EC number: NA

Molecular weight: Translated: 54929; Mature: 54929

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDHNRIRNAAFRAKVTTAEEAAYYIRPGSMVGMSGFTGSGYPKAVPQALAAIMEAEKAK
CCCHHHHHHHHHHEEEEEHHHCEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
GNSFRIRLFTGASTGPELDGALAKADGIAFRMPYNSDATLRGRINKGETEYLDMHLSHVA
CCEEEEEEEECCCCCCCCCCHHHHCCCEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHH
PMVWQGFFGEMDTAVIEAVAIREDGTIVPSSSVGNNKTWLESARQVIIEVNSWQDAALEG
HHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHEEEEEECCCHHHHHHH
MHDIWYGAALPPERQPIPLLRPDDRIGQATLRVDPSKVVAVVETHAPDRNAPFTPPDASA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHEEEEEEECCCCCCCCCCCCCCCH
KAIAGHLMEFFRHEVARGRLPQSLLPLQSGVGNVANAVMSGLEEGPFEDLTAFTEVIQDG
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
MLGMLESGKMRVASATAFSLSPEAAESLNARMAEFRSKIILRPQDISNHPELIRRLGCIA
HHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHH
MNGLIESDIYGNVNSTQIMGSRIQNGIGGSGDFARNAYISVFMTPSTAKGGKISAIVPMA
HHCCHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEECHH
SHVDHITQDSQVLVTEQGLADLRGLSPKQRAEVIIKNCAHPDYRPGLQDYFKRAKEGSYG
HHHHHHCCCCEEEEECCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCC
LQSPHLLTESLSWHQRFIETGSMLPT
CCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIDHNRIRNAAFRAKVTTAEEAAYYIRPGSMVGMSGFTGSGYPKAVPQALAAIMEAEKAK
CCCHHHHHHHHHHEEEEEHHHCEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
GNSFRIRLFTGASTGPELDGALAKADGIAFRMPYNSDATLRGRINKGETEYLDMHLSHVA
CCEEEEEEEECCCCCCCCCCHHHHCCCEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHH
PMVWQGFFGEMDTAVIEAVAIREDGTIVPSSSVGNNKTWLESARQVIIEVNSWQDAALEG
HHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHEEEEEECCCHHHHHHH
MHDIWYGAALPPERQPIPLLRPDDRIGQATLRVDPSKVVAVVETHAPDRNAPFTPPDASA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHEEEEEEECCCCCCCCCCCCCCCH
KAIAGHLMEFFRHEVARGRLPQSLLPLQSGVGNVANAVMSGLEEGPFEDLTAFTEVIQDG
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
MLGMLESGKMRVASATAFSLSPEAAESLNARMAEFRSKIILRPQDISNHPELIRRLGCIA
HHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHH
MNGLIESDIYGNVNSTQIMGSRIQNGIGGSGDFARNAYISVFMTPSTAKGGKISAIVPMA
HHCCHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEECHH
SHVDHITQDSQVLVTEQGLADLRGLSPKQRAEVIIKNCAHPDYRPGLQDYFKRAKEGSYG
HHHHHHCCCCEEEEECCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCC
LQSPHLLTESLSWHQRFIETGSMLPT
CCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: propionyl-CoA; succinate [C]

Specific reaction: propionyl-CoA + succinate = propionate + succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]